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1. 发明授权

US07276582B2 Control of function of intracellular Ca ion 失效
标题翻译：细胞内Ca离子的功能控制
公开(公告)号：US07276582B2
公开(公告)日：2007-10-02
申请号：US11283193
申请日：2005-11-18
申请人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
发明人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
IPC分类号： A61K38/44 , A61K38/00
CPC分类号： A61K38/1709 , C07K14/4702
摘要： Analysis of substance capable of binding with inositol-1, 4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+ release. More specifically, a regulator for the activity of inositol-1,4, 5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calsium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.
摘要翻译：分析能够与肌醇-1,4,5-三磷酸（IP 3 N 3）受体（IP 3 R R）结合的物质，优选具有IP 3 < 分析IP 3的功能; 以及建立与IP 3 R相关的各种故障和疾病的治疗或诊断方法。特别地，控制细胞内Ca 2+释放的活性。更具体地，由碳酸酐酶相关蛋白质（肌醇-1,5,5-三磷酸（IP 3 N 3 R））的肌醇-1,4,5-三磷酸（IP 3 N 3 R）活性调节剂鲤鱼）; 由碳酸酐酶相关蛋白（CARP）组成的用于细胞内钙离子释放的控制剂; 及其控制方法。

2. 发明授权

US07709441B2 Control of function of intracellular Ca ion 有权
标题翻译：细胞内Ca离子的功能控制
公开(公告)号：US07709441B2
公开(公告)日：2010-05-04
申请号：US11811588
申请日：2007-06-11
申请人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
发明人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
IPC分类号： A61K8/66 , A61K38/00
CPC分类号： A61K38/1709 , C07K14/4702
摘要： Analysis of substance capable of binding with inositol-1,4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+ release. More specifically, a regulator for the activity of inositol-1,4,5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calcium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.
摘要翻译：分析能够与肌醇-1,4,5-三磷酸（IP3）受体（IP3R）结合的物质，优选具有IP3R的调节结构域; 分析IP3R的功能; 并建立与IP3R相关的各种故障和疾病的治疗或诊断方法。特别是控制细胞内Ca2 +释放的活性。更具体地，由碳酸酐酶相关蛋白（CARP）组成的肌醇-1,4,5-三磷酸（IP3）受体（IP3R）的活性调节剂; 由碳酸酐酶相关蛋白（CARP）组成的细胞内钙释放控制剂; 及其控制方法。

3. 发明申请

US20080064082A1 Control of function of intracellular Ca ion 有权
标题翻译：细胞内Ca离子的功能控制
公开(公告)号：US20080064082A1
公开(公告)日：2008-03-13
申请号：US11811588
申请日：2007-06-11
申请人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
发明人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
IPC分类号： C12N1/00
CPC分类号： A61K38/1709 , C07K14/4702
摘要： Analysis of substance capable of binding with inositol-1,4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+ release. More specifically, a regulator for the activity of inositol-1,4,5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calcium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.
摘要翻译：分析能够与肌醇-1,4,5-三磷酸（IP 3 N 3）受体（IP 3 R R）结合的物质，优选具有IP 3 < 分析IP 3的功能; 以及建立与IP 3 R相关的各种故障和疾病的治疗或诊断方法。特别地，控制细胞内Ca 2+释放的活性。更具体地，由碳酸酐酶相关蛋白质（肌醇-1,5,5-三磷酸（IP 3 N 3 R））的肌醇-1,4,5-三磷酸（IP 3 N 3 R）的活性调节剂鲤鱼）; 由碳酸酐酶相关蛋白（CARP）组成的细胞内钙释放控制剂; 及其控制方法。

4. 发明申请

US20060166880A1 Control of function of intracellular Ca ion 失效
标题翻译：细胞内Ca离子的功能控制
公开(公告)号：US20060166880A1
公开(公告)日：2006-07-27
申请号：US11283193
申请日：2005-11-18
申请人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
发明人： Katsuhiko Mikoshiba , Junji Hirota , Hideaki Ando
IPC分类号： A61K38/50 , C12N9/16
CPC分类号： A61K38/1709 , C07K14/4702
摘要： Analysis of substance capable of binding with inositol-1,4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+ release. More specifically, a regulator for the activity of inositol-1,4,5-triphosphate (IP3) receptor (IP3R), comprised of carbonic anhydrase related protein (CARP); a control agent for intracellular calsium release, comprised of carbonic anhydrase related protein (CARP); and a method of control therewith.
摘要翻译：分析能够与肌醇-1,4,5-三磷酸（IP 3 N 3）受体（IP 3 R R）结合的物质，优选具有IP 3 < 分析IP 3的功能; 以及建立与IP 3 R相关的各种故障和疾病的治疗或诊断方法。特别地，控制细胞内Ca 2+释放的活性。更具体地，由碳酸酐酶相关蛋白质（肌醇-1,5,5-三磷酸（IP 3 N 3 R））的肌醇-1,4,5-三磷酸（IP 3 N 3 R）的活性调节剂鲤鱼）; 由碳酸酐酶相关蛋白（CARP）组成的用于细胞内钙离子释放的控制剂; 及其控制方法。

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