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1. 发明申请

WO2012154009A3 THIENOPYRIMIDINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD FOR PREPARING THIENOPYRIMIDINE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION CONTAINING THIENOPYRIMIDINE DERIVATIVES AS ACTIVE INGREDIENTS FOR PREVENTING OR TREATING DIABETES-RELATED DISEASES 审中-公开
标题翻译：三硝基嘧啶衍生物，其药学上可接受的盐，其制备三亚氨基嘧啶衍生物的方法，以及作为用于预防或治疗与糖尿病相关的疾病的活性成分的三硝基嘧啶衍生物的药物组合物
公开(公告)号：WO2012154009A3
公开(公告)日：2013-03-21
申请号：PCT/KR2012003722
申请日：2012-05-11
申请人： KOREA RES INST CHEM TECH , JEON MOON KOOK , AHN JIN HEE , KANG SEUNG KYU , LEE KYU MYUNG , RHEE SANG DAL , KIM HI YOUN , JUNG WON HOON , KIM KWANG ROK , BAE MYUNG-AE , SONG JIN SOOK , SUH JEE HEE , KANG MYOUNG KU , KIM MIN HYE
发明人： JEON MOON KOOK , AHN JIN HEE , KANG SEUNG KYU , LEE KYU MYUNG , RHEE SANG DAL , KIM HI YOUN , JUNG WON HOON , KIM KWANG ROK , BAE MYUNG-AE , SONG JIN SOOK , SUH JEE HEE , KANG MYOUNG KU , KIM MIN HYE
IPC分类号： C07D495/04 , A61K31/519 , A61P3/10 , C07D401/12
CPC分类号： C07D401/12 , C07D495/04
摘要： The present invention relates to novel thienopyrimidine derivatives, and to a pharmaceutical composition containing thienopyrimidine derivatives as active ingredients for preventing or treating diabetes or various diabetes-related diseases. The thienopyrimidine derivatives of the present invention efficiently accelerate the activity of G protein-coupled receptor 119 (GPR119), which has the effects of increasing glucose-dependent insulin secretion and inhibiting increases in appetite and body weight, thus enhancing glucose metabolism and lipid metabolism. Therefore, the thienopyrimidine derivatives of the present invention may be valuably used in a composition for efficiently preventing and treating not only diabetes but also various complications of diabetes such as obesity, hyperlipidemia, and diabetic vascular diseases.
摘要翻译：本发明涉及新颖的噻吩并嘧啶衍生物，以及含有噻吩并嘧啶衍生物作为预防或治疗糖尿病或各种糖尿病相关疾病的有效成分的药物组合物。本发明的噻吩并嘧啶衍生物有效加速G蛋白偶联受体119（GPR119）的活性，其具有增加葡萄糖依赖性胰岛素分泌和抑制食欲和体重增加的作用，从而增强葡萄糖代谢和脂质代谢。因此，本发明的噻吩并嘧啶衍生物可以有价值地用于不仅有效预防和治疗糖尿病的组合物，还包括肥胖症，高脂血症和糖尿病性血管疾病等糖尿病的各种并发症。

2. 发明申请

WO2012081893A3 NOVEL 3-INDOLINONE DERIVATIVE AND COMPOSITION HAVING SAME 审中-公开
标题翻译：新颖的3-吲哚酮衍生物和具有该组合物的组合物
公开(公告)号：WO2012081893A3
公开(公告)日：2012-08-16
申请号：PCT/KR2011009597
申请日：2011-12-13
申请人： KOREA RES INST CHEM TECH , AHN JIN-HEE , BAE MYUNG-AE , CHOI EUN-BOK
发明人： AHN JIN-HEE , BAE MYUNG-AE , CHOI EUN-BOK
IPC分类号： C07D209/36 , A61K31/4015 , A61K31/404 , A61K49/00
CPC分类号： A61K31/4015 , A61K31/404 , A61K49/006 , C07D209/42
摘要： The present invention relates to a novel 3-indolinon derivative and a composition having same, which enable selective fluorescent dyeing of fat in particular, and thus, can be useful as a bio-diagnostic reagent.
摘要翻译：本发明涉及新的3-吲哚满酮衍生物和具有该衍生物的组合物，其特别是能够对脂肪进行选择性荧光染色，因此可用作生物诊断试剂。

3. 发明申请

WO2013162298A8 NOVEL BETA-ALANINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译：新型β-氨基葡萄糖衍生物，其药学上可接受的盐，以及包含其作为活性成分的药物组合物
公开(公告)号：WO2013162298A8
公开(公告)日：2013-12-27
申请号：PCT/KR2013003557
申请日：2013-04-25
申请人： KOREA RES INST CHEM TECH , HANDOK PHARMACEUTICALS CO LTD
发明人： AHN JIN HEE , H S PAGIRE , RHEE SANG DAL , KIM KI YOUNG , JUNG WON HOON , BAE MYUNG-AE , SONG JIN SOOK , KIM KWANG-ROK , KWAK HYUN JUNG
IPC分类号： C07C233/25 , A61K31/16 , A61P1/16 , A61P3/04
CPC分类号： C07D213/82 , A61K31/167 , A61K31/216 , A61K31/27 , A61K31/403 , A61K31/415 , A61K31/421 , A61K45/06 , C07B2200/07 , C07C237/04 , C07C237/12 , C07C237/22 , C07C271/22 , C07C2601/14 , C07D209/20 , C07D209/42 , C07D213/56 , C07D231/12 , C07D231/14 , C07D239/26 , C07D261/08 , C07D261/10 , C07D263/32 , C07D263/34 , C07D271/06 , C07D277/30 , C07D277/56 , C07D417/12
摘要： The present invention relates to novel beta-alanine derivatives, to the pharmaceutically acceptable salts thereof, and to a pharmaceutical composition comprising same as an active ingredient. The novel beta-alanine derivatives and pharmaceutically acceptable salts thereof according to the present invention may effectively inhibit the activity of DGAT1, which is an enzyme serving as a catalyst in the final step of the synthesis of neutral lipids, and therefore can be effectively used as a pharmaceutical composition for preventing or treating various diseases relating to lipid metabolism belonging to the group consisting of obesity, dyslipidemia, fatty liver, insulin resistance syndrome, and hepatitis.
摘要翻译：本发明涉及新颖的β-丙氨酸衍生物及其药学上可接受的盐，以及包含其作为活性成分的药物组合物。根据本发明的新型β-丙氨酸衍生物及其药学上可接受的盐可有效抑制DGAT1的活性，DGAT1作为在中性脂质合成的最后步骤中用作催化剂的酶，因此可有效地用作用于预防或治疗属于由肥胖症，血脂异常，脂肪肝，胰岛素抵抗综合征和肝炎组成的组中的脂质代谢相关的各种疾病的药物组合物。

4. 发明公开

EP2475649A4 INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 有权
标题翻译： INDENONDERIVAT和药物成分，以便
公开(公告)号：EP2475649A4
公开(公告)日：2013-02-13
申请号：EP09849272
申请日：2009-10-21
申请人： KOREA RES INST CHEM TECH
发明人： HEO JUNG NYOUNG , BAE MYUNG-AE , KIM NACK JEONG , CHANG SUNG YOUN , KANG NAMSOOK , YOO SUNG EUN , HWANG EUN SOOK
IPC分类号： C07D213/50 , A61K31/44 , A61P19/08 , C07D213/89 , C07D239/26 , C07D241/12 , C07D295/088 , C07D333/22
CPC分类号： C07D213/50 , C07D213/89 , C07D239/26 , C07D241/12 , C07D295/088 , C07D333/22

6. 发明专利

CA2771799A1 INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 未知
公开(公告)号：CA2771799A1
公开(公告)日：2011-03-17
申请号：CA2771799
申请日：2009-10-21
申请人： KOREA RES INST CHEM TECH
发明人： HEO JUNG NYOUNG , BAE MYUNG-AE , KIM NACK JEONG , CHANG SUNG YOUN , KANG NAMSOOK , YOO SUNG EUN , HWANG EUN SOOK
IPC分类号： C07D265/33
摘要： An indenone derivative of formula (1) is effective in enhancing the activity of osteoblastic cells and inhibiting bone resorption by osteoclastic cells, and a pharmaceutical composition comprising the indenone derivative or a pharmaceutically acceptable salt thereof is useful for preventing or treating bone diseases such as osteoporosis.

7. 发明专利

EA021353B1 ПРОИЗВОДНОЕ ИНДЕНОНА И СОДЕРЖАЩАЯ ЕГО ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ 未知
公开(公告)号：EA021353B1
公开(公告)日：2015-05-29
申请号：EA201270410
申请日：2009-10-21
申请人： KOREA RES INST CHEM TECH
发明人： HEO JUNG NYOUNG , BAE MYUNG-AE , KIM NACK JEONG , CHANG SUNG YOUN , KANG NAM SOOK , YOO SUNG EUN , HWANG EUN SOOK
IPC分类号： C07D265/33
摘要： Производноеинденонаформулы (1)обладаетэффектамиусиленияактивностиостеобластови ингибированиярезорбциикостиостеокластами, афармацевтическаякомпозиция, содержащаяпроизводноеинденонаилиегофармацевтическиприемлемуюсоль, применимадляпрофилактикиилилеченияболезнейкостей, такихкакостеопороз.

8. 发明专利

ES2521517T3 Derivado de indenona y composición farmacéutica que comprende el mismo 未知
公开(公告)号：ES2521517T3
公开(公告)日：2014-11-12
申请号：ES09849272
申请日：2009-10-21
申请人： KOREA RES INST CHEM TECH
发明人： HEO JUNG NYOUNG , BAE MYUNG-AE , KIM NACK JEONG , CHANG SUNG YOUN , KANG NAMSOOK , YOO SUNG EUN , HWANG EUN SOOK
IPC分类号： C07D213/50 , A61K31/44 , A61P19/08 , C07D213/89 , C07D239/26 , C07D241/12 , C07D295/088 , C07D333/22
摘要： Un derivado de indenona de fórmula (1) o una sal farmacéuticamente aceptable del mismo:**Fórmula** en la que, n es 0, 1 o 2; X es uno o más sustituyentes introducidos en posición orto, meta o para del grupo fenilo, cada uno seleccionado independientemente del grupo que consiste en hidrógeno, halógeno, -CN, -CF3, alquilo C1-6, alcoxi C1-6, cicloalquilo C3-10 y cicloalcoxi C3-8; R1 es arilo C6-10 sustituido con al menos un sustituyente seleccionado del grupo que consiste en halógeno, oxo, - CF3, -CN, amino, hidroxi, carboxi, carbamoílo, nitro, tiol, alquilo C1-6, alquenilo C2-6, alcoxi C1-6, cicloalquilo C3-10, cicloalcoxi C3-8, arilo C6-10, ariloxi C6-10, -C(O)R4, -C(O)OR4, -C(O)NR4R5, -S(O)R4, -S(O2)R4, -S(O2)NR4R5, -NR4R5 y -NR4C(O)R5, siendo cada R4 y R5 independientemente hidrógeno, alquilo C1-6 o cicloalquilo C3-10, o heteroarilo de 5 a 10 miembros; Y es CH, N, N+(-alquilo C1-6) o N+(-O-); y R2 y R3 son cada uno independientemente hidrógeno, alquilo C1-6, alcoxi C1-6, arilo C6-10, o heteroarilo de 5 a 10 miembros o están condensados junto con Y para formar cicloalquilo C3-10 o heterocicloalquilo de 5 a 10 miembros; en la que el arilo C6-10 de R2 y R3, heteroarilo de 5 a 10 miembros, cicloalquilo C3-10 y heterocicloalquilo de 5 a 10 miembros son cada uno independientemente y están opcionalmente sustituidos con al menos un sustituyente seleccionado del grupo que consiste en halógeno, oxo, -CF3, -CN, amino, hidroxi, carboxi, carbamoílo, nitro, tiol, alquilo C1-6, alquenilo C2-6, alcoxi C1-6, cicloalquilo C3-10, cicloalcoxi C3-8, arilo C6-10, ariloxi C6-10, -C(O)R4, -C(O)OR4, -C(O)NR4R5, -S(O)R4, -S(O2)R4, -S(O2)NR4R5, -NR4R5 y -NR4C(O)R5, siendo cada R4 y R5 independientemente hidrógeno, alquilo C1-6 o cicloalquilo C3-10.

9. 发明专利

DK2475649T3 INDENONDERIVAT OG FARMACEUTISK SAMMENSÆTNING OMFATTENDE SAMME 未知
公开(公告)号：DK2475649T3
公开(公告)日：2014-11-03
申请号：DK09849272
申请日：2009-10-21
申请人： KOREA RES INST CHEM TECH
发明人： HEO JUNG NYOUNG , BAE MYUNG-AE , KIM NACK JEONG , CHANG SUNG YOUN , KANG NAMSOOK , YOO SUNG EUN , HWANG EUN SOOK
IPC分类号： C07D213/50 , A61K31/44 , A61P19/08 , C07D213/89 , C07D239/26 , C07D241/12 , C07D295/088 , C07D333/22

10. 发明专利

HK1166633A1 INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 未知
公开(公告)号：HK1166633A1
公开(公告)日：2012-11-02
申请号：HK12107309
申请日：2012-07-25
申请人： KOREA RES INST CHEM TECH
发明人： HEO JUNG NYOUNG , BAE MYUNG-AE , KIM NACK JEONG , CHANG SUNG YOUN , KANG NAMSOOK , YOO SUNG EUN , HWANG EUN SOOK
IPC分类号： C07D20060101
摘要： An indenone derivative of formula (1) is effective in enhancing the activity of osteoblastic cells and inhibiting bone resorption by osteoclastic cells, and a pharmaceutical composition comprising the indenone derivative or a pharmaceutically acceptable salt thereof is useful for preventing or treating bone diseases such as osteoporosis.

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