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1. 发明申请

WO2012026748A2 PHARMACEUTICAL COMPOSITION CONTAINING MELASTOMA SANGUINEUM EXTRACTS OR FRACTIONS THEREOF AS ACTIVE INGREDIENTS FOR PREVENTING AND TREATING DIABETIC COMPLICATIONS 审中-公开
标题翻译：含有MELASTOMA SANGUINEUM提取物或其组分作为有效成分用于预防和治疗糖尿病并发症的药物组合物
公开(公告)号：WO2012026748A2
公开(公告)日：2012-03-01
申请号：PCT/KR2011006231
申请日：2011-08-23
申请人： KOREA INST ORIENTAL MEDICINE , KIM JIN SOOK , KIM JUNGHYUN , KIM CHAN-SIK , KIM YOUNG SOOK , KIM OHN SOON , KIM KI MO , SHON EUNJIN , JUNG DONG HO , LEE YUN MI
发明人： KIM JIN SOOK , KIM JUNGHYUN , KIM CHAN-SIK , KIM YOUNG SOOK , KIM OHN SOON , KIM KI MO , SHON EUNJIN , JUNG DONG HO , LEE YUN MI
IPC分类号： A61K36/185 , A61P3/00 , A61P3/10
CPC分类号： A61K36/185 , A61K2236/35
摘要： The present invention relates to a composition containing Melastoma sanguineum extracts or fractions thereof as active ingredients for preventing or treating diabetic complications. More particularly, Melastoma sanguineum extracts, or ethyl acetate fractions and n-butanol fractions which are systematic fractions thereof, inhibit the formation of advanced glycation end-products as well as the activity of aldose reductases, which may serve as an index of the onset of diabetic complications. The Melastoma sanguineum extracts or ethyl acetate fractions and n-butanol fractions have the effects of potently inhibiting vasodilatation caused by hyperglycemia in zebrafish, which are vertebrates, and inhibiting diabetic complications when administered to animal models for diabetic disease. Therefore, the Melastoma sanguineum extracts or ethyl acetate fractions and n-butanol fractions, which are systematic fractions thereof, according to the present invention may be used as active ingredients for a pharmaceutical composition for preventing and treating diabetic complications.
摘要翻译：本发明涉及一种含有血细胞弹性蛋白（melastoma sanguineum）提取物或其部分作为活性成分用于预防或治疗糖尿病并发症的组合物。更具体地说，作为系统级分的乙酰胆碱提取物或乙酸乙酯馏分和正丁醇馏分抑制晚期糖基化终产物的形成以及醛糖还原酶的活性，醛糖还原酶的活性可以作为糖尿病并发症当用于糖尿病疾病的动物模型中时，白僵菌提取物或乙酸乙酯部分和正丁醇部分具有有效抑制由斑马鱼（其为脊椎动物）中的高血糖引起的血管舒张作用并且抑制糖尿病并发症的作用。因此，根据本发明，作为其系统性部分的血细胞弹性蛋白提取物或乙酸乙酯部分和正丁醇部分可用作用于预防和治疗糖尿病并发症的药物组合物的活性成分。

2. 发明申请

WO2008020709A9 COMPOSITION AND FUNCTIONAL FOOD FOR PREVENTION AND TREATMENT OF DIABETIC COMPLICATIONS 审中-公开
标题翻译：用于预防和治疗糖尿病综合症的组合物和功能食品
公开(公告)号：WO2008020709A9
公开(公告)日：2008-05-29
申请号：PCT/KR2007003903
申请日：2007-08-14
申请人： KOREA INST ORIENTAL MEDICINE , KIM JIN SOOK , JANG DAE SIK , LEE YUN MI , KIM JONG MIN , KIM YOUNG SOOK , SOHN EUN JIN , KIM CHAN SIK , LEE GA YOUNG , CHEUG DONG HO
发明人： KIM JIN SOOK , JANG DAE SIK , LEE YUN MI , KIM JONG MIN , KIM YOUNG SOOK , SOHN EUN JIN , KIM CHAN SIK , LEE GA YOUNG , CHEUG DONG HO
IPC分类号： A61K36/482 , A23L33/00 , A61P3/08
CPC分类号： A61K36/482 , A23L33/105 , A23V2002/00 , A23V2200/328 , A23V2250/21
摘要： Disclosed herein are a composition and functional food for preventing or treating diabetic complications, which contain, as an active ingredient, a n-butanol fraction obtained by successively fractionating Cassiae Semenextract. The n-butanol fraction, obtained by successively fractionating the Cassiae Semen extract, has a blood glucose lowering effect and significantly improves proteinuria and creatinine clearance (CCr). Also, it significantly increases or reduce many relevant factors, including VEGF mRNA, ET-I mRNA, ECE mRNA, TGF-ßl, type III collagen mRNA, a PKCa/ßll protein, an eNOS protein, a type IV collagen protein, an AGE protein, a RAGE protein, etc., which are abnormally expressed in the kidneys due to chronic diabetes and appear on the onset of diabetic complications caused by chronic hyperglycemia. Accordingly, the disclosed n-butanol fraction, obtained by successively fractionating the Cassiae Semen extract, may be used in compositions and functional foods for the prevention or treatment of diabetic complications.
摘要翻译：本文公开了用于预防或治疗糖尿病并发症的组合物和功能性食品，其包含通过连续分馏焦糖精液得到的正丁醇级分作为活性成分。通过连续分馏焦糖提取物获得的正丁醇级分具有降血糖作用，显着提高蛋白尿和肌酐清除率（CCr）。此外，它显着增加或减少许多相关因素，包括VEGF mRNA，ET-I mRNA，ECE mRNA，TGF-β1，III型胶原mRNA，PKCa /βII蛋白，eNOS蛋白，IV型胶原蛋白，AGE 蛋白质，RAGE蛋白等，其由于慢性糖尿病在肾脏中异常表达，并且出现在由慢性高血糖引起的糖尿病并发症发作。因此，通过连续分选焦糖精萃取物获得的所公开的正丁醇级分可用于预防或治疗糖尿病并发症的组合物和功能性食品中。

3. 发明申请

WO2012023803A3 COMPOSITION FOR PREVENTING AND TREATING COMPLICATIONS OF DIABETES MELLITUS, CONTAINING BRANDISIA HANCEI HOOK. F. EXTRACT OR FRACTION THEREOF AS ACTIVE INGREDIENT 审中-公开
标题翻译：用于预防和治疗包含BRANDISIA HANCEI HOOK的糖尿病综合征的组合物。 F.作为主动成分的提取或分类
公开(公告)号：WO2012023803A3
公开(公告)日：2012-05-03
申请号：PCT/KR2011006046
申请日：2011-08-17
申请人： KOREA INST ORIENTAL MEDICINE , KIM JIN SOOK , KIM JUNGHYUN , KIM CHAN-SIK , KIM YOUNG SOOK , KIM OHN SOON , KIM KI MO , SHON EUNJIN , JUNG DONG HO , LEE YUN MI
发明人： KIM JIN SOOK , KIM JUNGHYUN , KIM CHAN-SIK , KIM YOUNG SOOK , KIM OHN SOON , KIM KI MO , SHON EUNJIN , JUNG DONG HO , LEE YUN MI
IPC分类号： A61K36/80 , A61P3/00 , A61P3/10
CPC分类号： A61K36/64
摘要： The present invention relates to a composition for preventing and treating complications of diabetes mellitus, containing a Brandisia hancei Hook. f. extract or a fraction thereof as an active ingredient. More specifically, a Brandisia hancei Hook. f. extract or a fraction thereof inhibits the generation of an advanced glycation end product, which is an indicator of diabetes mellitus complications, and the activity of aldose reductase, and is strongly effective for complications of diabetes mellitus including diabetic retinopathy,and thus can be useful as an active ingredient of a composition for preventing and treating complications of diabetes mellitus.
摘要翻译：本发明涉及用于预防和治疗含有白念珠菌钩虫的糖尿病并发症的组合物。 F。提取物或其一部分作为活性成分。更具体地说，是一个布兰迪丝hancei Hook。 F。提取物或其一部分抑制作为糖尿病并发症的指标的晚期糖基化终产物的产生和醛糖还原酶的活性，并且对包括糖尿病性视网膜病变在内的糖尿病并发症是有效的，因此可用于用于预防和治疗糖尿病并发症的组合物的活性成分。

4. 发明申请

WO2012121423A8 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING COMPLICATIONS OF DIABETES CONTAINING A TRADITIONAL ORIENTAL MEDICINE EXTRACT OR A FRACTION THEREOF AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：用于预防和治疗包含传统医学提取物的糖尿病或其作为活性成分的分类的药物组合物
公开(公告)号：WO2012121423A8
公开(公告)日：2013-09-26
申请号：PCT/KR2011000896
申请日：2011-03-07
申请人： KOREA INST ORIENTAL MEDICINE , KIM JIN SOOK , KIM JUNG HYUN , KIM YOUNG SOOK , KIM CHAN-SIK , KIM OHN SOON , SHON EUN JIN , YOO NAM-HEE , LEE YUN MI , JUNG DONG HO
发明人： KIM JIN SOOK , KIM JUNG HYUN , KIM YOUNG SOOK , KIM CHAN-SIK , KIM OHN SOON , SHON EUN JIN , YOO NAM-HEE , LEE YUN MI , JUNG DONG HO
IPC分类号： A61K36/47 , A23L33/00 , A61P3/10 , A61P17/00 , A61P35/00
CPC分类号： A61K36/00 , A23C2240/15 , A23K20/10 , A23K50/10 , A23K50/30 , A23K50/75 , A23L2/52 , A23L13/426 , A23L23/00 , A23L29/03 , A23L33/105 , A61K36/47
摘要： The present invention relates to a pharmaceutical composition for preventing and treating complications of diabetes containing Homonoia riparia Lour. extract or a fraction thereof as an active ingredient, and, more specifically, the Homonoia riparia Lour. extract or the fraction thereof suppresses the action of aldose reductase and the production of advanced glycosylated end products which are indicators of complications of diabetes, and exhibits a powerful action in suppressing complications of diabetes via its effects in countering cataracts, retinopathy and nephropathy, and thus can be used to advantage as an active ingredient in a pharmaceutical composition for preventing and treating complications of diabetes.
摘要翻译：本发明涉及用于预防和治疗含有Homonoia riparia Lour的糖尿病并发症的药物组合物。提取物或其一部分作为活性成分，更具体地说，是同源鬣蜥。提取物或其部分抑制醛糖还原酶的作用和作为糖尿病并发症指标的晚期糖基化终产物的产生，并且通过其对抗白内障，视网膜病变和肾病的效果，显示出抑制糖尿病并发症的强大作用，因此可用作用于预防和治疗糖尿病并发症的药物组合物中的活性成分。

5. 发明申请

WO2012021035A3 COMPOSITION FOR PREVENTING AND TREATING DIABETES COMPLICATIONS CONTAINING LITSEA JAPONICA EXTRACT OR FRACTION THEREOF AS ACTIVE INGREDIENT 审中-公开
标题翻译：用于预防和治疗含有LIASEA JAPONICA提取物或其作为活性成分的糖尿病综合症的组合物
公开(公告)号：WO2012021035A3
公开(公告)日：2012-05-10
申请号：PCT/KR2011005963
申请日：2011-08-12
申请人： KOREA INST ORIENTAL MEDICINE , KIM JIN SOOK , KIM JUNG HYUN , KIM YOUNG SOOK , SHON EUN JIN , KIM CHAN-SIK , KIM KI MO , KIM OHN SOON , LEE YUN MI , LEE YOUNG SEOP
发明人： KIM JIN SOOK , KIM JUNG HYUN , KIM YOUNG SOOK , KIM CHAN-SIK , KIM KI MO , KIM OHN SOON , LEE YUN MI , LEE YOUNG SEOP
IPC分类号： A61K36/54 , A61P3/00 , A61P3/10
CPC分类号： A61K36/54
摘要： The present invention relates to a composition for preventing and treating diabetes complications containing Litsea japonica extract or fractions thereof as an active ingredient, and more particularly, to Litsea japonica extract or fractions thereof for suppressing the generation of an advanced glycation end product, which is an indicator of diabetes complications, and the activity of aldose reductase, preventing diabetic eye diseases (diabetic cataract and retinopathy) that are early symptoms of diabetes complications and the loss of podocytes, wherein decreasing expression of nephrin, which is a slit diagram protein that plays an important role in podocyte functions, is suppressed in particular, thereby rendering the present invention useful as the active ingredient in the composition for preventing and treating diabetes complications including diabetic nephropathy.
摘要翻译：本发明涉及用于预防和治疗含有蓟马提取物或其部分作为活性成分的糖尿病并发症的组合物，更具体地，涉及用于抑制晚期糖基化终产物的产生的日本粳稻提取物或其部分，其为糖尿病并发症的指标和醛糖还原酶的活性，预防作为糖尿病并发症的早期症状和足细胞丧失的糖尿病性眼病（糖尿病性白内障和视网膜病变），其中降低表达，其为缝隙图蛋白足细胞功能的重要作用被特别抑制，从而使本发明用作预防和治疗包括糖尿病性肾病的糖尿病并发症的组合物中的活性成分。

6. 发明申请

WO2012021013A3 NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARING NOVEL BIPHENYL COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTING OR TREAT 审中-公开
标题翻译：新的联苯基化合物或其药学上可接受的盐，制备新型联苯基化合物或其药物可接受的盐的方法，以及含有该化合物作为活性成分的药物组合物用于预防或治疗
公开(公告)号：WO2012021013A3
公开(公告)日：2012-04-19
申请号：PCT/KR2011005913
申请日：2011-08-11
申请人： KOREA INST ORIENTAL MEDICINE , KIM JIN SOOK , KIM YOUNG SOOK , KIM JUNG HYUN , SHON EUN JIN , KIM KI MO , KIM CHAN-SIK , JUNG DONG HO , LEE YUN MI , JO KYU HYUNG , KIM OHN SOON , YOO NAM-HEE
发明人： KIM JIN SOOK , KIM YOUNG SOOK , KIM JUNG HYUN , SHON EUN JIN , KIM KI MO , KIM CHAN-SIK , JUNG DONG HO , LEE YUN MI , JO KYU HYUNG , KIM OHN SOON , YOO NAM-HEE
IPC分类号： C07C43/23 , A23L33/00 , A61K36/73 , A61P3/10 , C07C33/26
CPC分类号： C07C43/23 , A21D2/24 , A23C2240/15 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K36/73 , C07C41/38 , A23V2200/328 , A23V2250/156 , A23V2250/70
摘要： The present invention aims to provide a novel biphenyl compound or a pharmaceutically acceptable salt thereof, a method for preparing the novel biphenyl compound or pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing same as an active ingredient for preventing or treating diabetes complications. The novel biphenyl compound, according to the present invention, effectively suppresses generation activity of an advanced glycation end product, which causes diabetes complications and is a criterion for evaluating the effectiveness of a treating agent for diabetes complications, and shows effective treatment of retinal veins on the retina subject to diabetic retinopathy, increased occluding, and decreased angiogenesis growth factors, thereby rendering the novel biphenyl compound invention useful as an active ingredient in a composition for preventing or treating diabetes complications such as diabetic retinopathy.
摘要翻译：本发明的目的是提供一种新的联苯化合物或其药学上可接受的盐，该新型联苯化合物或其药学上可接受的盐的制备方法，以及含有该联苯化合物或其药学上可接受的盐作为用于预防或治疗糖尿病并发症的活性成分的药物组合物。根据本发明的新型联苯化合物有效地抑制引起糖尿病并发症的晚期糖基化终产物的生成活性，并且是评价治疗剂对于糖尿病并发症的有效性的标准，并且显示出对视网膜静脉的有效治疗受到糖尿病性视网膜病变的视网膜，增加的闭塞和降低的血管生成生长因子，从而使该新型联苯化合物发明可用作用于预防或治疗糖尿病并发症如糖尿病性视网膜病的组合物中的活性成分。

7. 发明申请

WO2012021038A2 COMPOSITION FOR PREVENTING AND TREATING DIABETES COMPLICATIONS INCLUDING SPENCERIA RAMALANA EXTRACT OR FRACTION THEREOF AS ACTIVE INGREDIENT 审中-公开
标题翻译：用于预防和治疗糖尿病综合症的组合物，包括作为活性成分的SPENCERIA RAMALANA提取物或其分类
公开(公告)号：WO2012021038A2
公开(公告)日：2012-02-16
申请号：PCT/KR2011005968
申请日：2011-08-12
申请人： KOREA INST ORIENTAL MEDICINE , KIM JIN SOOK , KIM JUNG HYUN , KIM YOUNG SOOK , SHON EUN JIN , KIM KI MO , KIM OHN SOON , JUNG DONG HO , KIM CHAN-SIK , LEE YUN MI , LEE YOUNG SEOP
发明人： KIM JIN SOOK , KIM JUNG HYUN , KIM YOUNG SOOK , SHON EUN JIN , KIM KI MO , KIM OHN SOON , JUNG DONG HO , KIM CHAN-SIK , LEE YUN MI , LEE YOUNG SEOP
IPC分类号： A61K36/73 , A61P3/00 , A61P3/10
CPC分类号： A61K36/73
摘要： The present invention relates to a composition for preventing and treating diabetes complications including Speceria ramalana extract or fractions thereof as an active ingredient, and more particularly, to Spenceria ramalana extract or fractions thereof, which suppresses the generation of an advanced glycation end product, which is an indicator of diabetes complications, suppresses the activity of aldose reductase, and shows effective and significant prevention and treatment of diabetic retinopathy, thereby rendering the present invention useful as the active ingredient in the composition for preventing and treating various diabetes complications including diabetic retinopathy.
摘要翻译：本发明涉及一种用于预防和治疗糖尿病并发症的组合物，其包括作为活性成分的芥兰提取物或其部分，更具体地，涉及抑制晚期糖基化终产物的产生的Spenceria ramalana提取物或其部分，其是糖尿病并发症的指标，抑制醛糖还原酶的活性，并且显示出有效和显着地预防和治疗糖尿病性视网膜病变，从而使得本发明可用作预防和治疗包括糖尿病性视网膜病变的各种糖尿病并发症的组合物中的活性成分。

8. 发明专利

CA2703130C EXTRACTS OF ASTER KORAIENSIS, AND PHARMACEUTICAL COMPOSITION AND FUNCTIONAL FOOD COMPRISING THE SAME 未知
公开(公告)号：CA2703130C
公开(公告)日：2016-12-13
申请号：CA2703130
申请日：2008-03-07
申请人： KOREA INST ORIENTAL MEDICINE
发明人： KIM JIN SOOK , JANG DAE SIK , LEE YUN MI , KIM JONG MIN , KIM YOUNG SOOK , SHON EUN JIN , KIM CHAN SIK , KIM JUNG HYUN , KIM OHN SOON , JUNG DONG HO , KIM JOO HWAN
IPC分类号： A61K36/28
摘要： Disclosed herein are a leaf and stem extract of Aster koraiensis, a root extract of Aster koraiensis, a flower extract of Aster koraiensis, a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, in which each of the compositions and the foods contain, as an active ingredient, at least one of said Aster koraiensis extracts. Each of the extracts is obtained by drying and finely cutting each of the leaf and stem part, root and flower of Aster koraiensis, extracting the cut plant with alcohol or aqueous alcohol solution, filtering the extracted solution and concentrating the filtrate under reduced pressure. Also disclosed are a pharmaceutical composition for the prevention or treatment of diabetic complications, a health functional food for the improvement of diabetic complications, and a pharmaceutical composition and health functional food for the prevention or delay of aging, which contain, as an active ingredient, at least one of fractions obtained by fractionating each of said Aster koraiensis extracts in the order of hexane, ethyl acetate, n-butanol and water fractions. The leaf and stem extract of Aster koraiensis, the root extract of Aster koraiensis and the flower extract of Aster koraiensis have the effect of inhibiting the production of advanced glycation endproducts (AGEs), the causes of diabetic complications, and effectively inhibit aldose redductase (AR) activity. Thus, the disclosed extracts will be highly useful for the prevention or treatment of diabetic complications and the prevention of aging.

9. 发明专利

ES2865478T3 Composición farmacéutica para prevenir o tratar la degeneración macular que contiene extracto de mezcla natural como ingrediente activo 未知
公开(公告)号：ES2865478T3
公开(公告)日：2021-10-15
申请号：ES15796502
申请日：2015-05-21
申请人： KOREA INST ORIENTAL MEDICINE
发明人： KIM JIN SOOK , KIM JUNGHYUN , KIM CHAN-SIK , SHON EUNJIN , LEE YUN MI , CHOI SOJIN , LEE IK SOO , KIM YOUNG SOOK , JUNG DONG HO , PYUN BO-JEONG , JUNG SEUNG-HYUN
IPC分类号： A61K36/54 , A61K36/65 , A61P3/00 , A61P3/10 , A61P9/00 , A61P35/00
摘要： Una composición farmacéutica para su uso en la prevención o el tratamiento de la degeneración macular, que contiene un ingrediente activo que consiste en un extracto de una mezcla de ramita de canela y corteza de raíz de peonía, o ramita de canela y raíz de peonía.

10. 发明专利

HK1170958A1 COMPOSITIONS FOR TREATMENT AND PREVENTION OF DIABETIC COMPLICATIONS USING OSTEOMELES SCHWERINAE 未知
公开(公告)号：HK1170958A1
公开(公告)日：2013-03-15
申请号：HK12111929
申请日：2012-11-22
申请人： KOREA INST ORIENTAL MEDICINE
发明人： KIM JIN SOOK , JANG DAE SIK , KIM YOUNG SOOK , LEE YUN MI , KIM JOO-HWAN , SHON EUNJIN , KIM JUNGHYUN , KIM CHAN-SIK , JUNG DONG HO , KIM NAN HEE , YOO NAM-HEE , LEE JUN
IPC分类号： A61K20060101 , A23L20060101 , A61P20060101

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