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1. 发明公开

EP1251130A4 FUSED PURINE DERIVATIVES 有权
标题翻译：简明的嘌呤衍生物
公开(公告)号：EP1251130A4
公开(公告)日：2003-05-02
申请号：EP00985847
申请日：2000-12-22
申请人： KYOWA HAKKO KOGYO KK
发明人： UENO KIMIHISA , OGAWA AKIRA , OHTA YOSHIHISA , NOMOTO YUJI , TAKASAKI KOTARO , KUSAKA HIDEAKI , YANO HIROSHI , SUZUKI CHIHARU , NAKANISHI SATOSHI
IPC分类号： A61P3/10 , C07D487/14 , A61K31/505 , A61K31/519 , A61K31/522 , A61K31/5377
CPC分类号： C07D487/14
摘要： Fused purine derivatives represented by the general formula (I) or pharmacologically acceptable salts thereof, wherein X--Y--Z represents R1N-C=O (wherein R1 is hydrogen, lower alkyl, or the like) or N=C-W (wherein W is halogeno, an aromatic heterocyclic group, an aliphatic heterocyclic group, or the like); R2 is hydrogen, lower alkyl, aralkyl, aryl, an aromatic heterocyclic group, an aliphatic heterocyclic group, or the like; R3 is hydrogen, lower alkyl, aralkyl, or the like; n is an integer of 0 to 3; V1 is hydrogen, lower alkyl, aralkyl, aryl, or an aromatic heterocyclic group; and V2 is substituted lower alkyl or an aromatic heterocyclic group, with the proviso that V2 may represent lower alkyl, aralkyl, or aryl in, e.g., cases wherein V1 is hydrogen, lower alkyl, aralkyl, or aryl; X--Y--Z is R1aN-C=O (wherein R1a is the same as defined for R1, except substituted lower alkyl); and R2 is substituted lower alkyl, aralkyl, or an aliphatic heterocyclic group.

2. 发明专利

CA2490526A1 HETERO-BICYCLIC COMPOUNDS 未知
公开(公告)号：CA2490526A1
公开(公告)日：2003-12-31
申请号：CA2490526
申请日：2003-06-25
申请人： KYOWA HAKKO KOGYO KK
发明人： IWASE MIHO , ARAI HITOSHI , KUSAKA HIDEAKI , YANO HIROSHI , MACHII DAISUKE , MATSUMURA TSUTOMU , TAKASAKI KOTARO , SUZUKI KOJI , OGINO FUMIKO , NAKANISHI SATOSHI
IPC分类号： A61K31/437 , A61K31/445 , A61K31/4453 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/55 , A61P3/10 , A61P9/10 , A61P13/12 , A61P25/00 , A61P43/00 , C07D471/04 , C07D487/04
摘要： Compounds represented by the general formula (I) or pharmacologically acceptable salts thereof: (I) wherein X.cndot..cndot.Y.cndot..cndot.Z is R5N - C=O (wherein R5 is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted lower alkenyl, or substituted or unsubstituted lower alkynyl) or the like; R1 and R2 are each independently hydrogen, substituted or unsubstituted lower alkyl, o r the like; and R3 and R4 are each independently hydrogen, substituted or unsubstituted lower alkyl, or the like.

3. 发明专利

AU2003231538A1 METHOD OF SEARCHING SUBSTANE HAVING ANTIDIABETIC ACTIVITY 未知
公开(公告)号：AU2003231538A1
公开(公告)日：2003-12-02
申请号：AU2003231538
申请日：2003-05-16
申请人： KYOWA HAKKO KOGYO KK
发明人： ISHIGURO HIROKI , OSHIMA YUKO , SUGIMOTO SEIJI , MATSUBARA MASAHIRO , UENO KIMIHISA , MORI KIYOTOSHI , NAKANISHI SATOSHI , YANO HIROSHI
IPC分类号： A61K31/53 , A61K31/5377 , A61K31/55 , A61P3/10 , A61P5/50 , A61P43/00 , C07D487/14 , C12Q1/32 , G01N33/50 , G01N33/569 , G01N33/66 , C12Q1/04 , G01N33/15 , C07K14/47 , C12N9/02 , A61K45/00 , C07D251/70 , C07D403/14 , C07D405/14
摘要： The present invention provides a screening method of a substance which inhibits binding of a condensed purine derivative to a pancreatic beta cell or a treated product of the cell, a substance which inhibits binding of a condensed purine derivative to a protein capable of the condensed purine derivative, and a substance which inhibits the expression or enzymatic activity of a protein capable of a condensed purine derivative, which comprises using the condensed purine derivative and a pancreatic beta cell or a treated product of the cell or a protein capable of binding to the condensed purine derivative.

4. 发明专利

CA2395414A1 CONDENSED PURINE DERIVATIVE 未知
公开(公告)号：CA2395414A1
公开(公告)日：2001-07-05
申请号：CA2395414
申请日：2000-12-22
申请人： KYOWA HAKKO KOGYO KK
发明人： SUZUKI CHIHARU , YANO HIROSHI , KUSAKA HIDEAKI , OHTA YOSHIHISA , OGAWA AKIRA , UENO KIMIHISA , TAKASAKI KOTARO , NOMOTO YUJI , NAKANISHI SATOSHI
IPC分类号： A61P3/10 , C07D487/14 , C07D239/26 , A61K31/519 , A61K31/522 , A61K31/5377 , C07D233/58 , C07D239/58 , C07D233/64
摘要： Fused purine derivatives represented by the general formula (I) or pharmacologically acceptable salts thereof, wherein X--Y--Z represents R1N-C =O (wherein R1 is hydrogen, lower alkyl, or the like) or N=C-W (wherein W is halogeno, an aromatic heterocyclic group, an aliphatic heterocyclic group, o r the like); R2 is hydrogen, lower alkyl, aralkyl, aryl, an aromatic heterocyclic group, an aliphatic heterocyclic group, or the like; R3 is hydrogen, lower alkyl, aralkyl, or the like; n is an integer of 0 to 3; V1 i s hydrogen, lower alkyl, aralkyl, aryl, or an aromatic heterocyclic group; and V2 is substituted lower alkyl or an aromatic heterocyclic group, with the proviso that V2 may represent lower alkyl, aralkyl, or aryl in, e.g., cases wherein V1 is hydrogen, lower alkyl, aralkyl, or aryl; X--Y--Z is R1aN-C=O (wherein R1a is the same as defined for R1, except substituted lower alkyl); and R2 is substituted lower alkyl, aralkyl, or an aliphatic heterocyclic gro up.

5. 发明专利

DE60018216D1 未知
公开(公告)号：DE60018216D1
公开(公告)日：2005-03-24
申请号：DE60018216
申请日：2000-12-22
申请人： KYOWA HAKKO KOGYO KK
发明人： UENO KIMIHISA , OGAWA AKIRA , OHTA YOSHIHISA , NOMOTO YUJI , TAKASAKI KOTARO , KUSAKA HIDEAKI , YANO HIROSHI , SUZUKI CHIHARU , NAKANISHI SATOSHI
IPC分类号： A61P3/10 , C07D487/14 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/505
摘要： A condensed purine derivative represented by Formula (I): wherein X--Y--Z represents R N-C=O or N=C-W, R represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, a substituted or unsubstituted alicyclic heterocyclic group or the like, n represents an integer of from 0 to 3, V represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, V represents a substituted lower alkyl group or a substituted or unsubstituted aromatic heterocyclic group, and when V represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group, and for example, X--Y--Z represents R N-C=O and R represents a substituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a halogen atom, a lower alkylthio group, -NR R , -CO2H, a lower alkoxycarbonyl group, -COHal, -CONR R or -CHO, V may represent a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group; or a pharmacologically acceptable salt thereof.

6. 发明专利

AU2003248246A1 HETERO-BICYCLIC COMPOUNDS 未知
公开(公告)号：AU2003248246A1
公开(公告)日：2004-01-06
申请号：AU2003248246
申请日：2003-06-25
申请人： KYOWA HAKKO KOGYO KK
发明人： MACHII DAISUKE , SUZUKI KOJI , MATSUMURA TSUTOMU , ARAI HITOSHI , IWASE MIHO , YANO HIROSHI , NAKANISHI SATOSHI , OGINO FUMIKO , TAKASAKI KOTARO , KUSAKA HIDEAKI
IPC分类号： A61K31/437 , A61K31/445 , A61K31/4453 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/55 , A61P3/10 , A61P9/10 , A61P13/12 , A61P25/00 , A61P43/00 , C07D471/04 , C07D487/04
摘要： The present invention provides a compound represented by formula (I): Äwherein X--Y--Z represents R N-C=O (wherein R represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted lower alkenyl, or substituted or unsubstituted lower alkynyl), etc; R and R may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, etc; and R and R may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, etcÜ, or a pharmaceutically acceptable salt thereof.

7. 发明专利

DE69935718T2 未知
公开(公告)号：DE69935718T2
公开(公告)日：2007-12-27
申请号：DE69935718
申请日：1999-07-02
申请人： KYOWA HAKKO KOGYO KK
发明人： SHIMADA JUNICHI , OHTA YOSHIHISA , TAKASAKI KOTARO , SUDA MIHO , KUSAKA HIDEAKI , YANO HIROSHI , NAKANISHI SATOSHI , MATSUDA YUZURU
IPC分类号： A61K31/505 , A61K31/519 , C07D487/14

8. 发明专利

ES2284256T3 MEDICAMENTOS PARA LA DIABETES. 未知
公开(公告)号：ES2284256T3
公开(公告)日：2007-11-01
申请号：ES99926903
申请日：1999-07-02
申请人： KYOWA HAKKO KOGYO KK
发明人： SHIMADA JUNICHI , OHTA YOSHIHISA , TAKASAKI KOTARO , SUDA MIHO , KUSAKA HIDEAKI , YANO HIROSHI
IPC分类号： A61K31/505 , A61K31/519 , C07D487/14
摘要： Uso de un compuesto representado por la fórmula general (I) (Ver fórmula) [en el que R 1 representa un grupo alquilo C1 - 10, un grupo arilo C6 - 14 sustituido o no sustituido, o un grupo heterocíclico aromático sustituido o no sustituido que tiene al menos un heteroátomo seleccionado del grupo que consiste en un átomo de nitrógeno, un átomo de azufre, y un átomo de oxígeno, R 2 representa un grupo alquilo C1 - 10, un grupo aralquilo C7 - 15 sustituido o no sustituido, o un grupo arilo C6 - 14 sustituido o no sustituido, R 3 representa un átomo de hidrógeno, X 1 y X 2 representan independientemente un átomo de hidrógeno, un grupo alquilo C1 - 10, un grupo aralquilo C7 - 15 sustituido o no sustituido, o un grupo arilo C6 - 14 sustituido o no sustituido, y el símbolo ¿n¿ representa 0; en el que el/los sustituyente(s) en el grupo arilo C6 - 14 sustituido, el grupo aralquilo C7 - 15 sustituido y el grupo heterocíclico aromático substituido pueden ser iguales o diferentes, y de uno a tres sustituyentes seleccionados del grupo que consiste en un grupo alquilo C1 - 10 que puede estar sustituido con de 1 a 3 sustituyente(s) A independientemente, un grupo alquenilo C2 - 6 que puede estar sustituido con de 1 a 3 sustituyente(s) A independientemente, un grupo alquinilo C2 - 6 que puede estar sustituido con de 1 a 3 sustituyente(s) A independientemente, un grupo aralquilo C7 - 15 que puede estar sustituido con de 1 a 3 sustituyente(s) A independientemente, un grupo arilo C6 - 14 que puede estar sustituido con de 1 a 3 sustituyente(s) A independientemente, un grupo hidroxilo, un grupo alcoxilo C1 - 10 que puede estar sustituido con de 1 a 3 sustituyente(s) A independientemente, un grupo aralquiloxilo C7 - 15 que puede estar sustituido con de 1 a 3 sustituyente(s) A independientemente, un grupo ariloxilo C6 - 14 que puede estar sustituido con de 1 a 3 sustituyente(s) A independientemente, un grupo aroílo C7 - 15 que puede estar sustituido con de 1 a 3 sustituyente(s) A independientemente,un grupo alcoxicarbonilo C1 - 10 que puede estar sustituido con de 1 a 3 sustituyente(s) A independientemente, un grupo alquiltio C1 - 10 que puede estar sustituido con de 1 a 3 sustituyente(s) A independientemente, un grupo alquilsulfonilo C1 - 10 que puede estar sustituido con de 1 a 3 sustituyente(s) A independientemente, un grupo carboxilo, un grupo carbamoílo, un grupo alcanoílo C2 - 11 que puede estar sustituido con de 1 a 3 sustituyente(s) A independientemente, un átomo de halógeno, un grupo nitro, un grupo amino, un grupo amino mono- o di-sustituido con alquilo C1 - 10, un grupo ciano, un grupo metilendioxilo, un grupo etilenedioxilo; en el que el/los sustituyente(s) A se selecciona/n del grupo que consiste en un grupo hidroxilo, un átomo de halógeno, un grupo carboxilo, un grupo sulfo, un grupo fosfono, un grupo éster alquílico C1 - 10 derivado de un grupo carboxilo, un grupo sulfo o un grupo fosfono, un grupo éster aralquílico C7 - 15 derivado de un grupo carboxilo, un grupo sulfoo un grupo fosfono, un grupo éster arílico C6 - 14 derivado de un grupo carboxilo, un grupo sulfo o un grupo fosfono] o una sal fisiológicamente aceptable del mismo para una fabricación de un agente terapéutico para la diabetes.

9. 发明专利

DE60018216T2 未知
公开(公告)号：DE60018216T2
公开(公告)日：2006-02-16
申请号：DE60018216
申请日：2000-12-22
申请人： KYOWA HAKKO KOGYO KK
发明人： UENO KIMIHISA , OGAWA AKIRA , OHTA YOSHIHISA , NOMOTO YUJI , TAKASAKI KOTARO , KUSAKA HIDEAKI , YANO HIROSHI , SUZUKI CHIHARU , NAKANISHI SATOSHI
IPC分类号： A61K31/505 , A61K31/519 , A61K31/522 , A61K31/5377 , A61P3/10 , C07D487/14
摘要： A condensed purine derivative represented by Formula (I): wherein X--Y--Z represents R N-C=O or N=C-W, R represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, a substituted or unsubstituted alicyclic heterocyclic group or the like, n represents an integer of from 0 to 3, V represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, V represents a substituted lower alkyl group or a substituted or unsubstituted aromatic heterocyclic group, and when V represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group, and for example, X--Y--Z represents R N-C=O and R represents a substituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a halogen atom, a lower alkylthio group, -NR R , -CO2H, a lower alkoxycarbonyl group, -COHal, -CONR R or -CHO, V may represent a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group; or a pharmacologically acceptable salt thereof.

10. 发明专利

AU2223501A Fused purine derivatives 未知
公开(公告)号：AU2223501A
公开(公告)日：2001-07-09
申请号：AU2223501
申请日：2000-12-22
申请人： KYOWA HAKKO KOGYO KK
发明人： UENO KIMIHISA , OGAWA AKIRA , OHTA YOSHIHISA , NOMOTO YUJI , TAKASAKI KOTARO , KUSAKA HIDEAKI , YANO HIROSHI , SUZUKI CHIHARU , NAKANISHI SATOSHI
IPC分类号： A61P3/10 , C07D487/14 , A61K31/519 , A61K31/522 , A61K31/5377 , C07D233/58 , C07D233/64 , C07D239/58 , C07D239/26
摘要： A condensed purine derivative represented by Formula (I): wherein X--Y--Z represents R N-C=O or N=C-W, R represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, a substituted or unsubstituted alicyclic heterocyclic group or the like, n represents an integer of from 0 to 3, V represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, V represents a substituted lower alkyl group or a substituted or unsubstituted aromatic heterocyclic group, and when V represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group, and for example, X--Y--Z represents R N-C=O and R represents a substituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a halogen atom, a lower alkylthio group, -NR R , -CO2H, a lower alkoxycarbonyl group, -COHal, -CONR R or -CHO, V may represent a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group; or a pharmacologically acceptable salt thereof.

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