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1. 发明授权

US07829657B2 Polycationically charged polymer and the use of the same as a carrier for nucleic acid 有权
标题翻译：聚阳离子电荷的聚合物和其作为核酸的载体的使用
公开(公告)号：US07829657B2
公开(公告)日：2010-11-09
申请号：US11884146
申请日：2006-02-08
申请人： Kazunori Kataoka , Keiji Itaka , Nobuhiro Nishiyama , Shigeto Fukushima , Woo-Dong Jang , Kanjiro Miyata , Masataka Nakanishi , Shunsaku Asano , Naoki Kanayama
发明人： Kazunori Kataoka , Keiji Itaka , Nobuhiro Nishiyama , Shigeto Fukushima , Woo-Dong Jang , Kanjiro Miyata , Masataka Nakanishi , Shunsaku Asano , Naoki Kanayama
IPC分类号： C08G69/08
CPC分类号： A61K48/0041 , A61K47/60 , A61K47/6455 , C08G18/0814 , C08G63/6854 , C08G69/10 , C08G73/028 , C08G73/0293 , C12N15/88
摘要： Disclosed is a composition for the delivery of nucleic acid to target cells or tissues, which comprises a polycationically charged polymer as a carrier of nucleic acid. The polycationically charged polymer is a polymer which may comprise a charged polymer segment having a main chain based on poly(amino acid), polysaccharide, polyester, polyether, polyurethane or vinyl polymer and having, as a side chain, a group of formula —NH—(CH2)a—(NH(CH2)2)e—NH2 (wherein a and e independently denote an integer of 1 to 5) which is connected to the main chain either directly or via a linker. The disclosed composition has low toxicity, and has a high efficiency in introducing nucleic acid into cells.
摘要翻译：公开了用于将核酸递送至靶细胞或组织的组合物，其包含作为核酸载体的聚阳离子带电聚合物。聚阳离子带电聚合物是聚合物，其可以包含具有基于聚（氨基酸），多糖，聚酯，聚醚，聚氨酯或乙烯基聚合物的主链的带电聚合物链段，并且具有作为侧链的式-NH基团 - （CH 2）a - （NH（CH 2）2）e-NH 2（其中a和e独立地表示1至5的整数），其直接或通过连接体与主链连接。所公开的组合物具有低毒性，并且在将核酸引入细胞中具有高效率。

2. 发明申请

US20080249049A1 Polycationically Charged Polymer and the Use of the Same as a Carrier for Nucleic Acid 有权
标题翻译：聚阳离子充电聚合物及其作为核酸载体的用途
公开(公告)号：US20080249049A1
公开(公告)日：2008-10-09
申请号：US11884146
申请日：2006-02-08
申请人： Kazunori Kataoka , Keiji Itaka , Nobuhiro Nishiyama , Shigeto Fukushima , Woo-Dong Jang , Kanjiro Miyata , Masataka Nakanishi , Shunsaku Asano , Naoki Kanayama
发明人： Kazunori Kataoka , Keiji Itaka , Nobuhiro Nishiyama , Shigeto Fukushima , Woo-Dong Jang , Kanjiro Miyata , Masataka Nakanishi , Shunsaku Asano , Naoki Kanayama
IPC分类号： A61K48/00 , C12N5/00 , C08G12/00 , A61P43/00
CPC分类号： A61K48/0041 , A61K47/60 , A61K47/6455 , C08G18/0814 , C08G63/6854 , C08G69/10 , C08G73/028 , C08G73/0293 , C12N15/88
摘要： A composition for the delivery of nucleic acid to target cells or tissues, which comprises polycationically charged polymer as a carrier of nucleic acid is provided. Said polycationically charged polymer is a polymer which may comprise a charged polymer segment having a main chain based on poly(amino acid), polysaccharide, polyester, polyether, polyurethane or vinyl polymer and having, as a side chain, a group of formula —NH—(CH2)a—(NH(CH2)2)e—NH2 (wherein a and e independently denote an integer of 1 to 5) which is connected to said main chain either directly or via a linker. This composition is low-toxic, and has a high efficiency in introducing nucleic acid into cells.
摘要翻译：提供了用于将核酸递送至靶细胞或组织的组合物，其包含作为核酸载体的聚阳离子带电聚合物。所述聚阳离子带电聚合物是聚合物，其可以包含带有聚合物链段，该聚合物链段具有基于聚（氨基酸），多糖，聚酯，聚醚，聚氨酯或乙烯基聚合物的主链，并且具有作为侧链的式-NH - （CH 2）2 - （NH（CH 2）2） - （CH 2）其中a和e独立地表示1〜5的整数），其直接或通过连接体与所述主链连接。该组合物是低毒的，并且在将核酸引入细胞中具有高效率。

3. 发明申请

US20120196810A1 ANIONIC POLYMER, POLYION COMPLEX AND TERNARY POLYMER COMPOSITE USING ANIONIC POLYMER, AND PHARMACEUTICAL COMPOSITION 有权
标题翻译：使用阴离子聚合物和药物组合物的阴离子聚合物，聚合物和季铵盐聚合物复合物
公开(公告)号：US20120196810A1
公开(公告)日：2012-08-02
申请号：US13386554
申请日：2010-07-23
申请人： Kazunori Kataoka , Atsushi Ishii , Hiroyasu Takemoto , Masataka Nakanishi , Nobuhiro Nishiyama , Kanjiro Miyata
发明人： Kazunori Kataoka , Atsushi Ishii , Hiroyasu Takemoto , Masataka Nakanishi , Nobuhiro Nishiyama , Kanjiro Miyata
IPC分类号： A61K38/14 , C07K2/00
CPC分类号： C08L79/02 , C08G69/10 , C08G73/0206 , C08G73/028 , C08L77/04
摘要： There are provided an anionic polymer, a polyion complex, and a ternary polymer composite, each of which is stable in a biological environment and is capable of realizing small RNA delivery without causing any undesired immune response. An anionic polymer according to an embodiment of the invention includes: a main chain which includes repeating units having carboxyl groups; and a side chain which is linked with part of the carboxyl groups in the main chain and is represented by the following formula: -A-B—X where : A represents a residue having one or more aminoethyl bonds; B represents an in vivo cleavable bond; and X represents a small RNA. A polyion complex according to an embodiment of the invention includes the anionic polymer as described above and a cationic polymer. A ternary polymer composite according to an embodiment of the invention includes the polyion complex as described above and a charge conversional polymer.
摘要翻译：提供阴离子聚合物，聚离子络合物和三元聚合物复合材料，其中每一种在生物环境中都是稳定的并且能够实现小的RNA递送而不引起任何不期望的免疫应答。根据本发明实施方案的阴离子聚合物包括：主链，其包含具有羧基的重复单元; 和与主链中部分羧基连接并由下式表示的侧链：-A-B-X其中：A表示具有一个或多个氨基乙基的残基; B代表体内可剪切键; X表示小RNA。根据本发明实施方案的聚离子络合物包括如上所述的阴离子聚合物和阳离子聚合物。根据本发明实施方案的三元聚合物复合物包括如上所述的聚离子络合物和电荷转移聚合物。

4. 发明授权

US08450282B2 Anionic polymer, polyion complex and ternary polymer composite using anionic polymer, and pharmaceutical composition 有权
标题翻译：阴离子聚合物，聚离子络合物和三元聚合物复合材料使用阴离子聚合物，以及药物组成
公开(公告)号：US08450282B2
公开(公告)日：2013-05-28
申请号：US13386554
申请日：2010-07-23
申请人： Kazunori Kataoka , Atsushi Ishii , Hiroyasu Takemoto , Masataka Nakanishi , Nobuhiro Nishiyama , Kanjiro Miyata
发明人： Kazunori Kataoka , Atsushi Ishii , Hiroyasu Takemoto , Masataka Nakanishi , Nobuhiro Nishiyama , Kanjiro Miyata
IPC分类号： A61K38/00 , C07K14/72 , C07K14/705
CPC分类号： C08L79/02 , C08G69/10 , C08G73/0206 , C08G73/028 , C08L77/04
摘要： There are provided an anionic polymer, a polyion complex, and a ternary polymer composite, each of which is stable in a biological environment and is capable of realizing small RNA delivery without causing any undesired immune response. An anionic polymer according to an embodiment of the invention includes: a main chain which includes repeating units having carboxyl groups; and a side chain which is linked with part of the carboxyl groups in the main chain and is represented by the following formula: -A-B—X where: A represents a residue having one or more aminoethyl bonds; B represents an in vivo cleavable bond; and X represents a small RNA. A polyion complex according to an embodiment of the invention includes the anionic polymer as described above and a cationic polymer. A ternary polymer composite according to an embodiment of the invention includes the polyion complex as described above and a charge conversional polymer.
摘要翻译：提供阴离子聚合物，聚离子络合物和三元聚合物复合材料，其中每一种在生物环境中都是稳定的并且能够实现小的RNA递送而不引起任何不期望的免疫应答。根据本发明实施方案的阴离子聚合物包括：主链，其包含具有羧基的重复单元; 和与主链中部分羧基连接并由下式表示的侧链：-A-B-X其中：A表示具有一个或多个氨基乙基的残基; B代表体内可剪切键; X表示小RNA。根据本发明实施方案的聚离子络合物包括如上所述的阴离子聚合物和阳离子聚合物。根据本发明实施方案的三元聚合物复合物包括如上所述的聚离子络合物和电荷转移聚合物。

5. 发明申请

US20130323994A1 Epoxy Resin Composition For Transparent Sheets And Cured Product Thereof 有权
标题翻译：环氧树脂组合物透明片及其固化产品
公开(公告)号：US20130323994A1
公开(公告)日：2013-12-05
申请号：US13878564
申请日：2011-11-15
申请人： Noriko Kiyoyanagi , Masataka Nakanishi , Yoshihiro Kawata , Junko Ichikawa , Toru Kurihashi
发明人： Noriko Kiyoyanagi , Masataka Nakanishi , Yoshihiro Kawata , Junko Ichikawa , Toru Kurihashi
IPC分类号： C08K5/12 , D06M15/55
CPC分类号： C08G59/4215 , C03C17/326 , C08G59/4246 , C08K5/12 , C08L63/00 , C08L67/02 , C08L2201/08 , C08L2201/10 , C08L2205/025 , C09D163/00 , D06M15/55 , G02B1/04 , G02B1/14 , Y10T442/2951
摘要： To provide an epoxy resin composition that is suitable for producing optical sheets which exhibit excellent transparency, heat resistance, strength, smoothness and light resistance, and a cured product thereof.An epoxy resin composition for optical3 sheets, the composition comprising a polyvalent carboxylic acid (A) represented by formula (I): (wherein, R1's each independently represent a hydrogen atom, an alkyl group having 1 to 15 carbon atoms, or a carboxyl group; q represents the number of substituent R1's, and represents an integer from 1 to 4; and P represents any one of the following x, y and z): (wherein, there may be a plural number of R2's per ring, and R2's each independently represent a hydrogen atom or a methyl group; and * represents a bonding site linked to the oxygen atom; y. A linear alkylene linker having 6 to 20 carbon atoms, with a main chain having 3 or more carbon atoms and being substituted with an alkyl group in at least one site); (wherein, R's each independently represent a hydrogen atom, an alkyl group having 1 to 15 carbon atoms, or a carboxyl group; and * represents a bonding site linked to the oxygen atom, and an epoxy resin (B) having an aliphatic cyclic structure in the molecule).
摘要翻译：提供一种适用于制造透明性，耐热性，强度，光滑性，耐光性优异的光学片的环氧树脂组合物及其固化物。用于光学3片的环氧树脂组合物，该组合物包含由式（I）表示的多价羧酸（A）：（其中，R 1各自独立地表示氢原子，具有1至15个碳原子的烷基或羧基 ; q表示取代基R 1的数，表示1〜4的整数，P表示以下x，y，z中的任一个：（其中，每个环可以有多个R 2，独立地表示氢原子或甲基; *表示与氧原子连接的键合位置; y。具有6〜20个碳原子的直链亚烷基连接体，具有3个以上碳原子的主链，并被至少一个位点的烷基）; （其中，R 3各自独立地表示氢原子，碳原子数1〜15的烷基或羧基; *表示与氧原子连接的键合位置，具有脂肪族环状结构的环氧树脂（B）在分子中）。

6. 发明申请

US20130078514A1 CONDENSED POLYCYCLIC AROMATIC COMPOUND, PRODUCTION PROCESS OF SAME, AND POSITIVE ELECTRODE ACTIVE MATERIAL FOR LITHIUM ION SECONDARY BATTERY CONTAINING SAME 有权
标题翻译：稠合多环芳香族化合物，其生产方法和用于含有其的锂离子二次电池的正极电极活性材料
公开(公告)号：US20130078514A1
公开(公告)日：2013-03-28
申请号：US13701544
申请日：2011-05-26
申请人： Osamu Ohmori , Akiko Shima , Hitotoshi Murase , Masataka Nakanishi , Junichi Niwa , Kimihisa Yamamoto
发明人： Osamu Ohmori , Akiko Shima , Hitotoshi Murase , Masataka Nakanishi , Junichi Niwa , Kimihisa Yamamoto
IPC分类号： H01M4/60
CPC分类号： H01M4/606 , C07C251/22 , H01M4/60 , H01M4/608 , H01M10/052 , H01M2004/028 , Y02E60/122 , Y02P70/54
摘要： Provided is a condensed polycyclic aromatic compound, having superior lithium ion responsivity and is suitable for lithium ion secondary battery applications, a production process thereof, a positive electrode active material containing that condensed polycyclic aromatic compound, and a positive electrode for a lithium ion secondary battery provided therewith, and further provided is a lithium ion secondary battery, having high capacity and superior cycling adaptability, that has the positive electrode as a constituent thereof.The condensed polycyclic aromatic compound according to the present invention has at least four imino groups in a molecule thereof.
摘要翻译：提供了具有优异的锂离子响应性并且适合于锂离子二次电池应用的缩合多环芳香族化合物，其制造方法，含有缩合多环芳香族化合物的正极活性物质和锂离子二次电池用正极并且还提供具有高容量和优异的循环适应性的锂离子二次电池，其具有正极作为其组成。根据本发明的缩合多环芳族化合物在其分子中具有至少四个亚氨基。

7. 发明申请

US20100179353A1 Modified Liquid Epoxy Resin as Well as Epoxy Resin Composition Using the Same and Cured Product Thereof 有权
标题翻译：改性液体环氧树脂以及使用其的环氧树脂组合物及其固化产物
公开(公告)号：US20100179353A1
公开(公告)日：2010-07-15
申请号：US12377831
申请日：2007-08-14
申请人： Masataka Nakanishi , Katsuhiko Oshimi , Takao Sunaga
发明人： Masataka Nakanishi , Katsuhiko Oshimi , Takao Sunaga
IPC分类号： C07C43/03
CPC分类号： C08G59/063
摘要： This invention provides a modified liquid epoxy resin having a low viscosity and a high performance, which is obtained by reacting a mixture of a bisphenol and a phenol aralkyl resin with an epiholohydrin. The bisphenol is preferable to be bisphenol F and is further preferable to have a bifunctional form purity as detected by gel permeation chromatography at UV 254 nm of not less than 95% by area in view of the fluidity. Moreover, the mixture of bisphenol and the phenol aralkyl resin is preferable to have a ratio of the phenol aralkyl resin of 10-70% by mass.
摘要翻译：本发明提供一种具有低粘度和高性能的改性液体环氧树脂，其通过使双酚和苯酚芳烷基树脂的混合物与外露醇反应而获得。考虑到流动性，双酚优选为双酚F，并且进一步优选具有通过凝胶渗透色谱法在UV 254nm下检测不超过95％面积的双官能形式纯度。此外，双酚和苯酚芳烷基树脂的混合物的苯酚芳烷基树脂的比例优选为10-70质量％。

8. 发明申请

US20140050974A1 SODIUM SECONDARY BATTERY 审中-公开
标题翻译：钠二次电池
公开(公告)号：US20140050974A1
公开(公告)日：2014-02-20
申请号：US14114099
申请日：2012-01-12
申请人： Takuhiro Miyuki , Toshikatsu Kojima , Yasue Okuyama , Tetsuo Sakai , Masataka Nakanishi , Junichi Niwa , Kazuhito Kawasumi , Satoshi Nakagawa , Akira Kojima
发明人： Takuhiro Miyuki , Toshikatsu Kojima , Yasue Okuyama , Tetsuo Sakai , Masataka Nakanishi , Junichi Niwa , Kazuhito Kawasumi , Satoshi Nakagawa , Akira Kojima
IPC分类号： H01M4/583
CPC分类号： H01M4/583 , H01M4/136 , H01M4/38 , H01M4/62 , H01M4/625 , H01M10/054
摘要： Because of being equipped with a positive electrode, a negative electrode and a sodium-ion nonaqueous electrolyte, and because the positive electrode includes a sulfur-based positive-electrode active material containing carbon (C) and sulfur (S), it is possible to inhibit sulfur from eluting out into electrolytic solution, thereby resulting in a sodium secondary battery that makes it feasible to undergo charging and discharging for 100 cycles or more reversibly.
摘要翻译：由于配置有正极，负极和钠离子非水电解质，并且由于正极包含含有碳（C）和硫（S）的硫系正极活性物质，因此，抑制硫析出到电解液中，从而得到可以进行100次循环或更多次充放电的钠二次电池。

9. 发明授权

US07884172B2 Tetraglycidyl ether of 1,1,2,2-tetrakis(hydroxyphenyl)ethane 有权
标题翻译： 1,1,2,2-四（羟基苯基）乙烷的四缩水甘油醚
公开(公告)号：US07884172B2
公开(公告)日：2011-02-08
申请号：US12083284
申请日：2006-10-10
申请人： Masataka Nakanishi , Katsuhiko Oshimi , Ryutaro Tanaka , Toru Kurihashi
发明人： Masataka Nakanishi , Katsuhiko Oshimi , Ryutaro Tanaka , Toru Kurihashi
IPC分类号： C08G59/06 , C08L63/00
CPC分类号： C08G59/32 , C08G59/42
摘要： To provide an epoxy resin giving a cured object having high heat resistance, which is improved in impact resistance and moisture resistance as compared with conventional high-heat-resistance epoxy resins.The epoxy resin is obtained by glycidylating one or more phenol compounds comprising 95% or more 1,1,2,2-tetrakis (hydroxyphenyl)ethane, and is characterized in that in an examination by gel permeation chromatography, the epoxy resin has a tetranucleus-form content of 50 to 90% by area and an octanucleus-form content of at least 5% by area and has a total chlorine content of 5,000 ppm or smaller.
摘要翻译：为了提供具有高耐热性的固化物的环氧树脂，与常规的高耐热性环氧树脂相比，其耐冲击性和耐湿性得到改善。环氧树脂通过将一种或多种包含95％或更多的1,1,2,2-四（羟基苯基）乙烷的酚化合物缩水甘油化而获得，其特征在于在通过凝胶渗透色谱法的检查中，环氧树脂具有四核形式的含量为50〜90％的面积，8个核形式的含量为5面积％以上，总氯含量为5000ppm以下。

10. 发明申请

US20090117388A1 Epoxy Resin, Curable Resin Composition and Cured Product Thereof 失效
标题翻译：环氧树脂，可固化树脂组合物及其固化产物
公开(公告)号：US20090117388A1
公开(公告)日：2009-05-07
申请号：US12083030
申请日：2006-10-16
申请人： Masataka Nakanishi , Katsuhiko Oshimi , Kazuyuki Ohhashi , Toru Kurihashi
发明人： Masataka Nakanishi , Katsuhiko Oshimi , Kazuyuki Ohhashi , Toru Kurihashi
IPC分类号： B32B27/38 , C08G65/38 , C08L71/02 , C08L75/04 , C08K9/00
CPC分类号： C08G59/245 , B32B5/26 , B32B15/08 , B32B2260/023 , B32B2260/046 , B32B2262/0261 , B32B2262/0276 , B32B2262/10 , B32B2262/101 , B32B2262/106 , B32B2307/206 , B32B2307/306 , B32B2307/50 , B32B2307/546 , B32B2307/718 , B32B2457/04 , B32B2457/08 , C08J5/24 , C08J2363/00 , Y10T428/31511
摘要： Disclosed is a phenol aralkyl epoxy resin having a structure wherein at least a phenol or a naphthol is bound by using an aralkyl group as a linking group and a structure represented by formula (1) below, while satisfying the condition 1 below. This epoxy resin is excellent in workability during production of a composition and is easy to control quality. Condition 1: The following relation (α) is satisfied with A being the hydroxyl equivalent (as measured in accordance with JIS K 0070) of a phenol-modified epoxy resin obtained by adding an equivalent molar amount of phenol relative to the epoxy equivalent of the epoxy resin, and B being the epoxy equivalent of the epoxy resin. 50≦1000×(A−B)/B≦250 (α)
摘要翻译：公开了一种苯酚芳烷基环氧树脂，其具有以下结构，其中在满足下述条件1的同时，通过使用芳烷基作为连接基团和式（1）表示的结构，至少使苯酚或萘酚结合。该环氧树脂在组合物的制造中的加工性优异，容易控制质量。条件1：通过将等摩尔量的苯酚相对于环氧当量添加而得到的苯酚改性环氧树脂的羟基当量（按照JIS K 0070测定）满足下列关系式（α）：环氧树脂，B为环氧树脂的环氧当量。 50 <= 1000x（A-B）/ B <= 250（α）

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