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1. 发明申请

WO2011013987A3 2,2-DISUBSTITUTED-2H-CHROMENE COMPOUND 审中-公开
标题翻译： 2,2-二取代-2H-色烯化合物
公开(公告)号：WO2011013987A3
公开(公告)日：2011-08-25
申请号：PCT/KR2010004925
申请日：2010-07-27
申请人： KOREA RES INST CHEM TECH , SK CHEMICALS CO LTD , GONG YOUNG DAE , CHO HEE YEONG , LEE TAE HO , CHOI GIL DON , JEON MOON KOOK , PARK WOO KYU , KONG JAE YANG , HWANG SOON HEE , JEONG DAE YOUNG , LEE BONG YONG , UM KEY AN , KIM JAE SUN , RYU KEUN HO , RYU JE HO , KIM SHIN AE , HAN HYE YOUNG , SON HYUN JOO , LEE HYUN JUNG , KIM YOUNG HYUK , PARK SUNG HOON
发明人： GONG YOUNG DAE , CHO HEE YEONG , LEE TAE HO , CHOI GIL DON , JEON MOON KOOK , PARK WOO KYU , KONG JAE YANG , HWANG SOON HEE , JEONG DAE YOUNG , LEE BONG YONG , UM KEY AN , KIM JAE SUN , RYU KEUN HO , RYU JE HO , KIM SHIN AE , HAN HYE YOUNG , SON HYUN JOO , LEE HYUN JUNG , KIM YOUNG HYUK , PARK SUNG HOON
IPC分类号： C07D311/58 , A61K31/366 , A61P3/10 , C07D311/24
CPC分类号： C07D311/24 , C07D311/58
摘要： The present invention relates to a 2,2-disubstituted-2H-chromene compound, and to the medicinal use of the compound as an agent for preventing, controlling, and treating diseases related to the regulation of glucocorticoids using the selective inhibitory activity of the compound against the 11ß-HSD1 enzyme. The 2,2-disubstituted-2H-chromene compound of the present invention is useful as an agent for preventing, controlling, and treating disorders related to the regulation of glucocorticoids, in which human-derived 11ß-HSD1 enzyme is involved, for example metabolic syndrome-related disorders such as type 1 and type 2 diabetes, late diabetic complications, latent autoimmune diabetes in adults (LADA), insulin resistance, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), impaired glucose tolerance, dyslipidemia, arteriosclerosis, hypertension, etc.
摘要翻译：本发明涉及2,2-二取代-2H-色烯化合物以及该化合物作为用于使用化合物的选择性抑制活性来预防，控制和治疗与糖皮质激素调节有关的疾病的药物的医学用途对11β-HSD1酶。本发明的2,2-二取代-2H-色烯化合物可用作预防，控制和治疗涉及调节糖皮质激素的疾病的药剂，其中涉及人源11β-HSD1酶，例如代谢综合征相关疾病如1型和2型糖尿病，晚期糖尿病并发症，成人隐匿性自身免疫糖尿病（LADA），胰岛素抵抗，肥胖，葡萄糖耐量降低（IGT），空腹血糖受损（IFG），葡萄糖耐量降低，血脂异常，动脉硬化，高血压等

2. 发明专利

JP2002193954A NEW ISOOXAZOLYLALKYLPIPERAZINE DERIVATIVE HAVING SELECTIVE ACTIVITY ON DOPAMINE D3 AND D4 RECEPTORS AND METHOD FOR PRODUCING THE SAME 失效
公开(公告)号：JP2002193954A
公开(公告)日：2002-07-10
申请号：JP2001121712
申请日：2001-04-19
申请人： KOREA INST SCI & TECH , KOREA RES INST CHEM TECH
发明人： KOH HUN YEONG , CHOI KYUNG IL , CHO YONG SEO , PAE AE NIM , KANG KYUNG HO , CHA MI YOUNG , KONG JAE YANG , JEONG DAE YOUNG , LEE HAE-YOON
IPC分类号： A61K31/454 , A61K31/496 , A61P25/00 , A61P25/18 , A61P43/00 , C07D261/08 , C07D413/04 , C07D413/06 , C07D413/14
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a new compound which is useful in a field of medical treatment of mental disease and a dopamine antagonist having the same as an effective component. SOLUTION: This invention provides a new isooxazolylalkylpiperazine derivative represented by general formula 1, having a selective activity on dopamine D3 and D4 receptors and a method for producing the compound by using reducing amination reaction in the presence of a reducing agent.

3. 发明专利

JP2002193953A 4,5-DIHYDROISOOXAZOLYLALKYLPIPERAZINE DERIVATIVE AND METHOD FOR PRODUCING THE SAME 失效
公开(公告)号：JP2002193953A
公开(公告)日：2002-07-10
申请号：JP2001120229
申请日：2001-04-18
申请人： KOREA INST SCI & TECH , KOREA RES INST CHEM TECH , SEISHIN GAKUIN
发明人： KOH HUN YEONG , CHOI KYUNG IL , CHO YONG SEO , PAE AE NIM , KONG JAE YANG , JEONG DAE YOUNG , JUNG SUN HO , JUNG JI YOUNG , LEE HAE-YOON
IPC分类号： C07D261/04 , A61K31/454 , A61K31/496 , A61K31/506 , A61P25/00 , A61P25/18 , C07D261/08 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： PROBLEM TO BE SOLVED: To develope a new compound which is useful for medical treatment of mental disease, specially a compound which selectively effects on dopamine D3 and D4 receptors and provide a method for producing the same and dopamine antagonist having the same as an effective component. SOLUTION: The 4,5-dihydroisooxazolylalkylpiperazine derivative is a compound selected from compounds represented by formula (1) and their pharmacologically permissible salts. The compound is a dopamine antagonist which can be produced by using reducing amination reaction of the corresponding amine compound with an aldehyde compound in the presence of a reductant (wherein, R1 R2, R3, R4 and R5 are each independently H-atom, a halogen atom, alkyl, alkoxy, alkenyl, hydroxy, etc.; R6 is H-atom, a halogen atom, alkyl, 1-6C alkoxy, aryl, pyrimidine, or hetero ring; and X is CH or N-atom; n is 3 or 4).

4. 发明公开

EP2873419A4 PHARMACEUTICAL COMPOSITION COMPRISING AZATHIOPRINE AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING BRAIN TUMORS OR TEMODAL-RESISTANT GLIOBLASTOMAS 有权
标题翻译：硫唑嘌呤为有效防止或药物组合物脑肿瘤或治疗TEMODALRESISTENTEN胶质母细胞瘤
公开(公告)号：EP2873419A4
公开(公告)日：2015-06-10
申请号：EP13816643
申请日：2013-07-10
申请人： KOREA RES INST CHEM TECH , SAMSUNG LIFE PUBLIC WELFARE FOUNDATION
发明人： CHO HEEYEONG , CHOI GILDON , PARK WOO KYU , JEONG DAE YOUNG , KIM HYEON YOUNG , LEE SUNKYUNG , NAM DO HYUN , SEOL HO JUN
IPC分类号： A61K31/52 , A61P35/00
CPC分类号： A61K31/52 , A61K31/495

5. 发明专利

GB2369617B Novel 4,5-dihydroisoxazolylalkyl-piperazine or-piperidine derivatives having selective biological activity at dopamine D3orD4 receptor,and preparation thereof 未知
公开(公告)号：GB2369617B
公开(公告)日：2003-06-04
申请号：GB0110061
申请日：2001-04-24
申请人： KOREA INST SCI & TECH , KOREA RES INST CHEM TECH
发明人： KOH HUN YEONG , CHOI KYUNG , CHO YONG SEO , PAE AE NIM , KONG JAE YANG , JEONG DAE YOUNG , JUNG SUN HO , JUNG JI YOUNG , LEE HEE-YOON
IPC分类号： C07D261/04 , A61K31/454 , A61K31/496 , A61K31/506 , A61P25/00 , A61P25/18 , C07D261/08 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 and D4 receptors represented by the following Formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent,wherein R1, R2, X and n are the same as defined in the specification.

6. 发明专利

GB2369616B Novel isoxazolylalkyl-piperazine or -piperidine derivatives having selective biological activity at dopamine D3 or D4 receptor, and preparation thereof 未知
公开(公告)号：GB2369616B
公开(公告)日：2003-03-12
申请号：GB0110060
申请日：2001-04-24
申请人： KOREA INST SCI & TECH , KOREA RES INST CHEM TECH
发明人： KOH HUN YEONG , CHOI KYUNG , CHO YONG SEO , PAE AE NIM , KANG KYUNG HO , CHA MI YOUNG , KONG JAE YANG , JEONG DAE YOUNG , LEE HAE-YOON
IPC分类号： A61K31/454 , A61K31/496 , A61P25/00 , A61P25/18 , A61P43/00 , C07D261/08 , C07D413/04 , C07D413/06 , C07D413/14 , A61K31/4523
摘要： The present invention relates to a novel isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptors represented by the following formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent, wherein R1, R2, R3, R4, R5, R6, X and n are the same as defined in the specification.

7. 发明专利

GB2369617A Isoxazolylalkyl-piperazine and -piperidine derivatives having selective biological activity at dopamine D3 or D4 receptor 未知
公开(公告)号：GB2369617A
公开(公告)日：2002-06-05
申请号：GB0110061
申请日：2001-04-24
申请人： KOREA INST SCI & TECH , KOREA RES INST CHEM TECH
发明人： KOH HUN YEONG , CHOI KYUNG , CHO YONG SEO , PAE AE NIM , KONG JAE YANG , JEONG DAE YOUNG , JUNG SUN HO , JUNG JI YOUNG , LEE HEE-YOON
IPC分类号： C07D261/04 , A61K31/454 , A61K31/496 , A61K31/506 , A61P25/00 , A61P25/18 , C07D261/08 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to novel 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D 3 and D 4 receptors represented by the following Formula (1), and their preparation by amination in the presence of a reducing agent, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and n are the same as defined in the specification.

8. 发明专利

GB2369616A Isoxazolylalkylpiperazine and -piperidine derivatives having selective biological activity at dopamine D3 or D4 receptor 未知
公开(公告)号：GB2369616A
公开(公告)日：2002-06-05
申请号：GB0110060
申请日：2001-04-24
申请人： KOREA INST SCI & TECH , KOREA RES INST CHEM TECH
发明人： KOH HUN YEONG , CHOI KYUNG , CHO YONG SEO , PAE AE NIM , KANG KYUNG HO , CHA MI YOUNG , KONG JAE YANG , JEONG DAE YOUNG , LEE HAE-YOON
IPC分类号： A61K31/454 , A61K31/496 , A61P25/00 , A61P25/18 , A61P43/00 , C07D261/08 , C07D413/04 , C07D413/06 , C07D413/14 , A61K31/4523
摘要： The present invention relates to novel isoxazolylalkylpiperzine and -piperdine derivatives having selective biological activity at dopamine D 3 or D 4 receptors represented by the following formula (1), and their preparation by reductive amination wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and n are the same as defined in the specification.

9. 发明授权

KR101212778B1 Cloud computing based smart office system and server for managing the same and method for managing the same 有权
标题翻译：基于云计算的智能办公系统及其管理服务器及其管理方法
公开(公告)号：KR101212778B1
公开(公告)日：2012-12-18
申请号：KR20120043412
申请日：2012-04-25
申请人： JEONG DAE YOUNG
发明人： JEONG DAE YOUNG
IPC分类号： G06Q10/10 , G06F15/16
CPC分类号： G06Q10/10 , G06F15/16 , G06F17/248 , G06F17/3012 , G06F17/40 , H04W4/12
摘要： PURPOSE: A cloud computing based smart office system, a server and a method operating the same are provided to easily distribute a mobile web based solution to a cloud environment, thereby supplying a smart office system without a high price system. CONSTITUTION: A mobile terminal(100) processes data of a view page type by using a mobile network system. A cloud based mobile web server(200a) uses cloud in case of not installing a server in a local. An office data server(300) connected to the mobile web server processes data used in an office environment. A developer computer performs adaptor connection setting through CDK. [Reference numerals] (AA) Cloud(Windows azure); (BB,EE) SAMES(mobile web); (CC) SQL azure; (DD) Synchronization; (FF) Database; (GG) On premise
摘要翻译：目的：提供基于云计算的智能办公系统，服务器及其操作方法，以便将基于移动网络的解决方案轻松分配到云环境，从而提供无需高价格系统的智能办公系统。构成：移动终端（100）通过使用移动网络系统处理视图页面类型的数据。基于云的移动Web服务器（200a）在不在本地安装服务器的情况下使用云。连接到移动Web服务器的办公室数据服务器（300）处理在办公环境中使用的数据。开发者计算机通过CDK执行适配器连接设置。（附图标记）（AA）云（Windows azure）; （BB，EE）SAMES（移动网络）; （CC）SQL azure; （DD）同步; （FF）数据库; （GG）在前提下

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