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1. 发明授权

US06483008B1 Methods for producing plants with elevated oleic acid content 失效
标题翻译：用于生产具有较高油酸含量的植物的方法
公开(公告)号：US06483008B1
公开(公告)日：2002-11-19
申请号：US09304603
申请日：1999-05-03
申请人： Katayoon Dehesh , Vic C. Knauf , Gregory A. Thompson
发明人： Katayoon Dehesh , Vic C. Knauf , Gregory A. Thompson
IPC分类号： A01H500
CPC分类号： C12N9/1029 , C12N9/0083 , C12N15/52 , C12N15/8247 , C12P7/6409 , C12P7/6463 , C12Y114/19002
摘要： By this invention, methods to produce oleic fatty acids in plant seed oils are provided. The methods of the present invention generally involve the suppression of a host plant cells endogenous &bgr;-ketoacyl-ACP synthase I protein. Also described in the instant invention are the plants, cells and oils obtained therefrom.
摘要翻译：通过本发明，提供了在植物种子油中制备油酸脂肪酸的方法。本发明的方法通常涉及抑制宿主植物细胞内源性β-酮酸酰-ACP合酶I蛋白。在本发明中也描述了由其获得的植物，细胞和油。

2. 发明授权

US07498455B2 Plant oils with altered oleic acid content 失效
标题翻译：具有油酸含量变化的植物油
公开(公告)号：US07498455B2
公开(公告)日：2009-03-03
申请号：US10259604
申请日：2002-09-30
申请人： Katayoon Dehesh , Vic C. Knauf , Gregory A. Thompson
发明人： Katayoon Dehesh , Vic C. Knauf , Gregory A. Thompson
IPC分类号： C07C53/00 , C07C57/00
CPC分类号： C12N9/1029 , C12N9/0083 , C12N15/52 , C12N15/8247 , C12P7/6409 , C12P7/6463 , C12Y114/19002
摘要： By this invention, methods to produce oleic fatty acids in plant seed oils are provided. The methods of the present invention generally involve the suppression of a host plant cells endogenous β-ketoacyl-ACP synthase I protein. Also described in the instant invention are the plants, cells and oils obtained therefrom.
摘要翻译：通过本发明，提供了在植物种子油中制备油酸脂肪酸的方法。本发明的方法通常涉及抑制宿主植物细胞内源性β-酮酸酰-ACP合酶I蛋白。在本发明中也描述了由其获得的植物，细胞和油。

3. 发明申请

US20050034190A9 Nucleic acid constructs and methods for producing altered seed oil compositions 有权
标题翻译：核酸构建体和用于产生改变的种子油组合物的方法
公开(公告)号：US20050034190A9
公开(公告)日：2005-02-10
申请号：US10393347
申请日：2003-03-21
申请人： Joanne Fillatti , Neal Bringe , Katayoon Dehesh
发明人： Joanne Fillatti , Neal Bringe , Katayoon Dehesh
IPC分类号： A01H1/00 , A01H5/00 , C12N5/04 , C12N9/10 , C12N15/82 , C12P21/02
CPC分类号： C12N15/8247 , A23D9/00 , A23K10/30 , A23K20/147 , A23K20/158 , C10L1/026 , C11B1/00 , C12N9/0083 , C12N15/8237 , Y02E50/13
摘要： The present invention is in the field of plant genetics and provides recombinant nucleic acid molecules, constructs, and other agents associated with the coordinate manipulation of multiple genes in the fatty acid synthesis pathway. In particular, the agents of the present invention are associated with the simultaneous enhanced expression of certain genes in the fatty acid synthesis pathway and suppressed expression of certain other genes in the same pathway. Also provided are plants incorporating such agents, and in particular plants incorporating such constructs where the plants exhibit altered seed oil compositions.
摘要翻译：本发明在植物遗传学领域，并且提供与脂肪酸合成途径中的多个基因的协调操作相关的重组核酸分子，构建体和其它试剂。特别地，本发明的试剂与脂肪酸合成途径中某些基因的同时增强表达相关联，并抑制同一途径中某些其他基因的表达。还提供了掺入这种试剂的植物，特别是掺入这种构建体的植物，其中植物表现出改变的种子油组合物。

4. 发明授权

US07812220B2 Engineering β-ketoacyl ACP synthase for novel substrate specificity 有权
标题翻译：工程与骨架ACP合成酶用于新颖的底物特异性
公开(公告)号：US07812220B2
公开(公告)日：2010-10-12
申请号：US12289255
申请日：2008-10-23
申请人： Katayoon Dehesh , Dale Val
发明人： Katayoon Dehesh , Dale Val
IPC分类号： C12N15/31 , C12N15/52 , C12N15/82 , A01H5/00 , A01H5/10
CPC分类号： C12N9/1029 , C12N15/8247 , C12P7/6409 , C12P7/6463
摘要： Methods of altering substrate specificity of beta-ketoacyl-ACP synthase, and engineered beta-ketoacyl-ACP synthases so produced are provided. DNA sequences and constructs for expression of engineered beta-ketoacyl-ACP synthases, as well as the novel beta-ketoacyl-ACP synthases produced therefrom are also provided. Such DNA sequences may be used for expression of the engineered beta-ketoacyl-ACP synthases in host cells, particularly seed cells of oilseed crop plants, for the modification of fatty acid composition.
摘要翻译：提供了改变β-酮酰基-ACP合成酶底物特异性的方法和如此制备的工程化β-酮酰基-ACP合成酶。还提供了用于表达工程化β-酮酸酰-ACP合酶的DNA序列和构建体，以及由其产生的新型β-酮酰基-ACP合成酶。这样的DNA序列可用于在宿主细胞，特别是油菜作物植物的种子细胞中表达改造的β-酮酸酰-ACP合酶，用于改变脂肪酸组成。

5. 发明授权

US06660849B1 Plant fatty acid synthases and use in improved methods for production of medium-chain fatty acids 失效
标题翻译：植物脂肪酸合成酶和用于生产中链脂肪酸的改进方法
公开(公告)号：US06660849B1
公开(公告)日：2003-12-09
申请号：US09057996
申请日：1998-04-09
申请人： Katayoon Dehesh
发明人： Katayoon Dehesh
IPC分类号： C07H2104
CPC分类号： C12N9/1029 , C11B1/00 , C12N9/16 , C12N15/8247
摘要： By this invention, compositions and methods of use related to &bgr;-ketoacyl-ACP synthases. Of special interest are synthases obtainable from Cuphea species. Amino acid and nucleic acid for synthase protein factors are provided, as well as methods to utilize such sequences in constructs for production of genetically engineered plants having altered fatty acid compositions. Of particular interest is the expression of synthase protein factors in conjunction with expression of plant medium-chain acyl-ACP thioesterases for production of increased levels and/or modified ratios of medium-chain fatty acids in oils of transgenic plant seeds.
摘要翻译：通过本发明，与β-酮酰基-ACP合酶相关的组合物和使用方法。特别感兴趣的是可从Cuphea物种获得的合成酶。提供用于合成酶蛋白质因子的氨基酸和核酸，以及在构建体中利用这些序列生产具有改变的脂肪酸组成的遗传工程植物的方法。特别令人感兴趣的是合成酶蛋白因子与植物中链酰基-ACP硫酯酶的表达的结合，用于产生转基因植物种子油中中链链脂肪酸的增加水平和/或修饰比例。

6. 发明授权

US06489461B1 Nucleic acid sequences encoding proteins involved in fatty acid beta-oxidation and methods of use 有权
标题翻译：编码参与脂肪酸β-氧化的蛋白质的核酸序列和使用方法
公开(公告)号：US06489461B1
公开(公告)日：2002-12-03
申请号：US09591095
申请日：2000-06-08
申请人： Katayoon Dehesh , Byron Froman
发明人： Katayoon Dehesh , Byron Froman
IPC分类号： C07H2104
CPC分类号： C12N9/001 , C12N9/1029 , C12N15/8247
摘要： The invention provides novel polynucleotide and polypeptide sequences involved in fatty acid beta-oxidation and to methods of producing such polypeptides using recombinannt techniques. In addition, methods are provided for using such sequences to alter lipid levels in plants by altering fatty acid beat-oxidation in host plant cells.
摘要翻译：本发明提供了涉及脂肪酸β-氧化的新型多核苷酸和多肽序列以及使用重组技术产生此类多肽的方法。此外，提供了使用这些序列通过改变宿主植物细胞中的脂肪酸搏动氧化来改变植物中的脂质水平的方法。

7. 发明授权

US07601888B2 Nucleic acid constructs and methods for producing altered seed oil compositions 有权
标题翻译：核酸构建体和用于产生改变的种子油组合物的方法
公开(公告)号：US07601888B2
公开(公告)日：2009-10-13
申请号：US10393347
申请日：2003-03-21
申请人： Joanne J. Fillatti , Neal A. Bringe , Katayoon Dehesh
发明人： Joanne J. Fillatti , Neal A. Bringe , Katayoon Dehesh
IPC分类号： A01H1/00 , A01H5/00 , C12N15/82
CPC分类号： C12N15/8247 , A23D9/00 , A23K10/30 , A23K20/147 , A23K20/158 , C10L1/026 , C11B1/00 , C12N9/0083 , C12N15/8237 , Y02E50/13
摘要： The present invention is in the field of plant genetics and provides recombinant nucleic acid molecules, constructs, and other agents associated with the coordinate manipulation of multiple genes in the fatty acid synthesis pathway. In particular, the agents of the present invention are associated with the simultaneous enhanced expression of certain genes in the fatty acid synthesis pathway and suppressed expression of certain other genes in the same pathway. Also provided are plants incorporating such agents, and in particular plants incorporating such constructs where the plants exhibit altered seed oil compositions.
摘要翻译：本发明在植物遗传学领域，并且提供与脂肪酸合成途径中的多个基因的协调操作相关的重组核酸分子，构建体和其它试剂。特别地，本发明的试剂与脂肪酸合成途径中某些基因的同时增强表达相关联，并抑制同一途径中某些其他基因的表达。还提供了掺入这种试剂的植物，特别是掺入这种构建体的植物，其中植物表现出改变的种子油组合物。

8. 发明授权

US06706950B2 Nucleic acid sequences encoding &bgr;-ketoacyl-ACP synthase and uses thereof 有权
标题翻译：编码β-酮酰基-ACP合酶的核酸序列及其用途
公开(公告)号：US06706950B2
公开(公告)日：2004-03-16
申请号：US09915182
申请日：2001-07-25
申请人： Katayoon Dehesh
发明人： Katayoon Dehesh
IPC分类号： C12N1531
CPC分类号： C12N9/1029 , A23D9/00 , C11B1/00 , C12N15/8247 , C12P7/6409 , C12P7/6463
摘要： This invention relates to sequences encoding &bgr;-ketoacyl-ACP synthase (KAS) and methods of use thereof. Also provided are methods for decreasing saturated fatty acid levels as a component of total triglycerides found in plant oils. The method generally comprises growing a soybean plant having integrated into its genome a DNA construct comprising, in the 5′ to 3′ direction of transcription, a promoter functional in a soybean plant seed cell, a DNA sequence encoding a KAS protein, and a transcription termination region functional in a plant cell. The present invention also provides a soybean seed with less than about 3.5 weight percent total saturated fatty acids.
摘要翻译：本发明涉及编码β-酮酸酰-ACP合酶（KAS）的序列及其使用方法。还提供了降低饱和脂肪酸水平作为在植物油中发现的总甘油三酯的组分的方法。该方法通常包括生长大豆植物，其整合到其基因组中，DNA构建体包含在转录的5'至3'方向上在大豆植物种子细胞中起作用的启动子，编码KAS蛋白的DNA序列和转录终止区在植物细胞中起作用。本发明还提供了具有小于约3.5重量％的总饱和脂肪酸的大豆种子。

9. 发明授权

US5955329A Engineering plant thioesterases for altered substrate specificity 失效
标题翻译：工程植物硫酯酶改变底物特异性
公开(公告)号：US5955329A
公开(公告)日：1999-09-21
申请号：US440845
申请日：1995-05-15
申请人： Ling Yuan , Katayoon Dehesh , Jean Kridl , Vic Knauf
发明人： Ling Yuan , Katayoon Dehesh , Jean Kridl , Vic Knauf
IPC分类号： C12N9/16 , C12N15/82 , C12N15/00 , C07H21/04
CPC分类号： C12N15/8247 , C12N9/16
摘要： Methods of altering substrate specificity of plant acyl-ACP thioesterases, and engineered plant acyl-ACP thioesterases so produced are provided. The C-terminal two thirds portion of plant thioesterases is identified as desirable for such modifications. DNA sequences and constructs for expression of engineered thioesterases, as well as the novel thioesterases produced therefrom are also provided. Such DNA sequences may be used for expression of the engineered thioesterases in host cells, particularly seed cells of oilseed crop plants, for the modification of fatty acid composition. A C12 preferring plant acyl-ACP thioesterase described herein may be altered to obtain a plant thioesterase having approximately equal activity on C14 and C12 substrates. Further modification of the C12 enzyme yields a thioesterase having greater activity on C14 as compared to C12 substrates. Also provided in the instant invention are novel plant acyl-ACP thioesterase sequences from Cuphea palustris and mangosteen (Garcinia mangifera), which demonstrate desirable thioesterase activity profiles for plant genetic engineering applications.
摘要翻译：提供了改变植物酰基-ACP硫酯酶底物特异性的方法，以及如此制备的工程化植物酰基-ACP硫酯酶。植物硫酯酶的C末端三分之二部分被鉴定为对于这种修饰是理想的。还提供了用于表达工程化硫酯酶的DNA序列和构建体，以及由其产生的新的硫酯酶。这样的DNA序列可用于在宿主细胞，特别是油籽作物植物的种子细胞中表达改性的硫酯酶，用于改变脂肪酸组成。可以改变本文所述的C12优选植物酰基-ACP硫酯酶以获得对C14和C12底物具有大致相同活性的植物硫酯酶。与C12底物相比，C12酶的进一步修饰产生对C14具有更大活性的硫酯酶。本发明还提供了来自Cuphea palustris和山竹（Garcinia mangifera）的新型植物酰基-ACP硫酯酶序列，其显示用于植物基因工程应用的期望的硫酯酶活性谱。

10. 发明申请

US20090119805A1 Nuleic acid constructs and methods for producing altered seed oil compositions 审中-公开
标题翻译： Nuleic酸构建体和用于生产改变的种子油组合物的方法
公开(公告)号：US20090119805A1
公开(公告)日：2009-05-07
申请号：US12318591
申请日：2008-12-31
申请人： Joanne J. Fillatti , Neal A. Bringe , Katayoon Dehesh
发明人： Joanne J. Fillatti , Neal A. Bringe , Katayoon Dehesh
IPC分类号： A01H5/10
CPC分类号： C12N15/8247 , A23D9/00 , A23K10/30 , A23K20/147 , A23K20/158 , C10L1/026 , C11B1/00 , C12N9/0083 , C12N15/8237 , Y02E50/13
摘要： The present invention is in the field of plant genetics and provides recombinant nucleic acid molecules, constructs, and other agents associated with the coordinate manipulation of multiple genes in the fatty acid synthesis pathway. In particular, the agents of the present invention are associated with the simultaneous enhanced expression of certain genes in the fatty acid synthesis pathway and suppressed expression of certain other genes in the sane pathway. Also provided are plants incorporating such agents, and in particular plants incorporating such constructs where the plants exhibit altered seed oil compositions.
摘要翻译：本发明在植物遗传学领域，并且提供与脂肪酸合成途径中的多个基因的协调操作相关的重组核酸分子，构建体和其它试剂。特别地，本发明的药剂与脂肪酸合成途径中某些基因的同时增强表达有关，并抑制某些其他基因在正常通路中的表达。还提供了掺入这种试剂的植物，特别是掺入这种构建体的植物，其中植物表现出改变的种子油组合物。

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