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1. 发明申请

WO2010005148A3 NOVEL ISOINDOLINONE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST T-TYPE CALCIUM CHANNEL AND METHOD FOR PREPARATION THEREOF 审中-公开
标题翻译：具有对T型钙通道的抑制活性的新型异吲哚啉酮衍生物及其制备方法
公开(公告)号：WO2010005148A3
公开(公告)日：2010-07-01
申请号：PCT/KR2008005784
申请日：2008-10-01
申请人： KOREA INST SCI & TECH , CHO YONG SEO , PAE AE NIM , CHOO HYUNAH , LEE JAE KYUN , OH YOU NA , SHIN HEE SUP , KIM DONG JIN , HAHN HOH GYU , CHOI KYUNG IL , NAM GHILSOO , SHIN KYE JUNG , KANG SOON BANG , ROH EUN JOO , SHIN DONG YUN , SEO SEON HEE , RHIM HYEWHON , KEUM GYO CHANG , KIM KEY-SUN , CHEONG CHAN SEONG , KIM EUNICE EUN-KYEONG , LEE CHEOLJU , KIM YOUNGSOO , CHOI KEE HYUN , NAM KEE DAL , PARK WOONG SEO , KANG YONG KOO , CHUNG HYE JIN
发明人： CHO YONG SEO , PAE AE NIM , CHOO HYUNAH , LEE JAE KYUN , OH YOU NA , SHIN HEE SUP , KIM DONG JIN , HAHN HOH GYU , CHOI KYUNG IL , NAM GHILSOO , SHIN KYE JUNG , KANG SOON BANG , ROH EUN JOO , SHIN DONG YUN , SEO SEON HEE , RHIM HYEWHON , KEUM GYO CHANG , KIM KEY-SUN , CHEONG CHAN SEONG , KIM EUNICE EUN-KYEONG , LEE CHEOLJU , KIM YOUNGSOO , CHOI KEE HYUN , NAM KEE DAL , PARK WOONG SEO , KANG YONG KOO , CHUNG HYE JIN
IPC分类号： C07D403/12
CPC分类号： C07D401/12 , A61K31/454
摘要： Disclosed are isoindolinone derivatives having inhibitory activity against T-type calcium channels, pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an active ingredient.
摘要翻译：公开了具有抑制T-型钙通道活性的异吲哚啉酮衍生物，其药学上可接受的盐，其制备方法以及包含其作为活性成分的药物组合物。

2. 发明申请

WO2012115446A2 COMPOUND BASED ON 5-(SUBSTITUTED ALKYL-AMINOMETHYL) ISOXAZOLE ACTING AS A T-TYPE CALCIUM CHANNEL ANTAGONIST 审中-公开
标题翻译：基于5-（取代的烷基氨基甲酰基）异噻唑作为T型钙通道拮抗剂的化合物
公开(公告)号：WO2012115446A2
公开(公告)日：2012-08-30
申请号：PCT/KR2012001340
申请日：2012-02-22
申请人： KOREA INST SCI & TECH , CHOO HYUN AH , PAE AE NIM , CHO YONG SEO , LEE HYO SEON , LEE JIE EUN , CHO GYEONG HI , RHIM HYE WHON , SEO SEON HEE , SONG CHI MAN , CHUNG HYE JIN , NAM GHIL SOO , KEUM GYO CHANG , KIM DONG JIN , CHOI KYUNG IL , CHOI KEE HYUN , LEE JAE KYUN , KANG YONG KOO , PARK WOONG SEO , LEE JU HYEON , SHIN SUN MI , AHMED ABDUL WAHEED , KIM YOUNG SOO , MIN SUN JOON
发明人： CHOO HYUN AH , PAE AE NIM , CHO YONG SEO , LEE HYO SEON , LEE JIE EUN , CHO GYEONG HI , RHIM HYE WHON , SEO SEON HEE , SONG CHI MAN , CHUNG HYE JIN , NAM GHIL SOO , KEUM GYO CHANG , KIM DONG JIN , CHOI KYUNG IL , CHOI KEE HYUN , LEE JAE KYUN , KANG YONG KOO , PARK WOONG SEO , LEE JU HYEON , SHIN SUN MI , AHMED ABDUL WAHEED , KIM YOUNG SOO , MIN SUN JOON
IPC分类号： C07D413/12 , A61K31/497 , A61P25/00 , A61P35/00
CPC分类号： C07D413/12
摘要： The present invention relates to: a compound based on 5-(substituted alkyl-aminomethyl) isoxazole which exhibits pharmaceutical activity with respect to T-type calcium channels; a pharmaceutically acceptable salt thereof; a production method for such a compound; and to a pharmaceutical composition containing such a compound as an active ingredient.
摘要翻译：本发明涉及：基于相对于T型钙通道具有药物活性的基于5-（取代的烷基 - 氨基甲基）异恶唑的化合物; 其药学上可接受的盐; 这种化合物的制备方法; 以及含有这种化合物作为活性成分的药物组合物。

3. 发明公开

KR20120021370A 2-AZACYCLICAMINO-4-PHENYLPYRIMIDINE DERIVATIVES AS IKK-β INHIBITORS 有权
标题翻译： 2-AZACYCLICAMINO-4-PHYYLPYRIMIDINE DERIVATIVES AS IKK-ßINHIBITORS
公开(公告)号：KR20120021370A
公开(公告)日：2012-03-09
申请号：KR20100073077
申请日：2010-07-28
申请人： KOREA INST SCI & TECH
发明人： CHOO HYUN AH , PAE AE NIM , SHIN KYE JUNG , NAM GHIL SOO , ROH EUN JOO , CHO YONG SEO , KIM SO RA , JUNG JIN KYO , CHUNG HYE JIN
IPC分类号： C07D401/12 , A61K31/506 , A61P29/00 , C07D403/12
摘要： PURPOSE: A 2-azacyclicamino-4-phenylpyrimidine derivative is provided to treat and prevent inflammatory disease such as rheumatoid arthritis and asthma. CONSTITUTION: A 2-azacyclic amino-4-phenylpyrimidine compound is denoted by chemical formula 1. A pharmaceutical composition for treating inflammatory diseases or cancer contains the compound of chemical formula 1 as an active ingredient. The inflammatory diseases are rheumatoid arthritis, degenerative arthritis, asthma, or chronic obstructive pulmonary disease.
摘要翻译：目的：提供2-氮杂环氨基-4-苯基嘧啶衍生物，以治疗和预防类风湿性关节炎和哮喘等炎性疾病。构成：2-氮杂环丁基-4-苯基嘧啶化合物由化学式1表示。用于治疗炎性疾病或癌症的药物组合物含有化学式1的化合物作为活性成分。炎性疾病是类风湿性关节炎，退行性关节炎，哮喘或慢性阻塞性肺疾病。

4. 发明申请

WO2012121577A2 COMPOSITION FOR STRENGTHENING TISSUE REGENERATIVE POWER OF STEM CELL HAVING PTEN 审中-公开
标题翻译： PTEN增强干细胞组织增殖力的组分
公开(公告)号：WO2012121577A2
公开(公告)日：2012-09-13
申请号：PCT/KR2012001795
申请日：2012-03-12
申请人： UNIV EWHA IND COLLABORATION , LEE SEUNG JIN , JUNG MI RA , SHIM IN KYUNG , PARK YOON JEONG , KIM JONG SEOK , YANG YOUNG IL , CHUNG HYE JIN
发明人： LEE SEUNG JIN , JUNG MI RA , SHIM IN KYUNG , PARK YOON JEONG , KIM JONG SEOK , YANG YOUNG IL , CHUNG HYE JIN
IPC分类号： C07K19/00 , C12N5/074
CPC分类号： C12N5/0667 , C07K14/4703 , C07K2319/10 , C12N9/16 , C12N2501/73
摘要： The present invention relates to a composition for strengthening the tissue regenerative power of a stem cell, the composition including PTEN, a kit for tissue regeneration, method for preparing a stem cell having strengthened tissue regenerative power using PTEN, and a method for regenerating a tissue. In addition, the present invention relates to a method for restoring a stem cell to a previous passage status using PTEN, a method for delaying the aging of a stem cell, and a composition for rejuvenating a stem cell, the composition including PTEN. The present invention resolves the problem of the decrease in the tissue regenerative power, auto regenerative power, and differentiation potency, which occurs due to an increase in the passage frequency, and secures multiple high quality stem cells outside the body.
摘要翻译：本发明涉及用于增强干细胞的组织再生能力的组合物，包含PTEN的组合物，用于组织再生的试剂盒，使用PTEN制备具有增强的组织再生能力的干细胞的方法，以及用于再生组织再生的方法。另外，本发明涉及使用PTEN将干细胞恢复至先前的传代状态的方法，用于延迟干细胞老化的方法以及用于使干细胞复壮的组合物，所述组合物包含PTEN。本发明解决了由于通过频率增加而发生的组织再生能力，自动再生能力和分化能力下降以及在体外确保多个高质量干细胞的问题。

5. 发明授权

KR101562321B1 램프점등 기능을 갖는 방범창 有权
标题翻译：带灯光功能的防盗窗
公开(公告)号：KR101562321B1
公开(公告)日：2015-10-21
申请号：KR20150004533
申请日：2015-01-13
申请人： CHUNG HYE JIN
发明人： CHUNG HYE JIN
IPC分类号： E06B5/11 , E06B3/663
CPC分类号： E06B5/11 , E06B3/66376
摘要： 이발명은램프점등기능을갖는방범창에관한것으로, 보다상세하게는방범창에 LED램프를구성하고, 외부침입자에의해방범창에설치된방범망에충격이가해지면 LED램프를점등하여, 무단침입상황을시각적으로주위에알리고외부침입자에게시각적충격효과를가함으로써, 외부침입자의침입시도중단을유도할수 있도록한 것이다. 특히, 이발명은방범망에가해지는충격량에따라안전, 주의및 경고상황으로구분하여판단하고, 각상황별로 LED램프의소등, 점등, 점멸, 밝기를제어함으로써, 주위에현재상황을보다명확히알림과동시에외부침입자에대한시각적충격효과를보다향상시킬수 있다. 따라서, 방범시스템분야, 특히방범창을이용한침입자방지분야는물론, 쇼윈도우나출입문등의각종창호의방범기능적용분야등의유사내지연관된분야에서신뢰성및 경쟁력을향상시킬수 있다.
摘要翻译：本发明涉及具有灯照明功能的防止犯罪窗口，更具体地，涉及通过对外部入侵者施加视觉冲击效应并且通过向外部入侵者视觉通知侵入情况的周围环境来防止外部入侵者入侵尝试中断的防止窗口在通过在防止犯罪的窗口中形成LED灯对外部入侵者施加的防止犯罪预防网络的防止网络施加影响时照亮LED灯。本发明通过根据施加到防止犯罪网络的影响量确定分为安全性，警戒性和警告性状况，明确地通知周围环境了解当前情况并改善对外来入侵者的视觉冲击效应并且通过每种情况控制LED灯的熄灭，亮起，闪烁和亮度。因此，本发明具有提高可靠性和竞争力的效果，不仅在犯罪预防系统领域，特别是在使用防止犯罪窗口的入侵者预防系统领域中，而且在各种窗口的防范功能应用领域，例如展示窗或入口等。

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