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1. 发明授权

US06472182B1 Process for producing transglutaminase by microorganism 失效
标题翻译：通过微生物生产转谷氨酰胺酶的方法
公开(公告)号：US06472182B1
公开(公告)日：2002-10-29
申请号：US08952959
申请日：1997-12-04
申请人： Katsunori Kobayashi , Shigeru Yamanaka , Yuko Tanita , Naoko Tsuyoshi , Ryosuke Fudo , Junko Shinozaki , Kenzo Yokozeki , Shunichi Suzuki
发明人： Katsunori Kobayashi , Shigeru Yamanaka , Yuko Tanita , Naoko Tsuyoshi , Ryosuke Fudo , Junko Shinozaki , Kenzo Yokozeki , Shunichi Suzuki
IPC分类号： C12P2104
CPC分类号： C12N9/1044 , C12Q1/16 , C12Y203/02013
摘要： The present invention provides a process for producing a transglutaminase, which comprises culturing microorganisms of any of the genus Micrococcus, Clostridium, Torulopsis, Rhizopus and Monascus in a medium to produce the intended transglutaminase in the medium or in the cells of the microorganisms and then isolating the transglutaminase, and a process for producing a gelled proten with the thus-obtained transglutaminase. According to the process of the present invention, transglutaminase can be rapidly produced at a low cost.
摘要翻译：本发明提供一种转谷氨酰胺酶的制造方法，其包括在培养基中培养微球菌属，梭菌属，梭菌属，根霉属和红曲霉属中的任一种的微生物，以在培养基中或微生物细胞中产生预期的转谷氨酰胺酶，然后分离转谷氨酰胺酶，以及由此获得的转谷氨酰胺酶制备凝胶化的保护膜的方法。根据本发明的方法，可以低成本快速生产转谷氨酰胺酶。

2. 发明授权

US5731183A Bacillus-derived transglutaminase 失效
标题翻译：芽孢杆菌衍生的转谷氨酰胺酶
公开(公告)号：US5731183A
公开(公告)日：1998-03-24
申请号：US596864
申请日：1996-02-09
申请人： Katsunori Kobayashi , Shigeru Yamanaka , Kiyoshi Miwa , Shunichi Suzuki , Yuzuru Eto , Yuko Tanita , Kenzo Yokozeki , Kenichi Hashiguchi
发明人： Katsunori Kobayashi , Shigeru Yamanaka , Kiyoshi Miwa , Shunichi Suzuki , Yuzuru Eto , Yuko Tanita , Kenzo Yokozeki , Kenichi Hashiguchi
IPC分类号： C12N15/09 , A23J3/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/54 , C12P21/04 , C12R1/125 , C12R1/19
CPC分类号： C12N9/1044 , Y10S435/839
摘要： The present invention relates to (1) a transglutaminase (hereinafter referred to as TG) isolated from a Bacilli such as those of Bacillus subtilis, (2) a fraction having transglutaminase activity, and (3) a method for producing a protein, a non-proteinaceous amino acid polymer, a peptide or derivatives thereof having a crosslinked structure, by crosslinking the glutamine and lysine residues in the same with the TG or the fraction having TG activity to thereby form intermolecular or intramolecular, crosslinked .epsilon.-(.gamma.-Glu)-Lys bonds. The present invention also relates to (4) a DNA coding for a TG derived from a Bacilli such as Bacillus subtilis, (5) a vector comprising said DNA coding for the TG, (6) a cell transformed with the vector, and (7) a method for producing a Bacillus-derived transglutaminase by incubating the transformant. The crosslinked polymers produced using the Bacillus-derived TG of the present invention can be used in foods such as tofu (soybean curd), pudding, yogurt, cheese, ground fish meat, boiled fish paste, sausage and other fish and meat products and also in cosmetics, etc.
摘要翻译：本发明涉及（1）从枯草芽孢杆菌等芽孢分离的转谷氨酰胺酶（以下称为TG），（2）具有转谷氨酰胺酶活性的级分，（3）蛋白质的制造方法，蛋白质氨基酸聚合物，具有交联结构的肽或其衍生物，通过与TG或具有TG活性的级分交联谷氨酰胺和赖氨酸残基，从而形成分子间或分子内交联的ε-（γ-Glu） -Lys债券。本发明还涉及（4）编码来自芽孢杆菌如枯草芽孢杆菌的TG的DNA，（5）包含编码TG的所述DNA的载体，（6）用载体转化的细胞和（7 ）通过温育转化体来生产芽孢杆菌来源的转谷氨酰胺酶的方法。使用本发明的芽孢杆菌来源的TG制备的交联聚合物可以用于诸如豆腐（豆腐），布丁，酸奶，奶酪，地面鱼肉，煮鱼酱，香肠和其他鱼和肉制品的食品中化妆品等

3. 发明授权

US5948662A Bacillus-derived transglutaminase 失效
标题翻译：芽孢杆菌衍生的转谷氨酰胺酶
公开(公告)号：US5948662A
公开(公告)日：1999-09-07
申请号：US989667
申请日：1997-12-12
申请人： Katsunori Kobayashi , Shigeru Yamanaka , Kiyoshi Miwa , Shunichi Suzuki , Yuzuru Eto , Yuko Tanita , Kenzo Yokozeki , Kenichi Hashiguchi
发明人： Katsunori Kobayashi , Shigeru Yamanaka , Kiyoshi Miwa , Shunichi Suzuki , Yuzuru Eto , Yuko Tanita , Kenzo Yokozeki , Kenichi Hashiguchi
IPC分类号： C12N15/09 , A23J3/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/54 , C12P21/04 , C12R1/125 , C12R1/19
CPC分类号： C12N9/1044 , Y10S435/839
摘要： A method for processing a protein, a non-proteinaceous amino acid polymer, or a non-proteinaceous amino acid polymer, or a peptide or derivatives thereof having a crosslinked structure, which entails contacting glutamine and lysine residues in a protein, a non-proteinaceous amino acid polymer, a peptide or derivatives thereof with a transglutaminase obtained from Bacillus subtilus to form intermolecular or intramolecular, crosslinked .epsilon.(.delta.-Glu)-Lys bonds between or in the molecules of the protein, non-proteinaceous amino acid polymer, peptide or derivatives thereof, wherein the transglutaminase has the physicochemical properties described herein.
摘要翻译：用于处理蛋白质，非蛋白质氨基酸聚合物或非蛋白质氨基酸聚合物的方法或具有交联结构的肽或其衍生物，其需要使蛋白质中的谷氨酰胺和赖氨酸残基接触，非蛋白质氨基酸聚合物，肽或其衍生物与从枯草芽孢杆菌获得的转谷氨酰胺酶在蛋白质，非蛋白质氨基酸聚合物，肽或肽的分子之间或之内形成分子间或分子内交联的ε（δ-Glu）-Lys键其衍生物，其中转谷氨酰胺酶具有本文所述的物理化学性质。

4. 发明授权

US5955124A Process for producing a condiment 失效
标题翻译：生产调味品的方法
公开(公告)号：US5955124A
公开(公告)日：1999-09-21
申请号：US594489
申请日：1996-01-31
申请人： Kaoru Kubota , Naoko Tsuyoshi , Shigeru Yamanaka , Toshio Kato , Hisao Fukuda
发明人： Kaoru Kubota , Naoko Tsuyoshi , Shigeru Yamanaka , Toshio Kato , Hisao Fukuda
IPC分类号： A23L23/00 , A23J3/16 , A23L13/30 , A23L13/70 , A23L27/00 , A23L27/10 , A23L27/21 , A23L27/24 , A23L27/26 , A23L27/50 , A23L27/60 , A23B4/10 , A23B4/20
CPC分类号： A23L23/00 , A23L13/30 , A23L13/74 , A23L27/24 , A23L27/26 , A23L27/50
摘要： The present invention provides a method for producing a condiment with decreased animal smell and which has increased beefwise taste and greater body flavor and complex flavor. The condiment is produced by blending therein denatured meat and/or the extract thereof, wherein the denatured meat is obtained by salting livestock meat, washing and then allowing microorganisms to ferment and ripen the meat.
摘要翻译：本发明提供一种生产具有降低的动物气味的调味品的方法，其具有增加的牛肉味和更大的身体风味和复杂的味道。调味品通过混合变性肉和/或其提取物而制备，其中变性肉通过盐化家畜肉，洗涤然后允许微生物发酵和成熟肉获得。

5. 发明授权

US06506431B2 Spore germination inhibitor and food containing the same 失效
标题翻译：孢子发芽抑制剂和含有相同的食物
公开(公告)号：US06506431B2
公开(公告)日：2003-01-14
申请号：US09781159
申请日：2001-02-13
申请人： Katsunori Kobayashi , Shigeru Yamanaka , Tomomi Kuwahara , Hiroshi Miyano , Kohki Ishikawa , Ryosuke Fudou
发明人： Katsunori Kobayashi , Shigeru Yamanaka , Tomomi Kuwahara , Hiroshi Miyano , Kohki Ishikawa , Ryosuke Fudou
IPC分类号： C09B29036
CPC分类号： C07D213/81 , A01N43/40 , A23L3/3508 , A23L3/3544
摘要： The spore germination inhibitor of the invention is 6-carbamoyl-2-pyridine carboxylic acid which is produced by a microorganism of genus Bacillus, such as Bacillus subtilis, and can inhibit germination of sporogenous bacteria resulting in the prevention of spoilage and putrefaction of foods, particularly in combination with D-alanine.
摘要翻译：本发明的孢子萌发抑制剂是由枯草芽孢杆菌属芽孢杆菌属微生物产生的6-氨基甲酰基-2-吡啶羧酸，能够抑制孢子细菌的发芽，从而防止食品的腐败和腐败，特别是与D-丙氨酸组合。

6. 再颁专利

USRE38792E1 Modified bacterial cellulose 有权
标题翻译：改良细菌纤维素
公开(公告)号：USRE38792E1
公开(公告)日：2005-09-06
申请号：US10140040
申请日：2002-05-08
申请人： Masaru Ishihara , Shigeru Yamanaka
发明人： Masaru Ishihara , Shigeru Yamanaka
IPC分类号： C12P19/04
CPC分类号： C12P19/04
摘要： This invention provides a bacterial cellulose comprising ribbon-shaped microfibrils having a thickness of 10 to 100 nm and a width of 160 to 1000 nm or a bacterial cellulose comprising ribbon-shaped microfibrils having a thickness of 10 to 100 nm and a width of 50 to 70 nm. The former bacterial cellulose can be produced by culturing cellulose-producing bacteria in a culture medium containing a cell division inhibitor, and the latter can be produced by culturing the bacterium in a culture medium containing an organic reducing agent. The bacterial cellulose is modified from conventional bacterial cellulose in the major axis, and is improved in Young's modulus, etc. This invention provides a bacterial cellulose comprising ribbon-shaped microfibrils having a thickness of 1 to 9 nm and a width of 160 to 1000 nm or a bacterial cellulose comprising ribbon-shaped microfibrils having a thickness of 1 to 9 nm and a width of 50 to 70 nm. The former bacterial cellulose can be produced by culturing cellulose-producing bacteria in a culture medium containing a cell division inhibitor, and the latter can be produced by culturing the bacterium in a culture medium containing an organic reducing agent. The bacterial cellulose is modified from conventional bacterial cellulose in the major axis, and is improved in Young's modulus, etc.
摘要翻译： <？delete-start id =“DEL-S-00001”date =“20050906”？本发明提供一种细菌纤维素，其包含厚度为10〜100nm，宽度为160〜1000nm的带状微原纤维，或细菌纤维素，其包含厚度为10〜100nm，宽度为50〜70nm的带状微原纤维。前者的细菌纤维素可以通过在含有细胞分裂抑制剂的培养基中培养纤维素生成细菌来制造，后者可以通过在含有有机还原剂的培养基中培养细菌来制备。细菌纤维素在长轴上由常规细菌纤维素改性，杨氏模量等改善。<？delete-end id =“DEL-S-00001”？> <？insert-start id =“INS-S -00001“日期=”20050906“？本发明提供一种细菌纤维素，其包含厚度为1〜9nm，宽度为160〜1000nm的带状微原纤维，或包含厚度为 1〜9nm，宽度为50〜70nm。前者的细菌纤维素可以通过在含有细胞分裂抑制剂的培养基中培养纤维素生成细菌来制造，后者可以通过在含有有机还原剂的培养基中培养细菌来制备。细菌纤维素在长轴上由常规细菌纤维素改性，杨氏模量等改善。<？insert-end id =“INS-S-00001”？>

7. 发明授权

US6060289A Modified bacterial cellulose 失效
标题翻译：改良细菌纤维素
公开(公告)号：US6060289A
公开(公告)日：2000-05-09
申请号：US900124
申请日：1997-07-25
申请人： Masaru Ishihara , Shigeru Yamanaka
发明人： Masaru Ishihara , Shigeru Yamanaka
IPC分类号： C12P19/04
CPC分类号： C12P19/04
摘要： This invention provides a bacterial cellulose comprising ribbon-shaped microfibrils having a thickness of 10 to 100 nm and a width of 160 to 1000 nm or a bacterial cellulose comprising ribbon-shaped microfibrils having a thickness of 10 to 100 nm and a width of 50 to 70 nm. The former bacterial cellulose can be produced by culturing cellulose-producing bacteria in a culture medium containig a cell division inhibitor, and the latter can be produced by culturing the bacterium in a culture medium containing an organic reducing agent. The bacterial cellulose is modified from conventional bacterial cellulose in the major axis, and is improved in Young's modulus, etc.
摘要翻译：本发明提供一种细菌纤维素，其包含厚度为10〜100nm，宽度为160〜1000nm的带状微原纤维，或包含厚度为10〜100nm，宽度为50〜50nm的带状微原纤维的细菌纤维素 70nm。前述细菌纤维素可以通过在含有细胞分裂抑制剂的培养基中培养纤维素生成细菌来制造，后者可以通过在含有有机还原剂的培养基中培养细菌来制备。细菌纤维素在长轴上由常规细菌纤维素改性，杨氏模量等改善。

8. 发明授权

US4465631A 5-Substituted-3-isoxazolecarboxylic acid derivatives 失效
标题翻译： 5-取代的3-异恶唑羧酸衍生物
公开(公告)号：US4465631A
公开(公告)日：1984-08-14
申请号：US482544
申请日：1983-04-06
申请人： Naohiko Yasuda , Hisao Iwagami , Eiji Nakanishi , Yukio Sasaki , Shigeru Yamanaka
发明人： Naohiko Yasuda , Hisao Iwagami , Eiji Nakanishi , Yukio Sasaki , Shigeru Yamanaka
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D499/00 , C07D499/64 , C07D499/68 , C07D499/70 , C07D501/20 , C07D501/22 , C07D501/44
CPC分类号： C07D499/00
摘要： A 5-substituted-3-isoxazolecarboxylic acid derivative of the general formula: ##STR1## wherein X stands for a phenyl group, thienyl group, furyl group or pyridyl group, each of which optionally may carry at least one substituent group; R stands for a phenyl group or hydroxyphenyl group; and A stands for a group of the formula: ##STR2## wherein Y stands for ##STR3## in which the carbon atom with which the carboxyl group combines with the nitrogen atom in A, M stands for a hydrogen atom or a substituent group, and Z stands for a hydrogen atom, hydroxy group, acyloxy group, carbamoyloxy group, aromatic heterocycle thio group or aromatic nitrogen-containing heterocycle quaternary ammonium group, is disclosed along with methods for producing these compounds.
摘要翻译：其中X代表苯基，噻吩基，呋喃基或吡啶基，其中每一个可以任选地带有至少一个取代基;一个5-取代的3-异恶唑羧酸衍生物，其通式如下： R代表苯基或羟基苯基; A代表下式的基团：其中Y代表其中羧基与A中的氮原子结合的碳原子，M代表氢原子或取代基的，以及 Z表示氢原子，羟基，酰氧基，氨基甲酰氧基，芳香族杂环硫基或芳香族含氮杂环季铵基，同时也包括这些化合物的制造方法。

9. 发明授权

US4458016A Production of 1-.beta.-D-ribofuranosyl-1,2,4-triazole 失效
标题翻译：生产1-β-D-呋喃核糖基-1,2,4-三唑
公开(公告)号：US4458016A
公开(公告)日：1984-07-03
申请号：US356405
申请日：1982-03-09
申请人： Shigeru Yamanaka , Takashi Utagawa , Tadao Kobayashi
发明人： Shigeru Yamanaka , Takashi Utagawa , Tadao Kobayashi
IPC分类号： C12P19/28 , C07H19/056 , C12P19/38 , C12R1/01 , C12R1/025 , C12R1/05 , C12R1/06 , C12R1/07 , C12R1/08 , C12R1/13 , C12R1/15 , C12R1/18 , C12R1/185 , C12R1/19 , C12R1/20 , C12R1/22 , C12R1/265 , C12R1/37 , C12R1/38 , C12R1/42 , C12R1/425 , C12R1/44 , C12R1/45 , C12R1/63 , C12R1/64 , C12R1/72 , C12R1/74 , C12R1/85 , C12R1/865 , C12P17/04 , C12P17/10 , C12P17/16
CPC分类号： C12P19/38 , C07H19/056
摘要： The production of a 1-.beta.-D-ribofuranosyl-1,2,4-triazole of the formula ##STR1## wherein R is hydroxy, amino, or alkoxy, is carried out by reacting a 1,2,4 triazole of formula ##STR2## wherein R is hydroxy, amino, or alkoxy group, with a greater than equimolar amount of a ribofuranosyl group donor in the presence of a nucleoside phosphorylase preparation at a temperature in the range from 40.degree. to 65.degree. C. for more than 10 minutes, and recovering a 1-.beta.-D-ribofuranosyl-1,2,4-triazole from the reaction solution. The temperature is preferably from 55.degree. to 65.degree. C. and the time is preferably 10 minutes to 20 hours. An elevated temperature higher than the usual enzyme reaction temperature isused to prevent undesirable enzymatic reactions.
摘要翻译：其中R是羟基，氨基或烷氧基的式“IMAGE”的1-β-D-呋喃核糖基-1,2,4-三唑的制备是通过使式 IMAGE>其中R是羟基，氨基或烷氧基，在核苷磷酸化酶制剂存在下，在40-65℃的温度范围内具有大于等摩尔量的呋喃核糖基供体，超过10 分钟，并从反应溶液中回收1-β-D-呋喃核糖基-1,2,4-三唑。温度优选为55〜65℃，优选为10分钟〜20小时。使用高于通常酶反应温度的升高温度来防止不期望的酶反应。

10. 发明申请

US20080031557A1 Rolling Guide Device 审中-公开
标题翻译：滚动导向装置
公开(公告)号：US20080031557A1
公开(公告)日：2008-02-07
申请号：US11663846
申请日：2005-09-30
申请人： Shigeru Yamanaka , Hong Yang
发明人： Shigeru Yamanaka , Hong Yang
IPC分类号： F16C33/30
CPC分类号： F16C29/0659 , C23C14/0623 , C23C14/35 , F16C29/0657 , F16C33/3706 , F16C33/3713 , F16C33/6696 , F16C2202/04 , F16C2202/54 , F16C2223/60 , F16C2240/60 , F16H25/20 , F16H2025/249 , Y02T10/865
摘要： A rolling guide device 160 is provided with a track rail 161 as a track member and a movable member 163 mounted to the track rail 161 to be movable through balls 162. A solid lubricant film is formed to the ball 162 by using a closed magnetic field unbalanced magnetron spattering apparatus (CUMS apparatus). The solid lubricant film has a low friction coefficient at the outermost surface of the film, withstands an inner repeated stress, and has a high adhesion performance. Such solid lubricant film has never been from its inside or boundary portion and wears at the minimum speed from the film surface, so that a reliable and highly ideal solid lubricating function can be attained, and by applying the solid lubricant film having improved adhesion performance and abrasion resistance to the rolling guide device, there can be provided a rolling guide device usable in a specific environmental condition such as an undesirable lubricating environment, high temperature vacuum condition, or an oil-free condition.
摘要翻译：滚动导向装置160设置有作为轨道构件的轨道161和安装到轨道161以可移动穿过球162的可动构件163。通过使用闭合磁场不平衡磁控溅射装置（CUMS装置），向球162形成固体润滑剂膜。固体润滑剂膜在膜的最外表面具有低摩擦系数，承受内部重复应力，并且具有高粘合性能。这种固体润滑剂膜从来没有从其内部或边界部分以最小速度从膜表面磨损，从而可以获得可靠和高度理想的固体润滑功能，并且通过涂覆具有改进的粘合性能的固体润滑剂膜和对滚动导向装置的耐磨性，可以提供可用于特殊环境条件如滚动导向装置，例如不良润滑环境，高温真空条件或无油条件。

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