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1. 发明专利

CA1130107A APPARATUS AND METHOD FOR LUMINESCENT DETERMINATION OF CONCENTRATION OF AN ANALYTE IN A SAMPLE 未知
公开(公告)号：CA1130107A
公开(公告)日：1982-08-24
申请号：CA329638
申请日：1979-06-13
申请人： KRICKA LARRY J , WHITEHEAD THOMAS P , BUNCE ROGER A , CARTER TIMOTHY J N , KENNEDY JOHN H
发明人： KRICKA LARRY J , WHITEHEAD THOMAS P , BUNCE ROGER A , CARTER TIMOTHY J N , KENNEDY JOHN H
IPC分类号： G01N33/58 , G01N21/01 , G01N21/76 , G01N21/13 , G01N21/63
摘要： Apparatus and method for luminescent determination of concentration of an analyte in a sample The apparatus comprises a movable member which carries a plurality of cuvettes containing material under test. Control means cause the member to be moved to bring the cuvettes successively into register with a photomultiplier, and in that position reagent is automatically added to a cuvette, giving rise to a luminescent reaction. Light from the reaction is detected by the photomultiplier and the resultant signal processed and recorded. The control means is triggered to stop the member, add reagent, record the signal from the luminescent reaction, and restart the member, from a photocell which is illuminated through the member only when a cuvette is in register with the photomultiplier. According to the method, sample material containing the analyte for determination is mixed with a knot amount or concentration of the same analyte labelled with a substance which is capable of taking part in a luminescent reaction. The mixture is then reacted with a known amount of another substance, capable of reacting with the analyte and giving rise to a luminescent reaction with the labelling substance. From quantitative observation of the light from the luminescent reaction the amount or concentration of the analyte in the sample material may be deduced.

2. 发明专利

CA1231079A DISPENSING DEVICE AND RECORDING APPARATUS 未知
公开(公告)号：CA1231079A
公开(公告)日：1988-01-05
申请号：CA441246
申请日：1983-11-15
申请人： WHITEHEAD THOMAS P , THORPE GARY H G H , KRICKA LARRY J , GIBBONS JOHN E C , BUNCE ROGER A
发明人： WHITEHEAD THOMAS P , THORPE GARY H G H , KRICKA LARRY J , GIBBONS JOHN E C , BUNCE ROGER A
IPC分类号： G01N35/00 , B01L3/02 , G01N21/76 , B01L3/00
摘要： A dispensing device, for dispensing reagent into an array of reaction wells in a photographic recording apparatus, comprises an array of tubes which are mounted in a support . The support contains a common chamber into which the tops of all the tubes open. The chamber is connected with atmosphere via an opening which is sealable manually to retain liquid in the tubes when the latter are immersed in a reservoir and which is unsealed to dispense the liquid. The recording apparatus has a housing closable at the top by part of the support . A plate having an array of holes therethrough rests on a shutter disposed above a photographic film holder . The plate carries the reaction wells in the holes

3. 发明申请

WO2006116686A3 NANOSTRUCTURE ENHANCED LUMINESCENT DEVICES 审中-公开
标题翻译：纳米结构增强发光器件
公开(公告)号：WO2006116686A3
公开(公告)日：2009-06-04
申请号：PCT/US2006016249
申请日：2006-04-26
申请人： UNIV PENNSYLVANIA , KRICKA LARRY J , PARK JASON Y
发明人： KRICKA LARRY J , PARK JASON Y
IPC分类号： C09K11/00 , F21K2/00
CPC分类号： F21K2/06
摘要： The present invention relates to a device comprising a light transmissible body defining a chamber; a first luminescent reactant; a second luminescent reactant; at least one of the reactants being associated with a nanostructure; and at least one of the first and second luminescent reactants being physically separated from each other, but selectively deliverable to the chamber. The nanostructure may comprise structures of fullerene, buckyball, nanotube, nanowire, nanofiber, and nanochannel, carbon or silica materials. Said luminescence comprises chemiluminescence and bioluminescence.
摘要翻译：本发明涉及一种包括限定腔室的透光体的装置; 第一发光反应物; 第二发光反应物; 所述反应物中的至少一种与纳米结构相关联; 并且所述第一和第二发光反应物中的至少一个在物理上彼此分离，但是选择性地输送到所述室。纳米结构可以包括富勒烯，巴基球，纳米管，纳米线，纳米纤维和纳米通道，碳或二氧化硅材料的结构。所述发光包括化学发光和生物发光。

4. 发明申请

WO2008048211A2 NANO-SCALE DEVICES 审中-公开
标题翻译：纳米尺寸设备
公开(公告)号：WO2008048211A2
公开(公告)日：2008-04-24
申请号：PCT/US2006026632
申请日：2006-07-07
申请人： UNIV PENNSYLVANIA , KRICKA LARRY J , PARK JASON Y
发明人： KRICKA LARRY J , PARK JASON Y
IPC分类号： A61K9/14 , B29B9/00
CPC分类号： A61K9/5192 , B01J19/0093 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00844 , B01J2219/00846
摘要： Nano-scale devices with filter zones that define the size of the resulting nanoparticles. The filter zones may have nanotubes with diameters that are the maximum dimension of the resulting particles or the filter zones may have filtering particles arranged in a predetermined array with interstices defining the maximum dimension of the resulting nanoparticles.
摘要翻译：具有限定所得纳米颗粒尺寸的过滤区的纳米级装置。过滤区可以具有直径为所得颗粒的最大尺寸的纳米管，或者过滤区可以具有以预定阵列排列的过滤颗粒，间隙限定所得纳米颗粒的最大尺寸。

5. 发明申请

WO2009137666A3 CHEMILUMINESCENCE ENHANCED DETECTION OF ENDOGENOUS ENZYME ACTIVITY 审中-公开
标题翻译：荧光素酶增强内源酶活性的检测
公开(公告)号：WO2009137666A3
公开(公告)日：2010-01-07
申请号：PCT/US2009043131
申请日：2009-05-07
申请人： UNIV PENNSYLVANIA , PARK JASON Y , KRICKA LARRY J
发明人： PARK JASON Y , KRICKA LARRY J
IPC分类号： G01N21/76
CPC分类号： G01N33/582 , C12Q1/34 , G01N33/5082 , G01N33/574
摘要： Provided are methods for detecting a disease or a condition in a subject, which disease or condition is known to be characterized by abnormal expression of an enzyme The present methods comprise contacting tissue of the subject with a substrate for the enzyme, the substrate chemiluminescing upon reaction with the enzyme, detecting chemiluminescence in the tissue, and, correlating the chemiluminescence to at least one of the presence or absence of the disease or condition in the subject, the stage of the disease or condition in the subject, or the response of the disease or condition in the subject to a therapy regimen The present invention permits sampling, diagnosis, and surveillance of conditions and diseases that are known to be characterized by abnormal expression of at least one enzyme.
摘要翻译：提供了用于检测受试者的疾病或病症的方法，已知该疾病或病症的特征在于酶的异常表达。本方法包括使受试者的组织与酶的底物接触，底物在反应时化学发光用该酶检测组织中的化学发光，并将化学发光与受试者中疾病或病症的存在或不存在，受试者中疾病或病症的阶段或疾病的反应中的至少一种相关联或受试者的状况本发明允许对已知以至少一种酶的异常表达为特征的病症和疾病的取样，诊断和监视。

6. 发明申请

WO2006116687A3 NANOASSAYS 审中-公开
公开(公告)号：WO2006116687A3
公开(公告)日：2007-12-13
申请号：PCT/US2006016250
申请日：2006-04-26
申请人： UNIV PENNSYLVANIA , KRICKA LARRY J , PARK JASON Y
发明人： KRICKA LARRY J , PARK JASON Y
IPC分类号： G01N33/53
CPC分类号： G01N33/54333
摘要： The present invention provides assays of nanometer-level dimension.
摘要翻译：本发明提供了纳米级尺寸的测定。

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