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1. 发明申请

WO2006129898A1 A MASS SEPARATION METHOD OF MAGNOLOL FROM MAGNOLIAE CORTEX ORMAGNOLIAE RADIX 审中-公开
标题翻译：来自魔芋胶原蛋白的大分子量分离方法
公开(公告)号：WO2006129898A1
公开(公告)日：2006-12-07
申请号：PCT/KR2005/001914
申请日：2005-06-21
申请人： KOREA INSTITUTE OF ORIENTAL MEDICINE , KIM, JIN SOOK , LEE, YUN MI , JANG, DAE SIK
发明人： KIM, JIN SOOK , LEE, YUN MI , JANG, DAE SIK
IPC分类号： C07C37/82
CPC分类号： C07C37/82 , C07C37/004 , C07C37/685 , C07C37/84 , C07C39/21
摘要： The present invention related to method for the mass separation of magnolol from Magnoliae cortex or Magnoliae radix. The method comprises the steps of: 1) crushing Magnoliae cortex or Magnoliae radix, extracting the crushed material with organic solvent, adding n-hexane to the extract so as to obtain a n-hexane layer; 2) concentrating the n-hexane layer in a water bath at a temperature of 30-40 0C and a revolution speed of 40-200 RPM under reduced pressure so as to form a crude crystal; and 3) removing the n-hexane from the crude crystal, completely dissolving the crude crystal in chloroform, adding n-hexane to the n-hexane-containing solution, and leaving the solution to stand at room temperature so as to recrystallize the solution. In the method, a column chromatography step which is necessarily carried out in the general separation process is omitted so that separation process steps are reduced, leading to a saving in separation time. Also, expensive equipment is not required, leading a reduction in separation cost. Accordingly, the method is effective for the mass separation of expensive magnolol.
摘要翻译：本发明涉及厚朴与厚朴与木兰质量分离的方法。该方法包括以下步骤：1）粉碎玉兰大麦或木兰，用有机溶剂萃取粉碎物，向提取液中加入正己烷，得到正己烷层; 2）将正己烷层在30-40℃的温度和40-200rpm的转速下在水浴中浓缩，以形成粗晶体; 3）从粗结晶中除去正己烷，将粗结晶完全溶解在氯仿中，向正己烷溶液中加入正己烷，使溶液在室温下静置，使溶液重结晶。在该方法中，省略了在一般的分离过程中必须进行的柱色谱步骤，从而减少了分离工艺步骤，从而节省了分离时间。此外，不需要昂贵的设备，导致分离成本的降低。因此，该方法对于昂贵的厚朴酚的质量分离是有效的。

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