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1. 发明申请

WO2011115456A3 TNF-? AND TWEAK DUAL ANTAGONIST FOR THE PROPHYLAXIS AND TREATMENT OF AUTOIMMUNE DISEASES 审中-公开
标题翻译： TNF-α 和双重拮抗剂用于预防和治疗自身免疫性疾病
公开(公告)号：WO2011115456A3
公开(公告)日：2012-01-26
申请号：PCT/KR2011001900
申请日：2011-03-18
申请人： KOREA RES INST OF BIOSCIENCE , INDUSTRY ACADEMIC COOPERATION FOUNDATION THE CATHOLIC UNIVERSITY OF KOREA , PARK YOUNG WOO , JO KI WON , YOO SROK HO , YU JUNG , KIM DONG JIN , YOON SUN-HA , SONG EUN JUNG , LEE EUN KYUNG , OH JIN MI , CHO KYU WON , CHO MI LA , KIM HO YOUN , PARK MI KYUNG , OH HYE JWA , PARK JIN SIL , WOO YUN JU , BYUN JAE KYEONG , RYU JUN GEOL
发明人： PARK YOUNG WOO , JO KI WON , YOO SROK HO , YU JUNG , KIM DONG JIN , YOON SUN-HA , SONG EUN JUNG , LEE EUN KYUNG , OH JIN MI , CHO KYU WON , CHO MI LA , KIM HO YOUN , PARK MI KYUNG , OH HYE JWA , PARK JIN SIL , WOO YUN JU , BYUN JAE KYEONG , RYU JUN GEOL
IPC分类号： C07K19/00 , A61P37/00 , C12N15/62 , C12N15/63
CPC分类号： C07K14/525 , C07K14/70575 , C07K2319/32 , Y10S514/814 , Y10S514/885 , Y10S514/886 , Y10S514/903
摘要： The present invention relates to a TNFR2-TWEAKR fusion protein, and more specifically the TNFR2-TWEAKR fusion protein of the present invention can be used advantageously as an active ingredient in compositions that are efficacious in the prophylaxis and treatment of autoimmune diseases since TNFR2-TWEAKR fusion protein plays the role of a dual antagonist with respect to TNF-a and TWEAK which are known to be major causes of one type of autoimmune disease namely autoimmune arthritis, and, when Th17 cells are treated with a composition comprising TNFR2-TWEAKR fusion protein as an active ingredient, secretion of inflammatory cytokine IL-17 is reduced while secretion of anti-inflammatory cytokine IL-10 produced from Treg cells is increased, and this effect means that not only is the effect of TNFR2-TWEAKR fusion protein far better than TNFR2-Fc and TWEAK-Fc single proteins, but also not only is a therapeutic effect exhibited against arthritis in CIA arthritic mice but also a therapeutic effect is exhibited against autoimmune arthritis due to increased expression of Treg cells which are immunosuppressive cells.
摘要翻译：本发明涉及本发明的TNFR2-TWEAKR融合蛋白，更具体地，TNFR2-TWEAKR融合蛋白可有效地用作组合物中有效的预防和治疗自身免疫疾病的有效成分，因为TNFR2-TWEAKR 融合蛋白起到相对于TNF-α和TWEAK的双重拮抗剂的作用，已知它们是一种类型的自身免疫疾病（即自身免疫性关节炎）的主要原因，并且当Th17细胞用包含TNFR2-TWEAKR融合蛋白的组合物作为活性成分，炎性细胞因子IL-17的分泌减少，而由Treg细胞产生的抗炎细胞因子IL-10的分泌增加，这意味着不仅TNFR2-TWEAKR融合蛋白的作用远远优于 TNFR2-Fc和TWEAK-Fc单一蛋白，而且不仅是在CIA关节炎小鼠中针对关节炎展现的治疗效果，而且还具有治疗效果由于免疫抑制细胞的Treg细胞的表达增加，其表现出针对自身免疫性关节炎。

2. 发明授权

KR101136249B1 Case for electric wire 有权
标题翻译：电线箱
公开(公告)号：KR101136249B1
公开(公告)日：2012-04-19
申请号：KR20100097700
申请日：2010-10-07
申请人： OH JIN MI
发明人： OH JIN MI
IPC分类号： H02G3/08 , H05K5/04
摘要： PURPOSE: A metal case for a one-touch assembling PTO(Power TakeOff) wire is provided to maximize production by one-touch assembling an upper case and a lower case in which a switch groove is included. CONSTITUTION: A switch groove(11a) is formed on an upper wall plate(11). An upper case(10) is composed of a sidewall plate(12) formed to down from both end sides of the upper wall plate. A lower case(20) is composed of a bottom plate and a rear wall plate. The front wall plate is vertically formed from a front end of the bottom plate to upward. The rear wall plate is vertically formed from the rear end of the bottom plate to upward and includes a wire through groove. A combining unit combines the upper case with the lower case in one touch type.
摘要翻译：目的：提供用于单触式组装PTO（Power TakeOff）线的金属外壳，以通过一触式组装包括开关槽的上壳体和下壳体来最大限度地提高产量。构成：在上壁板（11）上形成开关槽（11a）。上壳体（10）由从上壁板的两端侧向下形成的侧壁板（12）构成。下壳体（20）由底板和后壁板构成。前壁板从底板的前端向上垂直地形成。后壁板从底板的后端向上垂直地形成，并且包括导线槽。组合单元将上壳体与下壳体结合在一体式中。

3. 发明公开

KR20120036042A One touch type fixing zig 有权
标题翻译：一个触摸式固定ZIG
公开(公告)号：KR20120036042A
公开(公告)日：2012-04-17
申请号：KR20100097702
申请日：2010-10-07
申请人： OH JIN MI
发明人： OH JIN MI
IPC分类号： B25B11/00 , B23Q3/06 , B25B5/00 , B25B5/04
CPC分类号： B25B11/00 , B23Q3/06 , B25B5/065
摘要： PURPOSE: A one touch-type fixing jig is provided to improve work efficiency and to reduce work time because the manual fixing work of a worker is not required. CONSTITUTION: A one touch-type fixing jig comprises a jig unit(10), a lever unit(20), a push piece(30), an elastic body(40), and an operating piece(50). The jig unit has a pressing unit(10b), a mounting unit, and a first operating groove. The pressing unit is formed in one side of a body unit(10a), and the mounting unit is located at the other side thereof. The first operating groove is formed in the mounting unit. The lever unit has an insertion groove and a first hanging piece(22). The push piece has a second operating groove. The elastic body supplies restoring force to the push piece. The operating piece is inserted into the first and second operating grooves.
摘要翻译：目的：提供单触式固定夹具，以提高工作效率并减少工作时间，因为不需要工人的手动固定工作。构成：一触式固定夹具包括夹具单元（10），杆单元（20），推片（30），弹性体（40）和操作件（50）。夹具单元具有按压单元（10b），安装单元和第一操作槽。按压单元形成在主体单元（10a）的一侧，并且安装单元位于其另一侧。第一操作槽形成在安装单元中。杠杆单元具有插入槽和第一悬挂件（22）。推动件具有第二操作槽。弹性体向推动件提供恢复力。操作件插入到第一和第二操作槽中。

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