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1. 发明申请

WO2023072730A1 DEVICE, SYSTEM AND METHOD FOR CALIBRATING A BLOOD PRESSURE SURROGATE FOR USE IN MONITORING A SUBJECT'S BLOOD PRESSURE 审中-公开
公开(公告)号：WO2023072730A1
公开(公告)日：2023-05-04
申请号：PCT/EP2022/079239
申请日：2022-10-20
申请人： KONINKLIJKE PHILIPS N.V.
发明人： SCHMITT, Lars , MUEHLSTEFF, Jens , BRESCH, Erik
IPC分类号： A61B5/021 , A61B5/022 , A61B5/00
摘要： The present invention relates to a device, system and method for calibrating a blood pressure, BP, surrogate for use in monitoring a subject's blood pressure. The device comprises a BP input (51), a sensor input (52) and a processing unit (53) that is configured to compute a control signal for controlling the pressure-delivery system (10) to repeatedly inflate its cuff in directly consecutive partial inflations up to a cuff pressure equal to or below the subject's mean BP, compute pulse-related values from the first and second time-dependent sensor signals, measured during the repeated directly consecutive partial inflations of the cuff, using a first feature in the first time-dependent sensor signal and a second feature in the second time-dependent sensor signal, the pulse-related values being pulse arrival time, PAT, values or pulse transit time, PTT, values, and compute a calibration parameter for a BP surrogate from the BP measurement value and pairs of the pulse-related values and corresponding cuff pressure values, computed from the first and second time -dependent sensor signals measured during the repeated directly consecutive partial inflations of the cuff, a pair comprising a pulse-related value and a corresponding, temporally related cuff pressure value.

2. 发明申请

WO2019233903A1 METHOD AND APPARATUS FOR ESTIMATING A TREND IN A BLOOD PRESSURE SURROGATE 审中-公开
公开(公告)号：WO2019233903A1
公开(公告)日：2019-12-12
申请号：PCT/EP2019/064247
申请日：2019-06-03
申请人： KONINKLIJKE PHILIPS N.V.
发明人： MUEHLSTEFF, Jens , BRESCH, Erik , VAN DALEN, Jan , JUNYENT MORA, Ignasi , SCHMITT, Lars
IPC分类号： A61B5/021 , A61B5/00
摘要： According to an aspect, there is provided a computer-implemented method of estimating a trend in a blood pressure surrogate, the method comprising obtaining a set of blood pressure surrogate measurement values of a blood pressure surrogate for a subject; obtaining, for each blood pressure surrogate measurement value, an error value indicating a measurement error for the blood pressure surrogate measurement value; and analysing the set of blood pressure surrogate measurement values and the respective error values using Bayesian inference to determine a trend (4) in the blood pressure surrogate over time.

3. 发明申请

WO2020126576A1 CONTROL UNIT FOR DERIVING A MEASURE OF ARTERIAL COMPLIANCE 审中-公开
公开(公告)号：WO2020126576A1
公开(公告)日：2020-06-25
申请号：PCT/EP2019/084118
申请日：2019-12-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BOGATU, Laura Ioana , MUEHLSTEFF, Jens , KUENEN, Maarten Petrus Joseph , BRESCH, Erik
IPC分类号： A61B5/02
摘要： The invention provides a control unit (12) and method for deriving a measure of arterial compliance based on an acquired arterial volume variation signal and an acquired pulse arrival time signal. An oscillometric blood pressure measurement device is used to acquire the arterial volume variation signal. Arterial volume and variation in pulse arrival time are both measured as an applied pressure to an artery are varied by the oscillometric blood pressure measurement device. The arterial volume signal is transformed into a corresponding signal representative of variation in peak-to-peak amplitude of the arterial volume. A first model fitting procedure is used to transform this peak-to-peak amplitude signal into a signal indicative of arterial volume as a function of transmural pressure. A second model fitting procedure is used to generate from the derived arterial volume vs. transmural pressure signal, and the derived pulse arrival time variation signal a final output measure of arterial compliance.

4. 发明申请

WO2019016405A1 APPARATUS AND METHOD FOR DETERMINING BLOOD PRESSURE OF A SUBJECT 审中-公开
公开(公告)号：WO2019016405A1
公开(公告)日：2019-01-24
申请号：PCT/EP2018/069894
申请日：2018-07-23
申请人： KONINKLIJKE PHILIPS N.V.
发明人： SCHMITT, Lars , MUEHLSTEFF, Jens , BRESCH, Erik , YU, Xinchi
IPC分类号： A61B5/021 , A61B5/024 , A61B5/00
摘要： The present invention relates to an apparatus and method for determining blood pressure of a subject. To automatically trigger calibration the apparatus comprises a sensor signal input (31) configured to obtain an arterial pulse wave sensor signal (11) of the subject, a feature extraction unit (32) configured to extract multiple features (42) from the obtained arterial pulse wave sensor signal, an estimation unit (33) configured to determine multiple blood pressure estimation values (43) for individual extracted features and/or groups of extracted features and to determine the subject's blood pressure (44) from said multiple blood pressure estimation values, a calibration unit (34) configured to calibrate the estimation unit (33) based on blood pressure reference measurements (21), and a calibration trigger unit (35) configured to trigger calibration by the calibration unit (34) if the multiple blood pressure estimation values diverge more than a divergence limit.

5. 发明申请

WO2016135043A1 APPARATUS AND METHOD FOR PROVIDING A CONTROL SIGNAL FOR A BLOOD PRESSURE MEASUREMENT DEVICE 审中-公开
标题翻译：用于提供用于血压测量装置的控制信号的装置和方法
公开(公告)号：WO2016135043A1
公开(公告)日：2016-09-01
申请号：PCT/EP2016/053484
申请日：2016-02-18
申请人： KONINKLIJKE PHILIPS N.V.
发明人： MUEHLSTEFF, Jens , BRESCH, Erik , VAN DEN HEUVEL, Teun , SCHMITT, Lars , WOEHRLE, Dieter
IPC分类号： A61B5/021
CPC分类号： A61B5/0225 , A61B5/0006 , A61B5/0024 , A61B5/021 , A61B5/02141 , A61B5/02225 , A61B5/7275 , A61B8/04 , G06F19/00
摘要： The present invention relates to an apparatus (18) for providing a control signal for a blood pressure measurement device, comprising: an input interface (24) for obtaining a health state parameter being indicative of a health state of a patient (12); a processing unit (28) for determining one or more operation settings of a blood pressure measurement device (14) based on the health state parameter, said one or more operation settings including a parameter that can be adjusted at the blood pressure measurement device (14) when conducting a blood pressure measurement with the device and that affects a precision of said blood pressure measurement and a patient comfort resulting from said blood pressure measurement; and a control interface (30) for providing a control signal for a blood pressure measurement device (14) to perform a blood pressure measurement based on said one or more operation settings. The present invention further relates to a corresponding method. Still further, the present invention relates to a system for monitoring a patient.
摘要翻译：本发明涉及一种用于提供血压测量装置的控制信号的装置（18），包括：用于获得指示患者（12）的健康状态的健康状态参数的输入接口（24）; 用于基于健康状态参数确定血压测量装置（14）的一个或多个操作设置的处理单元（28），所述一个或多个操作设置包括可在血压测量装置（14）处调节的参数），当所述装置进行血压测量并且影响所述血压测量的精度和由所述血压测量产生的患者舒适度时; 以及控制接口（30），用于提供用于血压测量装置（14）的控制信号，以基于所述一个或多个操作设置执行血压测量。本发明还涉及相应的方法。此外，本发明涉及一种用于监测患者的系统。

6. 发明申请

WO2016055356A1 NON-INVASIVE BLOOD PRESSURE MONITORS, METHODS AND COMPUTER PROGRAM PRODUCT OF OPERATING THE SAME 审中-公开
标题翻译：非侵入式血液压力监测仪，其操作方法和计算机程序产品
公开(公告)号：WO2016055356A1
公开(公告)日：2016-04-14
申请号：PCT/EP2015/072730
申请日：2015-10-01
申请人： KONINKLIJKE PHILIPS N.V.
发明人： MÜHLSTEFF, Jens , VAN DEN HEUVEL, Teun , BRESCH, Erik , SCHMITT, Lars , WOEHRLE, Dieter
IPC分类号： A61B5/00 , A61B5/022
CPC分类号： A61B5/022 , A61B5/02028 , A61B5/02141 , A61B5/02225 , A61B5/024 , A61B5/7221 , A61B5/7275 , A61B5/74 , A61B2560/0266
摘要： Method of operating a non-invasive blood pressure, NIBP, monitor to measure the blood pressure of a subject, the NIBP monitor comprising a cuff, a pressure sensor for measuring the pressure in the cuff and for outputting a pressure signal representing the pressure in the cuff and a physiological parameter sensor, the method comprising obtaining a first measurement of pulse rate or heart rate for the subject during inflation of the cuff, the first measurement being obtained from the pressure signal; obtaining a second measurement of the pulse rate or heart rate for the subject during inflation of the cuff, the second measurement being obtained from the physiological parameter sensor; comparing the first measurement and the second measurement; and estimating the reliability of a blood pressure measurement obtained by the NIBP monitor during inflation of the cuff based on the result of the step of comparing.
摘要翻译：操作无创血压的方法，NIBP，监测器以测量受试者的血压，NIBP监测器包括袖带，压力传感器，用于测量袖带中的压力并输出表示压力的压力信号袖带和生理参数传感器，所述方法包括在袖带充气期间获得对象的脉搏率或心率的第一测量值，从压力信号获得第一测量值; 在袖带充气期间获得对象的脉搏率或心率的第二测量值，从生理参数传感器获得第二测量值; 比较第一测量和第二测量; 并且基于比较步骤的结果来估计在袖带充气期间由NIBP监视器获得的血压测量的可靠性。

7. 发明申请

WO2023088740A1 MONITORING AN ENTITY IN A MEDICAL FACILITY 审中-公开
公开(公告)号：WO2023088740A1
公开(公告)日：2023-05-25
申请号：PCT/EP2022/081211
申请日：2022-11-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BRESCH, Erik , BOUTS, Mark Jacobus Rosalie Joseph , ZUO, Fei , VAN DER HEIDE, Esther Marjan
IPC分类号： G06V10/82 , G06V40/20 , G06V20/52
摘要： A computer implemented method for use in monitoring a first entity in a medical facility comprises: i) obtaining an image of the medical facility, ii) using a machine learning process to fit a first articulated model to the first entity in the image, wherein the first articulated model comprises keypoints corresponding to joints and affinity fields that indicate links between the keypoints. The method further comprises iii) determining a location or posture of the first entity in the medical facility from relative locations of fitted keypoints of the first articulated model in the image.

8. 发明申请

WO2021115856A1 SYSTEMS AND METHODS FOR AUDIBLE SLEEP THERAPY 审中-公开
公开(公告)号：WO2021115856A1
公开(公告)日：2021-06-17
申请号：PCT/EP2020/084188
申请日：2020-12-02
申请人： KONINKLIJKE PHILIPS N.V.
发明人： BRESCH, Erik , GROSSEKATHOEFER, Ulf
IPC分类号： G16H20/30
摘要： The invention provides a system for providing an audio stimulus to a sleeping user. The system includes a user sensor adapted to acquire user sleep data from the sleeping user and a processor, which is adapted to determine a sleep stage of the sleeping user based on the user sleep data. The processor is further adapted to determine a predicted influence of an audio stimulus on the sleep stage of the sleeping user and generate a control signal based on the predicted influence of the audio stimulus. The system further comprises an audio output device, adapted to receive the control signal and generate an audio stimulus based on the control signal.

9. 发明申请

WO2019215306A1 SYSTEM AND METHOD FOR ENHANCING SENSORY STIMULATION DELIVERED TO A USER USING NEURAL NETWORKS 审中-公开
公开(公告)号：WO2019215306A1
公开(公告)日：2019-11-14
申请号：PCT/EP2019/061990
申请日：2019-05-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： GARCIA MOLINA, Gary, Nelson , PASTOOR, Sander, Theodoor , GROSSEKATHOEFER, Ulf , BRESCH, Erik , HEINRICH, Adrienne
IPC分类号： A61B5/00 , A61N1/04 , G16H50/70 , A61M21/00 , A61N1/36 , A61B5/0476
摘要： The present disclosure pertains to a system and method for delivering sensory stimulation to a user during a sleep session. The system comprises one or more sensors, one or more sensory stimulators, and one or more hardware processors. The processor(s) are configured to: determine one or more brain activity parameters indicative of sleep depth in the user based on output signals from the sensors; cause a neural network to indicate sleep stages predicted to occur at future times for the user during the sleep session; cause the sensory stimulator(s) to provide the sensory stimulation to the user based on the predicted sleep stages over time during the sleep session, and cause the sensory stimulator(s) to modulate a timing and/or intensity of the sensory stimulation based on the one or more brain activity parameters and values output from one or more intermediate layers of the neural network.

10. 发明申请

WO2016055614A1 NON-INVASIVE BLOOD PRESSURE MONITOR, A METHOD OF OPERATING THE SAME, AND A COMPUTER PROGRAM IMPLEMENTING SAID METHOD 审中-公开
标题翻译：非侵入式血压监测器，其操作方法和计算机程序实现方法
公开(公告)号：WO2016055614A1
公开(公告)日：2016-04-14
申请号：PCT/EP2015/073407
申请日：2015-10-09
申请人： KONINKLIJKE PHILIPS N.V.
发明人： MÜHLSTEFF, Jens , VAN DEN HEUVEL, Teun , BRESCH, Erik , SCHMITT, Lars , WOEHRLE, Dieter
IPC分类号： A61B5/022 , A61B5/024 , A61B5/00
CPC分类号： A61B5/02225 , A61B5/022 , A61B5/024 , A61B5/72 , A61B5/7235 , A61B5/725
摘要： According to an aspect there is provided a method of obtaining a measurement of the blood pressure of a subject using a non-invasive blood pressure, NIBP, monitor and including using a pulse rate sensor and a cuff that is to be placed around a limb of the subject, the method comprising using the pulse rate sensor to obtain information on the pulse rate of the subject; adapting a pressure signal filter according to the obtained information on the pulse rate of the subject; starting inflation of the cuff; obtaining a pressure signal representing the pressure in the cuff as the cuff is inflated; filtering the pressure signal using the adapted pressure signal filter during inflation of the cuff; and processing the filtered pressure signal to obtain a blood pressure measurement for the subject during inflation of the cuff.
摘要翻译：根据一个方面，提供了一种使用非侵入性血压NIBP监测器获得受试者的血压的测量的方法，并且包括使用脉搏率传感器和围绕肢体周围的袖带所述方法包括使用所述脉搏率传感器获得关于所述对象的脉搏率的信息; 根据获得的关于对象的脉搏率的信息来适配压力信号滤波器; 开始袖口膨胀; 当袖带膨胀时，获得表示袖带内的压力的压力信号; 在袖带充气期间使用适配的压力信号过滤器过滤压力信号; 以及处理过滤后的压力信号，以在袖带充气期间获得对象的血压测量。

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