专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012047495A3 METHODS FOR PREPARING SYNTHETIC BILE ACIDS AND COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：制备合成胆酸的方法及其组合物
公开(公告)号：WO2012047495A3
公开(公告)日：2012-08-09
申请号：PCT/US2011052204
申请日：2011-09-19
申请人： KYTHERA BIOPHARMACEUTICALS INC , MORIARTY ROBERT M , RAO PHOTON
发明人： MORIARTY ROBERT M , RAO PHOTON
IPC分类号： C07J21/00 , A61K31/56 , A61P3/04 , C07J9/00 , C07J41/00 , C07J75/00
CPC分类号： C07J41/0061 , A61K31/56 , A61K45/06 , C07J1/0011 , C07J5/0053 , C07J9/005 , C07J13/005 , C07J13/007 , C07J21/006 , C07J43/003 , A61K2300/00
摘要： This invention relates generally to methods for preparing certain bile acids from non-mammalian sourced starting materials as well as to synthetic bile acids and compositions comprising such acids wherein the acids are characterized by a different C14 population than naturally occurring bile acids as well as being free from any mammalian pathogens. This invention is also directed to the synthesis of intermediates useful in the synthesis of such bile acids. Accordingly, the C ring of the steroidal scaffold is oxidized to provide a synthetic route and intermediates to DCA. This invention also provides synthetic methods for preparing deoxycholic acid or a salt thereof starting from aromatic steroids such as estrogen, equilenin, and derivatives thereof. This invention is also directed to intermediates such as 12-oxo or delta-9,11-ene steroids as well as novel processes for their preparation. In preferred embodiments, bile acids are provided herein which have substituents on the B-ring and/or D-ring side chain and optionally on the hydroxy group of the A-ring.
摘要翻译：本发明一般涉及从非哺乳动物源起始原料以及合成胆汁酸制备某些胆汁酸的方法以及包含这些酸的组合物，其中酸的特征在于与天然存在的胆汁酸不同的C14种群以及游离的来自任何哺乳动物病原体。本发明还涉及可用于合成这种胆汁酸的中间体的合成。因此，甾体支架的C环被氧化以提供DCA的合成途径和中间体。本发明还提供从芳族类固醇如雌激素，平衡物及其衍生物制备脱氧胆酸或其盐的合成方法。本发明还涉及中间体，例如12-氧代或δ-9,11-烯类固醇，以及它们制备的新方法。在优选的实施方案中，本文提供了在B-环和/或D-环侧链和任选地在A环的羟基上具有取代基的胆汁酸。

2. 发明申请

WO2006065448A3 TOPOISOMERASE INHIBITORS AND PRODRUGS 审中-公开
标题翻译：拓扑异构酶抑制剂和PRODRUGS
公开(公告)号：WO2006065448A3
公开(公告)日：2006-10-26
申请号：PCT/US2005041959
申请日：2005-11-17
申请人： THRESHOLD PHARMACEUTICALS INC , MATTEUCCI MARK , DUAN JIAN-XIN , RAO PHOTON
发明人： MATTEUCCI MARK , DUAN JIAN-XIN , RAO PHOTON
IPC分类号： A01N43/58 , A01N43/42 , A01N43/60 , A61K31/44 , A61K31/495 , A61K31/50 , C07D237/26 , C07D239/00 , C07D239/70 , C07D457/00 , C07D471/00 , C07D471/02 , C07D471/04 , C07D487/00 , C07D487/04 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00
CPC分类号： C07D471/04 , C07D221/18 , C07D487/04 , C07D491/147 , C07D495/04
摘要： Compositions and methods for treating cancer and other hyperproliferatice disease conditions with topoisomerase inhibitors and their prodrugs are disclosed.
摘要翻译：公开了用拓扑异构酶抑制剂及其前药治疗癌症和其他过度增殖疾病病症的组合物和方法。

3. 发明申请

WO2006010077A2 PRODRUGS OF LONIDAMINE AND LONIDAMINE ANALOGS 审中-公开
标题翻译：罗丹明和洛匹坦胺类似物的研究
公开(公告)号：WO2006010077A2
公开(公告)日：2006-01-26
申请号：PCT/US2005024434
申请日：2005-07-08
申请人： THRESHOLD PHARMACEUTICALS INC , MATTEUCCI MARK , SELICK HAROLD E , RAO PHOTON
发明人： MATTEUCCI MARK , SELICK HAROLD E , RAO PHOTON
IPC分类号： A61K31/416
CPC分类号： C07D231/56
摘要： The invention provides prodrugs of lonidamine and lonidamine analogs as well as methods of using such prodrugs.
摘要翻译：本发明提供了罗丹明胺和罗丹明胺类似物的前药以及使用这些前药的方法。

4. 发明申请

WO2004087075A2 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2004087075A2
公开(公告)日：2004-10-14
申请号：PCT/US2004009667
申请日：2004-03-29
申请人： THRESHOLD PHARMACEUTICALS INC , MATTEUCCI MARK , RAO PHOTON , DUAN JIAN-XIN
发明人： MATTEUCCI MARK , RAO PHOTON , DUAN JIAN-XIN
IPC分类号： A61K20060101 , A61K31/415 , A61K31/44 , A61P35/00 , C07D233/02 , C07D401/00 , A61K
CPC分类号： A61K31/415 , A61K31/4166 , A61K31/44 , A61K31/5377 , A61K47/54 , A61K47/559 , A61K47/6899 , B82Y5/00
摘要： Hypoxia-activated prodrugs can be used to treat cancer when administered alone or in combination with one or more anti-neoplastic agents.
摘要翻译：当单独施用或与一种或多种抗肿瘤剂组合时，缺氧活化的前药可用于治疗癌症。

5. 发明申请

WO2006015191A3 MULTICYCLIC LONIDAMINE ANALOGS 审中-公开
标题翻译：多环喹啉类似物
公开(公告)号：WO2006015191A3
公开(公告)日：2006-11-09
申请号：PCT/US2005026929
申请日：2005-07-29
申请人： THRESHOLD PHARMACEUTICALS INC , MATTEUCCI MARK , RAO PHOTON , DUAN JIAN-XIN
发明人： MATTEUCCI MARK , RAO PHOTON , DUAN JIAN-XIN
IPC分类号： A61K31/404 , C07D403/04
CPC分类号： C07D235/24 , C07D209/52 , C07D231/56 , C07D403/04 , C07D405/04 , C07D409/04 , C07D498/04
摘要： The invention provides lonidamine analogs as well as methods of treating cancer and BPH.
摘要翻译：本发明提供了lonidamine类似物以及治疗癌症和BPH的方法。

6. 发明申请

WO2006015263A2 LONIDAMINE ANALOGS 审中-公开
标题翻译： LONIDAMINE类似物
公开(公告)号：WO2006015263A2
公开(公告)日：2006-02-09
申请号：PCT/US2005027092
申请日：2005-07-29
申请人： THRESHOLD PHARMACEUTICALS INC , MATTEUCCI MARK , RAO PHOTON , DUAN JIAN-XIN
发明人： MATTEUCCI MARK , RAO PHOTON , DUAN JIAN-XIN
IPC分类号： A61K31/445
CPC分类号： C07D231/56 , C07D209/44 , C07D307/87 , C07D333/72 , C07D401/12 , C07D401/14 , C07D417/12 , C07D471/04
摘要： Lonidamine analogs are useful in the treatment of cancer and BPH.
摘要翻译：龙胆胺类似物可用于治疗癌症和BPH。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式