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1. 发明授权

US07029868B2 Cell fusion assays using fluorescence resonance energy transfer 失效
公开(公告)号：US07029868B2
公开(公告)日：2006-04-18
申请号：US10204200
申请日：2001-02-13
申请人： Kathleen A. Sullivan , Diana Benincasa , Margaret A. Cascieri , Lyndon J. Mitnaul , Lin-Lin Shiao , Michael R. Tota
发明人： Kathleen A. Sullivan , Diana Benincasa , Margaret A. Cascieri , Lyndon J. Mitnaul , Lin-Lin Shiao , Michael R. Tota
IPC分类号： C12Q1/34 , C12Q1/00 , C12N5/00 , C12N15/02 , C07H19/04
CPC分类号： G01N33/505 , C12Q1/34 , G01N33/5005 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/542 , G01N2333/986 , G01N2500/20
摘要： Methods of identifying inhibitors of the fusion of two types of cells, particularly when fusion is mediated by the interaction of a viral protein and such cellular proteins as CD4 and chemokine receptors, are disclosed. The methods are suitable for identifying substances that are useful for the treatment and prevention of viral diseases. Particularly preferred methods are useful for the identification of inhibitors of HIV-1 infection.

2. 发明授权

US06511827B1 Nucleotide encoding human galanin receptor 3 (GALR3) 失效
标题翻译：编码人类甘丙肽受体3（GALR3）的核苷酸
公开(公告)号：US06511827B1
公开(公告)日：2003-01-28
申请号：US09595549
申请日：2000-06-16
申请人： Andrew D. Howard , Margaret A. Cascieri , Roy G. Smith , Kathleen A. Sullivan , Carina Tan , Leonardus H. T. Van Der Ploeg , Kevin R. Lynch
发明人： Andrew D. Howard , Margaret A. Cascieri , Roy G. Smith , Kathleen A. Sullivan , Carina Tan , Leonardus H. T. Van Der Ploeg , Kevin R. Lynch
IPC分类号： C12N1512
CPC分类号： C07K14/72 , A61K38/00
摘要： A new galanin receptor, GALR3, is described. Also provided are nucleic acids encoding same and various assays to identify ligands particular to said receptor. Ligands so identified are useful for the treatment of obesity, treatment of pain, and treatment of cognitive disorders.
摘要翻译：描述了一种新的甘丙肽受体GALR3。还提供了编码相同的核酸和用于鉴定所述受体特异性的配体的各种测定法。如此鉴定的配体可用于治疗肥胖症，治疗疼痛和治疗认知障碍。

3. 发明授权

US5468108A Spiral flex tree fastener 失效
标题翻译：螺旋弹性树紧固件
公开(公告)号：US5468108A
公开(公告)日：1995-11-21
申请号：US304154
申请日：1994-09-12
申请人： Kathleen A. Sullivan , Brian R. Peek
发明人： Kathleen A. Sullivan , Brian R. Peek
IPC分类号： F16B15/06 , F16B19/00 , F16B21/08
CPC分类号： F16B21/084 , Y10S411/908 , Y10S411/913
摘要： A spiral flex tree fastener, for use in securing a component to a panel by insertion into a hole provided therein, has a head, and a shank extending axially therefrom and ending in a conical rounded point. The head, shank, and point share a common axis, the head naturally being of greater diameter than the shank and point. The point has a maximum diameter substantially equal to the hole into which the fastener may be inserted. The shank is flattened, has two sides and a flange running axially along each of the two sides. The shank has a diagonally measured width equivalent to the maximum diameter of the point and merges smoothly thereinto, and the flanges ensure that the fastener remains centered in the appropriately sized hole into which it may be inserted. On each side of the shank are a plurality of flexible fins set at an oblique angle with respect to the axis of the fastener. A portion of each fin extends radially outward from the axis of the shank beyond the radial extent of the conical rounded point. The fins flex against the walls of the appropriately sized hole, securing the fastener therein, and are shaped to make its nondestructive withdrawal, if desired or necessary, possible but more difficult to effect than its original insertion.
摘要翻译：用于通过插入设置在其中的孔将部件固定到面板上的螺旋弯曲树形紧固件具有头部和从其轴向延伸并以圆锥形圆角终止的柄部。头，柄和点共享一个共同的轴线，头部自然直径大于柄和点。该点的最大直径基本上等于可以插入紧固件的孔。柄部扁平，两侧和两侧各沿轴向延伸。柄具有等同于该点的最大直径的对角测量宽度并且平滑地合并到其中，并且凸缘确保紧固件保持居中在可插入其中的适当尺寸的孔中。在柄的每一侧上是相对于紧固件的轴线倾斜设置的多个柔性翅片。每个翅片的一部分从柄的轴线径向向外延伸超过圆锥形圆角的径向范围。翅片相对于适当尺寸的孔的壁弯曲，将紧固件固定在其中，并且如果需要或必要的话，其形状可使其非破坏性地退回成为可能，但比其原始插入更难以实现。

4. 发明授权

US5387065A Reusable pin and grommet fastner 失效
标题翻译：可重复使用的销钉和扣环
公开(公告)号：US5387065A
公开(公告)日：1995-02-07
申请号：US84384
申请日：1993-06-29
申请人： Kathleen A. Sullivan
发明人： Kathleen A. Sullivan
IPC分类号： F16B5/06 , F16B19/10 , F16B13/06
CPC分类号： F16B19/1081 , F16B5/0642
摘要： A reusable pin and grommet fastener where the grommet includes a head, a shank, an axial bore extending through the head and shank and two legs flexibly hinged to a distal end of the shank and extending outwardly away from the shank with a slight taper toward the bore. The pin includes a shank with a tapered distal end and a plurality of grooves formed about the shank so that after initial insertion of the grommet within an aperture of an article the pin can be inserted within the bore of the grommet to lock the grommet in the aperture of the article and the legs of the grommet readily can flex outwardly with a slight insertion force until seated within a groove of the pin which retain the pin in the grommet with a substantial predetermined removal force that nevertheless enables removal of the pin without damaging either the pin or the grommet.
摘要翻译：一种可重复使用的销和索环紧固件，其中索环包括头部，柄部，延伸穿过头部和柄部的轴向孔，以及两个腿部，其柔性地铰接到柄的远端并且向外远离柄部向外延伸，朝向孔。销包括具有锥形远端的柄和围绕柄形成的多个槽，使得在将索环初始插入物品的孔中之后，该销可以插入到索环的孔内以将索环锁定在物品的孔径和护环的腿容易地以轻微的插入力向外弯曲，直到安置在销的凹槽内，该凹槽将销保持在索环中，具有基本上预定的移除力，但仍然能够消除销而不损坏销或索环。

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