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1. 发明授权

US5037612A Method and apparatus for analyzing fluid sample 失效
标题翻译：用于分析流体样品的方法和装置
公开(公告)号：US5037612A
公开(公告)日：1991-08-06
申请号：US435276
申请日：1982-10-19
申请人： Katsuaki Takahashi , Takehide Satou , Tetsuaki Abe
发明人： Katsuaki Takahashi , Takehide Satou , Tetsuaki Abe
IPC分类号： G01N21/76 , G01N21/75 , G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/025 , G01N35/0092 , G01N2035/0097 , G01N2035/0437 , Y10T436/114998
摘要： A row composed of reaction vessels is arranged on a turntable and one unit of sample dispenser mechanism as well as one photometer and a plurality units of reagent feeding mechanism are arranged near the turntable. After a sample is added to one specified reaction vessel, the turntable is rotated by 180.degree. or more and stopped so as to advance the reaction vessel containing said sample by half a revolution plus one cell. During this rotation, approximately half of all the vessels cross the light path of the photometer for the absorbance of fluid in each vessel to be measured.A reagent is added to the specified reaction vessel at the next stop position after sampling in order to start reaction. The turntable is again rotated and stopped so as to advance the reaction vessel by half a revolution plus one cell. During this rotation, the reaction vessel crosses said light path of the photometer for the absorbance of the reaction fluid to be measured. The reaction vessel stops at the second reaction vessel position beyond the initial sample adding position. During the course of repeated rotations, the specified reaction vessel crosses the light path of said photometer a number of times and is stopped at said sample adding position after it is washed to be ready for further use.
摘要翻译：由反应容器组成的一列设置在转台上，一个样品分配机构单元以及一个光度计，多个单元的试剂供给机构设置在转台附近。将样品加入到一个指定的反应容器中后，转台旋转180°以上，停止，使含有样品的反应容器前进一半加一个电池。在该旋转期间，大约一半的血管与光度计的光路交叉，以便测量每个容器中的液体的吸光度。为了开始反应，将试剂在采样后的下一停止位置添加到指定的反应容器中。转盘再次旋转和停止，以将反应容器推进半转加一个电池。在该旋转期间，反应容器与光度计的所述光路交叉，以测量待测反应流体的吸光度。反应容器在超过初始样品添加位置的第二反应容器位置停止。在反复旋转的过程中，指定的反应容器多次与所述光度计的光路交叉，并且在清洗之后停止在所述样品添加位置以准备进一步使用。

2. 发明授权

US4543238A Sampling apparatus 失效
标题翻译：取样装置
公开(公告)号：US4543238A
公开(公告)日：1985-09-24
申请号：US530630
申请日：1983-09-09
申请人： Tomonori Mimura , Hisayuki Sagusa , Takehide Satou , Katsuaki Takahashi
发明人： Tomonori Mimura , Hisayuki Sagusa , Takehide Satou , Katsuaki Takahashi
IPC分类号： G01N35/10 , G01N35/02 , G01N35/04
CPC分类号： G01N35/1004 , G01N2035/1025 , G01N2035/1086 , Y10T436/114998
摘要： A special cleaner is located between a sample cup at the sample absorbing position and a reaction case at the sample delivery position. This cleaner has a V-shaped recess, in which the cleaning liquid is filled in a pile. A pipetting tube is inserted into the sample cup, and a serum sample of the amount corresponding to a plurality of analysis items is absorbed and held by the pipetting tube. The pipetting tube hoisted upward is carried to the sample delivery position. In the process, the pipetting tube passes through cleaning liquid, so that the outer wall of the pipetting tube is cleaned within a short time, thus removing the excessive serum attached to the outer wall. The pipetting tube is lowered into the reaction case associated with the first analysis item to deliver a predetermined amount of serum sample thereinto. The pipetting tube is raised again and the train of reaction cases advances one step so that the tube is inserted into the next reaction case. After the delivery for a plurality of items, the inner and outer walls of the pipetting tube are cleaned.
摘要翻译：特殊的清洁剂位于样品吸收位置的样品杯和样品传送位置的反应盒之间。该清洁器具有V形凹部，其中清洁液体填充在一堆中。将移液管插入到样品杯中，并且与多个分析物相对应的量的血清样品被移液管吸收并保持。向上悬吊的移液管被运送到样品传送位置。在此过程中，移液管通过清洗液，从而在短时间内清洗移液管的外壁，从而去除附着在外壁上的过量血清。移液管下降到与第一分析项目相关联的反应室中，以将预定量的血清样品输送到其中。移液管再次升高，反应箱体前进一步，使管插入下一个反应情况。在输送多个物品之后，移液管的内壁和外壁被清洁。

3. 发明授权

US4291986A Optical rate assay apparatus 失效
标题翻译：光速测定装置
公开(公告)号：US4291986A
公开(公告)日：1981-09-29
申请号：US62115
申请日：1979-07-30
申请人： Takehide Satou , Kasumi Yoshida , Hisayuki Sagusa , Osamu Ohno , Tetuaki Abe
发明人： Takehide Satou , Kasumi Yoshida , Hisayuki Sagusa , Osamu Ohno , Tetuaki Abe
IPC分类号： G01N21/11 , G01N21/25 , G01N21/75 , G01N35/00 , G01N35/02 , G01N35/08 , G01N35/10 , G01N21/85
CPC分类号： G01N21/253 , G01N35/021 , G01N2035/00435 , G01N35/1079
摘要： A serum and a reagent are supplied into a reaction tube to prepare a reactive solution or a sample solution which is sucked up at a predetermined position into one of a plurality of flow cells. The flow cells are mounted on a thermostatic block to be heated to a predetermined temperature and alternatively supplied with the sample solution. After a sample solution has been introduced from a specified reaction tube into one of the flow cells and heated to the predetermined temperature, the sample solution in the one flow cell is irradiated with light to measure changes in absorbance of the sample solution for a predetermined time. During a period when the absorbance changes of the sample solution in one flow cell is measured, another sample solution is introduced from another reaction tube into another flow cell and heated to the predetermined temperature. Immediately after the measurement of the absorbance changes of the sample solution in the one flow cell has been completed, the other flow cell is irradiated with light to measure the changes in absorbance of the sample solution in the other flow cell. Thereafter, one and the other flow cells are alternately supplied with a sample solution to successively measure the absorbance changes. Thus, a waiting time for stabilizing the temperature of the sample solution introduced into the flow cell can be actually dispensed with, and therefore effective measurement can be made.
摘要翻译：将血清和试剂供给到反应管中以制备在预定位置吸入多个流动池中的一个流动池中的反应性溶液或样品溶液。将流动池安装在恒温块上以加热到预定温度，并交替地供应样品溶液。在将样品溶液从指定的反应管引入其中一个流通池中并加热到预定温度后，用一定流量池中的样品溶液照射样品溶液的吸光度变化达预定时间。在测量一个流动池中的样品溶液的吸光度变化的期间，将另一个样品溶液从另一个反应管引入另一个流通池并加热至预定温度。在一个流通池中的样品溶液的吸光度变化的测量完成之后，立即用光照射另一个流动池，以测量另一个流动池中的样品溶液的吸光度变化。此后，将一个和另一个流动池交替地供应样品溶液以连续测量吸光度变化。因此，实际上可以省去用于稳定引入流通池的样品溶液的温度的等待时间，因此可以进行有效的测量。

4. 发明授权

US4318615A Automatic rate analyzing method 失效
标题翻译：自动速率分析方法
公开(公告)号：US4318615A
公开(公告)日：1982-03-09
申请号：US27849
申请日：1979-04-06
申请人： Hisayuki Sagusa , Hiroshi Hashimoto , Yasushi Nomura , Takehide Satou , Ryohei Yabe
发明人： Hisayuki Sagusa , Hiroshi Hashimoto , Yasushi Nomura , Takehide Satou , Ryohei Yabe
IPC分类号： G01N21/75 , G01N21/25 , G01N21/27 , G01J3/42 , G01T1/00
CPC分类号： G01N21/253 , G01N21/272
摘要： An automatic rate analyzing method for determining a concentration of an item in concern contained in a sample to be analyzed comprises steps of irradiating the sample with light thereby to produce a transmitted light signal at a specific wavelength, converting the transmitted light signal into a corresponding electric signal and sampling the electric signal at a given interval thereby to produce a plurality of sample values. The plurality of sample values are grouped into groups each containing a predetermined number of sample values selected for every given number of the sample values. Each of the groups is deviated from the adjacent ones by a number of sample values smaller than the given number. The sample values in each of the groups are added together to produce sums associated with each of the groups. Difference between the sums of every two adjacent groups is determined and divided by the sum associated with either one of the two adjacent groups thereby to produce quotients which are then added together to produce a total sum representing the concentration of the item in concern.
摘要翻译：用于确定待分析样品中关注的物品的浓度的自动速率分析方法包括以下步骤：用光照射样品，从而产生特定波长的透射光信号，将透射光信号转换成相应的电以给定的间隔对电信号进行信号和采样，从而产生多个采样值。多个采样值被分组成各自包含为每个给定数量的采样值选择的预定数量的采样值的组。每个组通过小于给定数量的多个样本值偏离相邻组。将每个组中的样本值相加在一起以产生与每个组相关联的和。确定每两个相邻组的总和之间的差，除以与两个相邻组中的任一个相关联的总和，从而产生然后相加的商，以产生表示所关注的项目的集中的总和。

5. 发明授权

US5100622A Automatic analyzing apparatus and method for clinical examination 失效
标题翻译：自动分析装置和临床检查方法
公开(公告)号：US5100622A
公开(公告)日：1992-03-31
申请号：US492853
申请日：1990-03-13
申请人： Tomonori Mimura , Takehide Satou
发明人： Tomonori Mimura , Takehide Satou
IPC分类号： G01N33/49 , G01N21/31 , G01N33/52 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： G01N35/00603 , G01N35/00594 , G01N35/0095 , G01N2035/0097 , G01N2035/0415 , G01N2035/0444 , G01N2201/127 , G01N35/00693 , G01N35/025 , G01N35/10 , Y10T436/115831 , Y10T436/12
摘要： An automatic analyzing apparatus and method transfers a sample to be examined to a sampling position, fractionally injects the sample into a reaction vessel by using sampling means, adds a reagent to the reaction vessel holding therein the sample fractionally injected to cause reaction, and measures absorbance of the reaction solution at predetermined time intervals using a photometer. A first check for checking whether an abnormality is present in the measurement result of each measurement item is made, followed by a second check for checking whether an abnormality is present on the basis of a change in the rate of absorbance measured after the reagent is added to the sample in the reaction vessel. Then, a third check computes correlation of measured absorbance data and checks whether an abnormality is present on the basis of the result of computation. Finally, a determination is made, with respect to the sample in accordance with an abnormal item when it is judged that an abnormality is present in the result of the first, second or third check, whether remeasurement is necessary, and for selecting, in case of remeasurement, either remeasurement under the same conditions or remeasurement with a reduced sample quantity as compared with that of the first measurement conditions. When remeasurement is determined, the sample is carried to the sampling position.

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