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1. 发明申请

WO2005063294A8 INHIBITOR FOR THE FORMATION OF gamma-SECRETASE COMPLEX 审中-公开
标题翻译：抑制剂，用于形成γ-分泌酶复合物
公开(公告)号：WO2005063294A8
公开(公告)日：2005-10-06
申请号：PCT/JP2004019628
申请日：2004-12-28
申请人： KOWA CO , NISSAN CHEMICAL IND LTD , URANO YASUOMI , HAMAKUBO TAKAO , KODAMA TATSUHIKO
发明人： URANO YASUOMI , HAMAKUBO TAKAO , KODAMA TATSUHIKO
IPC分类号： A61K31/135 , A61K31/35 , A61K31/47 , A61K31/724 , A61K45/00 , A61K45/06 , A61P25/28 , A61P43/00 , C12Q1/00
CPC分类号： A61K31/135 , A61K31/35 , A61K31/47 , A61K31/724 , A61K45/06 , A61K2300/00
摘要： It is intended to provide an inhibitor for the formation of a gamma-secretase complex which comprises a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator as the active ingredient; and use of a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator for producing the same. It is also intended to provide a method of screening a substance having an effect of inhibiting the formation of an active complex of gamma-secretase which comprises assaying the activity of inhibiting cholesterol synthesis or quantifying cholesterol accumulated in lipid rafts in cells. It is also intended to provide a method of screening a cholesterol synthesis inhibitor, a protein geranylgeranylation regulator or an HMG-CoA reductase inhibitor which comprises assaying the effect of inhibiting the formation of an active complex of gamma-secretase. Moreover, it is intended to provide a method of screening an effect of a test substance on gamma-secretase which comprises measuring the distribution of constituents (niscastrin, APH-1, Pen-2 and so on) required by gamma-secretase for the formation of its active complex in cells.
摘要翻译：旨在提供形成γ-分泌酶复合物的抑制剂，其包含胆固醇合成抑制剂或蛋白质香叶基香叶基化调节剂作为活性成分; 以及使用胆固醇合成抑制剂或蛋白质香叶基香叶基化调节剂来生产它们。还打算提供筛选具有抑制γ-分泌酶活性复合物形成作用的物质的方法，其包括测定抑制胆固醇合成的活性或定量细胞中脂质筏中积累的胆固醇。还旨在提供一种筛选胆固醇合成抑制剂，蛋白质香叶基香叶基ge牛儿基化调节剂或HMG-CoA还原酶抑制剂的方法，其包括测定抑制γ-分泌酶活性复合物形成的作用。此外，意图提供一种筛选测试物质对γ-分泌酶的作用的方法，其包括测量γ-分泌酶对于形成所需的成分（niscastrin，APH-1，Pen-2等）的分布它在细胞中的活性复合物。

2. 发明专利

AT535614T 未知
公开(公告)号：AT535614T
公开(公告)日：2011-12-15
申请号：AT04807983
申请日：2004-12-28
申请人： KOWA CO , NISSAN CHEMICAL IND LTD
发明人： URANO YASUOMI , HAMAKUBO TAKAO , KODAMA TATSUHIKO
IPC分类号： C12Q1/37 , A61K31/135 , A61K31/35 , A61K31/47 , A61K31/724 , A61K45/00 , A61K45/06 , A61P25/28 , A61P43/00 , C12N9/00 , C12Q1/00

3. 发明公开

EP1702626A4 INHIBITOR FOR THE FORMATION OF GAMMAD-SECRETASE COMPLEX 有权
标题翻译：地层gammad - 分泌酶复合体抑制剂的
公开(公告)号：EP1702626A4
公开(公告)日：2007-11-28
申请号：EP04807983
申请日：2004-12-28
申请人： KOWA CO , NISSAN CHEMICAL IND LTD
发明人： URANO YASUOMI , HAMAKUBO TAKAO , KODAMA TATSUHIKO
IPC分类号： A61K45/06 , A61K31/135 , A61K31/35 , A61K31/366 , A61K31/47 , A61K31/724 , A61K45/00 , A61P25/28 , A61P43/00 , C12Q1/00
CPC分类号： A61K31/135 , A61K31/35 , A61K31/47 , A61K31/724 , A61K45/06 , A61K2300/00
摘要： It is intended to provide an inhibitor for the formation of a Ϝ-secretase complex which comprises a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator as the active ingredient; and use of a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator for producing the same. It is also intended to provide a method of screening a substance having an effect of inhibiting the formation of an active complex of Ϝ-secretase which comprises assaying the activity of inhibiting cholesterol synthesis or quantifying cholesterol accumulated in lipid rafts in cells. It is also intended to provide a method of screening a cholesterol synthesis inhibitor, a protein geranylgeranylation regulator or an HMG-CoA reductase inhibitor which comprises assaying the effect of inhibiting the formation of an active complex of Ϝ-secretase. Moreover, it is intended to provide a method of screening an effect of a test substance on Ϝ-secretase which comprises measuring the distribution of constituents (niscastrin, APH-1, Pen-2 and so on) required by Ϝ-secretase for the formation of its active complex in cells.

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