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1. 发明授权

US10828507B2 Clinical decision support (CDS) for radiotherapy in prostate cancer 有权
公开(公告)号：US10828507B2
公开(公告)日：2020-11-10
申请号：US14770482
申请日：2014-03-07
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Carolina Ribbing , Katrin Bitter
IPC分类号： G01N33/48 , A61N5/10 , G01N33/68 , H01J49/00 , G06F19/00
摘要： A system (30) and method for detecting or predicting toxicity induced by radiation therapy. A device (34) is configured for determining polypeptide biomarkers present in a urine sample. At least one processor (36) is programmed to detect or predict radiation toxicity based on one or more polypeptide biomarkers determined to be in the urine sample.

2. 发明申请

US20150139401A1 METHOD OF TREATING A SURFACE LAYER OF A DEVICE CONSISTING OF ALUMINA AND RESPECTIVE DEVICE, PARTICULARLY X-RAY TUBE COMPONENT 审中-公开
标题翻译：处理包含氧化铝和相关器件的器件的表面层的方法，特别是X射线管组件
公开(公告)号：US20150139401A1
公开(公告)日：2015-05-21
申请号：US14412004
申请日：2013-07-01
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Carolina Ribbing , Christoph Martiny
IPC分类号： C04B41/00 , H01J35/16
CPC分类号： C04B41/0072 , C04B41/009 , C04B41/80 , C04B2111/94 , H01J35/16 , C04B35/10 , C04B41/4517 , C04B41/455
摘要： A method for treating a surface layer (3) of a device (1) consisting of alumina and a corresponding device (1) are proposed. The method comprises providing the device (1) with the surface layer (3) to be treated being exposed and heating the surface layer (3) of the device (1) in an oxygen-depleted atmosphere comprising e.g. one of an inert gas, nitrogen, hydrogen, argon and a combination thereof to a temperature higher than 1000° C., preferably higher than 1700° C. for a duration of preferably more than 2 hours. Due to such treatment, a superficial layer region (7) comprised in the surface layer (3) may obtain a significantly reduced electrical resistivity which is assumed to be the result of chemically reducing this superficial layer region (7). Such reduced superficial electrical resistivity may advantageously serve for example in components of electron beam devices such as x-ray tube components for preventing any charge build-up.
摘要翻译：提出了一种处理由氧化铝和相应的装置（1）组成的装置（1）的表面层（3）的方法。该方法包括提供待处理的表面层（3）暴露的装置（1），并在包含例如氧化铝的贫氧气氛中加热装置（1）的表面层（3）。惰性气体，氮气，氢气，氩气及其组合中的一种，其温度高于1000℃，优选高于1700℃，持续时间优选为2小时以上。由于这种处理，包含在表面层（3）中的表面层区域（7）可以获得显着降低的电阻率，这被认为是化学还原该表面层区域（7）的结果。这种降低的表面电阻率可以有利地用于例如电子束装置的部件，例如用于防止任何电荷积聚的X射线管部件。

3. 发明授权

US10757795B2 Device for determining spatially dependent x-ray flux degradation and photon spectral change 有权
公开(公告)号：US10757795B2
公开(公告)日：2020-08-25
申请号：US15765511
申请日：2016-10-04
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Lester Donald Miller , Carolina Ribbing , Dionys Van De Ven
IPC分类号： H05G1/26 , A61B6/00 , H05G1/54 , A61B6/03 , G01T1/36
摘要： The invention relates to a device (10) for determining spatially dependent x-ray flux degradation and photon spectral change, a system (1) for determining spatially dependent x-ray flux degradation and photon spectral change for an x-ray tube (20), a method for spatially dependent x-ray flux degradation and photon spectral change for an x-ray tube (20), a computer program element for controlling such device (10) or system (1) for performing such method and a computer readable medium having stored such computer program element. The device (10) for determining spatially dependent x-ray flux degradation and photon spectral change comprises an acquisition unit (11), a processing unit (12), a calculation unit (13), and a combination unit (14). The acquisition unit (11) is configured to acquire x-ray flux degradation data for the x-ray tube (20). The processing unit (12) is configured to process the x-ray flux degradation data into spatially dependent flux degradation data. The calculation unit (13) is configured to calculate at least a photon spectral change of the x-ray tube (20) and to convert the photon spectral change into a spatially dependent spectrum. The combination unit (14) is configured to combine the spatially dependent flux degradation data and the spatially dependent spectrum.

4. 发明授权

US10444381B2 Radiation detector and imaging apparatus 有权
公开(公告)号：US10444381B2
公开(公告)日：2019-10-15
申请号：US15778847
申请日：2016-12-02
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Roger Steadman Booker , Carolina Ribbing , Walter Ruetten , Gereon Vogtmeier
IPC分类号： G01J1/00 , G01T1/24 , G01T1/161 , G01T1/17 , G01T1/20
摘要： The present invention relates to a radiation detector, in particular a direct conversion radiation detector. To provide for simple distribution of provided high voltage the radiation detector comprises a plurality of detector modules (10, 20) arranged adjacent to each other. Each detector module comprises a sensor layer (14, 24) for converting incident radiation (100) into electrical charges, a first electrode (15, 25) deposited on a first surface of the sensor layer facing the incident radiation (100), a second electrode (16, 26) deposited on a second surface of the sensor layer opposite the first surface, a readout electronics (12, 22) in electrical contact with the second electrode, and a carrier (13, 23) for carrying the sensor layer and the readout electronics. The radiation detector further comprises an electrically conductive conduction layer (30, 32, 50) and an anti-scatter arrangement (40), which are arranged on top of each other and cover the plurality of detector modules on the side facing the incident radiation (100).

5. 发明申请

US20160008629A1 CLINICAL DECISION SUPPORT (CDS) FOR RADIOTHERAPY IN PROSTATE CANCER 审中-公开
标题翻译：临床决策支持（CDS）在前列腺癌中的放射治疗
公开(公告)号：US20160008629A1
公开(公告)日：2016-01-14
申请号：US14770482
申请日：2014-03-07
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Carolina Ribbing , Katrin Bitter
IPC分类号： A61N5/10 , H01J49/00 , G01N33/68
摘要： A system (30) and method for detecting or predicting toxicity induced by radiation therapy. A device (34) is configured for determining polypeptide biomarkers present in a urine sample. At least one processor (36) is programmed to detect or predict radiation toxicity based on one or more polypeptide biomarkers determined to be in the urine sample.
摘要翻译：一种用于检测或预测放射治疗引起的毒性的系统（30）和方法。设备（34）被配置用于确定尿样中存在的多肽生物标志物。至少一个处理器（36）被编程为基于确定在尿液样品中的一种或多种多肽生物标志物来检测或预测辐射毒性。

6. 发明申请

US20150003591A1 NUCLEAR IMAGING SYSTEM 审中-公开
标题翻译：核成像系统
公开(公告)号：US20150003591A1
公开(公告)日：2015-01-01
申请号：US14371286
申请日：2013-01-18
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Bernd Schweizer , Heinrich Johannes Eckhard Von Busc , Carolina Ribbing , Andreas Goedicke
IPC分类号： A61B6/00 , G01R33/48 , A61B6/03
CPC分类号： A61B6/4417 , A61B5/055 , A61B5/1114 , A61B6/037 , A61B6/4429 , A61B6/481 , A61B6/5247 , A61B6/5264 , A61B6/547 , G01R33/481 , G06T11/005
摘要： Nuclear Imaging System The invention relates to a nuclear imaging system (1) for imaging an object (3) in an examination region. Multiple x-rays sources (2) generate first radiation being x-ray radiation (5), wherein the x-ray sources are arranged such that the x-ray radiation is indicative of a property of the object. A detection unit (6) detects second radiation (7) from a nuclear element (8), after the second radiation has the traversed the object, and the first radiation generated by the multiple x-ray sources, thereby inherently registering the detection of the first radiation and the second radiation. A reconstruction unit (9) reconstructs a corrected nuclear image of the object based on the detected first radiation and the detected second radiation, wherein the nuclear image is corrected with respect to the property of the object and, because of the inherent registration, does not comprise image artifacts caused by registration errors.
摘要翻译：核成像系统本发明涉及一种用于对检查区域中的物体（3）进行成像的核成像系统（1）。多个x射线源（2）产生作为X射线辐射（5）的第一辐射，其中x射线源被布置成使得x射线辐射指示物体的特性。检测单元（6）在第二辐射已经穿过物体之后从核元件（8）检测第二辐射（7），并且由多个X射线源产生的第一辐射检测到，第一次辐射和第二次辐射。重建单元（9）基于检测到的第一辐射和检测到的第二辐射来重构物体的校正核图像，其中核图像相对于物体的属性被校正，并且由于固有的注册，不包括由注册错误引起的图像伪影。

7. 发明申请

US20140323794A1 ELECTRONIC BRACHYTHERAPY RADIATION APPLICATION APPARATUS COMPRISING A PIEZOELECTRICALLY POWERED X-RAY SOURCE 审中-公开
标题翻译：包含压电X射线源的电子横穿放射应用装置
公开(公告)号：US20140323794A1
公开(公告)日：2014-10-30
申请号：US14357692
申请日：2012-11-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Carolina Ribbing , Gereon Vogtmeier
IPC分类号： A61N5/10
CPC分类号： A61N5/1001 , A61N2005/1022 , F04C2270/041 , H01J35/06 , H01J35/32 , H01J2235/062 , H05G1/10
摘要： The invention relates to a radiation application apparatus for applying radiation at a location within an object. The radiation application apparatus comprises a transforming unit (2) for being arranged within the object at the location and for transforming ultrasound energy to electrical energy, and a radiation source (4) for being arranged within the object and for generating radiation (5) to be applied at the location within the object, wherein the radiation source (4) is driven by the electrical energy. Since the transforming unit transforms the ultrasound energy to electrical energy being used by the radiation source, it is not necessary to transfer electrical energy to the radiation source, i.e., for example, corresponding cables, which may have to be isolated, are not necessarily required. Insulation problems and corresponding safety problems, which may be present, if cables, in particular, corresponding high voltage cables, are used, can therefore be reduced.
摘要翻译：本发明涉及一种用于在物体内的位置处施加辐射的辐射施加装置。辐射施加装置包括：变换单元（2），用于在该位置处布置在物体内并用于将超声能量转换成电能;以及辐射源（4），用于布置在物体内并用于产生辐射（5）至施加在物体内的位置处，其中辐射源（4）由电能驱动。由于变换单元将超声能量转换为由辐射源使用的电能，所以不必将电能传递到辐射源，例如，不一定需要可能必须隔离的相应的电缆。因此，如果使用电缆，特别是相应的高压电缆，则可能存在的绝缘问题和相应的安全问题可以减少。

8. 发明授权

US10575391B2 Determining a status of an X-ray tube of an X-ray system 有权
公开(公告)号：US10575391B2
公开(公告)日：2020-02-25
申请号：US15779105
申请日：2016-11-18
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Roland Proksa , Rolf Karl Otto Behling , Carolina Ribbing , Lester Donald Miller , Alexander Eitel
IPC分类号： H05G1/54 , A61B6/00
摘要： The present invention relates to a device (34) and a method (70) for determining a status of an X-ray tube (10) of an X-ray system (36). Due to ageing and/or wear of the X-ray tube, the spectrum of the X-ray radiation (30) provided by the X-ray tube may change over the operation time of the X-ray tube. The present invention therefore suggests evaluating spectrally different values detected with an X-ray detector arrangement (32) of the X-ray system. A reference data set representing a reference condition of the X-ray tube by a plurality of spectrally different reference-values (44) and a working data set representing an aged condition of the X-ray tube by a plurality of spectrally different working-values (46) of detected X-ray radiation are used to determine an equivalent filtration function for an filtration material influencing a source X-ray radiation (26) emitted by an anode (16) of the X-ray tube. Accordingly, the filtration function provides the information about the material being used for the filtration and/or its length, which may provide the basis to determine the condition and thus the status of the X-ray tube.

9. 发明授权

US10456595B2 Portal imaging for brachytherapy 有权
公开(公告)号：US10456595B2
公开(公告)日：2019-10-29
申请号：US14904121
申请日：2014-07-07
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Carolina Ribbing , Raymond Chan , Luis Felipe Gutierrez
IPC分类号： A61N5/10 , A61B34/20
摘要： A system for interventional brachytherapy for generating data to be used directly for therapy and/or for therapy planning includes a radiation source which irradiates tissue of a patient and one or more radiation detectors which detect radiation delivered to the patient and generate radiation dosage data indicative thereof. One or more position sensors determine the position of the radiation source and a localization unit, in communication with the one or more position sensors, generates position data indicative of the position of the radiation source. An image database stores one or more anatomical images of the patient. A dose calculation unit which co-registers the one or more anatomical images with the positional and radiation dosage data and generates dose monitoring data based on the co-registration.

10. 发明授权

US09833202B2 System for generating spectral computed tomography projection data 有权
公开(公告)号：US09833202B2
公开(公告)日：2017-12-05
申请号：US15108401
申请日：2015-12-01
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Heiner Daerr , Roger Steadman Booker , Gereon Vogtmeier , Ewald Roessl , Gerhard Martens , Carolina Ribbing
IPC分类号： H05G1/26 , A61B6/03 , A61B6/00 , A61B6/06
CPC分类号： A61B6/032 , A61B6/06 , A61B6/4042 , A61B6/4078 , A61B6/4241 , A61B6/482 , A61B6/485 , A61B6/582 , H05G1/30 , H05G1/58
摘要： The invention relates to a system (31) for generating spectral computed tomography projection data. A spectral projection data generation device (6) comprising an energy-resolving detector generates spectral computed tomography projection databased on polychromatic radiation (4), which has been provided by a radiation device (2), after having traversed an examination zone (5), and a reference values generation device generates energy-dependent reference values based on radiation, which has not traversed the examination zone. A spectral parameter providing unit (12) provides a spectral parameter being indicative of a spectral property of the radiation device based on the energy-dependent reference values. In particular, spectral properties of the radiation device can be monitored over time, wherein this information can be used for, for instance, correcting the spectral computed tomography projection data, and/or, if undesired spectral properties of the radiation device are indicated, triggering a replacement of the radiation device.

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