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1. 发明授权

US06593304B1 RECOMBINANT DNA COMPRISING DNA CODING FOR MYOSIN HEAVY CHAIN SM1 ISO-FORM PROTEIN INSERTED INTO VECTOR DNA MICROORGANISM CARRYING THE RECOMBINANT DNA, AND AN AGENT FOR TREATMENT OF ARTERIOSCLEROSIS COMPRISING THE RECOMBINANT DNA 失效
标题翻译：将包含MYOSIN重链SM1 ISO-FormM蛋白的DNA编码的重组DNA插入载体重组DNA的载体DNA微生物中，以及用于治疗包含重组DNA的病原体的代理
公开(公告)号：US06593304B1
公开(公告)日：2003-07-15
申请号：US08875435
申请日：1997-07-25
申请人： Kazuhide Hasegawa , Emi Arakawa , Shoji Oda , Yuzuru Matsuda , Katsuhito Takahashi , Michihiro Sugahara , Haruo Ishiyama
发明人： Kazuhide Hasegawa , Emi Arakawa , Shoji Oda , Yuzuru Matsuda , Katsuhito Takahashi , Michihiro Sugahara , Haruo Ishiyama
IPC分类号： C07H2100
CPC分类号： C07K14/4716 , A61K38/00
摘要： The present invention relates to recombinant DNA comprising DNA coding for smooth-muscle-type myosin heavy chain SM1 isoform protein inserted into vector DNA, a microorganism carrying the recombinant DNA, and an agent for treatment of arteriosclerosis comprising the recombinant DNA. The recombinant DNA of the present invention can be used effectively as an agent for gene therapy of restenosis after PTCA treatment.
摘要翻译：本发明涉及包含编码插入到载体DNA中的平滑肌型肌球蛋白重链SM1同种型蛋白质的DNA的重组DNA，携带重组DNA的微生物和包含该重组DNA的动脉硬化治疗剂。本发明的重组DNA可以有效地用作PTCA治疗后的再狭窄基因治疗剂。

2. 发明授权

US08479970B2 High corrosion resistant equipment for a plant 有权
标题翻译：高耐蚀设备的植物
公开(公告)号：US08479970B2
公开(公告)日：2013-07-09
申请号：US13523404
申请日：2012-06-14
申请人： Ryo Ishibashi , Katsuhito Takahashi , Seunghwan Park , Shinya Imano , Haruo Akahoshi , Kenya Ohashi
发明人： Ryo Ishibashi , Katsuhito Takahashi , Seunghwan Park , Shinya Imano , Haruo Akahoshi , Kenya Ohashi
IPC分类号： B23K20/12
CPC分类号： B23K20/1265 , B23K20/129 , B23K2101/12 , B23K2103/14 , Y10T428/12 , Y10T428/12389
摘要： Provided is high corrosion resistant equipment for a plant having the lining structure which exhibits high reliability against breaking of a joining portion over a long use period. The high corrosion resistant equipment for a plant includes a lining plate and a support portion which are made of a high corrosion resistance material and a structural material portion made of a steel material or the like. The lining plate and the support portion include a joining portion to which friction stirring is applied. The support portion is assembled into or fastened to the structural material portion by means of the geometrical structure with a gap interposed between the support portion and the structural material portion. Due to such a constitution, high corrosion resistant equipment for a plant having the lining which exhibits high reliability can be acquired.
摘要翻译：本发明提供一种具有衬里结构的植物的高耐腐蚀性设备，其在长期使用期间表现出高的抗连接部分断裂的可靠性。用于植物的高耐腐蚀设备包括由高耐腐蚀材料制成的衬板和支撑部分以及由钢材等制成的结构材料部分。衬板和支撑部分包括施加摩擦搅拌的接合部分。支撑部分通过几何结构组装到结构材料部分中或者紧固到结构材料部分，间隙插入在支撑部分和结构材料部分之间。由于这样的结构，可以获得具有高可靠性的具有衬里的植物的高耐腐蚀性设备。

3. 发明授权

US07785870B2 Cell-specific expression/replication vector 有权
标题翻译：细胞特异性表达/复制载体
公开(公告)号：US07785870B2
公开(公告)日：2010-08-31
申请号：US10500173
申请日：2002-12-26
申请人： Katsuhito Takahashi , Hisako Yamamura
发明人： Katsuhito Takahashi , Hisako Yamamura
IPC分类号： C12N15/00 , A61K31/70
CPC分类号： C12N15/86 , A61K38/45 , A61K48/00 , A61K48/0058 , C12N15/85 , C12N2710/10343 , C12N2710/16643 , C12N2830/00 , C12N2830/008 , C12N2830/85 , C12N2840/203
摘要： The present invention provides a cell-specific expression/replication vector, and a method of treatment comprising introducing a cell-specific expression/replication vector into specific cells such as malignant tumors in order to selectively disrupt the specific cells. A vector according to the invention is constructed by: obtaining a transcriptional initiation regulatory region of human calponin gene that is specifically expressed in smooth muscle cell; linking the above region upstream to a replication-related gene of a virus such as ICP4 and the like; linking DNA that encodes a protein such as suppressive factor for tumor angiogenesis or apoptosis-related factors and the like via IRES to the replication-related gene of the virus; and integrating a thymidine kinase gene in an intact state into the viral DNA.
摘要翻译：本发明提供细胞特异性表达/复制载体和包括将细胞特异性表达/复制载体导入特异性细胞例如恶性肿瘤以选择性破坏特定细胞的方法。根据本发明的载体构建为：获得在平滑肌细胞中特异性表达的人calponin基因的转录起始调节区; 将上述区域上游连接到诸如ICP4等病毒的复制相关基因; 将编码蛋白质的DNA，例如通过IRES的肿瘤血管生成抑制因子或凋亡相关因子等连接到病毒的复制相关基因; 并将完整状态的胸苷激酶基因整合到病毒DNA中。

4. 发明授权

US4698118A Apparatus for forming plastic fastener and plastic accessory strips and uniting the same with a film 失效
标题翻译：用于形成塑料紧固件和塑料附件带并将其与薄膜结合在一起的装置
公开(公告)号：US4698118A
公开(公告)日：1987-10-06
申请号：US632661
申请日：1984-07-20
申请人： Katsuhito Takahashi
发明人： Katsuhito Takahashi
IPC分类号： B29C47/00 , B29C47/70 , B29C65/00 , B29C65/02 , B29D5/10 , B31B19/90 , B29C69/00 , B32B1/04
CPC分类号： B29C66/4722 , B29C47/0019 , B29C47/70 , B29C65/028 , B29C66/474 , B29C66/83413 , B29C66/83415 , B29D5/10 , B29C47/0021 , B29C47/003 , B29C47/0033 , B29C47/0038 , B29C47/0047 , B29C47/0057 , B29C47/0059 , B29C47/0064 , B29L2005/00 , B31B2219/9019 , Y10S425/814 , Y10T156/1712 , Y10T156/1741 , Y10T428/1334 , Y10T428/24612
摘要： For producing a plastic film having a plastic fastener, with male and female interlockable profiles, and accessory strips, such as ribs and strips, in preparation of a reclosable plastic bag, there is provided a first forming die which extrudes the accessory strips, a separate second forming die which extrudes the fastener, a pair of nip rolls for press-bonding the accessory strips onto the surface of the film being fed in the vicinity of the first forming die, and a bonding roll for receiving the film with press-bonded accessory strips and the fastener from the second forming die placed onto the film surface such that the fastener is bonded to the surface of the film at the bonding roll by virtue of heat.
摘要翻译：为了制备具有塑料紧固件的塑料膜，具有阳和阴互锁型材以及附件条（例如肋条和条），在制备可再封闭的塑料袋时，提供了第一成形模，其挤出附件条，第二成形模挤出紧固件，一对夹持辊，用于将附件带压接到在第一成形模具附近供给的膜的表面上;粘合辊，用于用压接附件接收膜条带和紧固件从第二成形模具放置在膜表面上，使得紧固件通过热量在粘合辊上结合到膜的表面。

5. 发明授权

US4279677A Method of means for joining plastic fastener strip to film 失效
标题翻译：将塑料拉链带连接到薄膜上的方法
公开(公告)号：US4279677A
公开(公告)日：1981-07-21
申请号：US94763
申请日：1979-11-16
申请人： Katsuhito Takahashi
发明人： Katsuhito Takahashi
IPC分类号： B29C47/00 , B29C65/00 , B29C65/02 , B31B19/90 , B29D7/08 , B32B7/04 , B32B31/16
CPC分类号： B29C65/028 , B29C47/0021 , B29C66/344 , B29C66/474 , B29C66/83415 , B29C47/00 , B29L2005/00 , B29L2031/7128 , B29L2031/7282 , B31B2219/9019
摘要： A method of an apparatus for joining plastic fastener strip continuously to a film. The film of substantial width is run continuously longitudinally through a joining station. A selected longitudinal area of the film is maintained in a stable tensioned condition relative to the remainder of the film as it runs through the joining station. In the joining station, there is joined and secured to the tensioned area a fastener strip running in the same direction and at the same speed as the film. The selected area tensioning is effected by maintaining such area offset relative to the remainder of the film. Downstream from the joining station the film and fastener strip assembly is progressively conditioned until thoroughly stabilized.
摘要翻译：一种将塑料紧固带连续地连接到薄膜上的装置的方法。相当宽度的胶片通过连接台连续纵向延伸。当膜穿过连接台时，膜的选定的纵向区域相对于膜的其余部分保持在稳定的张紧状态。在接合站中，连接并固定到张紧区域，该紧固带沿与膜相同的方向和速度相同地延伸。所选择的区域张紧通过相对于膜的其余部分保持这样的面积偏移来实现。在连接站下游，膜和紧固件条组件被逐渐调节直到彻底稳定。

6. 发明授权

US07696332B2 Replication vector showing cell-specific expression 失效
标题翻译：显示细胞特异性表达的复制载体
公开(公告)号：US07696332B2
公开(公告)日：2010-04-13
申请号：US10477797
申请日：2002-04-30
申请人： Katsuhito Takahashi , Hisako Yamamura , Shin-ichi Miyatake
发明人： Katsuhito Takahashi , Hisako Yamamura , Shin-ichi Miyatake
IPC分类号： C07H21/02 , C07H21/04 , A61K31/70
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343 , C12N2710/16643 , C12N2830/008 , C12N2830/85
摘要： The present invention provides a cell-specific replication-competent vector system, which does not target normal cells. The vector system is constructed by linking a transcriptional initiation regulatory promoter region upstream of a viral replication-related gene that integrates the linked region into a viral DNA vector. The constructed vector, when introduced into malignant tumor cells, selectively injures only tumor cells or proliferating smooth muscle cells of tumor neovascular tissue due to the selective expression of the regulatory promoter region upstream of a viral replication-related gene. In particular, the present invention relates to a transcriptional initiation regulatory region of the human calponin gene that can selectively express in tumor cells or proliferating smooth muscle cells of tumor neovascular tissue. The present invention also relates to methods of constructing the cell-specific replication-competent vector system and to treatment methods using the vector system by introducing the vector system into particular living tissues or cells such as malignant tumors and the like.
摘要翻译：本发明提供了不针对正常细胞的细胞特异性复制能力的载体系统。通过将病毒复制相关基因上游的转录起始调节启动子区域连接到病毒DNA载体中来构建载体系统。构建的载体在引入恶性肿瘤细胞时，由于选择性地表达病毒复制相关基因上游的调节启动子区域，因此选择性地仅损伤肿瘤新生血管组织的肿瘤细胞或增殖平滑肌细胞。特别地，本发明涉及人钙调蛋白基因的转录起始调控区域，其可以选择性地在肿瘤细胞或肿瘤新生血管组织的增殖平滑肌细胞中表达。本发明还涉及构建细胞特异性复制能力载体系统的方法和使用载体系统通过将载体系统引入特定活组织或细胞如恶性肿瘤等中的治疗方法。

7. 发明申请

US20100003220A1 AGENTS FOR TREATING MALIGNANT MESOTHELIOMA 审中-公开
标题翻译：用于治疗恶性淋巴细胞的药剂
公开(公告)号：US20100003220A1
公开(公告)日：2010-01-07
申请号：US12309675
申请日：2007-07-27
申请人： Katsuhito Takahashi , Hisako Yamamura
发明人： Katsuhito Takahashi , Hisako Yamamura
IPC分类号： A61K45/00 , C12N5/08 , C12N7/00 , A61P35/00
CPC分类号： C12N5/0693 , A61K35/763 , C07K14/46 , C07K14/4728 , C12N2510/00 , C12N2710/16632 , C12N2830/008 , C12N2830/85
摘要： The present invention provides an effective therapeutic composition for malignant mesothelioma. Specifically, the present invention provides a therapeutic composition for mesothelioma, comprising a calponin-targeting and tumor-lysing variant of herpes simplex virus (HSV-1), preferably a strain d12.CALPfΔRR. The present invention further provides a method for generating a cell for treating mesothelioma, which comprises infecting mesothelioma cells removed from a patient with an F-type variant of herpes simplex virus proliferating with targeting a calponin gene, preferably a strain d12.CALPfΔRR. Also provided are a cell obtainable by the method, and a calponin-targeting and tumor-lysing variant of herpes simplex virus (HSV-1), preferably a strain d12.CALPfΔRR.
摘要翻译：本发明提供了恶性间皮瘤的有效治疗组合物。具体地，本发明提供了一种间皮瘤治疗组合物，其包含单纯疱疹病毒（HSV-1）的calponin靶向和肿瘤裂解变体，优选菌株d12.CALPfDeltaRR。本发明还提供了一种用于产生用于治疗间皮瘤的细胞的方法，其包括用靶向calponin基因，优选菌株d12.CALPfDeltaRR以增殖的单纯疱疹病毒的F型变体感染从患者中除去的间皮瘤细胞。还提供了可通过该方法获得的细胞，以及单纯疱疹病毒（HSV-1）的calponin靶向和肿瘤裂解变体，优选菌株d12.CALPfDeltaRR。

8. 发明申请

US20050032214A1 Cell-specific expression/replication vector 有权
标题翻译：细胞特异性表达/复制载体
公开(公告)号：US20050032214A1
公开(公告)日：2005-02-10
申请号：US10500173
申请日：2002-12-26
申请人： Katsuhito Takahashi , Hisako Yamamura
发明人： Katsuhito Takahashi , Hisako Yamamura
IPC分类号： C12N15/09 , A61K35/76 , A61K38/00 , A61K38/45 , A61K48/00 , A61P1/16 , A61P9/00 , A61P9/10 , A61P11/00 , A61P13/12 , A61P15/00 , A61P27/02 , A61P35/00 , A61P35/04 , A61P43/00 , C12N7/00 , C12N15/85 , C12N15/861 , C12N15/869 , C12Q1/48
CPC分类号： C12N15/86 , A61K38/45 , A61K48/00 , A61K48/0058 , C12N15/85 , C12N2710/10343 , C12N2710/16643 , C12N2830/00 , C12N2830/008 , C12N2830/85 , C12N2840/203
摘要： The present invention is to provide a method wherein a cell-specific expression/replication vector that express and replicate a gene specifically in specific cells such as malignant tumors and the like and does not injure normal cells, particularly a vector that can suppress the expression/replication at a desired period after the expression/replication is constructed, for the use in therapies for such as malignant tumors and the like, and treatment is conducted by introducing the vector to a particular living cell such as malignant tumor and the like for expression. A cell-specific expression/replication vector that does not act to adult normal cells is constructed by: a transcriptional initiation regulatory region of human calponin gene that is expressed in smooth muscle cell specifically is obtained; said region is linked upstream of the replication-related gene of virus such as ICP4 and the like; a DNA that encodes proteins such as suppressive factor for tumor angiogenesis or apoptosis-related factors and the like is linked via IRES to said replication-related gene of the virus; and thyimidine kinase gene in an intact state is integrated into a viral DNA. This vector thus constructed is infected and introduced to malignant tumor cells, and malignant tumor cells are selectively disrupted.
摘要翻译：本发明提供一种方法，其中特异性表达/复制载体在特异性细胞如恶性肿瘤等中特异性表达和复制，并且不损伤正常细胞，特别是可抑制表达/ 在构建表达/复制后的所需期间进行复制，用于恶性肿瘤等的治疗，并且通过将载体导入特定的活细胞如恶性肿瘤等进行表达来进行治疗。通过以下方法构建不对成年正常细胞起作用的细胞特异性表达/复制载体：通过特异性在平滑肌细胞中表达的人calponin基因的转录起始调节区获得; 所述区域与病毒的复制相关基因如ICP4等连接在上游; 编码蛋白质如肿瘤血管生成抑制因子或凋亡相关因子等的DNA通过IRES与病毒的所述复制相关基因相连接; 并且完整状态的甲嘧啶激酶基因整合到病毒DNA中。这样构建的载体被感染并导入恶性肿瘤细胞，恶性肿瘤细胞被选择性地破坏。

9. 发明申请

US20120321904A1 HIGH CORROSION RESISTANT EQUIPMENT FOR A PLANT 有权
标题翻译：一家工厂的高耐腐蚀设备
公开(公告)号：US20120321904A1
公开(公告)日：2012-12-20
申请号：US13523404
申请日：2012-06-14
申请人： Ryo Ishibashi , Katsuhito Takahashi , Seunghwan Park , Shinya Imano , Haruo Akahoshi , Kenya Ohashi
发明人： Ryo Ishibashi , Katsuhito Takahashi , Seunghwan Park , Shinya Imano , Haruo Akahoshi , Kenya Ohashi
IPC分类号： B32B3/30
CPC分类号： B23K20/1265 , B23K20/129 , B23K2101/12 , B23K2103/14 , Y10T428/12 , Y10T428/12389
摘要： Provided is high corrosion resistant equipment for a plant having the lining structure which exhibits high reliability against breaking of a joining portion over a long use period. The high corrosion resistant equipment for a plant includes a lining plate and a support portion which are made of a high corrosion resistance material and a structural material portion made of a steel material or the like. The lining plate and the support portion include a joining portion to which friction stirring is applied. The support portion is assembled into or fastened to the structural material portion by means of the geometrical structure with a gap interposed between the support portion and the structural material portion. Due to such a constitution, high corrosion resistant equipment for a plant having the lining which exhibits high reliability can be acquired.
摘要翻译：本发明提供一种具有衬里结构的植物的高耐腐蚀性设备，其在长期使用期间表现出高的抗连接部分断裂的可靠性。用于植物的高耐腐蚀设备包括由高耐腐蚀材料制成的衬板和支撑部分以及由钢材等制成的结构材料部分。衬板和支撑部分包括施加摩擦搅拌的接合部分。支撑部分通过几何结构组装到结构材料部分中或者紧固到结构材料部分，间隙插入在支撑部分和结构材料部分之间。由于这样的结构，可以获得具有高可靠性的具有衬里的植物的高耐腐蚀性设备。

10. 发明申请

US20110286972A1 VIRUS GROWING IN HYPOXIC CELL OR VIRUS VECTOR EXPRESSING GENE THEREIN 审中-公开
标题翻译：高血压病毒或病毒载体表达基因的病毒
公开(公告)号：US20110286972A1
公开(公告)日：2011-11-24
申请号：US12863028
申请日：2009-01-13
申请人： Katsuhito Takahashi , Hisako Yamamura , Masahiro Inoue
发明人： Katsuhito Takahashi , Hisako Yamamura , Masahiro Inoue
IPC分类号： A61K48/00 , C12N7/00 , C07H21/00 , A61P9/10 , A61P35/00 , A61P11/00 , A61P9/12 , C12N15/63 , C07K14/005
CPC分类号： C07K14/005 , A61K35/76 , A61K48/00 , C12N15/86 , C12N2710/16622 , C12N2710/16632 , C12N2710/16643 , C12N2840/203
摘要： The present invention provides a virus or a viral vector capable of expressing a gene specifically in a cell having replication ability in a hypoxic state such as a cancer stem cell and injuring the cell, and pharmaceutical composition comprising the same. Specifically, the present invention provides a virus or a viral vector which comprises a gene encoding a fusion protein of an ODD and a protein essentially required for viral proliferation, and a pharmaceutical composition comprising the same.
摘要翻译：本发明提供能够在具有缺氧状态的复制能力的细胞例如癌症干细胞中特异性表达基因的病毒或病毒载体，以及包含该基因的药物组合物。具体地说，本发明提供病毒或病毒载体，其包含编码ODD融合蛋白的基因和病毒增殖基本上必需的蛋白质，以及包含该蛋白质的药物组合物。

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