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1. 发明申请

WO2011081329A3 METHOD FOR DISCOVERING PHARMACOLOGICALLY ACTIVE SUBSTANCE OF NATURAL PRODUCTS USING HIGH RESOLUTION MASS SPECTROMETRY AND PHARMACOLOGICAL ACTIVITY TEST 审中-公开
标题翻译：使用高分辨质谱法和药理活性测试发现天然产物的药物活性物质的方法
公开(公告)号：WO2011081329A3
公开(公告)日：2011-11-17
申请号：PCT/KR2010008988
申请日：2010-12-15
申请人： KOREA BASIC SCIENCE INST , PARK KYU HWAN , KIM HYUN SIK , KWON KYUNG HOON , YOO JONG SHIN
发明人： PARK KYU HWAN , KIM HYUN SIK , KWON KYUNG HOON , YOO JONG SHIN
IPC分类号： G01N30/72 , B01D15/08 , G01N33/15
CPC分类号： G01N30/06 , G01N30/8686 , G01N30/96 , G01N33/6848 , G01N2030/8809 , G01N2030/8813 , G01N2500/00 , Y10T436/174614 , Y10T436/24 , Y10T436/25 , Y10T436/25375
摘要： Disclosed is a method for discovering pharmacologically active substances from natural products at high speed, including: obtaining an activity profile by testing pharmacological activity of a plurality of samples; obtaining a mass profile based on a mass spectrum resulting from analysis of the samples by mass spectrometry; and determining molecular weight of pharmacologically active substances by comparing and analyzing the activity profile and the mass profile. The disclosed method allows fast discovery of pharmacologically active substances by performing high resolution mass spectrometry for numerous components included in an extract sample of natural products and comparing with the activity test data. The information about the intensity of the activity of the pharmacologically active substances of the natural products allows effective utilization of the natural products.
摘要翻译：公开了一种从天然产物中高速发现药理活性物质的方法，包括：通过测试多个样品的药理活性来获得活性谱; 基于通过质谱分析样品得到的质谱获得质量曲线; 并通过比较和分析活性谱和质量分布来确定药理学活性物质的分子量。所公开的方法允许通过对包括在天然产物的提取物样品中的许多组分执行高分辨率质谱法并与活性测试数据进行比较来快速发现药理学活性物质。关于天然产物的药理活性物质的活性强度的信息允许有效利用天然产物。

2. 发明申请

WO2011081352A2 APPARATUS FOR ELECTROSPRAY IONIZATION AND METHOD FOR ELECTROSPRAY IONIZATION USING THE SAME 审中-公开
标题翻译：用于电泳电离的装置和使用该装置进行电泳电离的方法
公开(公告)号：WO2011081352A2
公开(公告)日：2011-07-07
申请号：PCT/KR2010009254
申请日：2010-12-23
申请人： KOREA BASIC SCIENCE INST , KANG DUK JIN , CHOI MYOUNG CHOUL , YOO JONG SHIN , KIM HYUN SIK
发明人： KANG DUK JIN , CHOI MYOUNG CHOUL , YOO JONG SHIN , KIM HYUN SIK
IPC分类号： G01N27/26 , G01N33/48 , G01N33/68 , H01J49/04
CPC分类号： H01J49/165 , H01J49/045
摘要： An apparatus for electrospray ionization may include: a platform including an inlet port, a first channel connected to the inlet port, a second channel connected to the first channel, and an outlet port connected to the second channel; a nebulizer provided in the first channel and configured to spray inert gas to a sample sprayed into the first channel through the inlet port; and a focusing lens provided in the second channel and configured to focus ions produced from the sprayed sample toward the outlet port.
摘要翻译：一种用于电喷雾电离的设备可以包括：平台，其包括入口端口，连接到入口端口的第一通道，连接到第一通道的第二通道和连接到第二通道的出口端口; 雾化器，其设置在所述第一通道中并且被配置为将惰性气体喷射到通过所述入口喷射到所述第一通道中的样品; 以及聚焦透镜，其设置在第二通道中并且被配置为将从喷射样本产生的离子聚焦到出口端口。

3. 发明申请

WO2011078544A2 ION INJECTOR, MASS SPECTROMETER COMPRISING THE SAME AND METHOD FOR FOCUSING IONS USING THE SAME 审中-公开
标题翻译：包含其的离子注射器，质谱仪和使用其聚焦离子的方法
公开(公告)号：WO2011078544A2
公开(公告)日：2011-06-30
申请号：PCT/KR2010009141
申请日：2010-12-21
申请人： KOREA BASIC SCIENCE INST , CHOI MYOUNG CHOUL , KIM HYUN SIK , YOO JONG SHIN
发明人： CHOI MYOUNG CHOUL , KIM HYUN SIK , YOO JONG SHIN
IPC分类号： H01J37/30 , H01J49/26
CPC分类号： H01J37/08 , H01J49/0404 , H01J49/067 , H01J2237/083
摘要： An ion injector may include: a first electrode comprising a first region allowing ions to pass; and a second electrode disposed to enclose one end of the first electrode. The second electrode may include: a second region aligned with the first region to allow the ions to pass; and a protruding portion extending along the path of the ions passing through the second region. A mass spectrometer may be configured by disposing the ion injector adjacent to a skimmer.
摘要翻译：离子注入器可以包括：第一电极，其包括允许离子通过的第一区域; 以及设置成包围第一电极的一端的第二电极。第二电极可以包括：与第一区域对准的第二区域以允许离子通过; 以及沿着穿过第二区域的离子的路径延伸的突出部分。可以通过将离子注入器邻近于撇渣器来配置质谱仪。

4. 发明申请

WO2012074234A3 FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETER AND METHOD FOR CONCENTRATING IONS FOR FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY 审中-公开
标题翻译：傅立叶变换离子回旋共振质谱仪及其离子回旋共振质谱分析方法
公开(公告)号：WO2012074234A3
公开(公告)日：2012-07-26
申请号：PCT/KR2011008866
申请日：2011-11-21
申请人： KOREA BASIC SCIENCE INST , CHOI MYOUNG CHOUL , PARK A LEUM , KIM HYUN SIK , KIM SEUNG YONG , YOO JONG SHIN
发明人： CHOI MYOUNG CHOUL , PARK A LEUM , KIM HYUN SIK , KIM SEUNG YONG , YOO JONG SHIN
IPC分类号： G01N27/62 , H01J49/26
CPC分类号： H01J49/02 , H01J49/0027 , H01J49/065 , H01J49/38
摘要： A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) includes: an ionization source generating ions; a deceleration lens, on which the ions generated by the ionization source and spatially dispersed are incident, selectively decelerating the incident ions so as to decrease the distance between the ions; and an ion cyclotron resonance cell on which the ions passing through the deceleration lens are incident. By preventing dispersing of ions due to mass difference and converging the ions using the deceleration lens, the mass range that can be measured at one time can be extended. Also, measurement sensitivity can be improved since the ions are effectively introduced to the ICR cell.
摘要翻译：傅立叶变换离子回旋共振质谱仪（FT-ICR MS）包括：产生离子的电离源; 一个减速透镜，在该减速透镜上，由电离源产生并在空间上分散的离子入射，有选择地使入射离子减速，从而减小离子之间的距离; 以及其上通过减速透镜的离子入射在其上的离子回旋共振单元。通过防止因质量差引起的离子扩散并使用减速透镜会聚离子，可以延长一次可测量的质量范围。而且，由于离子被有效地引入ICR单元，所以可以提高测量灵敏度。

5. 发明申请

WO2011081298A3 APPARATUS AND METHOD FOR CONTROLLING A PIPELINE-TYPE ION CYCLOTRON RESONANCE MASS SPECTROMETER 审中-公开
标题翻译：控制管式离子回旋共振质谱仪的装置和方法
公开(公告)号：WO2011081298A3
公开(公告)日：2011-11-03
申请号：PCT/KR2010008079
申请日：2010-11-16
申请人： KOREA BASIC SCIENCE INST , KIM SEUNG YONG , KIM HYUN SIK , YOO JONG SHIN
发明人： KIM SEUNG YONG , KIM HYUN SIK , YOO JONG SHIN
IPC分类号： H01J49/34 , G01N27/62 , H01J49/26
CPC分类号： H01J49/38 , H01J49/022
摘要： The present invention relates to an apparatus and method for controlling a pipeline-type ion cyclotron resonance mass spectrometer, in which an ion trap unit of the ion cyclotron resonance mass spectrometer is capable of using two digitizers at the same time, thus enabling a measurement process for detecting an electrical signal which indicates the mass of ions corresponding to a specific purpose, and another measurement process for detecting another electrical signal which indicates the mass of ions corresponding to another specific purpose, to be simultaneously performed. Accordingly, it is an aim of the present invention to provide an apparatus and method for controlling a pipeline-type ion cyclotron resonance mass spectrometer, which can overcome the problems of time delay among control procedures, and can present a signal detection step wherein an excitation electrode is utilized to improve the sensitivity and speed of signal detection.
摘要翻译：本发明涉及一种用于控制管道型离子回旋共振质谱仪的装置和方法，其中离子回旋共振质谱仪的离子阱单元能够同时使用两个数字转换器，从而能够进行测量过程用于检测指示对应于特定目的的离子的质量的电信号以及用于检测指示与另一特定目的对应的离子的质量的另一电信号的另一测量过程被同时执行。因此，本发明的一个目的是提供一种用于控制流水线式离子回旋共振质谱仪的装置和方法，该装置和方法可以克服控制过程中时间延迟的问题，并且可以提供一种信号检测步骤，其中激励电极用于提高信号检测的灵敏度和速度。

6. 发明专利

JP2008117738A Method for signal improvement of fourier transform ion cyclotron resonance mass spectrograph 有权
标题翻译： FOURIER变换离子循环共振质谱信号改进方法
公开(公告)号：JP2008117738A
公开(公告)日：2008-05-22
申请号：JP2006320747
申请日：2006-11-28
申请人： Korea Basic Science Inst , コリアベーシックサイエンスインスティテュート
发明人： KIM SUNG HWAN , CHOI MYOUNG CHOUL , YOO JONG SHIN , KIM HYUN SIK
IPC分类号： H01J49/38 , G01N27/62
CPC分类号： H01J49/38
摘要： PROBLEM TO BE SOLVED: To provide a method of improving signals by changing voltage applied to an analysis trap of a high resolution Fourier transform ion cyclotron resonance mass spectrometer (FT-ICRMS) according to measurement stages, and in details, provide a method in which independent voltage different from a trap electrode is applied on an electrode added to the center part of the trap electrode after ions are activated and this is maintained until one measurement cycle is over.
SOLUTION: When the method is applied, stability of ions confined in the trap becomes higher and a measured time region signal becomes longer. As for the time region signal that becomes longer, resolution and sensitivity of frequency or the region signal of a mass/charge ratio are enhanced.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种通过根据测量阶段改变施加到高分辨率傅里叶变换离子回旋共振质谱仪（FT-ICRMS）的分析阱的电压来改善信号的方法，并且具体地，提供一种在离子被激活之后，在与陷阱电极的中心部分相加的电极上施加与捕获电极不同的独立电压的方法，直到一个测量周期结束。解决方案：当应用该方法时，限制在阱中的离子的稳定性变得更高，并且测量的时间区域信号变得更长。对于变长的时间区域信号，提高了频率的分辨率和灵敏度或质量/电荷比的区域信号。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2008130534A Hybrid ion transmitting device 审中-公开
标题翻译：混合离子发射装置
公开(公告)号：JP2008130534A
公开(公告)日：2008-06-05
申请号：JP2006320702
申请日：2006-11-28
申请人： Korea Basic Science Inst , コリアベーシックサイエンスインスティテュート
发明人： CHOI MYOUNG CHOUL , KIM HYUN SIK , KIM SUNG HWAN , YOO JONG SHIN
IPC分类号： H01J49/06 , G01N27/62 , H01J49/38
CPC分类号： H01J49/063
摘要： PROBLEM TO BE SOLVED: To provide a hybrid ion transmitting device for enhancing transmission efficiency of an RF ion transmitting tube to which a gate valve is attached by using an electrostatic lens. SOLUTION: This hybrid ion transmitting device for enhancing detection sensitivity and resolution by using an electrostatic lens ion transmitting tube in the front, enabling use of a gate valve in the middle, and using an RF ion transmitting tube having good transmission efficiency in a high electric field in the back can be manufactured by combination of the electrostatic lens and the RF ion transmitting tube. That is, the hybrid ion transmitting device has a structure in which the electrostatic lens for transmitting injected ions and applying a voltage so that the ions can be focused on the center of the ion transmitting direction axis and the RF ion transmitting tube connected to the electrostatic lens to pass the ions focused on the center of the ion transmitting direction axis are connected through the gate valve. By this structure, the ion transmission efficiency is enhanced, and signal attenuation caused by collision with surrounding neutral gas is suppressed as much as possible by providing a stable vacuum state, and the hybrid ion transmitting device can enhance detection sensitivity and resolution thereby. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于通过使用静电透镜来提高安装有闸阀的RF离子传输管的传输效率的混合离子传输装置。解决方案：该混合离子传输装置用于通过使用前面的静电透镜离子透射管来提高检测灵敏度和分辨率，从而能够使用中间的闸阀，并且使用具有良好传输效率的RF离子传输管可以通过静电透镜和RF离子传输管的组合来制造背面的高电场。也就是说，混合离子发射装置具有这样的结构，其中静电透镜用于传输注入的离子并施加电压，使得离子可以聚焦在离子传输方向轴的中心和连接到静电的RF离子传输管透镜通过聚焦在离子传播方向轴中心的离子通过闸阀连接。通过这种结构，离子传递效率提高，并且通过提供稳定的真空状态尽可能地抑制与周围中性气体的碰撞引起的信号衰减，并且混合离子发射装置可以提高检测灵敏度和分辨率。版权所有（C）2008，JPO＆INPIT

8. 发明申请

WO2016108451A3 TIME-OF-FLIGHT MASS SPECTROMETER 审中-公开
标题翻译：飞行时间质谱分析仪
公开(公告)号：WO2016108451A3
公开(公告)日：2016-10-13
申请号：PCT/KR2015013252
申请日：2015-12-04
申请人： KOREA BASIC SCIENCE INST
发明人： YANG MO , KIM SEUNG YONG , KIM HYUN SIK , JEONG WAN SEOP
IPC分类号： H01J49/40
CPC分类号： H01J49/147 , H01J43/246 , H01J49/08 , H01J49/142 , H01J49/40
摘要： A time-of-flight mass spectrometer comprises: an ionization unit for receiving an electron beam and emitting ions; a cold electron supply unit for injecting an electron beam into the ionization unit; an ion detection unit for detecting ions discharged from the ionization unit; and an ion separation unit for connecting the ionization unit and the ion detection unit, wherein the cold electron supply unit comprises a microchannel plate, which receives ultraviolet rays and emits an electron beam, ions discharged from the ionization unit pass through the ion separation unit and reach the ion detection unit, and the ion separation unit has the shape of a straight tube.
摘要翻译：飞行时间质谱仪包括：用于接收电子束并发射离子的电离单元; 用于将电子束注入电离单元的冷电子供应单元; 离子检测单元，用于检测从电离单元排出的离子; 以及用于连接电离单元和离子检测单元的离子分离单元，其中冷电子供给单元包括接收紫外线并发射电子束的微通道板，从电离单元排出的离子穿过离子分离单元，以及到达离子检测单元，并且离子分离单元具有直管的形状。

9. 发明授权

KR101146229B1 A method and apparatus for improving of ion cyclotron resonance mass spectrometer signal 无效
标题翻译：用于改进离子共振质谱仪信号的方法和装置
公开(公告)号：KR101146229B1
公开(公告)日：2012-05-17
申请号：KR20100129681
申请日：2010-12-17
申请人： KOREA BASIC SCIENCE INST
发明人： KIM SEUNG YONG , KIM HYUN SIK , CHOI MYOUNG CHOUL , YOO JONG SHIN
IPC分类号： H01J49/26 , G01N27/62
CPC分类号： H01J49/02 , H01J49/022 , H01J49/38
摘要： PURPOSE: A control device for improving signal capability of an ion cyclotron resonance mass spectrograph is provided to improve signal sensibility by supplying voltage for ion movement and controlling deflection. CONSTITUTION: An excitation electrode control means applies a high frequency signal or a control signal from a high-frequency amplifier(7) to a first excitation electrode and a second excitation electrode. A detection electrode control means applies an arbitrary waveforms generated in first and second control signal generating units(21, 23) to each detection electrode. A detection electrode signal processing signal detects an ion signal from first and second detection electrodes and amplifies and changes the ion signal into a digital signal. An excitation electrode signal processing means detects an ion signal from the first and second excitation electrodes. The excitation electrode signal processing means amplifies and changes the ion signal into the digital signal. A first excitation switching unit(12) selectively outputs by a computer control program.
摘要翻译：目的：提供一种用于提高离子回旋共振质谱仪信号能力的控制装置，通过提供离子运动电压和控制偏转来提高信号灵敏度。构成：励磁电极控制装置将高频信号或来自高频放大器（7）的控制信号施加到第一激励电极和第二激励电极。检测电极控制装置将在第一和第二控制信号产生单元（21,23）中产生的任意波形施加到每个检测电极。检测电极信号处理信号检测来自第一和第二检测电极的离子信号，并将离子信号放大并变换为数字信号。励磁电极信号处理装置检测来自第一和第二激励电极的离子信号。激励电极信号处理装置将离子信号放大并变换为数字信号。第一激励切换单元（12）通过计算机控制程序有选择地输出。

10. 发明公开

KR20120039839A Fourier transform ion cyclotron resonance mass spectrometer using ultra-wideband rf amplifier and method for improving signal of fourier transform ion cyclotron resonance mass spectrometer 无效
标题翻译：使用超宽带RF放大器的FOURIER变压离子共振质谱仪和改进FOURIER变换离子循环共振质谱仪的信号的方法
公开(公告)号：KR20120039839A
公开(公告)日：2012-04-26
申请号：KR20100101270
申请日：2010-10-18
申请人： KOREA BASIC SCIENCE INST
发明人： CHOI MYOUNG CHOUL , KIM HYUN SIK , KIM SEUNG YONG
IPC分类号： G01N27/62 , H01L21/265 , H05H13/00
CPC分类号： H01J49/38
摘要： PURPOSE: A Fourier transform ion cyclotron resonance mass spectrometer using ultra-wideband RF amplifier and a method for improving signal of Fourier transform ion cyclotron resonance mass spectrometer are provided to add DC offset to high voltage signal by using wide operation frequency range. CONSTITUTION: A Fourier transform ion cyclotron resonance mass spectrometer comprises a signal generating unit(10), a voltage amplifier(20), a ion cyclotron trap(30). The signal generating unit generates a sine wave shaped first voltage signal having DC offset. The voltage amplifier receives the first voltage signal from the signal generating unit, and generates a second voltage signal. The ion cyclotron trap receives the second voltage signal, and generates ion cyclotron action around the location determined by the DC offset.
摘要翻译：目的：提供使用超宽带RF放大器的傅里叶变换离子回旋共振质谱仪和傅里叶变换离子回旋共振质谱仪的信号改进方法，通过使用宽工作频率范围向高压信号增加直流偏移。构成：傅里叶变换离子回旋共振质谱仪包括信号发生单元（10），电压放大器（20），离子回旋加速器捕集器（30）。信号产生单元产生具有DC偏移的正弦波状的第一电压信号。电压放大器从信号发生单元接收第一电压信号，并产生第二电压信号。离子回旋收集器接收第二电压信号，并且在由DC偏移确定的位置周围产生离子回旋加速器作用。

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