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1. 发明申请

US20090274687A1 ATTENUATION OF HYPOXIA INDUCED CARDIOVASCULAR DISORDERS 审中-公开
标题翻译： HYPOXIA诱发性心脏病的衰退
公开(公告)号：US20090274687A1
公开(公告)日：2009-11-05
申请号：US12434833
申请日：2009-05-04
申请人： Karen Young , Cleide Suguihara , Joshua M. Hare
发明人： Karen Young , Cleide Suguihara , Joshua M. Hare
IPC分类号： A61K31/7088 , A61K38/02 , A61K39/395 , A61P11/00 , C12N5/00 , C12Q1/02
CPC分类号： C07K16/24 , A61K2039/505 , G01N2500/04 , G01N2500/10 , G01N2800/12
摘要： Blockade of stromal derived factor-1 (SDF-1), a stem cell mobilizer and/or its receptor, chemokine receptor 4 (CXCR4) attenuates and reverses hypoxia-induced cardiopulmonary remodeling in vivo. Compositions for treating hypoxia-induced cardiovascular disorders modulate the SDF-1/CXCR4 axis.
摘要翻译：基质衍生因子-1（SDF-1），干细胞移动剂和/或其受体趋化因子受体4（CXCR4）的阻断减弱并逆转体内缺氧诱导的心肺重塑。用于治疗缺氧诱发的心血管疾病的组合物调节SDF-1 / CXCR4轴。

2. 发明授权

US07956062B2 Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof 有权
标题翻译：具有一氧化氮生物活性的活性氧发生酶抑制剂及其应用
公开(公告)号：US07956062B2
公开(公告)日：2011-06-07
申请号：US12554249
申请日：2009-09-04
申请人： Jonathan S. Stamler , Eric J. Toone , Joshua M. Hare
发明人： Jonathan S. Stamler , Eric J. Toone , Joshua M. Hare
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： A reactive oxygen generating enzyme inhibitor with NO donor bioactivity, e.g., nitrated allopurinol, is useful to treat heart failure, stable angina, ischemic disorder, ischemic reperfusion injury, atherosclerosis, sickle cell disease, diabetes, Alzheimer's disease, Parkinson's disease, ALS and asthma and to obtain proper contraction of heart, skeletal and smooth muscle.
摘要翻译：具有NO供体生物活性的活性氧产生酶抑制剂，例如硝化别嘌呤醇，可用于治疗心力衰竭，稳定性心绞痛，缺血性障碍，缺血再灌注损伤，动脉粥样硬化，镰状细胞病，糖尿病，阿尔茨海默病，帕金森病，ALS和哮喘并获得心脏，骨骼和平滑肌的适当收缩。

3. 发明申请

US20100310532A1 GENE TARGETS IN ANTI-AGING THERAPY AND TISSUE REPAIR 审中-公开
标题翻译：抗体治疗中的基因组和组织修复
公开(公告)号：US20100310532A1
公开(公告)日：2010-12-09
申请号：US12676003
申请日：2008-09-08
申请人： Joshua M. Hare , Bettina Heidecker
发明人： Joshua M. Hare , Bettina Heidecker
IPC分类号： A61K31/7088 , C12Q1/68 , C07K16/18 , C12N5/10 , C12N15/63 , A61K38/17 , A61K38/43 , A61K35/12 , C12Q1/02 , G01N33/53 , C40B30/04 , A61P9/00
CPC分类号： C07K14/47 , G01N33/5023 , G01N33/56966 , G01N2800/324 , G01N2800/325
摘要： Novel gene and protein targets are described for treatment of cardiac disorders, anti-aging therapies and tissue repair. Identified biomarkers are prognostic of long term survival of patients suffering from heart diseases and related disorders.
摘要翻译：描述了新的基因和蛋白质靶标用于治疗心脏病，抗衰老疗法和组织修复。识别的生物标志物是患有心脏病和相关疾病的患者的长期存活的预后。

4. 发明申请

US20180214486A1 BONE MARROW DERIVED CD271 PRECURSOR CELLS FOR CARDIAC REPAIR 审中-公开
公开(公告)号：US20180214486A1
公开(公告)日：2018-08-02
申请号：US15720373
申请日：2017-09-29
申请人： JOSHUA M. HARE
发明人： Joshua M. Hare , Ian K. McNiece
IPC分类号： A61K35/28
CPC分类号： A61K35/28
摘要： Methods for the isolation of CD271+ stem cell populations are important in the prevention or treatment of cardiovascular diseases and repair of cardiac tissue. The methods are applicable to stem cells from different sources and can be used to treat or prevent diseases or repair of tissues elsewhere in the organism's body.

5. 发明申请

US20120142544A1 DIAGNOSTIC TRANSCRIPTOMIC BIOMARKERS IN INFLAMMATORY CARDIOMYOPATHIES 审中-公开
标题翻译：诊断性心脏病中的诊断代谢生物标志物
公开(公告)号：US20120142544A1
公开(公告)日：2012-06-07
申请号：US13376046
申请日：2010-06-02
申请人： Joshua M. Hare , Bettina Heidecker
发明人： Joshua M. Hare , Bettina Heidecker
IPC分类号： C40B30/00 , G01N33/566 , C12N5/10 , C07H21/00 , C40B40/06 , C40B40/10 , C07K14/00 , C12Q1/68 , C12N15/63
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.
摘要翻译：识别出作为心肌炎，心脏病及其病症非常敏感的诊断生物标志物的分子标记。

6. 发明申请

US20100112587A1 TRANSCRIPTOMIC BIOMARKERS FOR INDIVIDUAL RISK ASSESSMENT IN NEW ONSET HEART FAILURE 审中-公开
标题翻译：在新的心脏失败中进行个体风险评估的代用生物标志物
公开(公告)号：US20100112587A1
公开(公告)日：2010-05-06
申请号：US12610529
申请日：2009-11-02
申请人： Joshua M. Hare , Bettina Heidecker
发明人： Joshua M. Hare , Bettina Heidecker
IPC分类号： C12Q1/68 , C12N5/00 , C12N15/63 , C40B40/06 , C07K16/00 , C07H21/00
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/6893 , G01N2800/325 , G01N2800/50
摘要： A novel transcriptomic biomarker for prognosis in heart failure has a direct clinical application in prediction of prognosis in new onset heart failure, heart disease, heart disorders and associated heart conditions. This approach should improve individualization of cardiac care and help identify patients at highest risk for circulatory collapse within the first years of presentation with heart failure.
摘要翻译：用于心力衰竭预后的新型转录组学生物标志物可直接用于预测新发心脏衰竭，心脏病，心脏病和相关心脏病症中的预后。这种方法应该改善心脏保健的个性化，并帮助确定患有心力衰竭的头几年内循环衰竭风险最高的患者。

7. 发明授权

US07067659B2 Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof 失效
标题翻译：具有一氧化氮生物活性的活性氧发生酶抑制剂及其应用
公开(公告)号：US07067659B2
公开(公告)日：2006-06-27
申请号：US10829940
申请日：2004-04-23
申请人： Jonathan S. Stamler , Eric J. Toone , Joshua M. Hare
发明人： Jonathan S. Stamler , Eric J. Toone , Joshua M. Hare
IPC分类号： C07D475/04 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： A reactive oxygen generating enzyme inhibitor with NO donor bioactivity, e.g., nitrated allopurinol, e.g., 1,5-bis(3-nitrooxypropyyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one is useful to treat heart failure, stable angina, ischemic disorder, ischemic reperfusion injury, atherosclerosis, sickle cell disease, diabetes, Alzheimer's disease, Parkinson's disease, ALS and asthma and to obtain proper contraction of heart, skeletal and smooth muscle. Where the disorder is heart failure, administration of the enzyme inhibitor mediates amelioration of acute coronary symptoms and/or myocardial infarction.
摘要翻译：具有NO供体生物活性的活性氧产生酶抑制剂，例如硝化别嘌呤醇，例如1,5-双（3-硝基氧基丙基）-1,5-二氢-4H-吡唑并[3,4-d]嘧啶-4-酮可用于治疗心力衰竭，稳定型心绞痛，缺血障碍，缺血再灌注损伤，动脉粥样硬化，镰状细胞病，糖尿病，阿尔茨海默氏病，帕金森病，ALS和哮喘，并获得心脏，骨骼和平滑肌的适当收缩。在疾病是心力衰竭的地方，酶抑制剂的施用介导急性冠状动脉症状和/或心肌梗死的改善。

8. 发明申请

US20140023621A1 BONE MARROW DERIVED CD271 PRECURSOR CELLS FOR CARDIAC REPAIR 审中-公开
标题翻译：骨髓衍生的CD271前列腺细胞用于心脏修复
公开(公告)号：US20140023621A1
公开(公告)日：2014-01-23
申请号：US13819154
申请日：2011-08-29
申请人： Joshua M. Hare , Ian K. McNiece
发明人： Joshua M. Hare , Ian K. McNiece
IPC分类号： A61K35/28
CPC分类号： A61K35/28
摘要： Methods for the isolation of CD271+ stem cell populations are important in the prevention or treatment of cardio-vascular diseases and repair of cardiac tissue. The methods are applicable to stem cells from different sources and can be used to treat or prevent diseases or repair of tissues elsewhere in the organism's body.
摘要翻译：分离CD271 +干细胞群体的方法在预防或治疗心血管疾病和修复心脏组织中是重要的。该方法适用于来自不同来源的干细胞，可用于治疗或预防生物体内其他地方的疾病或修复组织。

9. 发明申请

US20110159487A1 Identification of a Gene Expression Profile that Differentiates Ischemic and Nonischemic Cardiomyopathy 审中-公开
标题翻译：鉴定差异缺血性和非缺血性心肌病的基因表达谱
公开(公告)号：US20110159487A1
公开(公告)日：2011-06-30
申请号：US13041152
申请日：2011-03-04
申请人： Joshua M. Hare , Michelle M. Kittleson
发明人： Joshua M. Hare , Michelle M. Kittleson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N2800/325
摘要： A method of preparing a gene expression prediction profile for distinguishing ischemic and nonischemic cardiomyopathy comprises the steps of obtaining clinical specimens from patients suffering from ischemic or nonischemic cardiomyopathy, isolating nucleic acid sequences from at least a plurality of said specimens, obtaining a gene expression level corresponding to each individual of said nucleic acid sequence by a gene expression profiling method, identifying genes having differences in gene expression by comparing the gene expression level of an ischemic specimen with the gene expression level of a nonischemic specimen, and identifying a gene expression prediction profile comprises genes identified as having differences in gene expression so that said prediction profile distinguishes ischemic and nonischemic cardiomyopathy.
摘要翻译：制备用于区分缺血性和非缺血性心肌病的基因表达预测曲线的方法包括以下步骤：从患有缺血性或非缺血性心肌病的患者获得临床标本，从至少多个所述标本分离核酸序列，获得相应的基因表达水平通过基因表达谱分析方法对所述核酸序列的每个个体进行鉴定，通过比较缺血标本的基因表达水平与非缺血标本的基因表达水平来鉴定基因表达差异的基因，以及鉴定基因表达预测谱包括鉴定为具有基因表达差异的基因，使得所述预测特征区分缺血性和非缺血性心肌病。

10. 发明申请

US20100190650A1 TRANSCRIPTOMIC BIOMARKER OF MYOCARDITIS 审中-公开
标题翻译： MYOCARDITIS的转录生物标志物
公开(公告)号：US20100190650A1
公开(公告)日：2010-07-29
申请号：US12609194
申请日：2009-10-30
申请人： Joshua M. Hare , Bettina Heidecker
发明人： Joshua M. Hare , Bettina Heidecker
IPC分类号： C40B30/00 , C07K14/00 , G01N33/50 , C12Q1/68 , G01N33/53 , C07H21/00 , C07K16/00 , C40B40/06 , C12N15/74 , C12N5/071
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.
摘要翻译：识别出作为心肌炎，心脏病及其病症非常敏感的诊断生物标志物的分子标记。

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