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1. 发明授权

US08304413B2 Compounds and methods for treating inflammatory and fibrotic disorders 有权
标题翻译：用于治疗炎性和纤维化疾病的化合物和方法
公开(公告)号：US08304413B2
公开(公告)日：2012-11-06
申请号：US12477715
申请日：2009-06-03
申请人： Karl Kossen , Scott D. Seiwert , Vladimir Serebryany , Donald Ruhrmund , Leonid Beigelman , Luca Francesco Mario Raveglia , Stefania Vallese , Ivana Bianchi , Tao Hu
发明人： Karl Kossen , Scott D. Seiwert , Vladimir Serebryany , Donald Ruhrmund , Leonid Beigelman , Luca Francesco Mario Raveglia , Stefania Vallese , Ivana Bianchi , Tao Hu
IPC分类号： A61K31/50 , A61K31/497 , A61K31/437 , A61K31/44
CPC分类号： C07D213/63 , C07D213/22 , C07D213/64 , C07D213/69 , C07D213/71 , C07D213/85 , C07D237/14 , C07D239/36 , C07D239/54 , C07D241/18 , C07D251/10 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
摘要翻译：公开了用于治疗炎症和纤维化疾病的化合物和方法，包括用活性化合物调节应激活化蛋白激酶（SAPK）系统的方法，其中活性化合物表现出低的抑制p38MAPK的能力; 并且其中所述接触以对所述化合物抑制p38MAPK的抑制浓度低的SAPK调节浓度进行。还公开了吡非尼酮的衍生物和类似物，其可用于调节应激活化蛋白激酶（SAPK）系统。

2. 发明申请

US20090318455A1 COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS 有权
标题翻译：用于治疗炎症和纤维性疾病的化合物和方法
公开(公告)号：US20090318455A1
公开(公告)日：2009-12-24
申请号：US12477715
申请日：2009-06-03
申请人： Karl Kossen , Scott D. Seiwert , Vladimir Serebryany , Donald Ruhrmund , Leonid Beigelman , Luca F. Raveglia , Stefania Vallese , Ivana Bianchi , Tao Hu
发明人： Karl Kossen , Scott D. Seiwert , Vladimir Serebryany , Donald Ruhrmund , Leonid Beigelman , Luca F. Raveglia , Stefania Vallese , Ivana Bianchi , Tao Hu
IPC分类号： A61K31/50 , A61K31/497 , A61K31/437 , A61K31/44 , C07D237/02 , C07D241/02 , C07D471/02 , C07D213/63
CPC分类号： C07D213/63 , C07D213/22 , C07D213/64 , C07D213/69 , C07D213/71 , C07D213/85 , C07D237/14 , C07D239/36 , C07D239/54 , C07D241/18 , C07D251/10 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
摘要翻译：公开了用于治疗炎症和纤维化疾病的化合物和方法，包括用活性化合物调节应激活化蛋白激酶（SAPK）系统的方法，其中活性化合物表现出低的抑制p38MAPK的能力; 并且其中所述接触以对所述化合物抑制p38MAPK的抑制浓度低的SAPK调节浓度进行。还公开了吡非尼酮的衍生物和类似物，其可用于调节应激活化蛋白激酶（SAPK）系统。

3. 发明授权

US08412560B1 Price optimization using current offers 有权
标题翻译：使用当前优惠的价格优化
公开(公告)号：US08412560B1
公开(公告)日：2013-04-02
申请号：US12718032
申请日：2010-03-05
申请人： Faisal Masud , Stacy Saal , Paul D. Ohlhaut , Josiah P. Olivieri , Umair Bashir , Xiao Yu , Tao Hu
发明人： Faisal Masud , Stacy Saal , Paul D. Ohlhaut , Josiah P. Olivieri , Umair Bashir , Xiao Yu , Tao Hu
IPC分类号： G06Q30/00
CPC分类号： G06Q30/00
摘要： Disclosed are various embodiments for optimizing prices of items using current offers. Numerous current offers to sell an item are determined from a subset of sellers in an electronic marketplace. Each one of the subset of sellers is associated with a respective reputational score that meets a minimum threshold. A competitive price is generated for the item based at least in part on an average marketplace price determined from the current offers.
摘要翻译：公开了使用当前报价来优化物品价格的各种实施例。许多当前的出售物品的出售是从电子市场中的卖家的一部分确定的。卖方子集中的每一个都与符合最低门槛值的相应声誉评分相关联。至少部分基于从当前报价确定的平均市场价格，为该项目生成有竞争力的价格。

4. 发明授权

US6022983A Pyronin antibacterials, process and novel intermediates thereto 失效
公开(公告)号：US6022983A
公开(公告)日：2000-02-08
申请号：US2541
申请日：1998-01-02
申请人： Mark A. Wuonola , Gary R. Gustafson , James S. Panek , Tao Hu , Jennifer V. Schaus
发明人： Mark A. Wuonola , Gary R. Gustafson , James S. Panek , Tao Hu , Jennifer V. Schaus
IPC分类号： C07D309/38 , A61K31/351 , A61K31/366 , A61P31/04 , C07C45/29 , C07C45/30 , C07C45/38 , C07C47/21 , C07C49/203 , C07C57/66 , C07D309/36 , C07F7/08 , C07F7/18 , C07C33/03 , C07C45/26 , C07C67/30 , C07D309/32
CPC分类号： C07D309/36 , A61K31/366 , C07C45/29 , C07C45/298 , C07C45/30 , C07C47/21 , C07C57/66 , C07D309/38 , C07F7/0812 , C07F7/1856
摘要： The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.

5. 外观设计

USD944002S1 Foldable guitar stand 有权
公开(公告)号：USD944002S1
公开(公告)日：2022-02-22
申请号：US29716034
申请日：2019-12-06
申请人： Tao Hu
设计人： Tao Hu

6. 发明授权

US08770589B2 Shaft-seal device for high-temperature fluid 失效
标题翻译：高温液体轴封装置
公开(公告)号：US08770589B2
公开(公告)日：2014-07-08
申请号：US13532498
申请日：2012-06-25
申请人： Taiji Hashimoto , Tao Hu , Eiji Okumachi , Masanobu Ninomiya
发明人： Taiji Hashimoto , Tao Hu , Eiji Okumachi , Masanobu Ninomiya
IPC分类号： F16J15/34
CPC分类号： F16J15/40 , F16J15/3404 , F16J15/3484
摘要： A shaft-seal device for high-temperature fluid including a seal case (2) formed as a metallic cylindrical structure of a single unit and comprised of a main body portion (2a, 2b, 2c), first and second holding portions (2d, 2e), first and second partition portions (2f, 2h), a channel formation portion (2g) forming a minute annular channel (27) with the outer circumference surface of a rotary shaft (1), and an o-ring holding portion (2i). The seal case is installed in an apparatus housing (8) with first and second o-rings (2m, 2n) in between. The intra-seal case region (A1), in which sealing rings (31, 32, 41, 42, 51, 52) of mechanical seals (3, 4, 5) are provided, and the high-temperature fluid region, which is an intra-apparatus housing region (A), are partitioned by a cooling chamber (28) into and from which coolant (82) is supplied and discharged via feed/discharge coolant paths (80, 81).
摘要翻译：一种用于高温流体的轴封装置，包括形成为单个单元的金属圆柱形结构并由主体部分（2a，2b，2c）构成的密封壳体（2），第一和第二保持部分（2d， 2e），第一和第二分隔部分（2f，2h），形成具有旋转轴（1）的外周表面的微小环形通道（27）的通道形成部分（2g）和O形环保持部分 2i）。密封壳体安装在其间具有第一和第二O形环（2m，2n）的装置壳体（8）中。密封壳体区域（A1），其中设置有机械密封件（3,4,5）的密封环（31,32,31,42,51,52）和高温流体区域装置内的壳体区域（A）被冷却室（28）分隔开并从其中供应并通过供给/排出冷却剂通道（80,81）排出冷却剂（82）。

7. 外观设计

USD637158S1 HDMI cable connector 有权
公开(公告)号：USD637158S1
公开(公告)日：2011-05-03
申请号：US29366144
申请日：2010-07-20
申请人： Tao Hu
设计人： Tao Hu

8. 发明申请

US20090258850A1 STABILIZED THERAPEUTIC COMPOSITIONS AND FORMULATIONS 审中-公开
标题翻译：稳定的治疗组合物和制剂
公开(公告)号：US20090258850A1
公开(公告)日：2009-10-15
申请号：US12196271
申请日：2008-08-21
申请人： James M. Frincke , Steven K. White , Yu Ge , Weicheng Liaw , Tao Hu
发明人： James M. Frincke , Steven K. White , Yu Ge , Weicheng Liaw , Tao Hu
IPC分类号： A61K31/5685
CPC分类号： A61K9/10 , A61K9/0019
摘要： The invention relates to pharmaceutically acceptable formulations comprising an active pharmaceutical ingredient such as androst-5-ene-3β,17β-diol, androst-5-ene-3β,7β,17β-triol or derivatives of either of these compounds and an air oxidizable excipient that have been stabilized with respect to efficacy. Use of the efficacy-stabilized formulations to treat a number of conditions or symptoms thereof, such as a symptom associated with exposure to radiation is described.
摘要翻译：本发明涉及包含活性药物成分如雄甾-5-烯-3β，17β-二醇，雄甾-5-烯-3β，7beta，17β-三醇或这些化合物的衍生物的药学上可接受的制剂和可氧化的相关功效已被稳定的赋形剂。描述了使用功效稳定的制剂来治疗许多病症或症状，例如与暴露于辐射相关的症状。

9. 发明授权

US06396939B1 Method and system for segmentation of medical images 有权
标题翻译：医学图像分割方法与系统
公开(公告)号：US06396939B1
公开(公告)日：2002-05-28
申请号：US09321489
申请日：1999-05-27
申请人： Tao Hu , Francoys Labonté
发明人： Tao Hu , Francoys Labonté
IPC分类号： G06K900
CPC分类号： G06T7/0012 , G06T5/002 , G06T5/20 , G06T7/11 , G06T2207/10081 , G06T2207/10088 , G06T2207/30008
摘要： A segmentation method and system for medical images of a structure, including at least one substructure are described herein. Examples of such structure and substructures are a vertebra and its spinal canal or a sacrum with its two foramens. The method consists of first providing a plurality of digital images representing consecutive slices of the structure. The set of images is then divided into groups for which initial substructures center position are estimated. Using this information, the pixels corresponding to each substructure and common to all the images in the group are determined. Iterations are performed between these two last steps until the best candidates are obtained. The method consists then in estimating the substructures center position in each image of the group. After the substructures have been identified in each image, the images are then processed to remove noise in the substructures, in the rest of the structure and outside the structure.
摘要翻译：本文描述了包括至少一个子结构的结构的医学图像的分割方法和系统。这种结构和子结构的实例是椎骨及其椎管或具有其两个孔的骶骨。该方法包括首先提供表示结构的连续切片的多个数字图像。然后将该组图像划分成对其初始子结构中心位置进行估计的组。使用该信息，确定与每个子结构相对应的像素并且对于该组中的所有图像共同的像素。在这两个最后的步骤之间进行迭代，直到获得最佳候选者。该方法包括估计组中每个图像中的子结构中心位置。在每个图像中已经识别到子结构之后，然后处理图像以去除子结构中的噪声，在结构的其余部分和结构外部。

10. 发明授权

US10002593B2 Guitar capo applicable to different kinds of guitars 有权
公开(公告)号：US10002593B2
公开(公告)日：2018-06-19
申请号：US15616932
申请日：2017-06-08
申请人： Tao Hu
发明人： Tao Hu
IPC分类号： G10D3/04
CPC分类号： G10D3/043
摘要： A guitar capo applicable to different kinds of guitars, having upper shell silica gel fixed onto an upper shell; lower shell silica gel fixed onto a lower shell; a groove provided at a center position of each of the upper shell silica gel and the lower shell silica gel; a raised platform positioned at a periphery of each groove; a connecting end of the upper shell sleeving a connecting end of the lower shell; the connecting ends of the upper shell and the lower shell connected and fixed via the double rivet; a spring mounted on the double rivet; an end of an arm of the lower shell connecting to the upper shell being connected with the screw. The upper shell silica gel is applicable to an acoustic guitar. The lower shell silica gel is applicable to a classical guitar.

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