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1. 发明申请

WO2007001650A1 BREATH ACTUATED DRUG DELIVERY SYSTEM 审中-公开
标题翻译：肠道致动药物输送系统
公开(公告)号：WO2007001650A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/018252
申请日：2006-05-09
申请人： KOS LIFE SCIENCES, INC. , WILLIAMS, Robert , RUCKDESCHEL, Thomas , KHARE, Matthew , DEATON, Daniel
发明人： WILLIAMS, Robert , RUCKDESCHEL, Thomas , KHARE, Matthew , DEATON, Daniel
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61M15/0023 , A61M15/0026 , A61M15/009 , A61M15/0098 , A61M15/08
摘要： A nasal drug delivery system (100) for delivering a predetermined amount of medication to the nasal epithelia. The system includes a container (110) containing a substance to be delivered into the nasal passages of a user, a nasal shaft (108) extending from the drug delivery system for placement in or around the nose of user, the nasal shaft being in fluid communication with a valve (124) of the container, and an oral shaft (106) , extending from the drug delivery system for placement in the mouth of a user. The nasal drug delivery system also comprises a pressure activated diaphragm trigger (114, 116, 118, 120) wherein application of pressure to the oral shaft triggers the release of a predetermined amount of a substance from the container to the nasal shaft . In use, a user inserts the oral shaft into his mouth and inserts the nasal shaft into or around his nose. Pressurizing the oral shaft which activates the trigger, results in releasing a predetermined amount of medicament from the container into the nasal shaft and into the nasal passage of the user.
摘要翻译：一种用于将预定量的药物递送至鼻上皮的鼻用药递送系统（100）。所述系统包括容纳物体的容器（110），所述容器（110）将被输送到使用者的鼻通道中;从所述药物递送系统延伸的鼻轴（108），用于放置在使用者的鼻子中或其周围，所述鼻轴处于流体与容器的阀（124）的连通以及从药物输送系统延伸以便放置在使用者口中的口腔轴（106）。鼻用药物递送系统还包括压力激活的膜片触发器（114,116,118,120），其中施加到口腔轴的压力触发预定量的物质从容器释放到鼻轴。在使用中，使用者将口腔轴插入口中并将鼻轴插入鼻子中或其鼻部。加压激活触发器的口腔轴，导致将预定量的药物从容器释放到鼻腔中并进入使用者的鼻通道。

2. 发明申请

WO2007001585A1 BREATH ACTUATED NASAL DRUG DELIVERY SYSTEM 审中-公开
标题翻译：呼吸启动的NASAL药物递送系统
公开(公告)号：WO2007001585A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/012949
申请日：2006-04-07
申请人： KOS LIFE SCIENCES, INC. , WILLIAMS, Robert , RUCKDESCHEL, Thomas , KHARE, Matthew , DEATON, Daniel
发明人： WILLIAMS, Robert , RUCKDESCHEL, Thomas , KHARE, Matthew , DEATON, Daniel
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61M15/0023 , A61M15/0026 , A61M15/009 , A61M15/0098 , A61M15/08
摘要： A method of high-speed processing and monitoring of a product, such as a pharmaceutical powder or tablet, comprises: moving the product (C) past an inspection station; illuminating at least a portion of the product with light; spectrally filtering a first portion of light carrying invormation about the product, o.g., transmitted or reflected light, by passing said first portion through at least one multivariate optical element (148) and detecting said filtered light with a first detector (152),- detecting a deflected second portion of said light with a second detector (156); and determining at least one selected property of the product based on the detector outputs.
摘要翻译：产品如药物粉末或片剂的高速处理和监测方法包括：将产品（C）移动通过检查站; 用光照射产品的至少一部分; 通过使所述第一部分穿过至少一个多元光学元件（148）并通过第一检测器（152）检测所述滤波光，对产品，og，透射或反射光的携带入射光的第一部分进行光谱滤波， - 检测所述光的偏转的第二部分具有第二检测器（156）; 以及基于所述检测器输出确定所述产品的至少一个所选属性。

3. 发明申请

WO2006115732A2 BREATH ACTUATED INHALER 审中-公开
标题翻译：呼吸启动吸入器
公开(公告)号：WO2006115732A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/013087
申请日：2006-04-07
申请人： KOS LIFE SCIENCES, INC. , GENOVA, Perry , RUCKDESCHEL, Thomas , KHARE, Matthew , DEATON, Daniel
发明人： GENOVA, Perry , RUCKDESCHEL, Thomas , KHARE, Matthew , DEATON, Daniel
IPC分类号： A61M11/00
CPC分类号： A61M15/0091 , A61M11/001 , A61M15/0026 , A61M15/008 , A61M15/009 , A61M15/0096 , A61M2205/16 , A61M2205/276 , A61M2206/16
摘要： A breath actuated metered dose inhaler including a housing, a mouthpiece positioned at one end of the housing, and a mechanical release mechanism positioned at another end of the housing. The release mechanism is triggered by a diaphragm and the inhaler is configured such that the air inhalation pathway is unimpeded by the release mechanism.
摘要翻译：一种呼吸致动计量剂量吸入器，包括壳体，位于壳体一端的吸嘴以及位于壳体另一端的机械释放机构。释放机构由隔膜触发，并且吸入器构造成使得空气吸入通道不受释放机构的阻碍。

4. 发明申请

WO2008067254A2 NASAL DRUG DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：鼻药物递送装置和方法
公开(公告)号：WO2008067254A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/085539
申请日：2007-11-26
申请人： ABBOTT LABORATORIES , GENOVA, Perry A. , WILLIAMS III, Robert C. , DEATON, Daniel , KHARE, Matthew
发明人： GENOVA, Perry A. , WILLIAMS III, Robert C. , DEATON, Daniel , KHARE, Matthew
IPC分类号： A61M11/00
CPC分类号： A61M15/08 , A61M11/007 , A61M15/0068 , A61M2202/0468 , A61M2205/8281
摘要： A nasal drug delivery device includes a pump that supplies drug containing fluid to a spray port. The pump is actuated by the user pressing on an externally accessible actuator. The actuation force from the user can be transmitted to the pump in a controlled fashion such that the pump sees a more consistent actuation force. Additionally or alternatively, the forward direction of the device's housing and/or the direction of actuator motion can be oriented with respect to the device's direction of spray so that the device can be conveniently held by a user for optimum results.
摘要翻译：鼻腔给药装置包括将含药流体供应到喷射端口的泵。泵由用户按压外部可触及的致动器来致动。来自用户的致动力可以以受控的方式传输到泵，使得泵看到更一致的致动力。另外或可选地，装置的壳体的前向和/或致动器运动的方向可以相对于装置的喷射方向定向，使得装置可以由用户方便地保持以获得最佳结果。

5. 发明公开

EP1904132A1 BREATH ACTUATED NASAL DRUG DELIVERY SYSTEM 审中-公开
标题翻译：通过呼吸OPERATED供应系统鼻子研制
公开(公告)号：EP1904132A1
公开(公告)日：2008-04-02
申请号：EP06740682.7
申请日：2006-04-07
申请人： Kos Life Sciences, Inc.
发明人： WILLIAMS, Robert , RUCKDESCHEL, Thomas , KHARE, Matthew , DEATON, Daniel
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61M15/0023 , A61M15/0026 , A61M15/009 , A61M15/0098 , A61M15/08
摘要： A method of high-speed processing and monitoring of a product, such as a pharmaceutical powder or tablet, comprises: moving the product (C) past an inspection station; illuminating at least a portion of the product with light; spectrally filtering a first portion of light carrying invormation about the product, o.g., transmitted or reflected light, by passing said first portion through at least one multivariate optical element (148) and detecting said filtered light with a first detector (152),- detecting a deflected second portion of said light with a second detector (156); and determining at least one selected property of the product based on the detector outputs.

6. 发明公开

EP1877122A2 BREATH ACTUATED INHALER 审中-公开
标题翻译：呼吸促动吸入器
公开(公告)号：EP1877122A2
公开(公告)日：2008-01-16
申请号：EP06758288.2
申请日：2006-04-07
申请人： Kos Life Sciences, Inc.
发明人： GENOVA, Perry , RUCKDESCHEL, Thomas , KHARE, Matthew , DEATON, Daniel
IPC分类号： A61M11/00 , A61M16/00 , A61M15/00 , A61M15/08
CPC分类号： A61M15/0091 , A61M11/001 , A61M15/0026 , A61M15/008 , A61M15/009 , A61M15/0096 , A61M2205/16 , A61M2205/276 , A61M2206/16
摘要： A breath actuated metered dose inhaler including a housing, a mouthpiece positioned at one end of the housing, and a mechanical release mechanism positioned at another end of the housing. The release mechanism is triggered by a diaphragm and the inhaler is configured such that the air inhalation pathway is unimpeded by the release mechanism.
摘要翻译：一种呼吸致动式定量吸入器，包括壳体，位于壳体一端的吸嘴以及位于壳体另一端的机械释放机构。释放机构由隔膜触发，并且吸入器被配置为使得空气吸入通路不受释放机构阻碍。

7. 发明公开

EP1904133A1 BREATH ACTUATED DRUG DELIVERY SYSTEM 审中-公开
标题翻译：通过呼吸活化的药物输送系统
公开(公告)号：EP1904133A1
公开(公告)日：2008-04-02
申请号：EP06759571.0
申请日：2006-05-09
申请人： Kos Life Sciences, Inc.
发明人： WILLIAMS, Robert , RUCKDESCHEL, Thomas , KHARE, Matthew , DEATON, Daniel
IPC分类号： A61M15/00
CPC分类号： A61M15/0091 , A61M15/0023 , A61M15/0026 , A61M15/009 , A61M15/0098 , A61M15/08
摘要： A nasal drug delivery system (100) for delivering a predetermined amount of medication to the nasal epithelia. The system includes a container (110) containing a substance to be delivered into the nasal passages of a user, a nasal shaft (108) extending from the drug delivery system for placement in or around the nose of user, the nasal shaft being in fluid communication with a valve (124) of the container, and an oral shaft (106) , extending from the drug delivery system for placement in the mouth of a user. The nasal drug delivery system also comprises a pressure activated diaphragm trigger (114, 116, 118, 120) wherein application of pressure to the oral shaft triggers the release of a predetermined amount of a substance from the container to the nasal shaft . In use, a user inserts the oral shaft into his mouth and inserts the nasal shaft into or around his nose. Pressurizing the oral shaft which activates the trigger, results in releasing a predetermined amount of medicament from the container into the nasal shaft and into the nasal passage of the user.

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