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1. 发明申请

WO2012102511A2 GINGER EXTRACT PRODUCTION METHOD AND GINGER EXTRACT OBTAINED THEREBY 审中-公开
标题翻译： GINGER提取生产方法和获得的GINGER提取物
公开(公告)号：WO2012102511A2
公开(公告)日：2012-08-02
申请号：PCT/KR2012000437
申请日：2012-01-18
申请人： KOREA HEALTH INDUSTRY DEV INST KHIDI , UNIV KEIMYUNG IACF , YANG SEUN AH , CHOI HEE DON , LEE EUN JU , JEONG YEON SEOP , IM HYO GWON , LEE SAM PIN , KIM MIN JU , KIM HYUNG DAE
发明人： YANG SEUN AH , CHOI HEE DON , LEE EUN JU , JEONG YEON SEOP , IM HYO GWON , LEE SAM PIN , KIM MIN JU , KIM HYUNG DAE
IPC分类号： A23L27/10 , A23L33/00 , A61K36/906 , C11B1/10
CPC分类号： A61K36/9068 , A23L33/105 , A23V2002/00 , A61K2236/37 , A23V2200/30 , A23V2250/21
摘要： The present invention relates to a supercritical extraction method and to a method for producing ginger extract which has a potent anti-inflammatory effect by using the lees which remain after the extraction and to a ginger extract obtained thereby. More specifically, a method is provided for obtaining an extract with a high gingerol content while not only making it possible to either remove or complement the specific taste and smell of ginger but also affording a high extraction yield in a short time, by subjecting ginger powder to supercritical extraction at a temperature of between 35 and 55°C and a pressure of between 100 and 400 bar at a flow rate of between 1 and 3 mL/min for between 1 and 3 hours, using supercritical carbon dioxide. Also, provided is a method for obtaining a ginger extract having potent anti-inflammatory and anti-allergy activity through the use of ginger lees, by adding 60 to 90% alcohol to the lees which remain after the supercritical extraction, in an amount of between 5 and 15 times (w/v) the weight of the ginger lees, and allowing to stand for between 6 and 36 hours at room temperature.
摘要翻译：本发明涉及一种超临界提取方法和生姜姜提取物的制备方法，所述姜提取物通过使用在提取后保留的韭菜和由此得到的姜提取物具有有效的抗炎作用。更具体地说，提供一种获得高姜油含量的提取物的方法，而不仅可以去除或补充姜的特定味道和气味，而且在短时间内提供高提取产率，通过将姜粉使用超临界二氧化碳，以1-3mL / min的流速在35至55℃的温度和100-400巴的压力下超临界萃取1至3小时。此外，提供了通过使用生姜汁获得具有有效的抗炎和抗过敏活性的姜提取物的方法，通过向超临界提取后残留的by料中加入60至90％的醇，其量为 5和15次（w / v）姜汁的重量，并允许在室温下放置6至36小时。

2. 发明申请

WO2010110579A3 PERFUME AND COSMETIC COMPOSITION WITH ANTI-STRESS AND RELAXING EFFECT 审中-公开
标题翻译：香料和化妆品组合物具有抗应力和放松效应
公开(公告)号：WO2010110579A3
公开(公告)日：2011-02-24
申请号：PCT/KR2010001772
申请日：2010-03-23
申请人： AMOREPACIFIC CORP , LEE EUN JU , SEO HYUNG JYE , JEON BYEONG BAE
发明人： LEE EUN JU , SEO HYUNG JYE , JEON BYEONG BAE
IPC分类号： A61K8/92 , A61K8/97 , A61Q13/00
CPC分类号： A61Q13/00 , A61K8/922 , A61Q19/00
摘要： Disclosed is a perfume composition including grapefruit oil and bergamot oil and further including one or more selected from a group consisting of pine oil, lemon oil, cypress oil, rose oil and armoise oil. The perfume composition is useful in the field of beauty care, cosmetics, or the like.
摘要翻译：公开了包含葡萄柚油和香柠檬油的香料组合物，还包括选自由松油，柠檬油，柏油，玫瑰油和武装油组成的组中的一种或多种。香水组合物可用于美容，化妆品等领域。

3. 发明申请

WO2011043629A2 METHOD OF INDUCING HIGH ACTIVITY OF HUMAN ADIPOSE STEM CELL AND MEDIUM THEREFOR 审中-公开
标题翻译：诱导人脂肪干细胞高活性及其培养基的方法
公开(公告)号：WO2011043629A2
公开(公告)日：2011-04-14
申请号：PCT/KR2010006911
申请日：2010-10-08
申请人： SEOUL NAT UNIV HOSPITAL , KIM HYO SOO , KANG HYUN JAE , LEE EUN JU
发明人： KIM HYO SOO , KANG HYUN JAE , LEE EUN JU
IPC分类号： C12N5/071 , C12N5/02
CPC分类号： C12N5/0667 , C12N2500/36 , C12N2502/1305
摘要： The present invention relates to a method of inducing high activity of human adipose stem cells, highly active stem cells induced by the method, cell therapeutic agents comprising the highly active stem cells, and a medium for inducing high activity of human adipose stem cells. According to the present invention, if culture conditions are not appropriate for matured human adipocytes, securing adipocytes is difficult, or adipocytes become diseased, the method of the present invention enables a long-term culture of human adipose stem cells maintaining high activity and production of a high yield of stem cells maintaining differentiation potency by in vitro culture.
摘要翻译：本发明涉及诱导人脂肪干细胞高活性的方法，由该方法诱导的高活性干细胞，包含高活性干细胞的细胞治疗剂和用于诱导人脂肪干细胞高活性的培养基。根据本发明，如果培养条件不适合成熟的人类脂肪细胞，确保脂肪细胞困难或脂肪细胞变得病态，本发明的方法使人类脂肪干细胞的长期培养能够保持高活性和产生高产量的干细胞通过体外培养保持分化能力。

4. 发明申请

WO2012165831A3 AROMATIC COMPOSITION HAVING STRESS-RELIEVING AND RELAXING EFFECTS AND COSMETIC COMPOSITION CONTAINING SAME 审中-公开
标题翻译：具有应力消除和放松效果的芳香组合物和含有其的化妆品组合物
公开(公告)号：WO2012165831A3
公开(公告)日：2013-03-28
申请号：PCT/KR2012004212
申请日：2012-05-29
申请人： AMOREPACIFIC CORP , LEE EUN JU , SEO HYUNG JAE
发明人： LEE EUN JU , SEO HYUNG JAE
IPC分类号： A61K8/97 , A61Q19/00
CPC分类号： A61K8/922 , A61Q19/00
摘要： The present invention relates to an aromatic composition, and to a cosmetic composition containing same, the aromatic composition comprising, as an active ingredient, at least one natural oil selected from the group consisting of patchouli oil, frankincense, and sandalwood oil. The composition has physiological and psychological treatment effects, stress-relieving effects, tension-relieving effects, calming effects, emotionally-stabilizing effects, and relaxing effects, and is thus variously applicable in the beauty and cosmetic fields.
摘要翻译：本发明涉及一种芳香族组合物及含有该组合物的化妆品组合物，所述芳香族组合物含有选自广藿香油，乳香，檀香油中的至少一种天然油作为有效成分。该组合物具有生理和心理治疗作用，减轻压力，缓解作用，镇定效果，情绪稳定作用和放松效果，因此在美容和美容领域具有多种应用。

5. 发明申请

WO2010013906A3 METHOD FOR SEPARATING HIGHLY ACTIVE STEM CELLS FROM HUMAN STEM CELLS AND HIGHLY ACTIVE STEM CELLS SEPARATED THEREBY 审中-公开
标题翻译：从人类干细胞分离高活性干细胞和分离的高活性干细胞的方法
公开(公告)号：WO2010013906A3
公开(公告)日：2010-05-14
申请号：PCT/KR2009003954
申请日：2009-07-17
申请人： SEOUL NAT UNIV HOSPITAL , KIM HYO SOO , LEE EUN JU , KANG HYUN JAE , LEE HA NEUL , KIM KEUM HYUN
发明人： KIM HYO SOO , LEE EUN JU , KANG HYUN JAE , LEE HA NEUL , KIM KEUM HYUN
IPC分类号： C12N5/0775
CPC分类号： C12N5/0665 , C12N5/0662 , C12N2500/90
摘要： The present invention relates to a method for separating highly active stem cells from human stem cells, the highly active stem cells separated by the method, a cell therapeutic agent containing the stem cells, and a medium for separating the highly active stem cells from stem cells containing a specific cytokine. According to the present invention, the method is useful for separating the highly efficient stem cells from mesenchymal stem cells of various origins. Further, the method is very useful in developing a cell therapeutic agent of high efficiency because the method can be applicable to stem cells of various origins which are cultured under different conditions. Senescent stem cells increased by several passage times in vitro can be effectively sorted out, so the method can be used for reactivating the stem cells.
摘要翻译：本发明涉及从人类干细胞分离高活性干细胞的方法，通过该方法分离的高活性干细胞，含有干细胞的细胞治疗剂和用于从干细胞分离高活性干细胞的培养基含有特异性细胞因子。根据本发明，该方法可用于从各种来源的间充质干细胞分离高效的干细胞。此外，该方法在开发高效率的细胞治疗剂方面非常有用，因为该方法可适用于在不同条件下培养的各种来源的干细胞。衰老干细胞在体外增加数次传代次数可以有效地分选出来，因此该方法可用于再生干细胞。

6. 发明申请

WO2012138043A2 THERAPEUTIC COMPOSITION CONTAINING ENDOTHELIN AS AN ACTIVE COMPONENT 审中-公开
标题翻译：含有内皮素作为活性成分的治疗组合物
公开(公告)号：WO2012138043A2
公开(公告)日：2012-10-11
申请号：PCT/KR2011010320
申请日：2011-12-29
申请人： SEOUL NAT UNIV HOSPITAL , LEE EUN JU , KIM HYO SOO
发明人： LEE EUN JU , KIM HYO SOO
IPC分类号： A61K31/19 , A61P9/00 , A61P9/10
CPC分类号： A61K38/2278
摘要： The present invention relates to a composition for preventing or treating ischemic disease comprising endothelin or a nucleotide sequence encoding endothelin as an active ingredient, and more particularly to a composition for preventing or treating ischemic heart disease, myocardial infarction, angina pectoris, lower limb artery ischemia, distal limb ischemia and ischemic cerebrovascular disease, wherein the composition is administered by intramuscular injection. According to the present invention, administering endothelin-1 by intramuscular injection may efficiently inhibit the progress of ischemia, fibrosis and tissue necrosis, and induce angiogenesis, such that it is promising for preventing or treating the ischemic disease.
摘要翻译：本发明涉及用于预防或治疗缺血性疾病的组合物，其包含内皮素或编码内皮素作为活性成分的核苷酸序列，更具体地涉及用于预防或治疗缺血性心脏病，心肌梗死，心绞痛，下肢动脉缺血的组合物，远端肢体缺血和缺血性脑血管疾病，其中所述组合物通过肌内注射施用。根据本发明，通过肌内注射给予内皮素-1可有效抑制缺血，纤维化和组织坏死的进展，并诱导血管发生，从而有希望预防或治疗缺血性疾病。

7. 发明申请

WO2010117198A3 PRODUCTION PROCESS OF GENDER-SPECIFIC SERUM AND BIOMARKER USING THE SERUM 审中-公开
标题翻译：使用血清生产性别特异性血清和生物标志物的过程
公开(公告)号：WO2010117198A3
公开(公告)日：2010-12-23
申请号：PCT/KR2010002111
申请日：2010-04-06
申请人： IND ACADEMIC COOP , CHOI IN HO , LEE DONG MOK , CHANG JONG SOO , LEE HYUN JEONG , LEE EUN JU , PRATI BAJRACHARYA , SHIN YU MI
发明人： CHOI IN HO , LEE DONG MOK , CHANG JONG SOO , LEE HYUN JEONG , LEE EUN JU , PRATI BAJRACHARYA , SHIN YU MI
IPC分类号： G01N33/49 , C12Q1/68 , G01N33/15 , G01N33/92
CPC分类号： G01N33/92 , C12Q1/6883 , C12Q1/6888 , C12Q2600/124 , G01N33/743 , G01N2800/044
摘要： The present invention relates to a production process of a gender-specific serum and a biomarker using the serum. More specifically, the present invention uses a fatty acid that exhibits a specific expression pattern in a gender-specific serum as a biomarker not only for diagnosis of obesity or a disease related to obesity, but also for diagnosis of meat quality since the fatty acid promotes differentiation of muscle derived stem cells into adipose cells. In addition, the present invention can establish a research system studying the effects of steroid hormones on the cell culture by using sera separated from blood that is collected from individual mammal carcasses being disposed, and provide important clues for discovering a gene associated with the synthesis of steroid hormone and for developing treatments for human diseases. Further, the present invention may contribute to increased profits derived from producing high quality sera, a reduced cost with treatment for carcass wastes, and promotion of the eco-industry for reducing environmental hormones.
摘要翻译：本发明涉及性别特异性血清的生产方法和使用该血清的生物标志物。更具体而言，本发明使用在性别特异性血清中呈现特定表达模式的脂肪酸作为生物标志物，不仅用于诊断肥胖或与肥胖有关的疾病，而且用于肉质诊断，因为脂肪酸促进肌肉源干细胞分化为脂肪细胞。此外，本发明可以建立一种研究系统，该系统通过使用从处理的个体哺乳动物尸体采集的血液分离的血清来研究类固醇激素对细胞培养物的影响，并且提供了用于发现与合成有关的基因的重要线索类固醇激素和用于开发人类疾病的治疗。此外，本发明可以有助于增加生产高质量血清所获得的利润，减少处理屠体废物的成本，促进生态工业减少环境激素。

8. 发明申请

WO2010013906A2 METHOD FOR SEPARATING HIGHLY ACTIVE STEM CELLS FROM HUMAN STEM CELLS AND HIGHLY ACTIVE STEM CELLS SEPARATED THEREBY 审中-公开
标题翻译：从人体干细胞和高活性干细胞分离高活性干细胞的方法
公开(公告)号：WO2010013906A2
公开(公告)日：2010-02-04
申请号：PCT/KR2009003954
申请日：2009-07-17
申请人： SEOUL NAT UNIV HOSPITAL , KIM HYO SOO , LEE EUN JU , KANG HYUN JAE , LEE HA NEUL , KIM KEUM HYUN
发明人： KIM HYO SOO , LEE EUN JU , KANG HYUN JAE , LEE HA NEUL , KIM KEUM HYUN
IPC分类号： C12N5/0775
CPC分类号： C12N5/0665 , C12N5/0662 , C12N2500/90
摘要： The present invention relates to a method for separating highly active stem cells from human stem cells, the highly active stem cells separated by the method, a cell therapeutic agent containing the stem cells, and a medium for separating the highly active stem cells from stem cells containing a specific cytokine. According to the present invention, the method is useful for separating the highly efficient stem cells from mesenchymal stem cells of various origins. Further, the method is very useful in developing a cell therapeutic agent of high efficiency because the method can be applicable to stem cells of various origins which are cultured under different conditions. Senescent stem cells increased by several passage times in vitro can be effectively sorted out, so the method can be used for reactivating the stem cells.
摘要翻译：本发明涉及从人干细胞分离高活性干细胞的方法，通过该方法分离的高活性干细胞，含有该干细胞的细胞治疗剂和用于将高活性干细胞与干细胞分离的介质含有特定的细胞因子。根据本发明，该方法可用于从各种来源的间充质干细胞中分离高效干细胞。此外，该方法在开发高效率的细胞治疗剂方面非常有用，因为该方法可适用于在不同条件下培养的各种来源的干细胞。衰老干细胞体外传代几次后能够被有效分离出来，因此该方法可用于再生干细胞。

9. 发明申请

WO2012096461A3 COMPOSITION FOR SUSPENSION CULTURING OF STEM CELLS 审中-公开
标题翻译：用于悬挂培养干细胞的组合物
公开(公告)号：WO2012096461A3
公开(公告)日：2012-09-07
申请号：PCT/KR2011010159
申请日：2011-12-27
申请人： SEOUL NAT UNIV HOSPITAL , LEE EUN JU , KIM HYO SOO
发明人： LEE EUN JU , KIM HYO SOO
IPC分类号： C12N5/0775 , C07D213/72 , C12N5/02
CPC分类号： C12N5/0018 , A61K31/4409 , C12N5/0663 , C12N2501/727
摘要： The present invention relates to a composition for suppressing cell death of stem cells during suspension culturing, a composition for mass culturing of stem cells, and a method for suppressing cell death of stem cells during suspension culturing. The composition of the present invention can be usefully used for effective single suspension culturing of stem cells, particularly, mesenchymal stem cells, or used for mass suspension culturing under the circumstances in which cell aggregation does not occur.
摘要翻译：本发明涉及一种用于抑制悬浮培养期间干细胞的细胞死亡的组合物，用于干细胞的大规模培养的组合物，以及用于在悬浮培养期间抑制干细胞的细胞死亡的方法。本发明的组合物可有效地用于干细胞，特别是间充质干细胞的有效单悬液培养，或者在不发生细胞聚集的情况下用于大量悬浮培养。

10. 发明申请

WO2012043999A3 COSMETIC FOOD COMPOSITION FOR PREVENTING SKIN WRINKLES CAUSED BY PHOTOAGING 审中-公开
标题翻译：化妆品食品组合物，用于防止由照相引起的皮肤皱纹
公开(公告)号：WO2012043999A3
公开(公告)日：2012-05-31
申请号：PCT/KR2011006878
申请日：2011-09-16
申请人： CJ CHEILJEDANG CORP , LEE JIN HEE , HWANG SE HEE , CHANG JEONG HWA , LEE EUN JU , OHTO NOBUAKI
发明人： LEE JIN HEE , HWANG SE HEE , CHANG JEONG HWA , LEE EUN JU , OHTO NOBUAKI
IPC分类号： A23L33/00 , A61K8/97 , A61P17/16
CPC分类号： A61K8/97 , A23L33/105 , A61K8/602 , A61Q17/04 , A61Q19/08
摘要： The present invention relates to a cosmetic food composition having the effects of preventing and improving skin wrinkles caused by photoaging resulting from ultraviolet rays. More particularly, the present invention relates to a cosmetic food composition for oral administration, which contains two or more selected from starfruit leaf extracts, an enriched ginsenoside Rb1 fraction, and extracts from the bark of the maritime pine tree, and which has the effects of preventing skin wrinkles, degradation in skin elasticity, or the like caused by photoaging resulting from ultraviolet rays.
摘要翻译：本发明涉及具有防止和改善由紫外线引起的光老化引起的皮肤皱纹的作用的美容食品组合物。更具体地说，本发明涉及一种口服用化妆品食品组合物，其含有选自杨桃叶提取物，富集人参皂苷Rb1组分和海洋松树树皮提取物中的两种或更多种，并且具有防止由紫外线引起的光老化引起的皮肤皱纹，皮肤弹性降低等。

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