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1. 发明申请

WO2011117780A1 INTERFERENCE REDUCTION IN MONITORING A VITAL PARAMETER OF A PATIENT 审中-公开
标题翻译：监测患者健康参数的干扰减少
公开(公告)号：WO2011117780A1
公开(公告)日：2011-09-29
申请号：PCT/IB2011/051100
申请日：2011-03-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VEEN, Jeroen , JANSEN, Theodorus, Petrus, Henricus, Gerardus , FOKKENROOD, Steven, Antonie, Willem
发明人： VEEN, Jeroen , JANSEN, Theodorus, Petrus, Henricus, Gerardus , FOKKENROOD, Steven, Antonie, Willem
IPC分类号： A61B5/1455
CPC分类号： A61B5/14552
摘要： The invention relates to a method of and device for monitoring a vital parameter of a patient by emitting light onto tissue of the patient with at least one light source (1, 2) and collecting light which is transmitted through the tissue and/or which is reflected from the tissue. The emitted light is multiplexed according to a predefined multiplexing scheme having a plurality of multiplexing channels, and the collected light is detected according to the predefined multiplexing scheme, resulting in a plurality of detection channels (16, 17, 18, 19). At least one of the multiplexing channels is arranged to be a dark multiplexing channel for which no light is emitted by the at least one light source (1, 2), resulting in a dark detection channel (19), and the signal of this dark detection channel (19) is used for generating a reference signal for reducing interference in the signal of at least one of the other detection channels (16, 17, 18). In this way a versatile and reliable possibility of monitoring a vital parameter of a patient with a high signal-to-interference ratio is provided.
摘要翻译：本发明涉及一种用于通过用至少一个光源（1,2）发射光到患者的组织上并且收集透过组织的光和/或通过组织透射的光而监测患者的生命参数的方法和装置从组织反射。发射光根据具有多个复用信道的预定复用方案进行多路复用，并且根据预定的复用方案检测收集的光，从而产生多个检测通道（16,17,18,19）。多路复用通道中的至少一个被配置为暗的多路复用通道，由该至少一个光源（1,2）不发射光，导致暗检测通道（19），并且该暗信号检测通道（19）用于产生用于减少至少一个其它检测通道（16,17,18）的信号中的干扰的参考信号。以这种方式，提供了用于监视具有高信号与干扰比的患者的重要参数的通用且可靠的可能性。

2. 发明申请

WO2007042959A2 MAGNETIC SENSOR DEVICE WITH DIFFERENT INTERNAL OPERATING FREQUENCIES 审中-公开
标题翻译：具有不同内部操作频率的磁传感器装置
公开(公告)号：WO2007042959A2
公开(公告)日：2007-04-19
申请号：PCT/IB2006/053561
申请日：2006-09-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
CPC分类号： G01R33/09 , B82Y25/00 , G01N15/0656 , G01N27/745 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The invention relates to a magnetic sensor device (10) comprising wires (11, 13) for the generation of a magnetic field with a first frequency f 1 a GMR sensor (12) operated with an input current of a second frequency f 2 , and a demodulator (26) operated at a third frequency f 3 . In order to avoid signal corruption by phase noise and to improve the signal-to-noise ratio, the first, second and third frequencies are derived by a supply unit (121) from a common reference frequency f ref . Said derivation may for example be achieved with the help of digital frequency dividers. Furthermore, phase detectors (PD1, PD2) may be used in a feedback control loop to assure predetermined relations between the phases of the three frequencies. In another embodiment of the invention, the phase and/or amplitude of a model signal, which is used to process a desired signal component in the output of the sensor, is tracked by an adaptation algorithm, for example a gradient descent.
摘要翻译：本发明涉及一种磁传感器装置（10），其包括用于产生具有第一频率f 1的磁场的导线（11,13），GMR传感器（12）用输入电流第二频率f 2 2和在第三频率f 3 3处操作的解调器（26）。为了避免相位噪声的信号损坏并提高信噪比，第一，第二和第三频率由供电单元（121）从公共参考频率f ref 。所述推导可以例如在数字分频器的帮助下实现。此外，相位检测器（PD1，PD2）可用于反馈控制回路中以确保三个频率的相位之间的预定关系。在本发明的另一个实施例中，用于处理传感器的输出中的期望信号分量的模型信号的相位和/或幅度由适应算法（例如梯度下降）来跟踪。

3. 发明申请

WO2007132366A2 MICROELECTRONIC SENSOR DEVICE FOR CONCENTRATION MEASUREMENTS 审中-公开
标题翻译：用于浓度测量的微电子传感器装置
公开(公告)号：WO2007132366A2
公开(公告)日：2007-11-22
申请号：PCT/IB2007/051505
申请日：2007-04-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIEUWENHUIS, Jeroen Hans , VAN ZON, Hans , KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
发明人： NIEUWENHUIS, Jeroen Hans , VAN ZON, Hans , KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen , DE BOER, Bart Michiel , JANSEN, Theodorus Petrus Henricus Gerardus
IPC分类号： G01N33/543 , G01N35/00
CPC分类号： G01R33/093 , B82Y25/00 , G01N27/745 , G01R33/1269
摘要： The invention relates to a method and a magnetic sensor device for the determination of the concentration of target particles (2) in a sample fluid, wherein the amount of the target particles (2) in a sensitive region (14) is observed by sampling measurement signals with associated sensor units (10a-10d). The target particles (2) may optionally be bound to binding sites (3) in the sensitive region, and a parametric binding curve, e.g. a Langmuir isotherm, may be fitted to the sampled measurement signals to determine the desired particle concentration in the sample. Moreover, parameters like the sampling rate and the size of the sensitive region (14) can be dynamically fitted during the ongoing sampling process to improve the signal-to-noise ratio. In another embodiment of the invention, single events corresponding to the movement of target particles into, out of, or within the sensitive region are detected and counted.
摘要翻译：本发明涉及一种用于确定样品流体中目标颗粒（2）的浓度的方法和磁传感器装置，其中通过采样测量观察敏感区域（14）中的目标颗粒（2）的量信号与相关联的传感器单元（10a-10d）。目标颗粒（2）可以任选地结合到敏感区域中的结合位点（3）和参数结合曲线，例如， Langmuir等温线可以适应于取样的测量信号，以确定样品中所需的颗粒浓度。此外，在正在进行的采样过程中，可以动态地拟合诸如采样率和敏感区域（14）的尺寸的参数，以提高信噪比。在本发明的另一个实施例中，检测并计数对应于目标颗粒移动到，移出或在敏感区域内的单个事件。

4. 发明申请

WO2009138897A1 OXYGEN CONCENTRATION MEASUREMENT WITH GMR 审中-公开
标题翻译：氧气浓度测量与GMR
公开(公告)号：WO2009138897A1
公开(公告)日：2009-11-19
申请号：PCT/IB2009/051824
申请日：2009-05-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , DURIC, Haris , KAHLMAN, Josephus, Arnoldus, Henricus, Maria , VEEN, Jeroen
发明人： DURIC, Haris , KAHLMAN, Josephus, Arnoldus, Henricus, Maria , VEEN, Jeroen
IPC分类号： G01N27/74
CPC分类号： G01N27/74 , G01R33/091
摘要： In an embodiment, an oxygen sensor comprises a giant magnetoresistance device (10), and a magnetic field generator (14, 14a, 14b) arranged to generate a magnetic field (12, 12a, 12b) overlapping the giant magnetoresistance device and an examination region (20). A component (B x ) of the magnetic field detected by the giant magnetoresistance device is dependent upon an oxygen concentration in the examination region. In an embodiment, a chip (40) includes one or more electrically conductive traces (14a, 14b) disposed on or in the chip and a giant magnetoresistance device (10) disposed on or in the chip such that electrical current flowing in the trace or traces generates a magnetic field (12a, 12b) that overlaps the magnetic field sensor, said magnetic field being perturbed (B x ) by ambient oxygen (24) such that a signal output by the magnetic field sensor indicates ambient oxygen concentration.
摘要翻译：在一个实施例中，氧传感器包括巨磁电阻装置（10）和布置成产生与巨磁电阻装置重叠的磁场（12,12a，12b）的磁场发生器（14,14a，14b）和检查区（20）。由巨磁电阻装置检测的磁场的分量（Bx）取决于检查区域中的氧浓度。在一个实施例中，芯片（40）包括设置在芯片上或芯片中的一个或多个导电迹线（14a，14b）和设置在芯片上或芯片上的巨磁阻器件（10），使得流过迹线或轨迹产生与磁场传感器重叠的磁场（12a，12b），所述磁场被环境氧（24）扰动（Bx），使得由磁场传感器输出的信号表示环境氧浓度。

5. 发明申请

WO2007113724A2 MAGNETORESISTIVE SENSOR AS TEMPERATURE SENSOR 审中-公开
标题翻译：磁传感器作为温度传感器
公开(公告)号：WO2007113724A2
公开(公告)日：2007-10-11
申请号：PCT/IB2007/051030
申请日：2007-03-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NIEUWENHUIS, Jeroen, H. , JANSEN, Theodorus, P., H., G. , VEEN, Jeroen , KAHLMAN, Josephus, A., H., M. , IMMINK, Albert, H., J.
发明人： NIEUWENHUIS, Jeroen, H. , JANSEN, Theodorus, P., H., G. , VEEN, Jeroen , KAHLMAN, Josephus, A., H., M. , IMMINK, Albert, H., J.
IPC分类号： G01R33/09
CPC分类号： G01R33/09 , B82Y25/00 , G01R33/007 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： A detection system (100, 150) for qualitative or quantitative detection of a magnetic field property of a modulated magnetic field is described. The modulated magnetic field may e.g. stem from an adjacent electrical current (I adj ) or magnetic particles. The detection system (100, 150) comprises at least one magneto resistive sensor element (102), a current controller (104) for providing a sensing current (I sense ) flowing through the magnetic sensor element (102) and a controlling means (108). The controlling means (108) is adapted for deriving at a first frequency f 1 a temperature-related parameter of the at least one magneto resistive sensor. The controlling means (108) furthermore is adapted for deriving a qualitative or quantitative characteristic of the adjacent electrical current (I adj ) or magnetic particles, taking into account the derived temperature-related parameter. This second frequency (f 1 ) is different from the first frequency (f 1 }). The invention also relates to a corresponding method.
摘要翻译：描述了用于定性或定量检测调制磁场的磁场特性的检测系统（100,150）。调制磁场可以例如。来自相邻的电流（I SUB）或磁性颗粒。检测系统（100,150）包括至少一个磁阻传感器元件（102），电流控制器（104），用于提供流经磁传感器元件（102）的感测电流（I ）和控制装置（108）。控制装置（108）适于以至少一个磁阻传感器的温度相关参数的第一频率f 1导出。此外，控制装置（108）还适于导出相邻电流（I SUB）或磁性颗粒的定性或定量特性，同时考虑导出的温度相关参数。该第二频率（f 1> 1）不同于第一频率（f 1 N 1）。本发明还涉及相应的方法。

6. 发明申请

WO2012164462A1 METHOD AND SYSTEM FOR MONITORING THE SKIN COLOR OF A USER 审中-公开
标题翻译：用于监测用户皮肤颜色的方法和系统
公开(公告)号：WO2012164462A1
公开(公告)日：2012-12-06
申请号：PCT/IB2012/052630
申请日：2012-05-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , FAZZI, Alberto , VEEN, Jeroen , MEFTAH, Mohammed
发明人： FAZZI, Alberto , VEEN, Jeroen , MEFTAH, Mohammed
IPC分类号： A61B5/103 , A61B5/00 , A61G11/00 , G01J3/46 , H04N1/56
CPC分类号： G06K9/00671 , A61B5/0059 , A61B5/1032 , A61B5/441 , A61B2503/045 , A61G11/00 , G01J3/50 , G06T7/20
摘要： This invention relates to a method and a system for monitoring skin color of a user. The system comprises a capturing unit, an obtaining unit, a deriving unit and a determining unit. The capturing unit captures at least one image of the user over a predetermined time period, and the obtaining unit obtains motion-related information of the user over the predetermined time period. The deriving unit derives visual information from the at least one image on the basis of the motion-related information, and the determining unit determines the skin color on the basis of the derived visual information. In this way, the skin color of the user can be effectively monitored without exposing the user to strong environmental light.
摘要翻译：本发明涉及一种用于监测用户皮肤颜色的方法和系统。该系统包括捕获单元，获取单元，导出单元和确定单元。捕获单元在预定时间段内捕获用户的至少一个图像，并且获取单元在预定时间段内获取用户的运动相关信息。导出单元基于运动相关信息从至少一个图像导出视觉信息，并且确定单元基于导出的视觉信息来确定肤色。以这种方式，可以有效地监视用户的肤色，而不会使用户暴露于强烈的环境光。

7. 发明申请

WO2009153700A1 MONITORING A VITAL PARAMETER OF A PATIENT WITH "IN-SITU" MODULATION SCHEME TO AVOID INTERFERENCE 审中-公开
标题翻译：用“现场”调解方案监测患者的健康参数，避免干扰
公开(公告)号：WO2009153700A1
公开(公告)日：2009-12-23
申请号：PCT/IB2009/052435
申请日：2009-06-09
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VEEN, Jeroen , JANSEN, Theodorus, P., H., G. , VERBERNE, Henricus, R., M. , SCHENK, Tim, C., W. , FERI, Lorenzo
发明人： VEEN, Jeroen , JANSEN, Theodorus, P., H., G. , VERBERNE, Henricus, R., M. , SCHENK, Tim, C., W. , FERI, Lorenzo
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/0059
摘要： The invention relates to a method of monitoring a vital parameter of a patient by measuringattenuation of light emitted onto tissue of the patient, comprising the following steps: modulating the light with a modulation frequency or/and a modulation code; emitting the modulated light onto the tissue of the patient; collecting lightwhich is transmitted through the tissue or/and which is reflected from the tissue; demodulating the collected light; analyzing the demodulated collected light with regard to interference with ambient light; determining amodulation frequency or/and a modulation code for which interference with the ambient light is minimized or falls under a predefined threshold; and setting the modulation frequency or/and the modulation code for modulating the light according to the determined modulation frequency or/and a modulation code for which interference with the ambient light is minimized or falls under a predefined threshold. In this way a versatile and reliable possibility of monitoring a vital parameter of a patient with a high signal-to-interference ratio is provided.
摘要翻译：本发明涉及通过测量发射到患者组织上的光的测量来监测患者的重要参数的方法，包括以下步骤：用调制频率或/和调制码调制光; 将调制的光发射到患者的组织上; 收集透过组织的光和/或从组织反射的光; 解调收集的光; 分析与干扰环境光的解调收集的光; 确定调节频率或/和调节码，使对环境光的干扰最小化或落在预定阈值以下; 以及根据所确定的调制频率设置用于调制光的调制频率或/和调制码，或/和用于使环境光的干扰最小化或落在预定阈值以下的调制码。以这种方式，提供了用于监视具有高信号与干扰比的患者的重要参数的通用且可靠的可能性。

8. 发明申请

WO2008072183A1 SENSOR DEVICE COMPRISING MEANS FOR DETERMINING THE SAMPLE COVERED AREA OF THE SENSITIVE SURFACE 审中-公开
标题翻译：传感器装置包含用于确定敏感表面样品覆盖区域的方法
公开(公告)号：WO2008072183A1
公开(公告)日：2008-06-19
申请号：PCT/IB2007/055024
申请日：2007-12-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NIEUWENHUIS, Jeroen Hans , VAN ZON, Hans , DE THEIJE, Femke Karina , VEEN, Jeroen
发明人： NIEUWENHUIS, Jeroen Hans , VAN ZON, Hans , DE THEIJE, Femke Karina , VEEN, Jeroen
IPC分类号： G01N27/02 , G01N27/04 , G01N27/22
CPC分类号： G01N13/00 , G01N27/745 , G01N33/54326 , G01R33/1269
摘要： The invention relates to a microelectronic device (100) with means for the determination of the wetting grade of a sensitive surface (22) that lies adjacent to a sample chamber (1) with a sample fluid. In a particular embodiment, the device may be a magnetic sensor device comprising magnetic excitation wires (11, 13) for the generation of magnetic fields (B) in the sample chamber and a GMR sensor (12) for sensing reaction fields (B') generated by magnetized particles (2). A detector module (30) can optionally be adapted to measure the resistance of conductors (11, 12, 13) which depends, via the dissipation of heat generated by electrical currents, on the wetting grade of the sensitive surface (22). In another embodiment, the capacitance of conductors is measured, which is affected at the sensitive surface by the presence of gas bubbles (4).
摘要翻译：本发明涉及一种微电子器件（100），其具有用于利用样品流体确定位于样品室（1）附近的敏感表面（22）的润湿等级的装置。在特定实施例中，该装置可以是包括用于在样品室中产生磁场（B）的磁激励线（11,13）和用于感测反应场（B'）的GMR传感器（12）的磁传感器装置，由磁化颗粒（2）产生。检测器模块（30）可以可选地适于测量导体（11,12,13）的电阻，这取决于电流产生的热量消耗在敏感表面（22）的润湿等级上。在另一个实施例中，测量导体的电容，其通过气泡的存在而受到敏感表面的影响（4）。

9. 发明申请

WO2012164438A1 DETERMINING A FLOW CHARACTERISTIC OF AN OBJECT BEING MOVABLE IN AN ELEMENT 审中-公开
标题翻译：确定在元素中可移动的对象的流动特性
公开(公告)号：WO2012164438A1
公开(公告)日：2012-12-06
申请号：PCT/IB2012/052557
申请日：2012-05-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , VAN DER LEE, Alexander Marc , VEEN, Jeroen
发明人： VAN DER LEE, Alexander Marc , VEEN, Jeroen
IPC分类号： A61B5/00 , A61B5/026 , A61B3/12 , G01P5/26 , G01P3/36
CPC分类号： G01F1/00 , A61B5/0261 , A61B5/6801 , A61B2562/0233 , A61B2562/146 , G01N21/53 , G01P3/366 , G01P5/26 , G01S7/4916 , G01S7/4917 , G01S17/58 , G01S17/88
摘要： A sensor device (340) for determining a flow characteristic of an object (341) being movable in an element (342) comprises a light emitting unit (344) configured for emitting light towards the element (342) and a light detecting unit (344) configured for detecting light scattered back from the element (342). The sensor device (340) comprises an optical unit (346) configured for spatially separating a light incidence element portion (348) of the element (342) and a light detection element portion (350) of the element (342) from one another, wherein the light incidence element portion (348) is associated with the emitted light inciding on the element (342) and the light detection element portion (350) is associated with the back-scattered light scattered back from the element (342) for detection. The sensor device (340) comprises a determining unit (358) configured for determining the flow characteristic of the object (341) being movable in the element (342) based on light indicative of the emitted light and the detected back-scattered light. The sensor device (340) allows for an accurate and easy determination of the flow characteristic of the object (341).
摘要翻译：用于确定可在元件（342）中移动的物体（341）的流动特性的传感器装置（340）包括被配置为朝向元件（342）发射光的发光单元（344）和光检测单元（344）），其被配置用于检测从所述元件（342）向后散射的光。传感器装置（340）包括被配置用于将元件（342）的光入射元件部分（348）和元件（342）的光检测元件部分（350）彼此空间分离的光学单元（346）其中所述光入射元件部分（348）与所述元件（342）上的发射光相关联，并且所述光检测元件部分（350）与从所述元件（342）返回的用于检测的后向散射光相关联。传感器装置（340）包括确定单元（358），其被配置为基于指示所发射的光和检测到的反向散射光的光来确定可在元件（342）中移动的物体（341）的流动特性。传感器装置（340）允许准确和容易地确定物体（341）的流动特性。

10. 发明申请

WO2012077065A1 A METHOD AND APPARATUS FOR DETERMINING A PARTIAL CARBON DIOXIDE PRESSURE ARTERIAL BLOOD 审中-公开
标题翻译：一种二氧化碳气压二氧化碳血液测定方法及装置
公开(公告)号：WO2012077065A1
公开(公告)日：2012-06-14
申请号：PCT/IB2011/055510
申请日：2011-12-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , VEEN, Jeroen
IPC分类号： A61B5/083 , A61B5/08 , A61B5/145 , A61B5/0205
CPC分类号： A61B5/0836 , A61B5/02055 , A61B5/082 , A61B5/14542 , A61B2010/0087 , A61M16/0045 , A61M16/101 , A61M16/12 , A61M16/202 , A61M2016/1025 , A61M2016/103 , A61M2230/005 , A61M2230/205 , A61M2230/208 , A61M2230/42
摘要： The partial carbon dioxide pressure in arterial blood of a subject is determined by: modulating at least one parameter of a subject, such, for example, the mutual concentration of gases supplied to the subject or the arterial blood temperature of the subject; deriving oxygen saturation of the arterial blood of said subject; and determining partial carbon dioxide pressure from said derived oxygen saturation.
摘要翻译：受试者的动脉血中的部分二氧化碳压力通过：调节受试者的至少一个参数，例如供应给对象的气体相互浓度或受试者的动脉血温; 导出所述受试者的动脉血的氧饱和度; 以及从所述导出的氧饱和度确定部分二氧化碳压力。

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