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1. 发明授权

US07763462B2 BDNF facilitation of oocyte, zygote and pre-implantation embryo maturation 有权
标题翻译： BDNF促进卵母细胞，合子和植入前胚胎成熟
公开(公告)号：US07763462B2
公开(公告)日：2010-07-27
申请号：US11762606
申请日：2007-06-13
申请人： Kazuhiro Kawamura , Aaron J. W. Hsueh , Sabine M. Mulders
发明人： Kazuhiro Kawamura , Aaron J. W. Hsueh , Sabine M. Mulders
IPC分类号： C12N5/00 , A61B17/43
CPC分类号： C12N5/0609 , C12N2501/13 , C12N2517/10
摘要： Compositions and methods are provided for enhancing the survival and promoting the maturation of mammalian oocytes, zygotes and preimplantation embryos. BDNF or BDNF agonists may be administered to an individual, or to cells in vitro, to enhance cellular maturation, embryo growth and fertilization. Accordingly, compositions comprising BDNF are herein presented for use in promoting in vivo oocyte maturation as well as for use as a component in culture media for promoting preimplantation maturation of zygotes and embryos, for instance, for use with in vitro fertilization procedures and for the production of stem cells. Additionally, compounds that interfere with the binding of BDNF to its receptor may be administered to an individual to prevent oocyte maturation, thereby acting as a contraceptive. The BNDF receptor, TrkB, and BDNF also find use in the screening and design of agonists and antagonists for use in the methods of the invention.
摘要翻译：提供组合物和方法用于增强哺乳动物卵母细胞，合子和植入前胚胎的存活和促进成熟。 BDNF或BDNF激动剂可以在体外施用于个体或细胞，以增强细胞成熟，胚胎生长和受精。因此，本文提供了包含BDNF的组合物用于促进体内卵母细胞成熟以及用作培养基中的组分，用于促进受精卵和胚胎的植入前成熟，例如用于体外受精程序和用于生产的干细胞。此外，干扰BDNF与其受体的结合的化合物可以施用于个体以防止卵母细胞成熟，从而起避孕作用。 BNDF受体，TrkB和BDNF也用于筛选和设计用于本发明方法的激动剂和拮抗剂。

2. 发明授权

US08445281B2 In vitro exposure of immature oocytes to BDNF enhances generation of embryonic stem cells 有权
标题翻译：未成熟卵母细胞体外暴露于BDNF可增强胚胎干细胞的产生
公开(公告)号：US08445281B2
公开(公告)日：2013-05-21
申请号：US12818055
申请日：2010-06-17
申请人： Kazuhiro Kawamura , Aaron J. W. Hsueh , Sabine M. Mulders
发明人： Kazuhiro Kawamura , Aaron J. W. Hsueh , Sabine M. Mulders
IPC分类号： C12N15/00
CPC分类号： C12N5/0609 , C12N2501/13 , C12N2517/10
摘要： Compositions and methods are provided for enhancing the survival and promoting the maturation of mammalian oocytes, zygotes and preimplantation embryos. BDNF or BDNF agonists may be administered to an individual, or to cells in vitro, to enhance cellular maturation, embryo growth and fertilization. Accordingly, compositions comprising BDNF are herein presented for use in promoting in vivo oocyte maturation as well as for use as a component in culture media for promoting preimplantation maturation of zygotes and embryos, for instance, for use with in vitro fertilization procedures and for the production of stem cells. Additionally, compounds that interfere with the binding of BDNF to its receptor may be administered to an individual to prevent oocyte maturation, thereby acting as a contraceptive. The BNDF receptor, TrkB, and BDNF also find use in the screening and design of agonists and antagonists for use in the methods of the invention.
摘要翻译：提供组合物和方法用于增强哺乳动物卵母细胞，合子和植入前胚胎的存活和促进成熟。 BDNF或BDNF激动剂可以在体外施用于个体或细胞，以增强细胞成熟，胚胎生长和受精。因此，本文提供了包含BDNF的组合物用于促进体内卵母细胞成熟以及用作培养基中的组分，用于促进受精卵和胚胎的植入前成熟，例如用于体外受精程序和用于生产的干细胞。此外，干扰BDNF与其受体的结合的化合物可以施用于个体以防止卵母细胞成熟，从而起避孕作用。 BNDF受体，TrkB和BDNF也用于筛选和设计用于本发明方法的激动剂和拮抗剂。

3. 发明申请

US20110052599A1 Facilitation of Oocyte, Zygote and Pre-Implantation Embryo Maturation 有权
标题翻译：促进卵母细胞，合子和植入胚胎成熟
公开(公告)号：US20110052599A1
公开(公告)日：2011-03-03
申请号：US12818055
申请日：2010-06-17
申请人： Kazuhiro Kawamura , Aaron J.W. Hsueh , Sabine M. Mulders
发明人： Kazuhiro Kawamura , Aaron J.W. Hsueh , Sabine M. Mulders
IPC分类号： A61K39/395 , C12N5/075 , A61K38/18 , A61K31/55 , A61K31/7052 , C12Q1/02 , A61P15/08 , A61B17/43
CPC分类号： C12N5/0609 , C12N2501/13 , C12N2517/10
摘要： Compositions and methods are provided for enhancing the survival and promoting the maturation of mammalian oocytes, zygotes and preimplantation embryos. BDNF or BDNF agonists may be administered to an individual, or to cells in vitro, to enhance cellular maturation, embryo growth and fertilization. Accordingly, compositions comprising BDNF are herein presented for use in promoting in vivo oocyte maturation as well as for use as a component in culture media for promoting preimplantation maturation of zygotes and embryos, for instance, for use with in vitro fertilization procedures and for the production of stem cells. Additionally, compounds that interfere with the binding of BDNF to its receptor may be administered to an individual to prevent oocyte maturation, thereby acting as a contraceptive. The BNDF receptor, TrkB, and BDNF also find use in the screening and design of agonists and antagonists for use in the methods of the invention.
摘要翻译：提供组合物和方法用于增强哺乳动物卵母细胞，合子和植入前胚胎的存活和促进成熟。 BDNF或BDNF激动剂可以在体外施用于个体或细胞，以增强细胞成熟，胚胎生长和受精。因此，本文提供了包含BDNF的组合物用于促进体内卵母细胞成熟以及用作培养基中的组分，用于促进受精卵和胚胎的植入前成熟，例如用于体外受精程序和用于生产的干细胞。此外，干扰BDNF与其受体的结合的化合物可以施用于个体以防止卵母细胞成熟，从而起避孕作用。 BNDF受体，TrkB和BDNF也用于筛选和设计用于本发明方法的激动剂和拮抗剂。

4. 发明授权

US5530174A Method of vitrifying high-level radioactive liquid waste 失效
标题翻译：玻璃化高放射性废液的方法
公开(公告)号：US5530174A
公开(公告)日：1996-06-25
申请号：US520786
申请日：1995-08-30
申请人： Kazuhiro Kawamura , Masayuki Yoneya , Kenichi Sasage
发明人： Kazuhiro Kawamura , Masayuki Yoneya , Kenichi Sasage
IPC分类号： G21F9/16 , G21F9/30 , G21F9/00
CPC分类号： G21F9/305
摘要： A method of vitrifying a high-level radioactive liquid waste comprising removing a precipitate composed mainly of Mo and Zr from the high-level liquid waste, mixing the resulting high-level liquid waste with a raw glass material having a chemical composition wherein the B.sub.2 O.sub.3 /SiO.sub.2, ZnO/Li.sub.2 O and Al.sub.2 O.sub.3 /Li.sub.2 O ratios are at least 0.41, at least 1.00 and at least 2.58, respectively, and melt-solidifying the mixture to thereby form a vitrified waste. By using such a raw glass material, there can be obtained a vitrifled waste having the waste content of about 45% by oxide weight in which the same leaching rate as that of a conventional vitrified waste having the waste content of 25% by oxide weight is ensured without suffering from yellow phase separation.
摘要翻译：一种对高级放射性废液进行玻璃化的方法，包括从高级废液中除去主要由Mo和Zr组成的沉淀物，将所得高级废液与具有化学组成的原料玻璃材料混合，其中B 2 O 3 / SiO 2，ZnO / Li 2 O和Al 2 O 3 / Li 2 O比分别为至少0.41，至少1.00和至少2.58，并将混合物熔融固化，从而形成玻璃化废物。通过使用原料玻璃材料，可以得到废氧含量为约45％的玻璃化废物，其氧化物重量与通过氧化物重量为25％的废物含量相同的常规玻璃化废物的浸出率相同确保没有黄相分离。

5. 发明授权

US08146208B2 Assist grip 有权
标题翻译：辅助抓地力
公开(公告)号：US08146208B2
公开(公告)日：2012-04-03
申请号：US12733835
申请日：2009-12-24
申请人： Hideki Kajio , Shouji Kawakami , Kazuhiro Kawamura
发明人： Hideki Kajio , Shouji Kawakami , Kazuhiro Kawamura
IPC分类号： A45C13/26
CPC分类号： B60N3/023 , B60N3/026 , Y10T16/473 , Y10T16/513
摘要： An assist grip includes a mounting clip formed of metal having spring resiliency and bent into a generally U shape. The mounting clip includes a pair of resilient legs. Each of the resilient legs includes a bulging portion that bulges outwardly and is provided with a retention portion to be retained by a mounting location of a vehicle body structure. Each of the resilient legs further includes at the leading end a stepped region for engagement against an inner peripheral region of a rectangular opening of a hinge body. The stepped region includes an extended region and a retaining pawl that extends outwardly relative to the extended region.
摘要翻译：辅助夹具包括由具有弹簧弹性并弯曲成大致U形的金属形成的安装夹。安装夹包括一对弹性腿。每个弹性腿包括凸出部分，其向外凸出并设置有保持部分，以由车身结构的安装位置保持。每个弹性腿还在前端包括用于与铰链主体的矩形开口的内周区域接合的台阶区域。台阶区域包括延伸区域和相对于延伸区域向外延伸的保持爪。

6. 发明申请

US20070195853A1 Heat treatment apparatus and method of calibrating the apparatus 有权
标题翻译：热处理装置及其校准方法
公开(公告)号：US20070195853A1
公开(公告)日：2007-08-23
申请号：US10561976
申请日：2004-07-01
申请人： Youngchul Park , Kazuhiro Kawamura , Yuichi Takenaga
发明人： Youngchul Park , Kazuhiro Kawamura , Yuichi Takenaga
IPC分类号： G01K15/00
CPC分类号： C23C16/52 , C23C16/46 , H01L21/67103 , H01L21/67248
摘要： The present invention provides precise temperature estimation in a heat treatment apparatus that estimates temperatures of process objects by using a thermal model and performs a heat treatment while performing a temperature control based on the estimated temperatures. The heat treatment apparatus 1 includes a processing vessel 11 accommodating plural wafers W, plural heaters 31 to 33 and plural temperature sensors S1 to S5, and stores the thermal model. The heat treatment apparatus 1 estimates temperatures of the wafers W based on outputs of the temperature sensors S1 to S5 by using the thermal model and controls the heaters 31 to 33 based on the estimated temperatures, applying a heat treatment to the wafers W. The thermal model for an individual apparatus is made by calibrating a standard thermal model designed for a standard apparatus. The standard model calibration is performed by heating an interior of the processing vessel 11, measuring the temperatures of the wafers W in the processing vessel 11, estimating the temperatures of the wafers W by using the thermal model, comparing the measured temperature and the estimated temperature, and calibrating the standard thermal model so that the measured temperature substantially coincide with the estimated temperature.
摘要翻译：本发明在通过使用热模型估计过程物体的温度并在基于估计的温度执行温度控制的同时进行热处理的热处理设备中提供精确的温度估计。热处理装置1包括容纳多个晶片W的处理容器11，多个加热器31〜33以及多个温度传感器S1〜S5，并存储热模型。热处理装置1通过使用热模型，基于温度传感器S 1〜S 5的输出来估计晶片W的温度，并基于估计的温度控制加热器31〜33，对晶片W进行热处理。单个设备的热模型通过校准为标准设备设计的标准热模型来进行。通过加热处理容器11的内部，测量处理容器11中的晶片W的温度，通过使用热模型估计晶片W的温度，比较测量的温度和估计的温度来执行标准模型校准，并校准标准热模型，使得测量的温度基本上与估计的温度一致。

7. 发明申请

US20140179677A1 THERAPEUTIC AGENT FOR ECTOPIC PREGNANCY 审中-公开
标题翻译：用于经济性怀孕的治疗药物
公开(公告)号：US20140179677A1
公开(公告)日：2014-06-26
申请号：US13977434
申请日：2011-12-28
申请人： Kazuhiro Kawamura
发明人： Kazuhiro Kawamura
IPC分类号： C07D498/22 , G01N33/50
CPC分类号： C07D498/22 , A61K31/553 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K2039/505 , C07K16/22 , C07K16/2863 , G01N33/5044 , G01N33/74 , G01N2333/48 , G01N2333/71
摘要： A novel therapeutic agent for ectopic pregnancy having a therapeutic effect for ectopic pregnancy, especially unruptured ectopic pregnancy, and a novel method of screening a therapeutic agent for ectopic pregnancy are disclosed. The therapeutic agent for ectopic pregnancy contains as an effective ingredient a suppressor of brain-derived neurotrophic factor (BDNF) and/or of brain-derived neurotrophic factor receptor (TrkB). The method of screening a therapeutic agent for ectopic pregnancy includes measuring the kinase activity of TrkB in the presence of a test substance and the kinase activity of TrkB in the absence of the test substance; and selecting the test substance which decreases the kinase activity of TrkB.
摘要翻译：公开了用于异位妊娠的治疗效果的异位妊娠的新型治疗剂，特别是未破裂的异位妊娠，以及筛选异位妊娠治疗剂的新方法。用于异位妊娠的治疗剂含有作为脑源性神经营养因子（BDNF）和/或脑源性神经营养因子受体（TrkB）的抑制剂的有效成分。筛选用于异位妊娠的治疗剂的方法包括在存在测试物质的情况下测量TrkB的激酶活性和在没有测试物质的情况下测定TrkB的激酶活性; 并选择降低TrkB激酶活性的测试物质。

8. 发明申请

US20070074660A1 Thermal processing appratus and thermal processing method 审中-公开
标题翻译：热处理设备和热处理方法
公开(公告)号：US20070074660A1
公开(公告)日：2007-04-05
申请号：US10577145
申请日：2004-11-01
申请人： Youngchul Park , Kazuhiro Kawamura , Wenling Wang
发明人： Youngchul Park , Kazuhiro Kawamura , Wenling Wang
IPC分类号： C23C16/00
CPC分类号： H01L21/67248 , H01L21/324
摘要： The thermal processing apparatus of the present invention includes: a processing container for containing an object to be processed; a plurality of heaters for heating the object to be processed; a plurality of temperature sensors for respectively detecting temperatures at a plurality of predetermined positions in the processing container; a storing part that stores: a thermal model for forecasting a temperature of the object to be processed contained in the processing container from outputs of the plurality of temperature sensors, and a recipe in which a desired temperature of the object to be processed is defined; and a controlling part that forecasts a temperature of the object to be processed by using the outputs of the plurality of temperature sensors and the thermal model, and that controls the plurality of heaters so as to cause the forecasted temperature of the object to be processed to coincide with the desired temperature of the object to be processed defined in the recipe. The thermal model is configured to forecast, from the outputs of the plurality of temperature sensors, not only a temperature of the object to be processed contained in the processing container but also a temperature of at least one other predetermined portion in the processing container. A desired temperature of the predetermined portion is also defined in the recipe. The controlling part is adapted to forecast a temperature of the object to be processed and a temperature of the predetermined portion by using the outputs of the plurality of temperature sensors and the thermal model, and to control the plurality of heaters so as to cause the forecasted temperature of the object to be processed and the forecasted temperature of the predetermined portion to respectively coincide with the desired temperature of the object to be processed and the desired temperature of the predetermined portion defined in the recipe.
摘要翻译：本发明的热处理装置包括：处理容器，用于容纳被加工物; 多个用于加热待处理物体的加热器; 多个温度传感器，分别检测处理容器内的多个预定位置的温度; 存储部，其存储：用于从所述多个温度传感器的输出预测所述处理容器中包含的待处理对象的温度的热模型，以及定义所述待处理对象的期望温度的配方; 以及控制部件，其通过使用多个温度传感器和热模型的输出来预测待处理对象的温度，并且控制多个加热器以使得要处理对象的预测温度与食谱中定义的待处理对象的期望温度一致。热模型被配置为从多个温度传感器的输出预测不仅包含在处理容器中的待处理物体的温度，而且还预测处理容器中至少一个其它预定部分的温度。预定部分的期望温度也在配方中定义。控制部适于通过使用多个温度传感器和热模型的输出来预测待处理对象的温度和预定部分的温度，并且控制多个加热器以使预测的要处理的物体的温度和预定部分的预测温度分别与待处理物体的期望温度和配方中限定的预定部分的期望温度一致。

9. 发明授权

US5406329A Solid state image pickup apparatus having test signal generator 失效
标题翻译：具有测试信号发生器的固态摄像装置
公开(公告)号：US5406329A
公开(公告)日：1995-04-11
申请号：US98273
申请日：1993-08-02
申请人： Naoki Kashimura , Kazuhiro Kawamura
发明人： Naoki Kashimura , Kazuhiro Kawamura
IPC分类号： H03M1/12 , H04N5/217 , H04N5/335 , H04N5/365 , H04N5/378 , H04N9/093 , H04N17/00
CPC分类号： H04N5/3653 , H03M1/12 , H04N17/002 , H04N5/378 , H04N9/093
摘要： A solid state image pickup apparatus includes a solid state image pickup device for receiving an optical image of an object and generating an electrical image signal representing the optical image of the object in synchronism with a driving pulse from a driving circuit. A sampling circuit generates a sampled image signal by sampling the electrical image signal read out of the solid state image pickup device with a first sampling pulse from a first pulse circuit synchronized with the driving pulse. An analog-to-digital convertor converts the sampled image signal to a digital image signal with a second sampling pulse from a second pulse circuit. A test signal generator generates a test signal which is synchronized with the driving pulse and alternately changes in level between consecutive pixels. A controller controls the phase of the first sampling pulse and the phase of the second sampling pulse relative to each other by processing the test signal.
摘要翻译： PCT No.PCT / JP93 / 00007 Sec。 371日期：1993年8月2日 102（e）日期1993年8月2日PCT提交1993年1月7日PCT公布。公开号WO93 / 14602 日期：1993年7月22日。固态图像拾取装置包括：固态图像拾取装置，用于接收对象的光学图像，并且与来自驱动的驱动脉冲同步地产生表示对象的光学图像的电图像信号电路。采样电路通过利用与驱动脉冲同步的第一脉冲电路的第一采样脉冲对从固态摄像装置读出的电图像信号进行采样来生成采样图像信号。模拟 - 数字转换器将来自第二脉冲电路的采样图像信号转换成具有第二采样脉冲的数字图像信号。测试信号发生器产生与驱动脉冲同步的测试信号，并且在连续像素之间交替地改变电平。控制器通过处理测试信号来相对于彼此控制第一采样脉冲的相位和第二采样脉冲的相位。

10. 发明授权

US3981642A Protective device for rotary engine oil seal 失效
标题翻译：旋转发动机油封保护装置
公开(公告)号：US3981642A
公开(公告)日：1976-09-21
申请号：US478091
申请日：1974-06-10
申请人： Kazuhiro Kawamura , Kunihiko Mizutani
发明人： Kazuhiro Kawamura , Kunihiko Mizutani
IPC分类号： F01C19/08 , F01C21/04
CPC分类号： F01C19/08
摘要： An oil seal protector for rotary engines is provided to prevent deleterious combustion gases from damaging the oil sealing assemblies provided on each side of the engine rotor. The sealing assemblies include an O-ring and the protective device comprises annular grooves which extend completely about the sealing assembly on each side of the rotor and which are located radially outwardly from such sealing assemblies. A seal ring is fitted within each of the annular grooves of the protective device and spring means are provided for urging the ring against the sides of the engine housing.
摘要翻译：提供用于旋转发动机的油封保护器，以防止有害燃烧气体损坏设置在发动机转子两侧的油封组件。密封组件包括O形环，并且保护装置包括在转子的每一侧上完全围绕密封组件延伸并且从这种密封组件径向向外定位的环形凹槽。密封环安装在保护装置的每个环形槽内，并且提供弹簧装置用于将环推压到发动机壳体的侧面。

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