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1. 发明申请

US20060216834A1 Assay devices that utilize hollow particles 有权
标题翻译：使用中空颗粒的测定装置
公开(公告)号：US20060216834A1
公开(公告)日：2006-09-28
申请号：US11440956
申请日：2006-05-25
申请人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Chidebelu-Eze , Zdravko Atanassov
发明人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Chidebelu-Eze , Zdravko Atanassov
IPC分类号： G01N33/558
CPC分类号： G01N33/587 , G01N33/558
摘要： Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.
摘要翻译：提供了用于各种类型的测定装置的中空颗粒。由于其中空或空隙结构，颗粒可能表现出各种有益的性质。例如，中空颗粒通常是轻质的，因此与其它类型的颗粒相比相对便宜。中空颗粒也可以形成稳定的系统，而不需要制冷或旋转。此外，中空颗粒可以具有增强的光衍射能力，这在某些类型的测定装置中是特别有益的，例如基于衍射的测定装置。

2. 发明申请

US20070134810A1 Metering strip and method for lateral flow assay devices 有权
标题翻译：测量条和侧流测定装置的方法
公开(公告)号：US20070134810A1
公开(公告)日：2007-06-14
申请号：US11300650
申请日：2005-12-14
申请人： Kaiyuan Yang , Shawn Feaster , Ning Wei , Rosann Kaylor , Chibueze Chidebelu-Eze
发明人： Kaiyuan Yang , Shawn Feaster , Ning Wei , Rosann Kaylor , Chibueze Chidebelu-Eze
IPC分类号： G01N33/558
CPC分类号： G01N33/54366 , B01L3/5023 , B01L2200/027 , B01L2300/0681 , B01L2300/0825 , B01L2300/0867 , B01L2400/0406 , B01L2400/0683 , G01N33/558 , Y10S436/825 , Y10T436/107497 , Y10T436/108331
摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. The kit includes a housing, and a membrane disposed within the housing having a detection region and a collection region. A blood sample meter is provided having a first end for absorption of a blood sample, a filtering section adjacent to the first end that filters red blood cell components from the blood sample, and a storage section adjacent to the filtering section that receives plasma or serum from the filtering section. An opening in the housing is sized for insertion of the sample meter into the housing such that the storage section of the sample meter is disposed in fluid communication with the collection region of the membrane. The plasma or serum is transferred from the storage section of the sample meter to the collection region of the membrane for subsequent migration to the detection region.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。套件包括壳体和设置在壳体内的膜，其具有检测区域和收集区域。提供血样计，其具有用于吸收血液样本的第一端，与第一端相邻的过滤部分，其从血液样品中过滤红细胞成分，以及与过滤部相邻的存储部，其接收血浆或血清从过滤部分。壳体中的开口的尺寸适于将样品计量器插入壳体中，使得样品计量器的存储部分设置成与膜的收集区域流体连通。将血浆或血清从样品计量器的储存部分转移到膜的收集区域，以便随后迁移到检测区域。

3. 发明申请

US20050131287A1 Detection of premature rupture of the amniotic membrane 审中-公开
标题翻译：检测羊膜早破
公开(公告)号：US20050131287A1
公开(公告)日：2005-06-16
申请号：US10736662
申请日：2003-12-16
申请人： Rosann Kaylor , RameshBabu Boga , Kaiyuan Yang , Shawn Feaster , Curtis Sayre , David Cohen , Ning Wei , Chibueze Chidebelu-Eze , Stephen Quirk
发明人： Rosann Kaylor , RameshBabu Boga , Kaiyuan Yang , Shawn Feaster , Curtis Sayre , David Cohen , Ning Wei , Chibueze Chidebelu-Eze , Stephen Quirk
IPC分类号： A61B5/00 , A61F13/15 , B65D81/00
CPC分类号： A61F13/84 , A61B5/00 , A61F2013/8473 , A61F2013/8491
摘要： The premature rupture of amniotic fluid (PROM) may be discovered through a number of inventive means. Methods of evaluating whether PROM is present include; a) through the testing of the pH of vaginal fluids using an irreversible pH test; b) through the detection of analytes (e.g. enzymes) specific to amniotic fluid in the vaginal fluids; c) though the detection of hydrogen peroxide (H2O2) in the vaginal fluid; and d) through the detection of cholesterol in vaginal fluid. While individually indicative of PROM, it is desirable to combine at least two of these techniques to yield a powerful tool of even greater reliability. Test devices and feminine hygiene pads into which the test methods may be incorporated are also included herein.
摘要翻译：通过许多创造性手段可以发现羊水过早破裂（PROM）。评估PROM是否存在的方法包括： a）通过使用不可逆的pH测试来测试阴道液的pH值; b）通过检测阴道液中特异于羊水的分析物（例如酶）; c）尽管在阴道液中检测过氧化氢（H 2 O 2 O 2）; 和d）通过检测阴道液中的胆固醇。虽然单独指示PROM，但是期望将这些技术中的至少两种组合以产生更大可靠性的强大工具。本文还包括其中可以并入测试方法的测试装置和女性卫生衬垫。

4. 发明申请

US20060127886A1 Sample-efficient lateral flow immunoassay 审中-公开
标题翻译：采样效率的侧流免疫测定
公开(公告)号：US20060127886A1
公开(公告)日：2006-06-15
申请号：US11012759
申请日：2004-12-15
申请人： Rosann Kaylor , Ning Wei , Chibueze Chidebelu-Eze , Shawn Feaster , Paul Christopher
发明人： Rosann Kaylor , Ning Wei , Chibueze Chidebelu-Eze , Shawn Feaster , Paul Christopher
IPC分类号： C12Q1/70 , G01N33/554 , G01N33/53 , G01N33/558 , G01N33/569 , C12Q1/68
CPC分类号： G01N33/558
摘要： There is provided a lateral flow assay device for detecting the presence or quantity of an analyte residing in a test sample where the lateral flow assay device has a porous membrane in communication with a conjugate pad and a wicking pad. The porous membrane has a detection zone which has an immobilized first capture reagent configured to bind to at least a portion of the analyte and analyte-conjugate complexes to generate a detection signal. A control zone may be located downstream from the detection zone on the porous membrane and has a second capture reagent immobilized within the control zone. The conjugate pad is located upstream from the detection zone, and has detection probes with specific binding members for the analyte. The sample is deposited between the control and detection zones. A buffer release zone is located upstream of the conjugate pad and provides for buffer addition to the device, the buffer serving to move the detection probes to the detection and control zones.
摘要翻译：提供了一种侧流测定装置，用于检测驻留在测试样品中的分析物的存在或数量，其中侧流测定装置具有与缀合垫和芯吸垫连通的多孔膜。多孔膜具有检测区，其具有被配置为结合至少一部分分析物和分析物 - 共轭复合物的固定的第一捕获试剂以产生检测信号。控制区可以位于多孔膜上的检测区的下游，并且具有固定在控制区内的第二捕获试剂。缀合垫位于检测区的上游，并具有用于分析物的具有特异性结合构件的检测探针。样品沉积在控制区和检测区之间。缓冲区释放区位于缀合垫的上游，并为缓冲器添加缓冲区，该缓冲器用于将检测探针移动到检测和控制区。

5. 发明申请

US20110020541A1 Methods of Making Assay Devices Utilizing Hollow Particles 有权
标题翻译：使用中空颗粒制备测定装置的方法
公开(公告)号：US20110020541A1
公开(公告)日：2011-01-27
申请号：US12891967
申请日：2010-09-28
申请人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Obinna Chidebelu-Eze , Zdravko Savov Atanassov
发明人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Obinna Chidebelu-Eze , Zdravko Savov Atanassov
IPC分类号： B05D7/02
CPC分类号： G01N33/587 , G01N33/558
摘要： Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.
摘要翻译：提供了用于各种类型的测定装置的中空颗粒。由于其中空或空隙结构，颗粒可能表现出各种有益的性质。例如，中空颗粒通常是轻质的，因此与其它类型的颗粒相比相对便宜。中空颗粒也可以形成稳定的系统，而不需要制冷或旋转。此外，中空颗粒可以具有增强的光衍射能力，这在某些类型的测定装置中是特别有益的，例如基于衍射的测定装置。

6. 发明授权

US08034397B2 Methods of making assay devices utilizing hollow particles 有权
标题翻译：使用中空颗粒制备测定装置的方法
公开(公告)号：US08034397B2
公开(公告)日：2011-10-11
申请号：US12891967
申请日：2010-09-28
申请人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Obinna Chidebelu-Eze , Zdravko Savov Atanassov
发明人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Obinna Chidebelu-Eze , Zdravko Savov Atanassov
IPC分类号： G01N1/31
CPC分类号： G01N33/587 , G01N33/558
摘要： Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.
摘要翻译：提供了用于各种类型的测定装置的中空颗粒。由于其中空或空隙结构，颗粒可能表现出各种有益的性质。例如，中空颗粒通常是轻质的，因此与其它类型的颗粒相比相对便宜。中空颗粒也可以形成稳定的系统，而不需要制冷或旋转。此外，中空颗粒可以具有增强的光衍射能力，这在某些类型的测定装置中是特别有益的，例如基于衍射的测定装置。

7. 发明授权

US07829328B2 Assay devices that utilize hollow particles 有权
标题翻译：使用中空颗粒的测定装置
公开(公告)号：US07829328B2
公开(公告)日：2010-11-09
申请号：US11440956
申请日：2006-05-25
申请人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Obinna Chidebelu-Eze , Zdravko Savov Atanassov
发明人： Kaiyuan Yang , Ning Wei , Rosann Kaylor , Chibueze Obinna Chidebelu-Eze , Zdravko Savov Atanassov
IPC分类号： C12M1/34
CPC分类号： G01N33/587 , G01N33/558
摘要： Hollow particles for use in various types of assay devices are provided. Due to their hollow or voided structure, the particles may exhibit a variety of beneficial properties. For instance, hollow particles are generally lightweight, and thus, relatively inexpensive in comparison to other types of particles. Hollow particles may also form a stable system without requiring refrigeration or rotation. In addition, hollow particles may possess enhanced light diffraction capabilities, which may be particularly beneficial in certain types of assay devices, e.g., diffraction-based assay devices.
摘要翻译：提供了用于各种类型的测定装置的中空颗粒。由于其中空或空隙结构，颗粒可能表现出各种有益的性质。例如，中空颗粒通常是轻质的，因此与其它类型的颗粒相比相对便宜。中空颗粒也可以形成稳定的系统，而不需要制冷或旋转。此外，中空颗粒可以具有增强的光衍射能力，这在某些类型的测定装置中是特别有益的，例如基于衍射的测定装置。

8. 发明申请

US20090314946A1 Membrane-Based Assay Devices that Utilize Time-Resolved Fluorescence 审中-公开
标题翻译：使用时间分辨荧光的基于膜的测定装置
公开(公告)号：US20090314946A1
公开(公告)日：2009-12-24
申请号：US12551048
申请日：2009-08-31
申请人： Xuedong Song , Rosann Kaylor , Michael Knotts , Ning Wei
发明人： Xuedong Song , Rosann Kaylor , Michael Knotts , Ning Wei
IPC分类号： G01N21/64 , G01T1/20
CPC分类号： G01N21/274 , G01N21/6408 , G01N21/6428 , G01N33/525 , G01N33/533 , G01N33/542 , G01N33/558 , G01N33/582 , G01N2021/6439 , G01N2201/062 , G01N2201/0696
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes time-resolved fluorescence to detect the signals generated by excited fluorescent labels. Because the labels can have relatively long emission lifetime, short-lived background interference can be practically eliminated through delayed fluorescence detection. In addition, the resulting fluorescent reader can have a simple and inexpensive design. For instance, in one embodiment, the reader can utilize a silicon photodiode and a pulsed light-emitting diode (LED) to accurately excite labels and detect fluorescence on a membrane-based assay device without requiring the use of expensive components, such as monochromators or narrow emission band width optical filters.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置利用时间分辨荧光检测激发的荧光标记产生的信号。因为标签的发光寿命可以较长，所以通过延迟荧光检测实际上可以消除短暂的背景干扰。此外，所得到的荧光读取器可以具有简单且便宜的设计。例如，在一个实施例中，读取器可以利用硅光电二极管和脉冲发光二极管（LED）来精确地激发标签并在基于膜的测定装置上检测荧光，而不需要使用昂贵的组件，例如单色仪或窄发射带宽滤光片。

9. 发明授权

US07632653B2 Membrane-based assay devices that utilize time-resolved fluorescence 有权
标题翻译：利用时间分辨荧光的基于膜的测定装置
公开(公告)号：US07632653B2
公开(公告)日：2009-12-15
申请号：US10286342
申请日：2002-11-01
申请人： Xuedong Song , Rosann Kaylor , Michael Knotts , Ning Wei
发明人： Xuedong Song , Rosann Kaylor , Michael Knotts , Ning Wei
IPC分类号： G01N33/533
CPC分类号： G01N33/54326 , G01N21/274 , G01N21/6408 , G01N33/525 , G01N33/558 , G01N33/582 , G01N2021/6439 , Y10S435/803 , Y10S435/805 , Y10S435/97 , Y10S436/80 , Y10S436/806 , Y10S436/824 , Y10T436/13
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes time-resolved fluorescence to detect the signals generated by excited fluorescent labels. Because the labels can have relatively long emission lifetime, short-lived background interference can be practically eliminated through delayed fluorescence detection. In addition, the resulting fluorescent reader can have a simple and inexpensive design. For instance, in one embodiment, the reader can utilize a silicon photodiode and a pulsed light-emitting diode (LED) to accurately excite labels and detect fluorescence on a membrane-based assay device without requiring the use of expensive components, such as monochromators or narrow emission band width optical filters.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置利用时间分辨荧光检测激发的荧光标记产生的信号。因为标签的发光寿命可以较长，所以通过延迟荧光检测实际上可以消除短暂的背景干扰。此外，所得到的荧光读取器可以具有简单且便宜的设计。例如，在一个实施例中，读取器可以利用硅光电二极管和脉冲发光二极管（LED）来精确地激发标签并在基于膜的测定装置上检测荧光，而不需要使用昂贵的组件，例如单色仪或窄发射带宽滤光片。

10. 发明申请

US20060068500A1 Detecting yeast infections using a lateral flow assay 审中-公开
标题翻译：使用侧流测定法检测酵母菌感染
公开(公告)号：US20060068500A1
公开(公告)日：2006-03-30
申请号：US10951367
申请日：2004-09-28
申请人： Ning Wei , Shu-Ping Yang , Rosann Kaylor
发明人： Ning Wei , Shu-Ping Yang , Rosann Kaylor
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , G01N2333/40
摘要： There is provided a lateral flow assay device for detecting the presence or quantity of an analyte residing in a test sample where the lateral flow assay device has a porous membrane in liquid communication with a conjugate pad and a wicking pad. The conjugate pad has a gold colloid-containing detection probe. The porous membrane has a detection zone where an immobilized first capture reagent configured to bind to at least a portion of the analyte and analyte-conjugate complexes to generate a detection signal. The control zone is located downstream from the detection zone on the porous membrane and has a second capture reagent immobilized within the control zone. The conjugate pad is located upstream from the detection zone, and has detection probes with specific binding members for the analyte. A sample containing an analyte is deposited on the conjugate pad, interacts with the detection probes, and moves toward the control zone for detection.
摘要翻译：提供了一种侧流测定装置，用于检测驻留在测试样品中的分析物的存在或数量，其中侧流测定装置具有与结合垫和芯吸垫液体连通的多孔膜。共轭垫具有含金胶体的检测探针。多孔膜具有检测区，其中固定的第一捕获试剂被配置为结合至少一部分分析物和分析物 - 共轭复合物以产生检测信号。控制区位于多孔膜上的检测区的下游，并且具有固定在控制区内的第二捕获试剂。缀合垫位于检测区的上游，并具有用于分析物的具有特异性结合构件的检测探针。将含有分析物的样品沉积在共轭垫上，与检测探针相互作用，并朝向控制区移动进行检测。

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