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1. 发明申请

WO0120031A3 POLYMORPHISMS IN A KLOTHO GENE 审中-公开
标题翻译： KLOTHO基因的多态性
公开(公告)号：WO0120031A3
公开(公告)日：2002-03-14
申请号：PCT/GB0003457
申请日：2000-09-08
申请人： KYOWA HAKKO KOGYO KK , HASEGAWA KAZUHIDE , KIKUCHI YASUHIRO , NAKANO HIROFUMI , MOLLOY HELEN , CHIANO MATHIAS
发明人： HASEGAWA KAZUHIDE , KIKUCHI YASUHIRO , NAKANO HIROFUMI , MOLLOY HELEN , CHIANO MATHIAS
IPC分类号： C12N15/09 , A61K38/22 , A61K45/00 , A61P3/00 , A61P3/04 , A61P9/00 , A61P11/00 , A61P17/00 , A61P19/08 , A61P19/10 , A61P35/00 , A61P43/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/68 , C12N15/12 , C12N15/63
CPC分类号： C12Q1/6883 , C07K14/47 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Methods and means are described for diagnosing a disease or a predisposition to disease by genotyping a klotho gene from an individual and identifying the presence of one or more risk polymorphisms. These risk polymorphisms are associated either directly or indirectly with predisposition to a range of chronic diseases including osteoporosis, skin disorders, age-related disease, lung dysfunction and metabolic syndrome. Methods of treatment, kits for diagnostic purposes and an isolated klotho gene including all or some of a range of polymorphisms are also described as well as methods of isolating molecules that modulate a klotho gene.
摘要翻译：描述了通过从个体基因分型klotho基因并鉴定一种或多种风险多态性的存在来描述用于诊断疾病或疾病倾向的方法和手段。这些风险多态性直接或间接地与一系列慢性疾病（包括骨质疏松症，皮肤病症，年龄相关疾病，肺功能障碍和代谢综合征）倾向相关。还描述了治疗方法，用于诊断目的的试剂盒和包括一系列多态性的分离的klotho基因，以及分离调节klotho基因的分子的方法，基因。

2. 发明专利

AU680401B2 Novel plant gene 未知
公开(公告)号：AU680401B2
公开(公告)日：1997-07-31
申请号：AU2956092
申请日：1992-11-20
申请人： KYOWA HAKKO KOGYO KK
发明人： KIKUCHI YASUHIRO , KIYOKAWA SHIGETO , SHIMADA YUKIHISA , OHBAYASHI MASAYA , SHIMADA RITSUKO , OKINAKA YASUSHI
IPC分类号： A01H5/00 , A01H5/02 , C12N9/02 , C12N15/11 , C12N15/29 , C12N15/53 , C12N15/55 , C12N15/82 , C12N5/14 , C12Q1/68
摘要： A gene coding for flavonoid-3',5'-hydrogenase has been cloned by using a DNA probe prepared from a cDNA library derived from petunia petals by the SSP.PCR method using a gene sequence coding for the amino acid sequence of a hemebinding region of cytochrome P450 as a primer. Further, a transformed plant having bluer petals than usual has been obtained by introducing the cloned gene into a plant and expressing the same. The invention can provide a plant having a pigment pattern which the flower or fruit does not possess naturally.

3. 发明专利

CA1306963C PROCESS FOR PRODUCING L-THREONINE AND L-ISOLEUCINE 未知
公开(公告)号：CA1306963C
公开(公告)日：1992-09-01
申请号：CA510914
申请日：1986-06-05
申请人： KYOWA HAKKO KOGYO KK
发明人： KATSUMATA RYOICHI , MIZUKAMI TORU , YOKOI MASAKO , KIKUCHI YASUHIRO , OKA TETSUO
IPC分类号： C12N15/52 , C12P13/06 , C12P13/08 , C12N15/53 , C12N1/21 , C12N15/54
摘要： L-threonine and L-isoleucine are produced by constructing a recombinant DNA containing a gene coding for both enzymes of homoserine dehydrogenase and homoserine kinase responsible for the threonine biosynthesis in a microorganism belonging to the genus Corynebacterium or Brevibacterium, incorporating the recombinant DNA in a microorganism belonging to the genus Corynebacterium or Brevibacterium, culturing the microorganism in a medium, and recovering L-threonine or Lisoleucine accumulated in the culture broth.

4. 发明专利

DE3684511D1 未知
公开(公告)号：DE3684511D1
公开(公告)日：1992-04-30
申请号：DE3684511
申请日：1986-06-04
申请人： KYOWA HAKKO KOGYO KK
发明人： KATSUMATA RYOICHI , MIZUKAMI TORU , YOKOI MASAKO , KIKUCHI YASUHIRO , OKA TETSUO
IPC分类号： C12N15/52 , C12P13/06 , C12P13/08 , C12N15/31 , C07H21/04

5. 发明专利

AU706093B2 Novel yeast genes 未知
公开(公告)号：AU706093B2
公开(公告)日：1999-06-10
申请号：AU1152797
申请日：1996-12-27
申请人： KYOWA HAKKO KOGYO KK
发明人： KAWASAKI HIDEKI , TOKAI MASAYA , KIKUCHI YASUHIRO , OUCHI KOZO
IPC分类号： A21D8/04 , C07K14/395 , C12N15/31 , C12N15/81 , C12P7/06 , C12N1/18
摘要： The present invention relates to a protein having the amino acid sequence represented by SEQ ID NO: 1, or a protein being capable of complementing the mutation exhibiting low-temperature-sensitive fermentability and having an amino acid sequence wherein one or more amino acid residues are added, deleted or substituted in the amino acid sequence represented by SEQ ID NO: 1; a gene which encodes said protein; and a gene which comprises DNA having the nucleotide sequence represented by SEQ ID NO: 1, or comprises DNA being capable of complementing the mutation exhibiting low-temperature-sensitive fermentability and having a nucleotide sequence wherein one or more DNAs are added, deleted or substituted in the nucleotide sequence represented by SEQ ID NO: 1. The present invention also relates to yeast belonging to the genus Saccharomyces and having low-temperature-sensitive fermentability which is characterized in that the above-mentioned gene on the chromosome is inactivated; dough containing said yeast; a process for making bread which comprises adding said yeast to dough; and a process for producing ethanol which comprises culturing said yeast in a medium, allowing ethanol to accumulate in the culture, and recovering ethanol from the culture.

6. 发明专利

AU8997598A Process for preparing distilled liquor 未知
公开(公告)号：AU8997598A
公开(公告)日：1999-03-22
申请号：AU8997598
申请日：1998-09-04
申请人： KYOWA HAKKO KOGYO KK
发明人： AGO SHOJI , KIKUCHI YASUHIRO , FUKUDA KAZURO , KOBATA KENICHIRO
IPC分类号： C12H6/02 , C12G3/12

7. 发明公开

EP0632128A4 NOVEL PLANT GENE. 失效
标题翻译：新的植物关闭。
公开(公告)号：EP0632128A4
公开(公告)日：1996-04-24
申请号：EP92923991
申请日：1992-11-20
申请人： KYOWA HAKKO KOGYO KK
发明人： KIKUCHI YASUHIRO , KIYOKAWA SHIGETO , SHIMADA YUKIHISA , OHBAYASHI MASAYA , SHIMADA RITSUKO , OKINAKA YASUSHI
IPC分类号： A01H5/00 , A01H5/02 , C12N9/02 , C12N15/11 , C12N15/29 , C12N15/53 , C12N15/55 , C12N15/82
CPC分类号： C12N9/0071 , A01H5/02 , C12N15/825 , C12Y114/13088
摘要： A gene coding for flavonoid-3',5'-hydrogenase has been cloned by using a DNA probe prepared from a cDNA library derived from petunia petals by the SSP.PCR method using a gene sequence coding for the amino acid sequence of a hemebinding region of cytochrome P450 as a primer. Further, a transformed plant having bluer petals than usual has been obtained by introducing the cloned gene into a plant and expressing the same. The invention can provide a plant having a pigment pattern which the flower or fruit does not possess naturally.

8. 发明专利

AU1152797A Novel yeast genes 未知
公开(公告)号：AU1152797A
公开(公告)日：1997-07-28
申请号：AU1152797
申请日：1996-12-27
申请人： KYOWA HAKKO KOGYO KK
发明人： KAWASAKI HIDEKI , TOKAI MASAYA , KIKUCHI YASUHIRO , OUCHI KOZO
IPC分类号： A21D8/04 , C07K14/395 , C12N15/31 , C12N15/81 , C12P7/06 , C12N1/18
摘要： The present invention relates to a protein having the amino acid sequence represented by SEQ ID NO: 1, or a protein being capable of complementing the mutation exhibiting low-temperature-sensitive fermentability and having an amino acid sequence wherein one or more amino acid residues are added, deleted or substituted in the amino acid sequence represented by SEQ ID NO: 1; a gene which encodes said protein; and a gene which comprises DNA having the nucleotide sequence represented by SEQ ID NO: 1, or comprises DNA being capable of complementing the mutation exhibiting low-temperature-sensitive fermentability and having a nucleotide sequence wherein one or more DNAs are added, deleted or substituted in the nucleotide sequence represented by SEQ ID NO: 1. The present invention also relates to yeast belonging to the genus Saccharomyces and having low-temperature-sensitive fermentability which is characterized in that the above-mentioned gene on the chromosome is inactivated; dough containing said yeast; a process for making bread which comprises adding said yeast to dough; and a process for producing ethanol which comprises culturing said yeast in a medium, allowing ethanol to accumulate in the culture, and recovering ethanol from the culture.

9. 发明专利

DE3789428T2 未知
公开(公告)号：DE3789428T2
公开(公告)日：1994-07-21
申请号：DE3789428
申请日：1987-12-11
申请人： KYOWA HAKKO KOGYO KK
发明人： KATSUMATA RYOICHI , KIKUCHI YASUHIRO , NAKANISHI KEIKO
IPC分类号： C12P7/04 , C12N1/20 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/52 , C12N15/74 , C12P13/04 , C12R1/13 , C12R1/15 , C12R1/19
摘要： Described are plasmids having autonomous replicability in a microorganism belonging to the genus Corynebacterium or Brevibacterium which carry a selectable marker, a DNA-fragment from the E. coli lactose operon and a multiple cloning side upstream of this DNA-fragment. These plasmids are useful for the cloning of DNA-fragments responsible for gene expression control in coryneform bacteria. Further, the invention relates to a method for preparing recombinant plasmids containing a DNA fragment essential to the expression of a gene in coryneform microorganisms.

10. 发明专利

AU2956092A NOVEL PLANT GENE 未知
公开(公告)号：AU2956092A
公开(公告)日：1993-10-05
申请号：AU2956092
申请日：1992-11-20
申请人： KYOWA HAKKO KOGYO KK
发明人： KIKUCHI YASUHIRO , KIYOKAWA SHIGETO , SHIMADA YUKIHISA , OHBAYASHI MASAYA , SHIMADA RITSUKO , OKINAKA YASUSHI
IPC分类号： A01H5/00 , A01H5/02 , C12N9/02 , C12N15/11 , C12N15/29 , C12N15/53 , C12N15/55 , C12N15/82
摘要： A gene coding for flavonoid-3',5'-hydrogenase has been cloned by using a DNA probe prepared from a cDNA library derived from petunia petals by the SSP.PCR method using a gene sequence coding for the amino acid sequence of a hemebinding region of cytochrome P450 as a primer. Further, a transformed plant having bluer petals than usual has been obtained by introducing the cloned gene into a plant and expressing the same. The invention can provide a plant having a pigment pattern which the flower or fruit does not possess naturally.

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