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1. 发明申请

US20140315743A1 Methods and Compositions for the Treatment and Diagnosis of Ovarian Cancer 审中-公开
标题翻译：卵巢癌治疗和诊断的方法和组成
公开(公告)号：US20140315743A1
公开(公告)日：2014-10-23
申请号：US14348930
申请日：2012-10-03
申请人： Karen Chapman , Joseph Wagner , Michael West , Jennifer Lorrie Kidd
发明人： Karen Chapman , Joseph Wagner , Michael West , Jennifer Lorrie Kidd
IPC分类号： G01N33/574
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to methods, compositions and kits for the diagnosis, detection, and treatment of ovarian cancer.
摘要翻译：本发明涉及用于诊断，检测和治疗卵巢癌的方法，组合物和试剂盒。

2. 发明申请

US20140235486A1 Methods and Compositions for the Treatment and Diagnosis of Breast Cancer 审中-公开
标题翻译：乳腺癌治疗和诊断的方法和组成
公开(公告)号：US20140235486A1
公开(公告)日：2014-08-21
申请号：US14238726
申请日：2012-08-16
申请人： Karen Chapman , Joseph Wagner , Michael West , Jennifer Lorrie Kidd , Maria Prendes
发明人： Karen Chapman , Joseph Wagner , Michael West , Jennifer Lorrie Kidd , Maria Prendes
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N33/57415
摘要： The invention provides for methods of diagnosis, prognosis and treatment of cancer including, but not limited to, breast cancer.
摘要翻译：本发明提供了诊断，预后和治疗癌症的方法，包括但不限于乳腺癌。

3. 发明申请

US20140154691A1 Methods and Compositions for the Treatment and Diagnosis of Bladder Cancer 审中-公开
标题翻译：膀胱癌的治疗和诊断的方法和组成
公开(公告)号：US20140154691A1
公开(公告)日：2014-06-05
申请号：US14127895
申请日：2012-06-22
申请人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd
发明人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N33/57407 , G01N2800/60
摘要： Embodiments of the disclosure are directed to methods of diagnosis, prognosis and treatment of cancer. The methods are particularly suited for bladder cancer. The methods include targeting a marker that is expressed at abnormal levels in bladder cancer tissue in comparison to normal somatic tissue. Also disclosed are methods of treating cancer comprising administering a composition including a therapeutic that affects the expression or function of a target marker.
摘要翻译：本公开的实施方案涉及癌症的诊断，预后和治疗方法。该方法特别适用于膀胱癌。所述方法包括靶向与正常体细胞组织相比在膀胱癌组织中以异常水平表达的标记物。还公开了治疗癌症的方法，包括施用包含影响靶标志的表达或功能的治疗剂的组合物。

4. 发明申请

US20140221244A1 Methods and Compositions for the Treatment and Diagnosis of Colorectal Cancer 审中-公开
标题翻译：用于治疗和诊断结直肠癌的方法和组合
公开(公告)号：US20140221244A1
公开(公告)日：2014-08-07
申请号：US14240512
申请日：2012-08-31
申请人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria Prendes
发明人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria Prendes
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , G01N33/57419
摘要： The invention provides methods, compositions and kits relating to the detection, diagnosis, treatment of colorectal cancer.
摘要翻译：本发明提供了与结肠直肠癌的检测，诊断，治疗相关的方法，组合物和试剂盒。

5. 发明申请

US20140206574A1 Methods and Compositons for the Treatment and Diagnosis of Cancer 审中-公开
标题翻译：用于治疗和诊断癌症的方法和组合
公开(公告)号：US20140206574A1
公开(公告)日：2014-07-24
申请号：US14240698
申请日：2012-08-31
申请人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria J. Prendes
发明人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria J. Prendes
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57488 , C12Q1/6886 , G01N33/57484 , G01N33/6893
摘要： The invention relates to methods of detecting cancer in a sample obtained from a subject. The invention also provides kits and reagents for detecting cancer as well as therapeutics and methods of treating cancer.
摘要翻译：本发明涉及从受试者获得的样品中检测癌症的方法。本发明还提供用于检测癌症的试剂盒和试剂，以及治疗和治疗癌症的方法。

6. 发明申请

US20140141996A1 Methods and Compositions for the Treatment and Diagnosis of Cancer 审中-公开
标题翻译：癌症治疗和诊断的方法和组成
公开(公告)号：US20140141996A1
公开(公告)日：2014-05-22
申请号：US14127913
申请日：2012-06-23
申请人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria Prendes
发明人： Karen Chapman , Joseph Wagner , Michael West , Markus Daniel Lacher , Jennifer Lorie Kidd , Maria Prendes
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , G01N33/57407 , G01N33/57415 , G01N33/57484
摘要： Embodiments of the disclosure are directed to methods of diagnosis, prognosis and treatment of cancer. In some embodiments, the methods include targeting a marker that is expressed at abnormal levels in bladder cancer tissue in comparison to normal somatic tissue. Some embodiments are directed to methods of treating cancer comprising administering a composition including a therapeutic that affects the expression or function of a target marker. Some embodiments are directed to methods of detecting cancer comprising detecting a level of a target marker associated with the cancer,
摘要翻译：本公开的实施方案涉及癌症的诊断，预后和治疗方法。在一些实施方案中，所述方法包括靶向与正常体细胞组织相比在膀胱癌组织中以异常水平表达的标记。一些实施方案涉及治疗癌症的方法，包括施用包含影响靶标志的表达或功能的治疗剂的组合物。一些实施方案涉及检测癌症的方法，包括检测与癌症相关的靶标志的水平，

7. 发明授权

US10049384B2 System and method for directing targeted advertisements in IP telecommunications 有权
公开(公告)号：US10049384B2
公开(公告)日：2018-08-14
申请号：US12806243
申请日：2010-08-06
申请人： Joseph Wagner
发明人： Joseph Wagner
IPC分类号： G06Q30/00 , G06Q30/02 , H04W4/90
CPC分类号： G06Q30/0251 , G06Q30/02 , G06Q30/0269 , H04W4/90
摘要： A Voice over Internet Protocol (VoIP) targeted advertisement delivery method that is operable in a processor coupled to a memory. The method includes monitoring all outgoing communications on a server in order to identify a VoIP telephony signal. Upon detection of a VoIP telephony signal indicating that a VoIP call setup is in progress, the method determines whether a caller identifier associated with the VoIP telephony signal identifies an associated caller as a candidate for a targeted advertisement delivery. If the caller is a candidate for a targeted advertisement delivery, identifying and retrieving a targeted advertisement for presentation to the caller during the call setup.

8. 发明授权

US09969980B2 Cell populations which co-express CD49c and CD90 有权
公开(公告)号：US09969980B2
公开(公告)日：2018-05-15
申请号：US09960244
申请日：2001-09-21
申请人： Tony W. Ho , Gene C. Kopen , William F. Righter , J. Lynn Rutkowski , Joseph Wagner
发明人： Tony W. Ho , Gene C. Kopen , William F. Righter , J. Lynn Rutkowski , Joseph Wagner
IPC分类号： C12N5/00 , C12N5/077 , C12N5/0797 , C12N5/0775 , A61K35/12
CPC分类号： C12N5/0669 , A61K2035/124 , C12N5/0623 , C12N5/0663 , C12N2500/02 , C12N2500/32 , C12N2506/1353
摘要： Substantially homogenous cells populations which co-express CD49c, CD90 and telomerase are made. In one embodiment, humans suffering from a degenerative, traumatic, acute injury, cardiac or neurological condition are treated with the substantially homogenous cells populations which co-express CD49c, CD90 and telomerase. In another embodiment, committed progenitor cells are made are made by selecting from a cultured source of a cell population which co-express CD49c and CD90 and modifying the cell population. The committed progenitor cells can be employed to treat a human suffering from a degenerative, traumatic, acute injury, cardiac or neurological condition and formulate pharmaceutical compositions.

9. 发明申请

US20100306061A1 System and method for directing targeted advertisements in IP telecommunications 有权
标题翻译：在IP电信中指导目标广告的系统和方法
公开(公告)号：US20100306061A1
公开(公告)日：2010-12-02
申请号：US12806243
申请日：2010-08-06
申请人： Joseph Wagner
发明人： Joseph Wagner
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0251 , G06Q30/02 , G06Q30/0269 , H04W4/90
摘要： A Voice over Internet Protocol (VoIP) targeted advertisement delivery method that is operable in a processor coupled to a memory. The method includes monitoring all outgoing communications on a server in order to identify a VoIP telephony signal. Upon detection of a VoIP telephony signal indicating that a VoIP call setup is in progress, the method determines whether a caller identifier associated with the VoIP telephony signal identifies an associated caller as a candidate for a targeted advertisement delivery. If the caller is a candidate for a targeted advertisement delivery, identifying and retrieving a targeted advertisement for presentation to the caller during the call setup.
摘要翻译：互联网语音协议（VoIP）目标广告传递方法，其可在耦合到存储器的处理器中操作。该方法包括监视服务器上的所有传出通信，以便识别VoIP电话信号。当检测到指示VoIP呼叫建立正在进行的VoIP电话信号时，该方法确定与VoIP电话信号相关联的呼叫者标识符是否将相关联的呼叫者识别为用于目标广告传送的候选者。如果呼叫者是用于目标广告传送的候选者，则在呼叫建立期间识别和检索用于呈现给呼叫者的目标广告。

10. 发明申请

US20070231309A1 Cell populations which co-express CD49c and CD90 审中-公开
标题翻译：共表达CD49c和CD90的细胞群体
公开(公告)号：US20070231309A1
公开(公告)日：2007-10-04
申请号：US11723348
申请日：2007-03-19
申请人： Tony Ho , Gene Kopen , William Righter , J. Rutkowski , Joseph Wagner
发明人： Tony Ho , Gene Kopen , William Righter , J. Rutkowski , Joseph Wagner
IPC分类号： A61K48/00
CPC分类号： C12N5/0669 , A61K2035/124 , C12N5/0623 , C12N5/0663 , C12N2500/02 , C12N2500/32 , C12N2506/1353
摘要： Substantially homogenous cells populations which co-express CD49c, CD90 and telomerase are made. In one embodiment, humans suffering from a degenerative, traumatic, acute injury, cardiac or neurological condition are treated with the substantially homogenous cells populations which co-express CD49c, CD90 and telomerase. In another embodiment, committed progenitor cells are made are made by selecting from a cultured source of a cell population which co-express CD49c and CD90 and modifying the cell population. The committed progenitor cells can be employed to treat a human suffering from a degenerative, traumatic, acute injury cardiac or neurological condition and formulate pharmaceutical compositions.
摘要翻译：制备共表达CD49c，CD90和端粒酶的基本均匀的细胞群体。在一个实施方案中，患有退行性，创伤性，急性损伤，心脏或神经病症的人用共同表达CD49c，CD90和端粒酶的基本均匀的细胞群治疗。在另一个实施方案中，通过从共培养CD49c和CD90的细胞群的培养来源中选择并修饰细胞群体来制备确定的祖细胞。承诺的祖细胞可用于治疗患有退行性，创伤性，急性损伤心脏或神经病症的人，并配制药物组合物。

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