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    • 1. 发明申请
    • COMPOSITION FOR PROMOTING MEMORY AND LEARNING ABILITY
    • 促进记忆和学习能力的组合
    • WO2012036506A3
    • 2012-07-19
    • PCT/KR2011006853
    • 2011-09-16
    • KOREA FOOD RES INSTLEE CHANG-HOKIM IN-HOHAN DAE SEOKKIM YOUNG-EONPARK DONG-JUNCHOI JUN-HYEOKLEE HYE-SUNGCHO SUEONG-MOCK
    • LEE CHANG-HOKIM IN-HOHAN DAE SEOKKIM YOUNG-EONPARK DONG-JUNCHOI JUN-HYEOKLEE HYE-SUNGCHO SUEONG-MOCK
    • A61K36/282A61K36/235A61K36/31A61P25/00A61P25/28
    • A61K36/57A61K36/282A61K36/31A61K2300/00
    • The present invention relates to a composition for promoting memory or learning ability and to a composition for preventing and treating cognitive impairment, which comprise one, two or more plant extracts selected from the group consisting of Artemisia apiaceae extract, Illicium verum extract and Lepidium apefalum extract. The present invention has the effect of inhibiting neural cell damage, especially, neural cells of the basal part of the cerebrum by inhibiting acetylcholinesterase activity and through antioxidative activity (for example, inhibiting the generation of oxidative reactive species) and affinity for an NMDA receptor. The compositions of the present invention may have the effect of not only promoting memory or learning ability by protecting neural cells and preventing damage to neural cells but also of preventing and treating diseases caused by cognitive impairment. In addition, according to the present invention, Lepidium apefalum extract is provided as basic material for pharmaceuticals or food which has efficacy in promoting memory or learning ability or efficacy for preventing and treating cognitive impairment.
    • 本发明涉及用于促进记忆或学习能力的组合物,以及用于预防和治疗认知障碍的组合物,其包含选自青蒿提取物,八角茴香提取物和独行草提取物的一种,两种或更多种植物提取物 。 本发明通过抑制乙酰胆碱酯酶活性和通过抗氧化活性(例如,抑制氧化反应物质的生成)和对NMDA受体的亲和力而具有抑制神经细胞损伤,特别是大脑基部神经细胞的作用。 本发明的组合物不仅具有通过保护神经细胞和防止对神经细胞的损伤而促进记忆或学习能力的效果,而且还具有预防和治疗由认知障碍引起的疾病的效果。 此外,根据本发明,提供了独行草提取物作为用于具有促进记忆或学习能力的功效或用于预防和治疗认知障碍的功效的药物或食物的基础材料。