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1. 发明申请

WO2006064889A1 METHOD FOR REDUCTION, STABILIZATION AND PREVENTION OF RUPTURE OF LIPID RICH PLAQUE 审中-公开
标题翻译：减少，稳定和防止破碎的富含PLAQUE的方法
公开(公告)号：WO2006064889A1
公开(公告)日：2006-06-22
申请号：PCT/JP2005/023088
申请日：2005-12-09
申请人： KOWA CO., LTD. , KOBAYASHI, Hideyuki , YOSHINAKA, Yasunobu , SHIBUYA, Kimiyuki
发明人： KOBAYASHI, Hideyuki , YOSHINAKA, Yasunobu , SHIBUYA, Kimiyuki
IPC分类号： A61K31/497 , A61K31/47 , A61P9/10
CPC分类号： A61K31/497 , A61K31/47 , A61K2300/00
摘要： There is to provide is an agent for reduction of a lipid rich plaque, stabilization of a lipid rich plaque and/or prevention of rupture of a lipid rich plaque in an atherosclerotic lesion comprising an effective amount of 2-[4-[2-(benzimidazole-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide (hereinafter, referred to as compound 1), its pharmaceutically acceptable salt or a hydrate thereof and Pitavastatin, and a pharmaceutically acceptable carrier, wherein the agent is intended to be simultaneously administered, or separately administered with interval of time to a patient in need thereof. There is also to provide a method for reduction of a lipid rich plaque, stabilization of a lipid rich plaque and/or prevention of rupture of a lipid rich plaque in an atherosclerotic lesion, comprising simultaneously administering, or separately administering with interval of time an effective amount of the compound 1, its pharmaceutically acceptable salt or a hydrate thereof and an effective amount of Pitavastatin to a patient in need thereof.
摘要翻译：提供的是减少富含脂质的斑块，稳定富含脂质的斑块和/或预防动脉粥样硬化病变中脂质丰富斑块破裂的药剂，其包含有效量的2- [4- [2-（苯并咪唑-2-基硫基）乙基]哌嗪-1-基] -N- [2,4-双（甲硫基）-6-甲基-3-吡啶基]乙酰胺（以下称为化合物1），其药学上可接受的盐或其水合物和匹伐他汀，以及药学上可接受的载体，其中所述试剂旨在同时施用，或者分开施用于有需要的患者的时间间隔。还提供减少富含脂质的斑块，稳定富含脂质的斑块和/或防止动脉粥样硬化病变中富含脂质斑块的破裂的方法，其包括同时施用或分开施用一段时间间隔的有效化合物1的量，其药学上可接受的盐或其水合物和有效量的匹伐他汀给有需要的患者。

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