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1. 发明授权

US5333675A Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps 失效
标题翻译：用于使用加热和冷却步骤进行核酸序列的自动扩增和测定的装置和方法
公开(公告)号：US5333675A
公开(公告)日：1994-08-02
申请号：US21624
申请日：1993-02-22
申请人： Kary B. Mullis , Larry Johnson , Richard A. Leath , Timothy J. Wennberg , Louis M. Mezei , Joseph T. Widunas
发明人： Kary B. Mullis , Larry Johnson , Richard A. Leath , Timothy J. Wennberg , Louis M. Mezei , Joseph T. Widunas
IPC分类号： B01J19/00 , B01L7/00 , C07H21/00 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N35/02 , G05B17/00
CPC分类号： B01L7/52 , B01J19/0046 , C07H21/00 , B01J2219/00495 , B01J2219/0059 , B01J2219/00689 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y10T436/115831
摘要： There is disclosed herein a machine for performing nucleic acid amplification under computer control. The machine utilizes any one of a number of heating and cooling systems under control of a host computer which directs the heating and cooling systems to heat and cool a reaction-chamber-containing heat exchanger at appropriate times in the process. The reaction chambers are pre-loaded with the nucleic acid(s) to be amplified, a thermostable enzyme to catalyze polymerization, specific oligonucleotide primers, and four different nucleotide triphosphates. Also disclosed is the process for the amplification chain reaction implemented by the machine, which utilizes a thermostable enzyme.
摘要翻译：本文公开了一种用于在计算机控制下进行核酸扩增的机器。该机器在主机的控制下使用多个加热和冷却系统中的任何一个，其引导加热和冷却系统在该过程中适当的时间对含反应室的热交换器进行加热和冷却。反应室预先加载待扩增的核酸，催化聚合的热稳定酶，特异性寡核苷酸引物和四种不同的核苷酸三磷酸。还公开了由机器实现的扩增链反应的方法，其利用热稳定性酶。

2. 发明授权

US5656493A System for automated performance of the polymerase chain reaction 失效
标题翻译：用于自动化表现聚合酶链反应的系统
公开(公告)号：US5656493A
公开(公告)日：1997-08-12
申请号：US199505
申请日：1994-02-18
申请人： Kary B. Mullis , Larry Johnson , Richard A. Leath , Timothy J. Wennberg , Louis M. Mezei , Joseph T. Widunas
发明人： Kary B. Mullis , Larry Johnson , Richard A. Leath , Timothy J. Wennberg , Louis M. Mezei , Joseph T. Widunas
IPC分类号： B01J19/00 , B01L7/00 , C12Q1/68 , C40B40/06 , C40B60/14 , C12M3/02 , C12M1/00 , C12N15/00 , G01N21/00
CPC分类号： B01L7/52 , B01J19/0046 , C12Q1/686 , B01J2219/00495 , B01J2219/0059 , B01J2219/00689 , B01J2219/00722 , C40B40/06 , C40B60/14
摘要： There is disclosed herein a machine for performing nucleic acid amplification under computer control. The machine utilizes any one of a number of heating and cooling systems under control of a host computer which directs the heating and cooling systems to heat and cool a reaction-chamber-containing heat exchanger at appropriate times in the process. The reaction chambers are pre-loaded with the nucleic acid(s) to be amplified, a thermostable enzyme to catalyze polymerization, specific oligonucleotide primers, and four different nucleotide triphosphates. Also disclosed is the process for the amplification chain reaction implemented by the machine, which utilizes a thermostable enzyme.
摘要翻译：本文公开了一种用于在计算机控制下进行核酸扩增的机器。该机器在主机的控制下使用多个加热和冷却系统中的任何一个，其引导加热和冷却系统在该过程中适当的时间对含反应室的热交换器进行加热和冷却。反应室预先加载待扩增的核酸，催化聚合的热稳定酶，特异性寡核苷酸引物和四种不同的核苷酸三磷酸。还公开了由机器实现的扩增链反应的方法，其利用热稳定性酶。

3. 发明授权

US4586546A Liquid handling device and method 失效
标题翻译：液体处理装置及方法
公开(公告)号：US4586546A
公开(公告)日：1986-05-06
申请号：US663882
申请日：1984-10-23
申请人： Louis M. Mezei , Richard W. Reeves , Richard A. Leath , Joseph T. Widunas
发明人： Louis M. Mezei , Richard W. Reeves , Richard A. Leath , Joseph T. Widunas
IPC分类号： G01N35/10 , B65B3/04
CPC分类号： G01N35/1011 , G01N2035/1025 , G01N35/1083 , Y10T436/2575
摘要： An improved liquid handling device used for transferring a selected quantity of liquid from one receptacle to another. The device includes a meniscus tracking feature which minimizes mixing in a liquid sample and contact between the sample and a sample-handling pipette during a liquid-transfer operation. Further included is a volume-correcting feature for improving the accuracy of volume withdrawn into or dispensed from the pipette during a liquid handling operation.
摘要翻译：一种改进的液体处理装置，用于将选定量的液体从一个容器传送到另一个容器。该装置包括弯液面跟踪特征，其使液体样品中的混合最小化，并且在液体转移操作期间样品与样品处理移液管之间的接触最小化。还包括一种体积校正特征，用于在液体处理操作期间提高从移液管抽出或分配的体积的精度。

4. 发明授权

US07492461B2 Method and device for measuring reflected optical radiation 有权
标题翻译：用于测量反射光辐射的方法和装置
公开(公告)号：US07492461B2
公开(公告)日：2009-02-17
申请号：US11188079
申请日：2005-07-21
申请人： Raymond T. Hebert , Joel M. Blatt , Joseph T. Widunas
发明人： Raymond T. Hebert , Joel M. Blatt , Joseph T. Widunas
IPC分类号： G01N21/47
CPC分类号： G01N21/8483 , G01N21/253
摘要： The present invention provides an optics assembly, a reflectometer, and a diagnostic device for providing quantitative measurement of optical radiation reflected from a sampling area on an assay matrix. The reflectometer includes an optical radiation source and a detector. The optical radiation source and the detector are mounted in a single plane. An optics assembly is configured to direct the illumination from the optical radiation source to the sampling area on the assay matrix and to direct the radiation diffusely reflected from the sampling area to the detector. The optics assembly is positioned over the face of the circuit board having the optical radiation source and detector mounted directly thereto. The present invention also provides a method for determining the presence of one or more selected analytes in a sample employing a plurality of sampling areas on one or more assay matrixes.
摘要翻译：本发明提供了一种用于提供从测定矩阵上的取样区域反射的光辐射的定量测量的光学组件，反射计和诊断装置。反射计包括光辐射源和检测器。光学辐射源和检测器安装在单个平面中。光学组件被配置为将来自光辐射源的照明引导到测定矩阵上的采样区域并且将从采样区域漫反射的辐射引导到检测器。光学组件位于具有直接安装在其上的光辐射源和检测器的电路板的表面上。本发明还提供了一种用于确定在一个或多个测定矩阵上使用多个采样区域的样品中一种或多种选择的分析物的存在的方法。

5. 发明授权

US4873633A User controlled off-center light absorbance reading adjuster in a liquid handling and reaction system 失效
标题翻译：液体处理和反应系统中用户控制的偏心吸光度读数调节器
公开(公告)号：US4873633A
公开(公告)日：1989-10-10
申请号：US906101
申请日：1986-09-11
申请人： Mezei, Louis M. , Bradley S. Albom , Coppock, Stan , Stephen J. Moehle , Brent S. Noorda , Joseph T. Widunas , James A. Zeitlin
发明人： Mezei, Louis M. , Bradley S. Albom , Coppock, Stan , Stephen J. Moehle , Brent S. Noorda , Joseph T. Widunas , James A. Zeitlin
IPC分类号： G01N33/80 , G01N35/00
CPC分类号： G01N35/00 , G01N33/80
摘要： A host computer controls a plate reader which optically reads the results between donor samples and reagents. The system provides the user with the ability to change the position of off-center light absorbance readings to maximize the power of the machine to discriminate between positive and negative agglutination reactions. In addition, the user can tailor thresholds for absorbances used to distinguish between positive, negative and "no type determined" reactions.
摘要翻译：主计算机控制读板器，其光学地读取供体样品和试剂之间的结果。该系统为用户提供了改变偏心吸光度读数位置的能力，以使机器的功率最大化，以区分正和负凝集反应。此外，用户可以根据用于区分正，负和“无类型确定”反应的吸光度定制阈值。

6. 发明授权

US5837546A Electronic assay device and method 失效
标题翻译：电子测定装置及方法
公开(公告)号：US5837546A
公开(公告)日：1998-11-17
申请号：US657894
申请日：1996-06-07
申请人： Michael P. Allen , Joel M. Blatt , Joseph T. Widunas
发明人： Michael P. Allen , Joel M. Blatt , Joseph T. Widunas
IPC分类号： G01N21/78 , G01N21/86 , G01N27/04 , G01N27/327 , G01N33/543 , G01N37/00
CPC分类号： G01N21/8483 , G01N33/5438 , B01L2400/0406
摘要： The present invention provides an assay device for determining the presence of one or more selected analytes in a sample. The device includes a housing having an exterior surface and defining an interior area. A sample receptor receives the sample. A sample treatment strip reacts the sample with a reagent to yield a physically detectable change which correlates with the amount of selected analyte in the sample. A detector responds to the physically detectable change and produces an electrical signal which correlates to the amount of the selected analyte in the sample. A processor converts the electrical signal to a digital output. A starter automatically activates the processor and detector upon the application of the sample to the device. A display visually displays the digital output external to the housing and is connected to the processor. The present invention also provides a method for determining the presence of one or more selected analytes in a sample within a disposable housing, automatically starting a diagnostic device to analyze a sample, and displaying quantitative assay results for a plurality of selected analytes in a sample on a diagnostic device.
摘要翻译：本发明提供了用于确定样品中一种或多种选择的分析物的存在的测定装置。该装置包括具有外表面并限定内部区域的壳体。样品受体接收样品。样品处理带使样品与试剂反应，产生与样品中所选分析物的量相关的物理可检测的变化。检测器响应于物理上可检测的变化并产生与样品中所选分析物的量相关的电信号。处理器将电信号转换为数字输出。当样品应用于设备时，起动器会自动激活处理器和检测器。显示器可视地显示外壳外部的数字输出并连接到处理器。本发明还提供了一种用于确定一次性外壳内的样品中一种或多种所选分析物的存在的方法，自动启动诊断装置以分析样品，以及显示样品中多个选定分析物的定量测定结果诊断装置。

7. 发明授权

US5038852A Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps 失效
标题翻译：用于使用加热和冷却步骤进行核酸序列的自动扩增和测定的装置和方法
公开(公告)号：US5038852A
公开(公告)日：1991-08-13
申请号：US494174
申请日：1990-03-14
申请人： Larry J. Johnson , Joseph T. Widunas
发明人： Larry J. Johnson , Joseph T. Widunas
IPC分类号： B01J19/00 , B01L7/00 , C07H21/00 , C12Q1/68 , C40B40/06 , C40B60/14
CPC分类号： C07H21/00 , B01J19/0046 , B01L7/52 , B01J2219/00495 , B01J2219/0059 , B01J2219/00689 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y10T436/115831
摘要： There is disclosed herein a machine for performing nucleic acid amplification under computer control. The machine utilizes any one of a number of heating and cooling systems under control of a host computer which directs the heating and cooling systems to heat and cool a reaction-chamber-containing heat exchanger at appropriate times in the process. The reaction chambers are pre-loaded with the nucleic acid(s) to be amplified, a thermostable enzyme to catalyze polymerization, specific oligonucleotide primers, and four different nucleotide triphosphates. Also disclosed is the process for the amplification chain reaction implemented by the machine, which utilizes a thermostable enzyme.
摘要翻译：本文公开了一种用于在计算机控制下进行核酸扩增的机器。该机器在主机的控制下使用多个加热和冷却系统中的任何一个，其引导加热和冷却系统在该过程中适当的时间对含反应室的热交换器进行加热和冷却。反应室预先加载待扩增的核酸，催化聚合的热稳定酶，特异性寡核苷酸引物和四种不同的核苷酸三磷酸。还公开了由机器实现的扩增链反应的方法，其利用热稳定性酶。

8. 发明授权

US08045169B2 Method and device for measuring reflected optical radiation 有权
标题翻译：用于测量反射光辐射的方法和装置
公开(公告)号：US08045169B2
公开(公告)日：2011-10-25
申请号：US12235371
申请日：2008-09-22
申请人： Raymond T. Hebert , Joel M. Blatt , Joseph T. Widunas
发明人： Raymond T. Hebert , Joel M. Blatt , Joseph T. Widunas
IPC分类号： G01N21/55
CPC分类号： G01N21/8483 , G01N21/253
摘要： The present invention provides an optics assembly, a reflectometer, and a diagnostic device for providing quantitative measurement of optical radiation reflected from a sampling area on an assay matrix. The reflectometer includes an optical radiation source and a detector. The optical radiation source and the detector are mounted in a single plane. An optics assembly is configured to direct the illumination from the optical radiation source to the sampling area on the assay matrix and to direct the radiation diffusely reflected from the sampling area to the detector. The optics assembly is positioned over the face of the circuit board having the optical radiation source and detector mounted directly thereto. The present invention also provides a method for determining the presence of one or more selected analytes in a sample employing a plurality of sampling areas on one or more assay matrixes.
摘要翻译：本发明提供了一种用于提供从测定矩阵上的取样区域反射的光辐射的定量测量的光学组件，反射计和诊断装置。反射计包括光辐射源和检测器。光学辐射源和检测器安装在单个平面中。光学组件被配置为将来自光辐射源的照明引导到测定矩阵上的采样区域并且将从采样区域漫反射的辐射引导到检测器。光学组件位于具有直接安装在其上的光辐射源和检测器的电路板的表面上。本发明还提供了一种用于确定在一个或多个测定矩阵上使用多个采样区域的样品中一种或多种选择的分析物的存在的方法。

9. 发明申请

US20090027682A1 Method and Device For Measuring Reflected Optical Radiation 有权
标题翻译：用于测量反射光辐射的方法和装置
公开(公告)号：US20090027682A1
公开(公告)日：2009-01-29
申请号：US12235371
申请日：2008-09-22
申请人： Raymond T. Hebert , Joel M. Blatt , Joseph T. Widunas
发明人： Raymond T. Hebert , Joel M. Blatt , Joseph T. Widunas
IPC分类号： G01N21/55
CPC分类号： G01N21/8483 , G01N21/253
摘要： The present invention provides an optics assembly, a reflectometer, and a diagnostic device for providing quantitative measurement of optical radiation reflected from a sampling area on an assay matrix. The reflectometer includes an optical radiation source and a detector. The optical radiation source and the detector are mounted in a single plane. An optics assembly is configured to direct the illumination from the optical radiation source to the sampling area on the assay matrix and to direct the radiation diffusely reflected from the sampling area to the detector. The optics assembly is positioned over the face of the circuit board having the optical radiation source and detector mounted directly thereto. The present invention also provides a method for determining the presence of one or more selected analytes in a sample employing a plurality of sampling areas on one or more assay matrixes.
摘要翻译：本发明提供了一种用于提供从测定矩阵上的取样区域反射的光辐射的定量测量的光学组件，反射计和诊断装置。反射计包括光辐射源和检测器。光学辐射源和检测器安装在单个平面中。光学组件被配置为将来自光辐射源的照明引导到测定矩阵上的采样区域并且将从采样区域漫反射的辐射引导到检测器。光学组件位于具有直接安装在其上的光辐射源和检测器的电路板的表面上。本发明还提供了一种用于确定在一个或多个测定矩阵上使用多个采样区域的样品中一种或多种选择的分析物的存在的方法。

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