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1. 发明授权

US08147482B2 Electronic capsule for treating gastrointestinal disease 有权
标题翻译：用于治疗胃肠道疾病的电子胶囊
公开(公告)号：US08147482B2
公开(公告)日：2012-04-03
申请号：US12305118
申请日：2007-04-11
申请人： Jeff Shimizu , Karen I. Trovato
发明人： Jeff Shimizu , Karen I. Trovato
IPC分类号： A61K9/22 , A61K9/48 , A61M31/00 , A61B5/05
CPC分类号： A61B5/073 , A61B5/14539 , A61B5/4839 , A61K31/60 , A61M31/002
摘要： The present invention discloses an ingestible capsule containing drug and a method for controlled administration of the drug in a mammal for treatment of a disease of the GI tract. The capsule has electronic control means for dispensing the drug substantially to the diseased tissue sites of the GI tract, according to a pre-determined drug release profile obtained prior to administration from the specific mammal.
摘要翻译：本发明公开了含有药物的摄取性胶囊和哺乳动物用于治疗胃肠道疾病的药物的受控制剂的方法。胶囊具有电子控制装置，用于根据在从特定哺乳动物施用之前获得的预定药物释放曲线将药物基本上分配到GI道的患病组织部位。

2. 发明申请

US20090306632A1 MEDICAMENT DELIVERY SYSTEM AND PROCESS 有权
标题翻译：药物递送系统和过程
公开(公告)号：US20090306632A1
公开(公告)日：2009-12-10
申请号：US12306017
申请日：2007-04-12
申请人： Karen I. Trovato , Jeff Shimizu
发明人： Karen I. Trovato , Jeff Shimizu
IPC分类号： A61K9/22 , A61B1/00
CPC分类号： A61M31/002 , A61B1/00016 , A61B1/041 , A61B5/021 , A61B5/0402 , A61B5/073 , A61B5/145 , A61B5/14539 , A61B5/4839
摘要： A system and method for delivering a substance to a selected site in the alimentary canal of a human or animal is provided. The system has an ingestible capsule comprising: a compartment for storing the substance; a receiver suitable for receiving a signal through animal tissue; a processor for storing a programmed set of instructions; an electronic power source; and at least one transmitter, disposed on a medically relevant site on the body of the human or animal, for sending a signal to the receiver, wherein the receiver further comprises a proximity based detection means for measuring proximity of the receiver to the at least one transmitter, and wherein the processor instructs the releasing means to release the substance upon recognition of a pre-programmed pattern of transmitters.
摘要翻译：提供了将物质递送到人或动物的消化道中的选定部位的系统和方法。该系统具有可摄入胶囊，包括：用于储存物质的隔间; 适合通过动物组织接收信号的接收器; 用于存储编程的指令集的处理器; 电子电源; 以及至少一个发射器，其布置在人或动物的身体上的医学上相关的位置上，用于向接收器发送信号，其中所述接收器还包括接近度检测装置，用于测量所述接收器与所述至少一个发射器，并且其中处理器指示释放装置在识别出预编程的发射器模式时释放物质。

3. 发明授权

US08597278B2 Medicament delivery system and process 有权
标题翻译：药物输送系统和过程
公开(公告)号：US08597278B2
公开(公告)日：2013-12-03
申请号：US12306017
申请日：2007-04-12
申请人： Karen I. Trovato , Jeff Shimizu
发明人： Karen I. Trovato , Jeff Shimizu
IPC分类号： A61K9/22
CPC分类号： A61M31/002 , A61B1/00016 , A61B1/041 , A61B5/021 , A61B5/0402 , A61B5/073 , A61B5/145 , A61B5/14539 , A61B5/4839
摘要： A system and method for delivering a substance to a selected site in an alimentary canal of a human or animal includes an ingestible capsule. The capsule has a compartment for storing the substance; a receiver suitable for receiving a signal through animal tissue; a processor for storing a programmed set of instructions; and an electronic power source. The system and method further has at least one transmitter, disposed on a medically relevant site on a body of the human or animal, for sending the signal to the receiver. The receiver includes a proximity based detector for measuring proximity of the receiver to the at least one transmitter, and the processor instructs a releasing device of the capsule to release the substance upon recognition of a pre-programmed pattern of signals.
摘要翻译：用于将物质递送到人或动物的消化道中的选定部位的系统和方法包括可摄入胶囊。胶囊具有用于储存物质的隔间; 适合通过动物组织接收信号的接收器; 用于存储编程的指令集的处理器; 和电子电源。该系统和方法还具有至少一个位于人或动物的身体上的医疗相关部位的发射器，用于将信号发送到接收器。接收机包括用于测量接收器与至少一个发射器的接近度的接近度检测器，并且处理器指示胶囊的释放装置在识别出预编程的信号模式时释放物质。

4. 发明申请

US20090275923A1 ELECTRONIC CAPSULE FOR TREATING GASTROINTESTINAL DISEASE 有权
标题翻译：用于治疗胃肠疾病的电子胶囊
公开(公告)号：US20090275923A1
公开(公告)日：2009-11-05
申请号：US12305118
申请日：2007-04-11
申请人： Jeff Shimizu , Karen I. Trovato
发明人： Jeff Shimizu , Karen I. Trovato
IPC分类号： A61M5/00 , A61K9/48 , A61P1/06 , A61B5/05
CPC分类号： A61B5/073 , A61B5/14539 , A61B5/4839 , A61K31/60 , A61M31/002
摘要： The present invention discloses an ingestible capsule containing drug and a method for controlled administration of the drug in a mammal for treatment of a disease of the GI tract. The capsule has electronic control means for dispensing the drug substantially to the diseased tissue sites of the GI tract, according to a pre-determined drug release profile obtained prior to administration from the specific mammal.
摘要翻译：本发明公开了含有药物的摄取性胶囊和哺乳动物用于治疗胃肠道疾病的药物的受控制剂的方法。胶囊具有电子控制装置，用于根据在从特定哺乳动物施用之前获得的预定药物释放曲线将药物基本上分配到GI道的患病组织部位。

5. 发明申请

US20090306633A1 ELECTRONICALLY CONTROLLED CAPSULE 审中-公开
标题翻译：电子控制胶囊
公开(公告)号：US20090306633A1
公开(公告)日：2009-12-10
申请号：US11814248
申请日：2006-01-16
申请人： Karen I. Trovato , Judy R. Naamat
发明人： Karen I. Trovato , Judy R. Naamat
IPC分类号： A61M31/00
CPC分类号： A61B5/036 , A61B1/041 , A61B5/14539 , A61B5/411 , A61M31/002 , A61M2005/14208 , A61M2205/0244 , A61M2205/0294 , A61M2205/3507 , A61M2205/3576 , A61M2205/52 , A61M2210/1042
摘要： An electronically controlled capsule or medicament delivery system (900) is provided. Disposed within a housing (102) of the system (900) configured for internal placement within a patient is a reservoir (960) for storing medicament. The reservoir (960) communicates with at least one respective aperture (970) of the housing (102). A pressure mechanism (962) is provided for displacing medicament stored within the reservoir (960) for causing the medicament to exit the housing (102) through the at least one respective aperture (970). At least one a closure member (966) is provided. Respective closure members (966) are in fluid communication with an associated aperture. The respective closure members (966) are actuatable between a closed state for substantially blocking flow of the medicament through the respective closure member (966) and an open state for permitting flow of the medicament through the respective closure member (966) for dispensing of the medicament. Control circuitry (906) is provided for controlling at least one of the pressure mechanism (962) and actuation of the respective closure members (966).
摘要翻译：提供电子控制的胶囊或药物输送系统（900）。设置在构造成用于内部放置在患者体内的系统（900）的壳体（102）内的是用于储存药物的储存器（960）。储存器（960）与壳体（102）的至少一个相应的孔（970）连通。提供压力机构（962），用于移动存储在贮存器（960）内的药物，用于使药物通过至少一个相应的孔（970）离开壳体（102）。提供至少一个闭合构件（966）。各个关闭构件（966）与相关的孔流体连通。相应的关闭构件（966）可在关闭状态之间启动，用于基本上阻挡药物通过相应的封闭构件（966）的流动，并且用于允许药物流过相应的封闭构件（966）的打开状态用于分配药物。提供控制电路（906）用于控制压力机构（962）中的至少一个和相应的关闭部件（966）的致动。

6. 发明申请

US20080234700A1 3D Tool Path Planning, Simulation and Control System 有权
标题翻译： 3D工具路径规划，仿真与控制系统
公开(公告)号：US20080234700A1
公开(公告)日：2008-09-25
申请号：US12088870
申请日：2006-10-06
申请人： Karen I. Trovato , Eric Cohen-Solal , Douglas Summers-Stay
发明人： Karen I. Trovato , Eric Cohen-Solal , Douglas Summers-Stay
IPC分类号： A61B17/10 , G06G7/48
CPC分类号： A61B90/36 , A61B34/10 , A61B90/10 , A61B2017/00331 , A61B2034/107
摘要： A system, apparatus, and method are provided for control of a catheter (including an ablation catheter), bronchoscope/endoscope and beveled needle. Control of a bronchoscope (100) is calculated for a 3D environment based on capabilities of the bronchoscope and the patient morphology. This can be used to plan and simulate an optimal motion, train or compare surgical techniques or automate the procedure. A particular bronchoscope may be recommended based on its form and flexibility as well as based on the personal morphology of the patient rather than relying on statistical norms. For all tools, a 6 dimensional configuration space problem is solved using 3 storage dimensions and a ‘6D neighborhood’ for path planning. The present invention finds the kinematically feasible path from a ‘start’ to a goal, while avoiding obstacles and dangerous regions.
摘要翻译：提供了一种用于控制导管（包括消融导管），支气管镜/内窥镜和斜针的系统，装置和方法。基于支气管镜和患者形态的能力，针对3D环境计算支气管镜（100）的控制。这可以用于计划和模拟最佳运动，训练或比较手术技术或自动化程序。可以基于其形式和灵活性以及基于患者的个人形态而不是依赖于统计学规范来推荐特定的支气管镜。对于所有工具，使用3个存储尺寸和6D邻域来解决6维配置空间问题，用于路径规划。本发明从“开始”到目标发现运动学可行的路径，同时避免障碍物和危险区域。

7. 发明授权

US06766374B2 System creating chat network based on a time of each chat access request 失效
标题翻译：基于每个聊天访问请求的时间，系统创建聊天网络
公开(公告)号：US06766374B2
公开(公告)日：2004-07-20
申请号：US10154672
申请日：2002-05-23
申请人： Karen I. Trovato , Paul Rankin , Carolyn Ramsey
发明人： Karen I. Trovato , Paul Rankin , Carolyn Ramsey
IPC分类号： G06F1516
CPC分类号： H04L12/1818 , H04N7/17318 , H04N21/252 , H04N21/25841 , H04N21/25883 , H04N21/25891 , H04N21/44213 , H04N21/4788
摘要： When a person requests access to a chat session, the time of the request is used to determine which chat room the person is placed. Other parameters are used to determine the surrounding factors, or context, within which the person initiated the request, such as the particular television program that the person was watching at the time of the request. By forming chat rooms based on the time of entry and the context in which the request is made, the chat rooms are likely to contain people with a common topic to discuss, such as the television news story being broadcast at that time. These time-of-entry chat rooms can also be structured to be of limited duration, obviating the overhead burden of deleting topic-specific chat rooms when the topic ceases to be of interest.
摘要翻译：当个人请求访问聊天会话时，请求的时间用于确定该人被放置的聊天室。其他参数用于确定人发起请求的周围因素或环境，例如该人在请求时正在观看的特定电视节目。通过基于进入时间和提出请求的上下文形成聊天室，聊天室可能包含具有共同话题的人讨论，例如当时正在广播的电视新闻故事。这些入场聊天室也可以被构造成具有有限的时间，从而消除当主题不再感兴趣时删除主题特定聊天室的开销负担。

8. 发明授权

US06425012B1 System creating chat network based on a time of each chat access request 失效
标题翻译：基于每个聊天访问请求的时间，系统创建聊天网络
公开(公告)号：US06425012B1
公开(公告)日：2002-07-23
申请号：US09221947
申请日：1998-12-28
申请人： Karen I. Trovato , Paul Rankin , Carolyn Ramsey
发明人： Karen I. Trovato , Paul Rankin , Carolyn Ramsey
IPC分类号： G06F1516
CPC分类号： H04L12/1818 , H04N7/17318 , H04N21/252 , H04N21/25841 , H04N21/25883 , H04N21/25891 , H04N21/44213 , H04N21/4788
摘要： When a person requests access to a chat session, the time of the request is used to determine which chat room the person is placed. Other parameters are used to determine the surrounding factors, or context, within which the person initiated the request, such as the particular television program that the person was watching at the time of the request. By forming chat rooms based on the time of entry and the context in which the request is made, the chat rooms are likely to contain people with a common topic to discuss, such as the television news story being broadcast at that time. These time-of-entry chat rooms can also be structured to be of limited duration, obviating the overhead burden of deleting topic-specific chat rooms when the topic ceases to be of interest.
摘要翻译：当个人请求访问聊天会话时，请求的时间用于确定该人被放置的聊天室。其他参数用于确定人发起请求的周围因素或环境，例如该人在请求时正在观看的特定电视节目。通过基于进入时间和提出请求的上下文形成聊天室，聊天室可能包含具有共同话题的人讨论，例如当时正在广播的电视新闻故事。这些入场聊天室也可以被构造成具有有限的时间，从而消除当主题不再感兴趣时删除主题特定聊天室的开销负担。

9. 发明授权

US09895163B2 Active cannula configuration for minimally invasive surgery 有权
公开(公告)号：US09895163B2
公开(公告)日：2018-02-20
申请号：US12439840
申请日：2007-08-15
申请人： Karen I. Trovato
发明人： Karen I. Trovato
IPC分类号： A61B19/00 , A61B17/34 , A61M25/01 , A61B17/00 , A61M25/00 , A61B34/10
CPC分类号： A61B17/3421 , A61B17/3417 , A61B34/10 , A61B2017/003 , A61B2017/00331 , A61B2017/00991 , A61B2017/3443 , A61M25/0041 , A61M25/0105 , A61M2025/0175
摘要： The present disclosure provides for systems and methods for active cannula configuration. Active cannula systems include a plurality of telescoping, pre-shaped nitinol tubes configured and dimensioned to reach target locations within a particular anatomical region. A three dimensional image is read for the particular anatomical region. A series of arcs are generated between a point of the anatomical region and a target location. A pathway for the active cannula is calculated from the series of arcs. The pathway is used to configure and dimension the plurality of tubes. The active cannula system is adapted to reach relatively small and complex target locations.

10. 发明授权

US09747684B2 RF ablation planner 有权
公开(公告)号：US09747684B2
公开(公告)日：2017-08-29
申请号：US12523163
申请日：2008-01-10
申请人： Karen I. Trovato , Douglas Summers-Stay
发明人： Karen I. Trovato , Douglas Summers-Stay
IPC分类号： A61B18/12 , G06T7/00 , A61B90/00 , A61B34/10 , A61B34/20
CPC分类号： G06T7/0012 , A61B34/10 , A61B34/20 , A61B90/36 , A61B2034/104 , A61B2034/107 , G06T2207/30004
摘要： In planning an ablation procedure, a planned target volume (PTV) is imported, which is typically selected by a doctor but may be computer identified. An initial set of candidate ablation regions that covers the PTV is computed. Ablation probe trajectories that avoid critical structures are computed to provide surgical 5 options for safe entry points and angles. An optimization component determines a minimum number of ablation regions, which fully covers the PTV, and generates locations and orientations for each ablation. A tracking system can be given these ablation targets, enabling the surgeon to control the probe more precisely to the desired location.

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