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    • 6. 发明申请
    • AN OPTICAL PROBE
    • 光学探头
    • WO2009087527A1
    • 2009-07-16
    • PCT/IB2008/055483
    • 2008-12-22
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.HENDRIKS, Bernardus, H., W.BIERHOFF, Waltherus, C., J.BRAUN, Augustinus, L.MIHAJLOVIC, Nenad'T HOOFT, Gert
    • HENDRIKS, Bernardus, H., W.BIERHOFF, Waltherus, C., J.BRAUN, Augustinus, L.MIHAJLOVIC, Nenad'T HOOFT, Gert
    • A61B1/04A61B5/00
    • A61B5/0062A61B1/00096A61B1/00165A61B1/00183A61B1/0019A61B5/0084
    • The present invention relates to an optical probe (1) with an optical guide (2), e.g. an optical fibre, and a lens system (6) rigidly coupled to an end portion (2a) of the optical guide. The probehas a housing (3) with a cavity for the opticalguide, the housing having at its distalend a transparent window (4), the window having an insignificant optical power as compared to the opticalpower of the said lens system (6). Actuation means (8) displaces the 5 lens system so as to enable optical scanning of a region of interest (ROI). The invention is particularly suited for miniature applications e.g. for in-vivo medical application. By attaching the lens system (6) to the optical guide (2) via the mount (7), the field of view (FOV) of the optical probe (1) may be determined directly by the transverse stroke of the optical fibre (2). Hence only a relatively small stroke is required. The field of view is thus 10 effectively no longer limited by the transverse stroke. The optical probe is especially advantageous for non-linear optical imaging where the optical guide may be an optical fibre witha relatively low exit numerical aperture.
    • 本发明涉及一种具有光导(2)的光学探针(1),例如, 光纤,以及刚性地耦合到光导的端部(2a)的透镜系统(6)。 探针具有用于光导的空腔的壳体(3),所述壳体在其远端处具有透明窗口(4),所述窗口与所述透镜系统(6)的光焦度相比具有无效的光焦度。 驱动装置(8)使5透镜系统移位,以便对感兴趣区域(ROI)进行光学扫描。 本发明特别适用于微型应用,例如 用于体内医疗应用。 通过经由安装件(7)将透镜系统(6)附接到光导(2),光学探头(1)的视场(FOV)可以直接由光纤(2)的横向行程确定 )。 因此,只需要相对较小的行程。 因此,视场10不再受横向行程的限制。 光学探针对于非线性光学成像特别有利,其中光导可以是具有相对低的出射数值孔径的光纤。
    • 9. 发明申请
    • AN OPTICAL PROBE
    • 光学探头
    • WO2009087522A1
    • 2009-07-16
    • PCT/IB2008/055460
    • 2008-12-19
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.HENDRIKS, Bernardus, H., W.'T HOOFT, Gert
    • HENDRIKS, Bernardus, H., W.'T HOOFT, Gert
    • A61B1/04A61B1/07A61B5/00G02B6/00
    • A61B5/0062A61B1/00096A61B1/00165A61B1/00183A61B5/0068A61B5/0075A61B5/0084
    • The invention relates an optical probe (1) suitable for non- linear optics such as two-photon imaging for medical purposes. The probe has an optical guide (2) and a lens system (6) positioned rigidly at an end portion (2a) of the optical guide. Additionally, a housing (3) with a cavity for the optical guide (2) and the lens system (6), the housing having at its distal end a transparent window (4), is comprised in the probe. The optical guide (2) with the lens system (6) is displaceably mounted within the housing, preferably in a transverse direction. Also, the housing (3) has an auxiliary, peripheral optical guide (5) optically connected to the transparent window (4). The invention is advantageous for obtaining an optical probe with a significantly larger collection efficiency. The optical probe may advantageous be applied in connection with two-photon spectroscopy where both ballisitic photons and diffusing fluorescence photons can be used in the detection of an event.
    • 本发明涉及适用于非线性光学的光学探针(1),例如用于医疗目的的双光子成像。 探针具有光导件(2)和刚性地定位在光导的端部(2a)处的透镜系统(6)。 此外,具有用于光导(2)和透镜系统(6)的空腔的壳体(3),其外壳在其远端处具有透明窗口(4),其包括在探针中。 具有透镜系统(6)的光导(2)优选地在横向方向上可移动地安装在壳体内。 另外,壳体(3)具有与透明窗(4)光学连接的辅助外周光导(5)。 本发明有利于获得具有显着更大收集效率的光学探针。 结合双光子光谱可以有利地应用光探针,其中可以使用Ballisitic光子和扩散荧光光子来检测事件。
    • 10. 发明申请
    • A METHOD AND DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM
    • 一种用于成像涡轮介质内部的方法和装置
    • WO2007060602A2
    • 2007-05-31
    • PCT/IB2006/054349
    • 2006-11-21
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.BAKKER, Levinus, P.'T HOOFT, GertVAN DER MARK, Martinus, B.VAN BEEK, Michael, C.
    • BAKKER, Levinus, P.'T HOOFT, GertVAN DER MARK, Martinus, B.VAN BEEK, Michael, C.
    • A61B5/00
    • A61B5/4312A61B5/0091
    • The invention relates to a method and device (1) for imaging an interior of a turbid medium (55). A turbid medium (55) inside a measurement volume (15) is irradiated from a plurality of source positions (25a) with light from a light source (5), and light emanating from the measurement volume (15) is detected from a plurality of detection positions (25b). An image of the interior of the turbid medium (55) is reconstructed from the detected light. In both the method and the device (1), detector signals can be amplified for each source position-detection position pair by a multi-gain amplification unit comprising an amplifier circuit (60). The amplification factor is selected from a number of possible amplification factors based on detected signal strength in the prior art. According to the invention, however, the method and device are adapted such that the amplification factor is selected for at least one source position-detection position pair on the basis of an estimate of expected electrical signal strength.
    • 本发明涉及一种用于对混浊介质(55)的内部进行成像的方法和设备(1)。 利用来自光源(5)的光从多个源位置(25a)照射测量体积(15)内的混浊介质(55),并且从多个测量体积(15)中检测从测量体积(15)发出的光 检测位置(25b)。 从检测到的光重建混浊介质(55)的内部的图像。 在该方法和装置(1)中,可以通过包括放大器电路(60)的多增益放大单元为每个源位置检测位置对放大检测器信号。 基于现有技术中的检测信号强度,从许多可能的放大因子中选择放大因子。 然而,根据本发明,该方法和装置被调整为使得基于预期电信号强度的估计为至少一个源位置检测位置对选择放大因子。