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1. 发明授权

US07586091B2 Mass spectrometric system and mass spectrometry 失效
标题翻译：质谱系统和质谱
公开(公告)号：US07586091B2
公开(公告)日：2009-09-08
申请号：US10549587
申请日：2004-03-15
申请人： Katsutoshi Takahashi , Kazuhiro Iida , Masakazu Baba , Noriyuki Iguchi , Toru Sano , Hisao Kawaura , Toshitsugu Sakamoto , Wataru Hattori , Hiroko Someya
发明人： Katsutoshi Takahashi , Kazuhiro Iida , Masakazu Baba , Noriyuki Iguchi , Toru Sano , Hisao Kawaura , Toshitsugu Sakamoto , Wataru Hattori , Hiroko Someya
IPC分类号： H01J49/00
CPC分类号： H01J49/0418 , B01L3/502746 , B01L3/502753 , B01L2200/0663 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/16 , B01L2400/086 , G01N1/22 , G01N30/84 , G01N2030/8452
摘要： After a sample is previously separated into plural components in a channel formed in a microchip (353), the channel is irradiated along a separation direction with a laser beam from a laser oscillator (361) to sequentially ionize each fraction separated in the channel. The ionized fraction is detected by a mass spectrometry unit (363) and analyzed by an analytical result analyzing unit (371). The analytical result is stored in a memory (369) while associated with position information in a driver control unit (367) and information on laser beam irradiation condition in a laser control unit (373), and the analytical result is imaged by an imaging unit (375). The imaged analytical result is displayed on a display (377).
摘要翻译：在将样品预先分离成在微芯片（353）中形成的通道中的多个部件之后，通过激光振荡器（361）的激光束沿着分离方向照射通道，以顺序地电离通道中分离的每个部分。通过质谱分析单元（363）检测离子化分数，用分析结果分析单元（371）进行分析。分析结果与激光控制单元（373）中的驱动器控制单元（367）中的位置信息和激光束照射条件的信息相关联地存储在存储器（369）中，并且分析结果由成像单元（375）。成像分析结果显示在显示器上（377）。

2. 发明申请

US20060214101A1 Mass spectrometric system and mass spectrometry 失效
标题翻译：质谱系统和质谱
公开(公告)号：US20060214101A1
公开(公告)日：2006-09-28
申请号：US10549587
申请日：2004-03-15
申请人： Katsutoshi Takahashi , Kazuhiro Iida , Masakazu Baba , Noriyuki Iguchi , Toru Sano , Hisao Kawaura , Toshitsugu Sakamoto , Wataru Hattori , Hiroko Someya
发明人： Katsutoshi Takahashi , Kazuhiro Iida , Masakazu Baba , Noriyuki Iguchi , Toru Sano , Hisao Kawaura , Toshitsugu Sakamoto , Wataru Hattori , Hiroko Someya
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/0418 , B01L3/502746 , B01L3/502753 , B01L2200/0663 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/16 , B01L2400/086 , G01N1/22 , G01N30/84 , G01N2030/8452
摘要： After a sample is previously separated into plural components in a channel formed in a microchip (353), the channel is irradiated along a separation direction with a laser beam from a laser oscillator (361) to sequentially ionize each fraction separated in the channel. The ionized fraction is detected by a mass spectrometry unit (363) and analyzed by an analytical result analyzing unit (371). The analytical result is stored in a memory (369) while associated with position information in a driver control unit (367) and information on laser beam irradiation condition in a laser control unit (373), and the analytical result is imaged by an imaging unit (375). The imaged analytical result is displayed on a display (377).
摘要翻译：在将样品预先分离成在微芯片（353）中形成的通道中的多个部件之后，通过激光振荡器（361）的激光束沿着分离方向照射通道，以顺序地电离通道中分离的每个部分。通过质谱分析单元（363）检测离子化部分，并通过分析结果分析单元（371）进行分析。分析结果与激光控制单元（373）中的驱动器控制单元（367）中的位置信息和激光束照射条件的信息相关联地存储在存储器（369）中，并且分析结果由成像单元（375）。成像分析结果显示在显示器上（377）。

3. 发明申请

US20070035722A1 System for measuring the wavelength dispersion and nonlinear coefficient of an optical fiber 有权
标题翻译：用于测量光纤的波长色散和非线性系数的系统
公开(公告)号：US20070035722A1
公开(公告)日：2007-02-15
申请号：US11580473
申请日：2006-10-13
申请人： Masateru Tadakuma , Yu Mimura , Misao Sakano , Osamu Aso , Takeshi Nakajima , Katsutoshi Takahashi
发明人： Masateru Tadakuma , Yu Mimura , Misao Sakano , Osamu Aso , Takeshi Nakajima , Katsutoshi Takahashi
IPC分类号： G01N21/00
CPC分类号： G01M11/3172 , G01M11/31 , G01M11/3181 , G01M11/319 , G01M11/39
摘要： A method of simultaneously specifying the wavelength dispersion and nonlinear coefficient of an optical fiber. Pulsed probe light and pulsed pump light are first caused to enter an optical fiber to be measured. Then, the power oscillation of the back-scattered light of the probe light or idler light generated within the optical fiber is measured. Next, the instantaneous frequency of the measured power oscillation is obtained, and the dependency of the instantaneous frequency relative to the power oscillation of the pump light in a longitudinal direction of the optical fiber is obtained. Thereafter, a rate of change in the longitudinal direction between phase-mismatching conditions and nonlinear coefficient of the optical fiber is obtained from the dependency of the instantaneous frequency. And based on the rate of change, the longitudinal wavelength-dispersion distribution and longitudinal nonlinear-coefficient distribution of the optical fiber are simultaneously specified.
摘要翻译：一种同时指定光纤的波长色散和非线性系数的方法。首先引入脉冲探头光和脉冲泵浦光，进入要测量的光纤。然后，测量在光纤内产生的探测光或空载光的背散射光的功率振荡。接下来，获得测量的功率振荡的瞬时频率，并且获得瞬时频率相对于光纤在纵向方向上的功率振荡的依赖性。此后，根据瞬时频率的依赖性，获得相位不匹配条件和光纤的非线性系数之间的纵向变化率。并且基于变化率，同时规定了光纤的纵向波长色散分布和纵向非线性系数分布。

4. 发明授权

US5214048A Oxetanocins 失效
标题翻译：氧自由基
公开(公告)号：US5214048A
公开(公告)日：1993-05-25
申请号：US439270
申请日：1989-11-20
申请人： Nobuyoshi Shimada , Shigeru Hasegawa , Takayuki Tomizawa , Seiichi Saito , Kyoichi Shibuya , Akio Fujii , Hiroo Hoshino , Kenichi Matsubara , Takemitsu Nagahata , Katsutoshi Takahashi , Yukihiro Nishiyama
发明人： Nobuyoshi Shimada , Shigeru Hasegawa , Takayuki Tomizawa , Seiichi Saito , Kyoichi Shibuya , Akio Fujii , Hiroo Hoshino , Kenichi Matsubara , Takemitsu Nagahata , Katsutoshi Takahashi , Yukihiro Nishiyama
IPC分类号： C07D473/00 , C07D501/00 , C07H19/02
CPC分类号： C07D473/00 , C07D501/00 , C07H19/02
摘要： This invention relates to novel oxetanocins represented by the following general formula (I): ##STR1## wherein R represents a group represented by ##STR2## and their pharmacologically acceptable salts which have antiviral activities.
摘要翻译：本发明涉及由以下通式（I）表示的新型氧杂环丁酮：其中R表示由IMAGE＆lt; IMAGE＆gt;表示的基团及其具有抗病毒活性的药理学上可接受的盐。

5. 发明授权

US5179084A Antiviral phosphoric acid esters of oxetanocins 失效
标题翻译：氧化亚油酸的抗性磷酸酯
公开(公告)号：US5179084A
公开(公告)日：1993-01-12
申请号：US504393
申请日：1990-04-04
申请人： Seiichi Saito , Shigeru Hasegawa , Masayuki Kitagawa , Nobuyoshi Shimada , Katsutoshi Takahashi , Jun-ichi Seki , Hiroo Hoshino , Yukihiro Nishiyama , Kenichi Matsubara , Takemitsu Nagahata
发明人： Seiichi Saito , Shigeru Hasegawa , Masayuki Kitagawa , Nobuyoshi Shimada , Katsutoshi Takahashi , Jun-ichi Seki , Hiroo Hoshino , Yukihiro Nishiyama , Kenichi Matsubara , Takemitsu Nagahata
IPC分类号： C07H19/02
CPC分类号： C07H19/02
摘要： The present invention relates to phosphoric acid esters of oxetanocins having an antiviral activity which are represented by general formula (I): ##STR1## wherein R.sub.1 represents a phosphoric acid ester residue, X represents hydrogen, hydroxy or hydroxymethyl group, and B represents a purine base residue, and pharmacologically acceptable salts thereof.

6. 发明授权

US4956504A Novel spergualin-related compounds and process for producing the same 失效
标题翻译：新型精毒素相关化合物及其制备方法
公开(公告)号：US4956504A
公开(公告)日：1990-09-11
申请号：US32811
申请日：1987-04-01
申请人： Tomio Takeuchi , Tetsushi Saino , Masao Yoshida , Katsutoshi Takahashi , Teruya Nakamura , Hamao Umezawa, deceased
发明人： Tomio Takeuchi , Tetsushi Saino , Masao Yoshida , Katsutoshi Takahashi , Teruya Nakamura , Hamao Umezawa, deceased
IPC分类号： A61K31/40 , A61K31/16 , A61K38/00 , A61P35/02 , A61P37/00 , A61P37/06 , C07C67/00 , C07C239/00 , C07C279/14 , C07C279/18 , C07D207/16 , C07K5/06
CPC分类号： C07C279/14 , C07C279/18 , Y02P20/55
摘要： The present invention relates to novel Spergualin-related compounds represented by the general formula [I] ##STR1## (wherein X is ##STR2## R is --H or --CH.sub.2 OH; R.sub.1 is --H, ##STR3## R.sub.2 is a residue obtained by removing, from an amino acid or peptide, the hydroxyl group of the carboxyl group and, when R.sub.1 is a group other than --H, R.sub.2 is same as R.sub.1), or a pharmacologically acceptable salt thereof. Said compounds or salts thereof have an immuno-modulating action.
摘要翻译：本发明涉及由通式[I]＆lt; IMAGE＆gt;（其中X为R为-H或-CH 2 OH; R 1为-H，R 2为囟素或者其药理学上可接受的盐，通过从氨基酸或肽除去羧基的羟基而得到的残基，当R 1为除-H以外的基团时，R 2与R 1相同。所述化合物或其盐具有免疫调节作用。

7. 发明授权

US4607114A Novel platinum complexes 失效
标题翻译：新型铂络合物
公开(公告)号：US4607114A
公开(公告)日：1986-08-19
申请号：US661433
申请日：1984-10-16
申请人： Yuya Nakayama , Kenji Iwata , Katsutoshi Takahashi
发明人： Yuya Nakayama , Kenji Iwata , Katsutoshi Takahashi
IPC分类号： A61K31/28 , A61K31/282 , A61P35/00 , C07F15/00
CPC分类号： C07F15/0093
摘要： This invention relates to a novel platinum-diamine complexes represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each represents a lower alkyl group having 1 to 3 carbon atoms or jointly represent an alkylene group having 3 to 6 carbon atoms; two X's each represents a halogen atom, ##STR2## or jointly represent a group represented by ##STR3## in which R.sub.3 is a lower alkyl group or a group represented by --OM (wherein M is an atom which can become a monovalent cation); Y is --OH or a halogen atom; and n is 0 or 1, and n is 1 when R.sub.1 and R.sub.2 jointly represent an alkylene group having 5 carbon atoms and X is chlorine. The platinum-diamine complex of this invention has an excellent antitumor activity and a lower renal toxicity than cis-Platin now widely used as a carcinostatic as clinical medicine, and is expected as a carcinostatic lowered in toxicity.
摘要翻译：本发明涉及由以下通式表示的新颖的铂 - 二胺络合物：其中R 1和R 2各自表示具有1至3个碳原子的低级烷基或共同表示具有3至6个碳原子的亚烷基; 两个X各自表示卤素原子，或者共同表示由表示的基团，其中R3是低级烷基或由-OM表示的基团（其中M是可以成为单价阳离子的原子）; Y是-OH或卤素原子; 且n为0或1，当R 1和R 2共同表示具有5个碳原子的亚烷基且X为氯时，n为1。本发明的铂 - 二胺配合物与现在广泛用作制癌剂作为临床医学的顺铂具有优异的抗肿瘤活性和较低的肾毒性，并且预期其具有降低的致癌性。

8. 发明授权

US4472304A (Amido)N-substituted bleomycins, salts thereof and process for preparation thereof 失效
标题翻译：（酰氨基）N-取代的白霉素，其盐及其制备方法
公开(公告)号：US4472304A
公开(公告)日：1984-09-18
申请号：US451437
申请日：1982-12-20
申请人： Hamao Umezawa , Akio Fujii , Yasuhiko Muraoka , Tokuji Nakatani , Takeyo Fukuoka , Katsutoshi Takahashi
发明人： Hamao Umezawa , Akio Fujii , Yasuhiko Muraoka , Tokuji Nakatani , Takeyo Fukuoka , Katsutoshi Takahashi
IPC分类号： C07H15/26 , A61K31/70 , A61K31/7028 , A61P35/00 , C07H17/00 , C07K9/00 , C07C103/52
CPC分类号： C07K9/003 , Y10S930/19
摘要： A promising carcinostatic (amido)N-substituted bleomycin represented by the following formula, or a salt thereof and a process for the preparation thereof: ##STR1## wherein BM represents a moiety of bleomycin skeleton; X represents an alkyl of 1 to 18 carbon atoms, an aminoalkyl of 1 to 12 carbon atoms, a lower alkyl having a halogen, phenyl indolyl, 5- or 6-membered heterocyclic group, or (lower)alkylamino (the alkyl group may have a substituent group) as a substituent, naphthyl, thiazolyl, or N-phenyl(lower)alkylpiperazinyl; and R represents a terminal amino residue of the bleomycin.
摘要翻译：由下式表示的有希望的制癌（酰氨基）N-取代的博来霉素或其盐及其制备方法：其中BM表示博来霉素骨架的部分; X表示1〜18个碳原子的烷基，1〜12个碳原子的氨基烷基，具有卤素的低级烷基，苯基吲哚基，5元或6元杂环基或（低级）烷基氨基（该烷基可以具有取代基），萘基，噻唑基或N-苯基（低级）烷基哌嗪基; R代表博来霉素的末端氨基残基。

9. 发明授权

US07424191B2 System for measuring the wavelength dispersion and nonlinear coefficient of an optical fiber 有权
标题翻译：用于测量光纤的波长色散和非线性系数的系统
公开(公告)号：US07424191B2
公开(公告)日：2008-09-09
申请号：US11580473
申请日：2006-10-13
申请人： Masateru Tadakuma , Yu Mimura , Misao Sakano , Osamu Aso , Takeshi Nakajima , Katsutoshi Takahashi
发明人： Masateru Tadakuma , Yu Mimura , Misao Sakano , Osamu Aso , Takeshi Nakajima , Katsutoshi Takahashi
IPC分类号： G02B6/00 , H04B10/08 , H04B17/00 , G01N21/00
CPC分类号： G01M11/3172 , G01M11/31 , G01M11/3181 , G01M11/319 , G01M11/39
摘要： A method of simultaneously specifying the wavelength dispersion and nonlinear coefficient of an optical fiber. Pulsed probe light and pulsed pump light are first caused to enter an optical fiber to be measured. Then, the power oscillation of the back-scattered light of the probe light or idler light generated within the optical fiber is measured. Next, the instantaneous frequency of the measured power oscillation is obtained, and the dependency of the instantaneous frequency relative to the power oscillation of the pump light in a longitudinal direction of the optical fiber is obtained. Thereafter, a rate of change in the longitudinal direction between phase-mismatching conditions and nonlinear coefficient of the optical fiber is obtained from the dependency of the instantaneous frequency. And based on the rate of change, the longitudinal wavelength-dispersion distribution and longitudinal nonlinear-coefficient distribution of the optical fiber are simultaneously specified.
摘要翻译：一种同时指定光纤的波长色散和非线性系数的方法。首先引入脉冲探头光和脉冲泵浦光，进入要测量的光纤。然后，测量在光纤内产生的探测光或空载光的背散射光的功率振荡。接下来，获得测量的功率振荡的瞬时频率，并且获得瞬时频率相对于光纤在纵向方向上的功率振荡的依赖性。此后，根据瞬时频率的依赖性，获得相位不匹配条件和光纤的非线性系数之间的纵向变化率。并且基于变化率，同时规定了光纤的纵向波长色散分布和纵向非线性系数分布。

10. 发明申请

US20050058417A1 Method and system for measuring the wavelength dispersion and nonlinear coefficient of an optical fiber, method of manufacturing optical fibers, method of measuring wavelength-dispersion distribution, method of compensating for measurement errors, and method of specifying conditions of measurement 有权
标题翻译：用于测量光纤的波长色散和非线性系数的方法和系统，制造光纤的方法，测量波长色散分布的方法，补偿测量误差的方法以及指定测量条件的方法
公开(公告)号：US20050058417A1
公开(公告)日：2005-03-17
申请号：US10832875
申请日：2004-04-27
申请人： Masateru Tadakuma , Yu Mimura , Misao Sakano , Osamu Aso , Takeshi Nakajima , Katsutoshi Takahashi
发明人： Masateru Tadakuma , Yu Mimura , Misao Sakano , Osamu Aso , Takeshi Nakajima , Katsutoshi Takahashi
IPC分类号： G01M11/00 , G02B6/02 , H04B10/08 , H04B10/18
CPC分类号： G01M11/3172 , G01M11/31 , G01M11/3181 , G01M11/319 , G01M11/39
摘要： A method of simultaneously specifying the wavelength dispersion and nonlinear coefficient of an optical fiber. Pulsed probe light and pulsed pump light are first caused to enter an optical fiber to be measured. Then, the power oscillation of the back-scattered light of the probe light or idler light generated within the optical fiber is measured. Next, the instantaneous frequency of the measured power oscillation is obtained, and the dependency of the instantaneous frequency relative to the power oscillation of the pump light in a longitudinal direction of the optical fiber is obtained. Thereafter, a rate of change in the longitudinal direction between phase-mismatching conditions and nonlinear coefficient of the optical fiber is obtained from the dependency of the instantaneous frequency. And based on the rate of change, the longitudinal wavelength-dispersion distribution and longitudinal nonlinear-coefficient distribution of thee optical fiber are simultaneously specified.
摘要翻译：一种同时指定光纤的波长色散和非线性系数的方法。首先引入脉冲探头光和脉冲泵浦光，进入要测量的光纤。然后，测量在光纤内产生的探测光或空载光的背散射光的功率振荡。接下来，获得测量的功率振荡的瞬时频率，并且获得瞬时频率相对于光纤在纵向方向上的功率振荡的依赖性。此后，根据瞬时频率的依赖性，获得相位不匹配条件和光纤的非线性系数之间的纵向变化率。并根据变化率，同时规定了光纤的纵向波长色散分布和纵向非线性系数分布。

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