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1. 发明申请

US20050171350A1 Benzhydryl derivatives 审中-公开
标题翻译：二苯甲基衍生物
公开(公告)号：US20050171350A1
公开(公告)日：2005-08-04
申请号：US10498018
申请日：2002-12-16
申请人： Kazuhiko Take , Chiyoshi Kasahara , Shinji Shigenaga , Yoshiteru Eikyu , Takashi Tojo
发明人： Kazuhiko Take , Chiyoshi Kasahara , Shinji Shigenaga , Yoshiteru Eikyu , Takashi Tojo
IPC分类号： A61K31/4985 , A61K31/506 , A61K31/5377 , A61P1/00 , A61P11/00 , A61P11/06 , A61P11/10 , A61P17/00 , A61P17/04 , A61P19/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P27/02 , A61P27/14 , A61P27/16 , A61P29/00 , A61P35/00 , A61P43/00 , C07D403/06 , C07D403/12 , C07D403/14 , C07D487/04 , C07D487/02 , C07D43/02
CPC分类号： C07D403/14 , C07D403/06 , C07D487/04
摘要： A compound of the formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.
摘要翻译：式（I）的化合物：其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8和R 9，各自如说明书中所定义，或其盐。本发明的目的化合物具有速激肽拮抗作用等药理活性，可用于制备治疗或预防速激肽介导的疾病的药物。

2. 发明授权

US06787543B2 Benzhydryl derivatives 失效
标题翻译：二苯甲基衍生物
公开(公告)号：US06787543B2
公开(公告)日：2004-09-07
申请号：US10297937
申请日：2002-12-20
申请人： Kazuhiko Take , Chiyoshi Kasahara , Shinji Shigenaga , Hidenori Azami , Yoshiteru Eikyu , Kazuo Nakai , Masataka Morita
发明人： Kazuhiko Take , Chiyoshi Kasahara , Shinji Shigenaga , Hidenori Azami , Yoshiteru Eikyu , Kazuo Nakai , Masataka Morita
IPC分类号： A61K31495
CPC分类号： C07D265/30 , C07C45/71 , C07D241/04 , C07D241/08 , C07D403/10 , C07D487/04 , C07C47/575
摘要： A compound of the formula (I): in which Z, R1, R2, R8, R10, R11, R12, R13 and R14 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.
摘要翻译：式（I）的化合物：其中Z，R 1，R 2，R 8，R 10，R 11，R 12，R 13和R 13， 14>各自如说明书中所定义，或其盐。本发明的目的化合物具有速激肽拮抗作用等药理活性，可用于制备治疗或预防速激肽介导的疾病的药物。

3. 发明授权

US07166598B2 Piperazine derivatives 失效
标题翻译：哌嗪衍生物
公开(公告)号：US07166598B2
公开(公告)日：2007-01-23
申请号：US10968473
申请日：2004-10-20
申请人： Kazuhiko Take , Nobukiyo Konishi , Shinji Shigenaga , Natsuko Kayakiri , Hidenori Azami , Yoshiteru Eikyu , Kazuo Nakai , Junya Ishida , Masataka Morita
发明人： Kazuhiko Take , Nobukiyo Konishi , Shinji Shigenaga , Natsuko Kayakiri , Hidenori Azami , Yoshiteru Eikyu , Kazuo Nakai , Junya Ishida , Masataka Morita
IPC分类号： A61K31/5355 , C07D413/06 , A61K31/496 , C07D401/06
CPC分类号： C07D401/06 , C07D241/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D471/04 , C07D491/08 , C07D495/04 , C07D498/04 , C07D498/08 , C07F7/1804
摘要： This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.
摘要翻译：本发明涉及下式的哌嗪衍生物：其中每个符号如说明书中所定义，及其药学上可接受的盐，其制备方法，包含其的药物组合物及其用于治疗或预防的用途速激肽介导的人类或动物疾病。

4. 发明申请

US20070123532A1 PIPERAZINE DERIVATIVES 审中-公开
标题翻译：哌嗪衍生物
公开(公告)号：US20070123532A1
公开(公告)日：2007-05-31
申请号：US11562149
申请日：2006-11-21
申请人： Kazuhiko Take , Nobukiyo Konishi , Shinji Shigenaga , Natsuko Kayakiri , Hidenori Azami , Yoshiteru Eikyu , Kazuo Nakai , Junya Ishida , Masataka Morita
发明人： Kazuhiko Take , Nobukiyo Konishi , Shinji Shigenaga , Natsuko Kayakiri , Hidenori Azami , Yoshiteru Eikyu , Kazuo Nakai , Junya Ishida , Masataka Morita
IPC分类号： A61K31/5377 , A61K31/496
CPC分类号： C07D401/06 , C07D241/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D471/04 , C07D491/08 , C07D495/04 , C07D498/04 , C07D498/08 , C07F7/1804
摘要： This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.
摘要翻译：本发明涉及下式的哌嗪衍生物：其中每个符号如说明书中所定义，及其药学上可接受的盐，其制备方法，包含其的药物组合物及其用于治疗或预防的用途速激肽介导的人类或动物疾病。

5. 发明申请

US20060014948A1 Piperazine derivatives 失效
标题翻译：哌嗪衍生物
公开(公告)号：US20060014948A1
公开(公告)日：2006-01-19
申请号：US10968473
申请日：2004-10-20
申请人： Kazuhiko Take , Nobukiyo Konishi , Shinji Shigenaga , Natsuko Kayakiri , Hidenori Azami , Yoshiteru Eikyu , Kazuo Nakai , Junya Ishida , Masataka Morita
发明人： Kazuhiko Take , Nobukiyo Konishi , Shinji Shigenaga , Natsuko Kayakiri , Hidenori Azami , Yoshiteru Eikyu , Kazuo Nakai , Junya Ishida , Masataka Morita
IPC分类号： A61K31/5377 , C07D413/02 , C07D43/02
CPC分类号： C07D401/06 , C07D241/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D471/04 , C07D491/08 , C07D495/04 , C07D498/04 , C07D498/08 , C07F7/1804
摘要： This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.
摘要翻译：本发明涉及下式的哌嗪衍生物：其中每个符号如说明书中所定义，及其药学上可接受的盐，其制备方法，包含其的药物组合物及其用于治疗或预防的用途速激肽介导的人类或动物疾病。

6. 发明授权

US06924278B2 Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists 失效
标题翻译：芳酰哌嗪衍生物，它们的制备及其作为速激肽拮抗剂的用途
公开(公告)号：US06924278B2
公开(公告)日：2005-08-02
申请号：US10720021
申请日：2003-11-24
申请人： Hiroshi Miyake , Kazuhiko Take , Shinji Shigenaga , Hidenori Azami , Hiroshi Sasaki , Yoshiteru Eikyu , Kazuo Nakai , Junya Ishida , Takashi Manabe , Nobukiyo Konishi , Tadashi Terasaka
发明人： Hiroshi Miyake , Kazuhiko Take , Shinji Shigenaga , Hidenori Azami , Hiroshi Sasaki , Yoshiteru Eikyu , Kazuo Nakai , Junya Ishida , Takashi Manabe , Nobukiyo Konishi , Tadashi Terasaka
IPC分类号： A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61P1/00 , A61P9/00 , A61P11/00 , A61P11/06 , A61P25/00 , A61P25/04 , A61P27/02 , A61P29/00 , A61P43/00 , C07D241/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/08 , C07D417/14 , C07D521/00 , A61K31/33 , A61K31/495 , A61K31/54 , C07D413/00 , C07D417/00
CPC分类号： C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/06 , C07D413/06 , C07D417/14
摘要： This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.
摘要翻译：本发明涉及下式的哌嗪衍生物：其中每个符号如说明书中所定义，及其药学上可接受的盐，其制备方法，包含其的药物组合物及其用于治疗或预防的用途速激肽介导的人类或动物疾病。

7. 发明申请

US20050027121A1 Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists 失效
公开(公告)号：US20050027121A1
公开(公告)日：2005-02-03
申请号：US10720021
申请日：2003-11-24
申请人： Hiroshi Miyake , Kazuhiko Take , Shinji Shigenaga , Hidenori Azami , Hiroshi Sasaki , Yoshiteru Eikyu , Kazuo Nakai , Junya Ishida , Takashi Manabe , Nobukiyo Konishi , Tadashi Terasaka
发明人： Hiroshi Miyake , Kazuhiko Take , Shinji Shigenaga , Hidenori Azami , Hiroshi Sasaki , Yoshiteru Eikyu , Kazuo Nakai , Junya Ishida , Takashi Manabe , Nobukiyo Konishi , Tadashi Terasaka
IPC分类号： A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61P1/00 , A61P9/00 , A61P11/00 , A61P11/06 , A61P25/00 , A61P25/04 , A61P27/02 , A61P29/00 , A61P43/00 , C07D241/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/08 , C07D417/14 , C07D521/00 , C07D413/02 , C07
CPC分类号： C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/06 , C07D413/06 , C07D417/14
摘要： This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

8. 发明授权

US6087357A Piperazine derivatives as tachykinin antagonists 失效
标题翻译：哌嗪衍生物作为速激肽拮抗剂
公开(公告)号：US6087357A
公开(公告)日：2000-07-11
申请号：US91269
申请日：1998-06-18
申请人： Masaaki Matsuo , Takashi Manabe , Nobukiyo Konishi , Kazuhiko Take , Norihiro Igari , Shinji Shigenaga , Hiroshi Matsuda , Tadashi Terasaka
发明人： Masaaki Matsuo , Takashi Manabe , Nobukiyo Konishi , Kazuhiko Take , Norihiro Igari , Shinji Shigenaga , Hiroshi Matsuda , Tadashi Terasaka
IPC分类号： A61K31/00 , A61K31/495 , A61K31/4965 , A61K31/497 , A61K31/535 , A61K31/5375 , A61K31/54 , A61K31/541 , A61K31/55 , A61P1/00 , A61P1/08 , A61P25/00 , A61P43/00 , C07D241/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D413/14 , C07D417/14 , C07D471/08 , C07D487/08 , C07D495/04 , C07D413/00 , C07D417/00
CPC分类号： C07D401/12 , C07D241/04 , C07D401/14 , C07D403/04 , C07D403/06
摘要： This application is a 371 of PCT/JP96/03641 filed Dec. 12, 1996.
摘要翻译： PCT No.PCT / JP96 / 03641 Sec。 371日期1998年6月18日 102（e）1998年6月18日PCT 1996年12月12日PCT PCT。公开号WO97 / 22597 日期：1997年6月26日

9. 发明授权

US06521643B1 Pyridine compounds and their pharmaceutical use 失效
标题翻译：吡啶化合物及其药物用途
公开(公告)号：US06521643B1
公开(公告)日：2003-02-18
申请号：US09913715
申请日：2001-08-17
申请人： Masaki Tomishima , Kazuhiko Take
发明人： Masaki Tomishima , Kazuhiko Take
IPC分类号： A61K3144
CPC分类号： C07D401/04 , C07D213/58 , C07D213/61 , C07D213/63 , C07D213/73 , C07D213/85 , C07D417/04 , C07D417/06 , C07D417/12
摘要： A compound of formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NOS(nitric oxide synthasey)-mediated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, insulin-ependent diabetes mellitus, ulcerative colitis, cerebral infarction, rheumatoid arthritis, osteoarthritis, osteoporosis, systemic lupus erythematosus, rejection by organ transplantation, asthma, pain, ulcer, and the like in human being and animals.
摘要翻译：式（I）的化合物，其中每个符号如说明书中所定义，及其药学上可接受的盐。本发明的化合物（I）及其药学上可接受的盐对一氧化氮（NO）的产生具有很强的抑制活性，可用于预防和/或治疗NOS（一氧化氮合酶）介导的疾病，例如成人呼吸窘迫综合征，心肌炎，滑膜炎，脓毒性休克，胰岛素 - 后遗症糖尿病，溃疡性结肠炎，脑梗死，类风湿性关节炎，骨关节炎，骨质疏松症，系统性红斑狼疮，器官移植排斥反应，哮喘，疼痛，溃疡等人类和动物。

10. 发明申请

US20120184521A1 SUBSTITUTED AMIDE COMPOUND 有权
标题翻译：取代的化合物
公开(公告)号：US20120184521A1
公开(公告)日：2012-07-19
申请号：US13498159
申请日：2010-09-24
申请人： Eiji Kawaminami , Tatsuhisa Takahashi , Takatoshi Kanayama , Yuta Fukuda , Hiroyuki Kaizawa , Yutaka Kondoh , Ryushi Seo , Kazuyuki Kuramoto , Kazuhiko Take , Kazuyuki Sakamoto
发明人： Eiji Kawaminami , Tatsuhisa Takahashi , Takatoshi Kanayama , Yuta Fukuda , Hiroyuki Kaizawa , Yutaka Kondoh , Ryushi Seo , Kazuyuki Kuramoto , Kazuhiko Take , Kazuyuki Sakamoto
IPC分类号： A61K31/426 , C07D417/12 , A61K31/427 , A61K31/496 , A61P43/00 , A61K31/513 , A61K31/538 , A61K31/454 , A61K31/541 , C07D277/56 , A61K31/4439
CPC分类号： A61K31/426 , A61K31/341 , A61K31/381 , A61K31/401 , A61K31/415 , A61K31/42 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/4965 , C07D207/34 , C07D213/81 , C07D263/34 , C07D277/56 , C07D307/68 , C07D333/38 , C07D417/12
摘要： A substituted amide compound is useful as an active ingredient of a pharmaceutical composition, in particular a pharmaceutical composition for treating diseases caused by lysophosphatidic acid (LPA). The compound is of a formula: In this formula, A is an optionally substituted aryl, etc.; B is an optionally substituted 5-membered aromatic hetero ring group; X is a single bond or —(CRX1RX2)n—; n is 1, 2, 3, or 4; RX1 and RX2 are hydrogen, etc.; Y1 to Y5 are each CRY or N; each RY is hydrogen, etc.; R1 and R2 are hydrogen, etc.; m is 1, 2, or 3; R3 is hydrogen, etc.; and R4 is an optionally substituted lower alkyl, etc.
摘要翻译：取代的酰胺化合物可用作药物组合物的活性成分，特别是用于治疗由溶血磷脂酸（LPA）引起的疾病的药物组合物。该化合物具有下式：在该式中，A是任选取代的芳基等; B是任选取代的5元芳族杂环基团; X是单键或 - （CRX1RX2）n-; n为1,2,3或4; RX1和RX2是氢等; Y1〜Y5分别为CRY或N; 每个RY是氢等; R1和R2是氢等; m为1,2或3; R3是氢等; 并且R 4是任选取代的低级烷基等。

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