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1. 发明申请

WO2011059263A3 PEPTIDE WHICH PASSES THROUGH BLOOD-BRAIN BARRIER AND TARGETS APOPTOSIS OF NEURODEGENERATIVE BRAIN DISEASE SITE AND USES THEREOF 审中-公开
标题翻译：通过血脑屏障通过的肽和靶向神经损伤性脑病的病原体及其用途
公开(公告)号：WO2011059263A3
公开(公告)日：2011-11-10
申请号：PCT/KR2010008000
申请日：2010-11-12
申请人： KYUNGPOOK NAT UNIV IND ACAD , LEE BYUNG-HEON , KIM IN SAN , BAE JAE SUNG , JIN HEE KYOUNG , HAN HYUNG SOO
发明人： LEE BYUNG-HEON , KIM IN SAN , BAE JAE SUNG , JIN HEE KYOUNG , HAN HYUNG SOO
IPC分类号： A61K38/08 , A61K49/00 , A61P25/16 , A61P25/28
CPC分类号： A61K49/0002 , A61K38/00 , A61K47/64 , A61K49/0032 , A61K49/0056 , B82Y5/00 , C07K7/06
摘要： The invention relates to a peptide which passes through a blood-brain barrier and targets apoptosis of degenerative brain disease sites and uses thereof, and more specifically, to a composition for delivering drugs to brain tissues comprising a peptide having an amino acid sequence as represented in SEQ ID NO:1 as an active ingredient, a composition for detecting apoptotic cells of neurodegenerative brain disease sites, and a composition for imaging the sites of neurodegenerative brain disease and said peptide and a composition combined therewith for preventing, treating or therapeutically diagnosing neurodegenerative brain diseases. The peptide having the amino acid sequence as represented by SEQ ID NO:1 of the present invention can pass through the blood-brain barrier and specifically bind to apoptotic cells in tissues of neurodegenerative brain diseases. Therefore the peptide of the present invention can be used for a variety of purposes such as detection of apoptosis in neurodegenerative brain diseases, and further, detection and imaging diagnosis of apoptotic cells (particularly, apoptotic nerve cells) in tissues of neurodegenerative brain diseases, delivery of target drugs, diagnosis for treatment, and the like.
摘要翻译：本发明涉及通过血脑屏障并靶向退行性脑部疾病部位的凋亡及其用途的肽，更具体地，涉及用于将药物递送至脑组织的组合物，所述组合物包含具有下述氨基酸序列的肽： SEQ ID NO：1作为活性成分，用于检测神经变性脑病变部位的凋亡细胞的组合物，以及用于成像神经变性性脑病的位点和所述肽及其组合物的组合物，用于预防，治疗或诊断神经变性脑疾病。具有本发明的SEQ ID NO：1所示的氨基酸序列的肽可以通过血脑屏障，并特异性结合神经退行性脑病的组织中的凋亡细胞。因此，本发明的肽可以用于各种目的，例如检测神经变性脑疾病中的细胞凋亡，以及进一步检测和成像诊断神经变性脑疾病，递送的组织中的凋亡细胞（特别是凋亡神经细胞）目标药物，治疗诊断等。

2. 发明申请

WO2009148252A3 STROKE-TARGETING PEPTIDE AND USE THEREOF 审中-公开
标题翻译： STROKE-TARGETING PEPTIDE及其用途
公开(公告)号：WO2009148252A3
公开(公告)日：2010-05-27
申请号：PCT/KR2009002937
申请日：2009-06-02
申请人： KYUNGPOOK NAT UNIV IND ACAD , LEE BYUNG HEON , KIM IN SAN , HAN HYUNG SOO , YOO JEONG SOO
发明人： LEE BYUNG HEON , KIM IN SAN , HAN HYUNG SOO , YOO JEONG SOO
IPC分类号： C07K7/06
CPC分类号： C07K7/06
摘要： The present invention relates to a stroke-targeting peptide and use thereof. More specifically, the present invention relates to: a stroke-targeting peptide wherein it is represented by an amino acid sequence selected from the group consisting of sequence numbers 1 to 4; and use of the stroke-targeting peptide. The peptide provided by the present invention is characterized by binding specifically to stroke cells within a living body, and thus it can beneficially be used in stroke-diagnosing markers and kits, and drug-delivery compositions and pharmaceutical compositions targeting stroke, and stroke-imaging compositions.
摘要翻译：本发明涉及卒中靶向肽及其用途。更具体地，本发明涉及：中风靶向肽，其中由选自序列号1至4的氨基酸序列表示; 和使用中风靶向肽。本发明提供的肽的特征在于特异性结合生物体内的中风细胞，因此可有利地用于中风诊断标记物和试剂盒，以及药物递送组合物和靶向中风和中风成像的药物组合物成分。

3. 发明申请

WO2009148252A2 STROKE-TARGETING PEPTIDE AND USE THEREOF 审中-公开
标题翻译： STROKE-TARGETING PEPTIDE及其用途
公开(公告)号：WO2009148252A2
公开(公告)日：2009-12-10
申请号：PCT/KR2009002937
申请日：2009-06-02
申请人： KYUNGPOOK NAT UNIV IND ACAD , LEE BYUNG HEON , KIM IN SAN , HAN HYUNG SOO , YOO JEONG SOO
发明人： LEE BYUNG HEON , KIM IN SAN , HAN HYUNG SOO , YOO JEONG SOO
IPC分类号： C07K7/06
CPC分类号： C07K7/06
摘要： The present invention relates to a stroke-targeting peptide and use thereof. More specifically, the present invention relates to: a stroke-targeting peptide wherein it is represented by an amino acid sequence selected from the group consisting of sequence numbers 1 to 4; and use of the stroke-targeting peptide. The peptide provided by the present invention is characterized by binding specifically to stroke cells within a living body, and thus it can beneficially be used in stroke-diagnosing markers and kits, and drug-delivery compositions and pharmaceutical compositions targeting stroke, and stroke-imaging compositions.
摘要翻译：本发明涉及卒中靶向肽及其用途。更具体地，本发明涉及：中风靶向肽，其中由选自序列号1至4的氨基酸序列表示; 和使用中风靶向肽。本发明提供的肽的特征在于特异性结合生物体内的中风细胞，因此可有利地用于中风诊断标记物和试剂盒，以及药物递送组合物和靶向中风和中风成像的药物组合物成分。

4. 发明申请

WO2012144799A3 PROTEIN SKELETAL MODULE WHICH INCREASES THE BINDING AFFINITY AND BINDING SPECIFICITY OF ACTIVE POLYPEPTIDES 审中-公开
标题翻译：蛋白质骨架模块增加了活性多聚体的结合亲和性和结合特异性
公开(公告)号：WO2012144799A3
公开(公告)日：2013-01-17
申请号：PCT/KR2012002958
申请日：2012-04-18
申请人： KYUNGPOOK NAT UNIV IND ACAD , CHA KIWEON , SO IN-SEOP , KIM SOYOUN , LEE BYUNG-HEON , KIM IN SAN
发明人： CHA KIWEON , SO IN-SEOP , KIM SOYOUN , LEE BYUNG-HEON , KIM IN SAN
IPC分类号： C07K14/705 , C12N15/12 , G01N33/68
CPC分类号： C07K14/485 , C07K14/47 , C07K14/5406 , C07K14/705 , C07K2319/00 , G01N33/68
摘要： The present invention relates to a novel protein skeletal module which increases the binding affinity or binding specificity of active polypeptides. More particularly, the present invention relates to a protein skeletal module comprising polypeptides consisting of the 1st to 19th amino acids of the amino acid sequence expressed in sequence number 1; polypeptides comprising active polypeptides; and polypeptides consisting of the 29th to 86th amino acids of the amino acid sequence expressed in sequence number 1. The present invention also relates to a method for preparing the protein skeletal module. The protein skeletal module of the present invention increases the binding affinity or binding specificity of active polypeptides embedded therein, and therefore is effective in diagnosing and treating diseases.
摘要翻译：本发明涉及增加活性多肽的结合亲和力或结合特异性的新型蛋白质骨架模块。更具体地说，本发明涉及蛋白质骨架模块，其包含由序列1表示的氨基酸序列的第1至第19个氨基酸组成的多肽; 包含活性多肽的多肽; 和由序列号1表示的氨基酸序列的第29〜第86位氨基酸组成的多肽。本发明还涉及蛋白质骨架模块的制备方法。本发明的蛋白质骨架模块增加嵌入其中的活性多肽的结合亲和力或结合特异性，因此有效地诊断和治疗疾病。

5. 发明申请

WO2011081443A3 TARGET-AIMING DRUG DELIVERY SYSTEM FOR DIAGNOSIS AND TREATMENT OF CANCER CONTAINING LIPOSOME LABELED WITH PEPTIDES WHICH SPECIFICALLY TARGETS INTERLEUKIN-4 RECEPTORS, AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：用于诊断和治疗含有特异靶向白细胞介素-4受体的肽的含脂质体的脂质体的靶向药物递送系统及其制造方法
公开(公告)号：WO2011081443A3
公开(公告)日：2011-12-01
申请号：PCT/KR2010009495
申请日：2010-12-29
申请人： KYUNGPOOK NAT UNIV IND ACAD , IND TECH RES INST , KIM IN SAN , LEE BYUNG HEON , LU MAGGIE JM , LIANG HSIANG-FA , KO YI-JU , LO YA-CHIN , CHANG LI-WEN , WEI MING-CHEN
发明人： KIM IN SAN , LEE BYUNG HEON , LU MAGGIE JM , LIANG HSIANG-FA , KO YI-JU , LO YA-CHIN , CHANG LI-WEN , WEI MING-CHEN
IPC分类号： A61K9/127 , A61K38/20 , A61K47/18 , A61K47/30 , A61P35/00
CPC分类号： A61K31/704 , A61K9/1271 , A61K38/00 , A61K47/6911
摘要： The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo (molecular) imaging and early diagnosis of tumors. Therefore, the liposome which contains anticancer drugs labeled with IL4RPep peptides of the present invention can be applied, as the target-aiming drug delivery system, effectively to the diagnosis and treatment of cancers.
摘要翻译：用于诊断和治疗癌症的靶向药物递送系统及其制造方法技术领域本发明涉及一种用于诊断和治疗癌症的靶向药物递送系统及其制造方法，该系统包含特异性靶向白细胞介素-4受体的肽，含有根据本发明制备的IL4RPep肽标记的抗癌药物的脂质体可以将药物递送至其中IL-4受体通过与IL-4受体特异性结合的IL4RPep肽过表达的癌细胞，并且药物递送可以识别癌症细胞特别是由标签。因此，IL4RPep肽可以仅增加药物对癌症组织的作用，同时显着降低对正常组织的副作用，这使得体内（分子）成像和肿瘤的早期诊断成为可能。因此，含有本发明的IL4RPep肽标记的抗癌药物的脂质体可以作为靶向药物递送系统有效地用于癌症的诊断和治疗。

6. 发明申请

WO2011059262A3 USES OF APOPTOTIC CELL-TARGETING PEPTIDES, LABEL SUBSTANCES AND LIPOSOMES CONTAINING A THERAPEUTIC AGENT FOR PREVENTING, TREATING OR THERAPEUTICALLY DIAGNOSING APOPTOSIS-RELATED DISEASES 审中-公开
标题翻译：凋亡细胞靶向肽，标记物质和含有治疗剂的脂质体用于预防，治疗或治疗与细胞凋亡相关的疾病的用途
公开(公告)号：WO2011059262A3
公开(公告)日：2011-10-27
申请号：PCT/KR2010007999
申请日：2010-11-12
申请人： KYUNGPOOK NAT UNIV IND ACAD , LEE BYUNG-HEON , KIM IN SAN , OH YU KYOUNG
发明人： LEE BYUNG-HEON , KIM IN SAN , OH YU KYOUNG
IPC分类号： A61K9/127 , A61K38/08 , A61K49/00 , A61P35/00
CPC分类号： A61K49/0084 , A61K9/0019 , A61K9/127 , A61K31/704 , A61K31/7048 , A61K47/6911 , A61K49/0032 , A61K49/0056
摘要： The invention relates to compositions for preventing, treating or therapeutically diagnosing apoptosis-related diseases which comprises: apoptotic cell-targeting peptides, label substances and liposomes containing a therapeutic agent as an active ingredient. The compositions of the present invention can be used for a variety of purposes such as delivery of target drugs to apoptotic cells in cancer or tumor tissue, apoptotic myocardial cells in myocardial infarction tissue, apoptotic nerve cells in cerebral apoplexy tissue and apoptotic cells in arteriosclerotic tissue, and further, detection and imaging diagnosis of these cells, therefore they can be used not only for preventing or treating said diseases but also for therapeutically diagnostic purposes.
摘要翻译：本发明涉及用于预防，治疗或治疗性诊断细胞凋亡相关疾病的组合物，其包含：凋亡细胞靶向肽，标记物质和含有治疗剂作为活性成分的脂质体。本发明的组合物可以用于多种目的，例如将靶药物递送至癌症或肿瘤组织中的凋亡细胞，心肌梗塞组织中的凋亡心肌细胞，脑卒中组织中的凋亡神经细胞和动脉硬化组织中的凋亡细胞并进一步对这些细胞进行检测和成像诊断，因此它们不仅可用于预防或治疗所述疾病，而且还用于治疗诊断目的。

7. 发明申请

WO2012074330A2 FUSION PEPTIDE COMPRISING DHFAS-1 DOMAIN AND MMP SUBSTRATE AND USE THEREOF FOR PREVENTING AND TREATING RHEUMATOID ARTHRITIS 审中-公开
标题翻译：包含DHFAS-1结构域和MMP基质的融合肽及其用于预防和治疗类风湿关节炎的用途
公开(公告)号：WO2012074330A2
公开(公告)日：2012-06-07
申请号：PCT/KR2011009318
申请日：2011-12-02
申请人： KYUNGPOOK NAT UNIV IND ACAD , KANG YOUNG MO , KIM IN SAN , KANG JIN HEE , SA KEUM HEE
发明人： KANG YOUNG MO , KIM IN SAN , KANG JIN HEE , SA KEUM HEE
IPC分类号： C07K19/00 , A61K38/17 , A61P19/02 , C12N15/62
CPC分类号： C07K14/435 , A61K38/00 , C07K14/475 , C07K2319/50 , C07K2319/74
摘要： The present invention relates to a fusion peptide comprising dhFas-1 domain and MMP substrate and use thereof. More specifically, the present invention relates to a fusion peptide, comprising a) a dhFas-1 domain which is the fourth fas-1 domain of ßig-h3 lacking H1 and H2 regions; b) a MMP (Matrix metalloproteinase) substrate; and c) a peptide comprising RGD motif and an use thereof for preventing and treating inflammatory disease. The fusion peptide of the present invention inhibits expension of rheumatoid arthritis by adhesion and migration of sinoviocytes and may be used for preventing or treating inflammatory disease by inhibiting infiltration of immune cells.
摘要翻译：本发明涉及包含dhFas-1结构域和MMP底物的融合肽及其用途。更具体地说，本发明涉及融合肽，其包含a）dhFas-1结构域，其是缺少H1和H2区的βig-h3的第4个fas-1结构域; b）MMP（基质金属蛋白酶）底物; 和c）包含RGD基序的肽及其用于预防和治疗炎性疾病的用途。本发明的融合肽通过粘附和迁移窦状细胞抑制类风湿性关节炎的扩张，并可用于通过抑制免疫细胞的浸润来预防或治疗炎性疾病。

8. 发明申请

WO2009107971A3 POLYPEPTIDE SPECIFICALLY COUPLED TO PHOSPHATIDYLSERINE AND USE THEREOF 审中-公开
标题翻译：多肽特异性地与磷酸二酯结合并使用
公开(公告)号：WO2009107971A3
公开(公告)日：2009-11-26
申请号：PCT/KR2009000882
申请日：2009-02-25
申请人： KYUNGPOOK NAT UNIVERISTY INDUS , KIM IN SAN , LEE BYUNG HEON , NARENDRA THAPA
发明人： KIM IN SAN , LEE BYUNG HEON , NARENDRA THAPA
IPC分类号： C07K7/06
CPC分类号： G01N33/57492 , A61K47/64 , A61K49/0043 , C07K7/06 , G01N33/92 , G01N2405/04 , G01N2510/00
摘要： The present invention relates to a polypeptide which is specifically coupled to a phosphatidylserine and the use thereof, and more particularly: to a polypeptide which has an amino acid sequence represented by sequence number 1, and is specifically coupled to phosphatidylserine; to the phosphatidylserine detection use thereof; to a phosphatidylserine detection method using same; to the use thereof in dead cell detection; to the drug delivery use thereof; to the use thereof as a neoplastic disease treatment; to the neoplastic disease part imaging use thereof; and the like. The polypeptide of the present invention, having an amino acid sequence represented by sequence number 1, can be specifically coupled to a phosphatidylserine. Therefore, the polypeptide of the present invention is useful in detecting a phosphatidylserine, and further in detecting or imaging a dead cell which reveals phosphatidylserine on the surface of the cell, and a tumor cell.
摘要翻译：本发明涉及与磷脂酰丝氨酸特异性偶联的多肽及其用途，更具体地说，涉及具有序列号1所示的氨基酸序列并与磷脂酰丝氨酸特异性结合的多肽; 涉及磷脂酰丝氨酸检测用途; 涉及使用其的磷脂酰丝氨酸检测方法; 在死细胞检测中的用途; 其药物用途; 将其用作肿瘤疾病治疗; 涉及肿瘤疾病部位成像用途; 等等。具有序列号1所示的氨基酸序列的本发明的多肽可以与磷脂酰丝氨酸特异性结合。因此，本发明的多肽可用于检测磷脂酰丝氨酸，并且进一步检测或成像在细胞表面上显示磷脂酰丝氨酸的死细胞和肿瘤细胞。

9. 发明公开

EP2826492A4 DRUG DELIVERY CONJUGATE CAPABLE OF CONTROLLED RELEASE, AND USE THEREOF 审中-公开
标题翻译：药物输出与控制释放共用及其用途
公开(公告)号：EP2826492A4
公开(公告)日：2015-10-21
申请号：EP13761996
申请日：2013-03-12
申请人： POSTECH ACAD IND FOUND , KYUNGPOOK NAT UNIV IND ACAD
发明人： KIM WON JONG , NAMGUNG RAN , LEE BYUNG HEON , KIM IN SAN , HOFFMAN ALLAN
IPC分类号： A61K47/40 , A61K9/00 , A61K9/51 , A61K31/337 , A61K47/30 , A61K47/48 , A61P35/00
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/5161 , A61K47/58 , A61K47/62 , A61K47/6951 , B82Y5/00

10. 发明公开

EP2280024A4 POLYPEPTIDE SPECIFICALLY COUPLED TO PHOSPHATIDYLSERINE AND USE THEREOF 有权转让
标题翻译：具体磷脂酰丝氨酸偶联多肽及其用途
公开(公告)号：EP2280024A4
公开(公告)日：2011-03-30
申请号：EP09714117
申请日：2009-02-25
申请人： KYUNGPOOK NAT UNIV IND ACAD
发明人： KIM IN SAN , LEE BYUNG HEON , NARENDRA THAPA
IPC分类号： C07K7/06 , A61K47/48 , G01N33/574 , G01N33/92
CPC分类号： G01N33/57492 , A61K47/64 , A61K49/0043 , C07K7/06 , G01N33/92 , G01N2405/04 , G01N2510/00
摘要： The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.

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