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1. 发明申请

US20090175825A1 INTERFERON ALPHA AND ANTISENSE K-RAS RNA COMBINATION GENE THERAPY 审中-公开
标题翻译：干扰素和抗原K-RAS RNA组合基因治疗
公开(公告)号：US20090175825A1
公开(公告)日：2009-07-09
申请号：US12390091
申请日：2009-02-20
申请人： Kazunori AOKI , Teruhiko Yoshida
发明人： Kazunori AOKI , Teruhiko Yoshida
IPC分类号： A61K38/21 , A61P35/00
CPC分类号： C12N15/1135 , A61K48/005 , C12N2310/11 , C12N2310/111 , C12N2320/31
摘要： An antiproliferative effect of IFN-α gene transduction in pancreatic cancer cells. The invention relates to expression of IFN-α to effectively induce growth suppression and cell death in pancreatic cancer cells, an effect which appeared to be more prominent when compared with other types of cancers and normal cells. Another aspect of the invention relates to targeting the characteristic genetic aberration, K-ras point mutation, in pancreatic cancer, and that the expression of antisense K-ras RNA significantly suppresses the growth of pancreatic cancer cells. When these two gene therapy strategies are combined, the expression of antisense K-ras RNA significantly enhanced IFN-α-induced cell death (1.3-3.5 fold), and suppressed subcutaneous growth of pancreatic cancer cells in mice. The invention also relates to a method of suppressing pancreatic cancer cells using double strand RNA formed by antisense and endogeneous K-ras RNA in combination with the anti-tumor activity of IFN-α. The invention relates to the combination of IFN-α and antisense K-ras RNA as an effective gene therapy strategy against pancreatic cancer. The invention also relates to a method of treating pancreatic cancer cells disseminated throughout the body by administering the inventive combination to localized pancreatic cancer cell tumor. The invention also relates to inducing indirect immunological antitumor activity to provide systemic immunity against pancreatic cancer cells.
摘要翻译： IFN-α基因转导在胰腺癌细胞中的抗增殖作用。本发明涉及IFN-α的表达，以有效诱导胰腺癌细胞的生长抑制和细胞死亡，与其他类型的癌症和正常细胞相比，这种作用似乎更加突出。本发明的另一方面涉及靶向胰腺癌中的特征性遗传差异K-ras点突变，反义K-ras RNA的表达显着抑制胰腺癌细胞的生长。当这两种基因治疗策略相结合时，反义K-ras RNA的表达显着增强了IFN-α诱导的细胞死亡（1.3-3.5倍），并抑制了小鼠胰腺癌细胞的皮下生长。本发明还涉及使用由反义和内源K-ras RNA形成的双链RNA与IFN-α的抗肿瘤活性组合来抑制胰腺癌细胞的方法。本发明涉及IFN-α和反义K-ras RNA的组合，作为对胰腺癌的有效基因治疗策略。本发明还涉及通过将本发明组合施用于局部胰腺癌细胞肿瘤来治疗遍及全身的胰腺癌细胞的方法。本发明还涉及诱导间接免疫抗肿瘤活性以提供对胰腺癌细胞的全身免疫。

2. 发明申请

US20090074727A1 METHOD OF TREATING SOLID TUMOR 失效
标题翻译：治疗固体肿瘤的方法
公开(公告)号：US20090074727A1
公开(公告)日：2009-03-19
申请号：US11857667
申请日：2007-09-19
申请人： Kazunori AOKI , Teruhiko YOSHIDA
发明人： Kazunori AOKI , Teruhiko YOSHIDA
IPC分类号： A61K31/70 , A61K35/00 , A61P43/00
CPC分类号： A61K38/212 , A61K31/70 , A61K35/26
摘要： The present invention provides a method of immune/gene combination therapy that has an effect of suppressing growth of an intractable solid tumor and is useful for treatment of such a tumor, and a therapeutic composition used for said method.
摘要翻译：本发明提供了具有抑制难治性实体瘤生长的作用的免疫/基因组合疗法的方法，可用于治疗这种肿瘤，以及用于该方法的治疗组合物。

3. 发明申请

US20120283031A1 PROPELLER SHAFT 有权
标题翻译：螺旋桨轴
公开(公告)号：US20120283031A1
公开(公告)日：2012-11-08
申请号：US13551330
申请日：2012-07-17
申请人： Tomoki OGAWA , Satoshi ARAKI , Yukinobu NISHIYAMA , Yoshinori SATOU , Kazunori AOKI
发明人： Tomoki OGAWA , Satoshi ARAKI , Yukinobu NISHIYAMA , Yoshinori SATOU , Kazunori AOKI
IPC分类号： F16D3/06 , B23P11/00 , B32B37/00 , C23C16/00 , B23K20/12
CPC分类号： F16C3/023 , F16C3/03 , F16C2206/04 , F16C2326/06 , Y10T29/49945 , Y10T156/10
摘要： A propeller shaft includes a first shaft having a yoke at one end, a second shaft slidably connected to the other end of the first shaft, and a surface treated member which is arranged at a connecting portion, at which the first shaft and the second shaft are connected to each other, and to which surface treatment for improving slidability of the second shaft with respect to the first shaft is applied. The surface treated member is formed by a substrate which is separate from the first shaft and the second shaft and to which the surface treatment has been applied. The surface treated member is arranged at the connecting portion, at which the first shaft and the second shaft are connected to each other, after the surface treatment is applied.
摘要翻译：传动轴包括：一端具有轭的第一轴，与第一轴的另一端可滑动连接的第二轴;以及布置在连接部分处的第一轴和第二轴的表面处理部件彼此连接，并且施加用于改善第二轴相对于第一轴的滑动性的表面处理。表面处理部件由与第一轴和第二轴分离并且已经施加表面处理的基板形成。在施加表面处理之后，表面处理部件布置在第一轴和第二轴彼此连接的连接部分处。

4. 发明申请

US20110143845A1 PROPELLER SHAFT 有权
标题翻译：螺旋桨轴
公开(公告)号：US20110143845A1
公开(公告)日：2011-06-16
申请号：US12959660
申请日：2010-12-03
申请人： Tomoki OGAWA , Satoshi ARAKI , Yukinobu NISHIYAMA , Yoshinori SATOU , Kazunori AOKI
发明人： Tomoki OGAWA , Satoshi ARAKI , Yukinobu NISHIYAMA , Yoshinori SATOU , Kazunori AOKI
IPC分类号： F16C3/02
CPC分类号： F16C3/023 , F16C3/03 , F16C2206/04 , F16C2326/06 , Y10T29/49945 , Y10T156/10
摘要： A propeller shaft includes a first shaft having a yoke at one end, a second shaft slidably connected to the other end of the first shaft, and a surface treated member which is arranged at a connecting portion, at which the first shaft and the second shaft are connected to each other, and to which surface treatment for improving slidability of the second shaft with respect to the first shaft is applied. The surface treated member is formed by a substrate which is separate from the first shaft and the second shaft and to which the surface treatment has been applied. The surface treated member is arranged at the connecting portion, at which the first shaft and the second shaft are connected to each other, after the surface treatment is applied.
摘要翻译：传动轴包括：一端具有轭的第一轴，与第一轴的另一端可滑动连接的第二轴;以及布置在连接部分处的第一轴和第二轴的表面处理部件彼此连接，并且施加用于改善第二轴相对于第一轴的滑动性的表面处理。表面处理部件由与第一轴和第二轴分离并且已经施加表面处理的基板形成。在施加表面处理之后，表面处理部件布置在第一轴和第二轴彼此连接的连接部分处。

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