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1. 发明专利

AU2004206856A1 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions 未知
公开(公告)号：AU2004206856A1
公开(公告)日：2004-08-05
申请号：AU2004206856
申请日：2004-01-16
申请人： HK PHARMACEUTICALS INC , KOSTER HUBERT
发明人： LITTLE DANIEL PAUL , SIDDIQI SUHAIB MAHMOOD , GREALISH MATTHEW PETER , MARAPPAN SUBRAMANIAN , HASSMAN CHESTER FREDERICK III , YIP PING , KOSTER HUBERT
IPC分类号： C07C69/76 , C07C69/96 , C07D207/40 , C07D207/404 , C07D207/46 , C07D209/48 , C07D211/60 , C07D211/78 , C07D213/79 , C07D215/48 , C07D239/54 , C07D239/545 , C07D241/44 , C07D261/12 , C07D271/06 , C07D271/07 , C07D303/14 , C07D303/16 , C07D317/36 , C07D401/12 , C07D405/10 , C07D405/12 , C07D495/04 , C07D498/18 , C07D519/00 , G01N33/68
摘要： A capture compound and a method of identifying drug target non-target proteins in a mixture of proteins is provided, comprising the steps of interacting the mixture with a capture compound of the formula Q-Z-( Xm)-Yn, wherein Z is a trivalent moiety for presenting X, Y and Q; moiety X is selected to covalently bind to proteins; moiety Y is a pharmaceutical drug, drug fragment, drug metabolite, prodrug, enzyme substrate, enzyme inhibitor, transition-state analogue or a ligand to a receptor; Q is a sorting function selected to permit physical arraying or other addressable separation method suitable for analysis, Q comprises a biotin moiety, a (His) 6 moiety, a BODIPY moiety (4, 4-difluoro-4-bora-3a, 4a-diaza-s-indacene), an oligonucleotide or PNA (peptide nucleic acid), an antibody, an immunotoxin conjugate, an adhesive peptide, a lectin, an activated dextran or a peptide; and analyzing the captured proteins to identify drug target or drug non-target.

2. 发明专利

AU2003224674A8 Compounds and methods for analyzing the proteome 未知
公开(公告)号：AU2003224674A8
公开(公告)日：2003-09-29
申请号：AU2003224674
申请日：2003-03-11
申请人： KOSTER HUBERT , HK PHARMACEUTICALS INC
发明人： KOSTER HUBERT , LITTLE DANIEL P , SHCHEPINOV MIKHAIL S
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/543 , G01N33/68 , G01N31/00 , C07B61/00 , C07K1/04 , G01N21/55
摘要： Gradient arrays for the analysis of biomolecules are provided. In particular, arrays and methods are provided for analyzing complex protein mixtures, such as the proteome. The arrays provide bifunctional reagents that allow for the separation and isolation of complex protein mixtures. Automated instruments for performing the methods are also provided.

3. 发明专利

AU2003224674A1 COMPOUNDS AND METHODS FOR ANALYZING THE PROTEOME 未知
公开(公告)号：AU2003224674A1
公开(公告)日：2003-09-29
申请号：AU2003224674
申请日：2003-03-11
申请人： HK PHARMACEUTICALS INC , KOSTER HUBERT
发明人： KOSTER HUBERT , SHCHEPINOV MIKHAIL S , LITTLE DANIEL P
IPC分类号： C12M1/34 , C12Q1/68 , G01N33/543 , G01N33/68
摘要： Gradient arrays for the analysis of biomolecules are provided. In particular, arrays and methods are provided for analyzing complex protein mixtures, such as the proteome. The arrays provide bifunctional reagents that allow for the separation and isolation of complex protein mixtures. Automated instruments for performing the methods are also provided.

4. 发明申请

WO9833808A2 A REVERSIBLE STOICHIOMETRIC PROCESS FOR CONJUGATING BIOMOLECULES 审中-公开
标题翻译：用于结合生物分子的可逆的方法
公开(公告)号：WO9833808A2
公开(公告)日：1998-08-06
申请号：PCT/US9802007
申请日：1998-02-04
申请人： KOSTER HUBERT
发明人： KOSTER HUBERT
IPC分类号： G01N33/53 , A61K47/48 , C07H21/00 , C07H21/02 , C07H21/04 , C07K1/107 , C07K1/22 , C07K17/02 , C12N9/16 , C12N11/00 , C12N11/08 , C12N15/09 , C12Q1/68 , G01N33/566
CPC分类号： C07H21/00 , A61K47/62 , C07K1/1077 , C07K1/22 , C12N11/08
摘要： Compositions comprised of at least two biopolymers (e.g., nucleic acids or polypeptides), which are conjugated to an insoluble support by two different reversible linkages, which are cleavable under selective conditions, as well as methods and components for producing the same are described.
摘要翻译：描述了由至少两种生物聚合物（例如核酸或多肽）组成的组合物，其通过在选择性条件下可切割的两个不同的可逆键连接到不溶性载体上，以及用于制备它们的方法和组分。

5. 发明申请

WO9820020A3 HIGH DENSITY IMMOBILIZATION OF NUCLEIC ACIDS 审中-公开
标题翻译：核酸的高密度固定
公开(公告)号：WO9820020A3
公开(公告)日：1998-10-22
申请号：PCT/US9720195
申请日：1997-11-06
申请人： SEQUENOM INC , DONNELL MARYANNE J O , CANTOR CHARLES R , LITTLE DANIEL P , KOSTER HUBERT
发明人： O'DONNELL MARYANNE J , CANTOR CHARLES R , LITTLE DANIEL P , KOSTER HUBERT
IPC分类号： G01N27/62 , B01J19/00 , B01L3/02 , C07B61/00 , C07F9/24 , C07H21/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/53 , G01N33/566 , G01N35/00 , G01N35/10 , G01N37/00
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00387 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00504 , B01J2219/00511 , B01J2219/0052 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/0262 , B01L3/0268 , B01L2200/025 , B01L2300/0838 , B01L2400/0439 , B01L2400/0487 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07H21/00 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6858 , C12Q1/6872 , C12Q1/6883 , C12Q1/6886 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1037 , G01N2035/1069 , C12Q2525/197 , C12Q2523/10 , C12Q2531/113 , C12Q2565/537 , C12Q2565/627 , C12Q2565/507 , C12Q2565/518 , C12Q2535/101
摘要： The invention provides a dispensing apparatus for dispensing nanovolumes of fluid in chemical or biological procedures onto the surface of a substrate, comprising: a housing having a plurality of sides and a bottom portion having formed therein a plurality of apertures, said sides and bottom portion of said housing defining an interior volume, one or more fluid transmitting vesicles, mounted within said apertures, having a nanovolume sized fluid holding chamber for holding nanovolumes of fluid, said fluid holding chamber being disposed in fluid communication with said interior volume of said housing, and dispensing means in communication with said interior volume of said housing for selectively dispensing nanovolumes of fluid from said nanovolume sized fluid transmitting vesicles when the fluid is loaded with said fluid holding chambers of said vesicles, whereby said dispensing means dispenses nanovolumes of the fluid onto the surface of the substrate when the apparatus is disposed over and in registration with the substrate.

6. 发明专利

CA3082859A1 [2-[(5-NITRO-1,3-THIAZOL-2-YL)CARBAMOYL]PHENYL]ETHANOATE FOR USE IN LYMPHANGIOLEIOMYOMATOSIS AND OTHER DISEASES 未知
公开(公告)号：CA3082859A1
公开(公告)日：2019-05-23
申请号：CA3082859
申请日：2018-11-19
申请人： KOSTER HUBERT
发明人： KOSTER HUBERT
IPC分类号： A61K31/155 , A61K31/426 , A61P1/16 , A61P25/16 , A61P25/28
摘要： The present invention relates to the use of the compound [2-[(5-nitro-1,3-thiazol-2- yl)carbamoyl]phenyl]ethanoate in a method of treatment or prophylaxis of vascular and respiratory disease, fibrotic disease and neurodegenerative disease, particularly interstitial pneumonia, tuberous sclerosis or lymphangioleiomyomatosis, collagen disease, interstitial lung disease, human kidney disease, nephritic syndrome, liver fibrosis or liver cirrhosis, Alzheimer's disease or Parkinson's disease.

7. 发明专利

AU2004206856A8 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions 未知
公开(公告)号：AU2004206856A8
公开(公告)日：2006-09-07
申请号：AU2004206856
申请日：2004-01-16
申请人： KOSTER HUBERT
发明人： YIP PING , GREALISH MATTHEW PETER , MARAPPAN SUBRAMANIAN , KOSTER HUBERT , LITTLE DANIEL PAUL , SIDDIQI SUHAIB MAHMOOD , HASSMAN CHESTER FREDERICK III
IPC分类号： G01N33/68 , C07C69/76 , C07C69/96 , C07D207/40 , C07D207/404 , C07D207/46 , C07D209/48 , C07D211/60 , C07D211/78 , C07D213/79 , C07D215/48 , C07D239/54 , C07D239/545 , C07D241/44 , C07D261/12 , C07D271/06 , C07D271/07 , C07D303/14 , C07D303/16 , C07D317/36 , C07D401/12 , C07D405/10 , C07D405/12 , C07D495/04 , C07D498/18 , C07D519/00
摘要： A capture compound and a method of identifying drug target non-target proteins in a mixture of proteins is provided, comprising the steps of interacting the mixture with a capture compound of the formula Q-Z-( Xm)-Yn, wherein Z is a trivalent moiety for presenting X, Y and Q; moiety X is selected to covalently bind to proteins; moiety Y is a pharmaceutical drug, drug fragment, drug metabolite, prodrug, enzyme substrate, enzyme inhibitor, transition-state analogue or a ligand to a receptor; Q is a sorting function selected to permit physical arraying or other addressable separation method suitable for analysis, Q comprises a biotin moiety, a (His) 6 moiety, a BODIPY moiety (4, 4-difluoro-4-bora-3a, 4a-diaza-s-indacene), an oligonucleotide or PNA (peptide nucleic acid), an antibody, an immunotoxin conjugate, an adhesive peptide, a lectin, an activated dextran or a peptide; and analyzing the captured proteins to identify drug target or drug non-target.

8. 发明专利

AU6141698A A reversible stoichiometric process for conjugating biomolecules 未知
公开(公告)号：AU6141698A
公开(公告)日：1998-08-25
申请号：AU6141698
申请日：1998-02-04
申请人： KOSTER HUBERT
发明人： KOSTER HUBERT
IPC分类号： G01N33/53 , A61K47/48 , C07H21/00 , C07H21/02 , C07H21/04 , C07K1/107 , C07K1/22 , C07K17/02 , C12N9/16 , C12N11/00 , C12N11/08 , C12N15/09 , C12Q1/68 , G01N33/566
摘要： Compositions comprised of at least two biopolymers (e.g., nucleic acids or polypeptides), which are conjugated to an insoluble support by two different reversible linkages, which are cleavable under selective conditions, as well as methods and components for producing the same are described.

9. 发明专利

IT1198910B 未知
公开(公告)号：IT1198910B
公开(公告)日：1988-12-21
申请号：IT948284
申请日：1984-08-17
申请人： KOSTER HUBERT
发明人： KOSTER HUBERT , DUAL SINHA NANDA
IPC分类号： C07H19/067 , C07F9/26 , C07H19/073 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C07H
摘要： PCT No. PCT/EP84/00244 Sec. 371 Date Jun. 18, 1985 Sec. 102(e) Date Jun. 18, 1985 PCT Filed Aug. 10, 1984 PCT Pub. No. WO85/00816 PCT Pub. Date Feb. 28, 1985.The invention relates to a process for the preparation of oligonucleotides by the following steps: reaction of a nucleoside with a phosphine derivative, reaction of the nucleotide derivative thus obtained with a nucleoside bonded to a polymeric carrier, oxidation of the carrier-bound nucleoside-nucleotide thus obtained with formation of phosphotriester groups, blocking of free primary 5'-OH groups, elimination of a protective group from the terminal 5'-OH group, where appropriate single or multiple repetition of the abovementioned steps to introduce further nucleoside phosphate or oligonucleoside phosphate units, and cleavage of the nucleoside-carrier bond and, where appropriate, elimination of all protective groups present in the oligonucleoside phosphates. The phosphine derivative used is a compound of the general formula III (III) in which X and L can react with OH groups of the sugar units in the oligonucleotides, and R3 is a protective group which can be liberated by beta -elimination.

10. 发明专利

AU2004206856B9 Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions 未知
公开(公告)号：AU2004206856B9
公开(公告)日：2006-11-02
申请号：AU2004206856
申请日：2004-01-16
申请人： KOSTER HUBERT
发明人： YIP PING , GREALISH MATTHEW PETER , MARAPPAN SUBRAMANIAN , KOSTER HUBERT , LITTLE DANIEL PAUL , SIDDIQI SUHAIB MAHMOOD , HASSMAN CHESTER FREDERICK III
IPC分类号： G01N33/68 , C07C69/76 , C07C69/96 , C07D207/40 , C07D207/404 , C07D207/46 , C07D209/48 , C07D211/60 , C07D211/78 , C07D213/79 , C07D215/48 , C07D239/54 , C07D239/545 , C07D241/44 , C07D261/12 , C07D271/06 , C07D271/07 , C07D303/14 , C07D303/16 , C07D317/36 , C07D401/12 , C07D405/10 , C07D405/12 , C07D495/04 , C07D498/18 , C07D519/00
摘要： A capture compound and a method of identifying drug target non-target proteins in a mixture of proteins is provided, comprising the steps of interacting the mixture with a capture compound of the formula Q-Z-( Xm)-Yn, wherein Z is a trivalent moiety for presenting X, Y and Q; moiety X is selected to covalently bind to proteins; moiety Y is a pharmaceutical drug, drug fragment, drug metabolite, prodrug, enzyme substrate, enzyme inhibitor, transition-state analogue or a ligand to a receptor; Q is a sorting function selected to permit physical arraying or other addressable separation method suitable for analysis, Q comprises a biotin moiety, a (His) 6 moiety, a BODIPY moiety (4, 4-difluoro-4-bora-3a, 4a-diaza-s-indacene), an oligonucleotide or PNA (peptide nucleic acid), an antibody, an immunotoxin conjugate, an adhesive peptide, a lectin, an activated dextran or a peptide; and analyzing the captured proteins to identify drug target or drug non-target.

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