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1. 发明申请

WO2011095916A1 APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A FIELD OF VIEW HAVING AN ARRAY OF SINGLE-SIDED TRANSMIT COIL SETS 审中-公开
标题翻译：在具有单面发射线圈组的视场范围内影响和/或检测磁性颗粒的装置和方法
公开(公告)号：WO2011095916A1
公开(公告)日：2011-08-11
申请号：PCT/IB2011/050374
申请日：2011-01-28
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BUZUG, Thorsten, Manuel , SATTEL, Timo, Frederik , KNOPP, Tobias , BIEDERER, Sven
发明人： BUZUG, Thorsten, Manuel , SATTEL, Timo, Frederik , KNOPP, Tobias , BIEDERER, Sven
IPC分类号： A61B5/05 , G01R33/38
CPC分类号： A61B5/05 , A61B5/0515
摘要： The present invention relates to an apparatus and a method for influencing and/or detecting magnetic particles in a field of view. To increase the field of view and, at the same time, allow access to the patient during imaging, the apparatus comprises two or more transmit coil sets (200) wherein neighboring coil sets are partially overlapping, a transmit coil set comprising: a pair (210) of concentrically arranged selection field coils (211, 212) for generating a magnetic selection field (50) having a pattern in space of its magnetic field strength such that a first sub-zone (52) having a low magnetic field strength and a second sub-zone (54) having a higher magnetic field strength are formed in the field of view (28), and at least one pair (220, 230) of drive field coils (221, 222; 231, 232) for changing the position in space of the two sub-zones (52, 54) in the field of view (28) by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, said at least one pair (220, 230) of drive field coils being arranged parallel to said pair (210) of selection field coils (211, 212) and being formed by two neighboring coil loops.
摘要翻译：本发明涉及在视场中影响和/或检测磁性颗粒的装置和方法。为了增加视野，并且同时在成像期间允许对患者的访问，该装置包括两个或更多个发射线圈组（200），其中相邻线圈组部分重叠，发射线圈组包括：一对 210），用于产生具有其磁场强度空间中的图案的磁选择场（50），使得具有低磁场强度的第一子区（52）和在视场（28）中形成具有较高磁场强度的第二子区（54）和至少一对（220,230）的驱动场线圈（221,222,231,232），用于改变通过磁驱动场在视场（28）中的两个子区（52,54）的空间中的位置，使得磁性颗粒的磁化在局部变化，所述至少一对（220,230）的驱动场线圈平行于所述选择场线圈（211,212）的所述对（210）布置）并且由两个相邻的线圈环形成。

2. 发明申请

WO2011021165A1 APPARATUS AND METHOD FOR GENERATING AND MOVING A MAGNETIC FIELD HAVING A FIELD FREE LINE 审中-公开
标题翻译：用于产生和移动具有现场自由线的磁场的装置和方法
公开(公告)号：WO2011021165A1
公开(公告)日：2011-02-24
申请号：PCT/IB2010/053749
申请日：2010-08-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KNOPP, Tobias , SATTEL, Timo, Frederik , BIEDERER, Sven , BUZUG, Thorsten, Manuel
发明人： KNOPP, Tobias , SATTEL, Timo, Frederik , BIEDERER, Sven , BUZUG, Thorsten, Manuel
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/0515 , G01R33/445
摘要： The present invention relates to an apparatus and a method for generating and changing a magnetic field in a field of view (28), said magnetic field having a, in particular ball-shaped or line-shaped, first sub-zone (62) having a low magnetic field strength and a second sub-zone (64) having a higher magnetic field strength. The proposed apparatus comprises at least three pairs of first coils (136a - 136d), wherein the coils are arranged along a ring around the field of view and wherein the two coils of each pair are opposingly arranged on opposite sides of the field of view, at least one pair of second coils (116) opposingly arranged on opposite sides of the field of view at the open sides of said ring, generator means (110, 130) for generating current signals for provision to said first and second coils for generating the desired magnetic fields by said first and second coils, and control means (150) for controlling said generator means.
摘要翻译：本发明涉及一种用于在视场（28）中产生和改变磁场的装置和方法，所述磁场具有特别是球形或线状的第一子区（62），其具有低磁场强度和具有较高磁场强度的第二子区域（64）。所提出的装置包括至少三对第一线圈（136a-136d），其中线圈沿着围绕视场的环布置，并且其中每对的两个线圈相对布置在视场的相对侧上，至少一对第二线圈（116），其相对地布置在所述环的开放侧的视场的相对侧上，用于产生电流信号，用于提供所述第一和第二线圈以产生所述第二线圈所述第一和第二线圈所需的磁场，以及用于控制所述发生器装置的控制装置（150）。

3. 发明申请

WO2011030275A1 APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES 审中-公开
标题翻译：影响和/或检测磁性颗粒的装置和方法
公开(公告)号：WO2011030275A1
公开(公告)日：2011-03-17
申请号：PCT/IB2010/053995
申请日：2010-09-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BIEDERER, Sven , SATTEL, Timo, Frederik , KNOPP, Tobias , BUZUG, Thorsten, Manuel
发明人： BIEDERER, Sven , SATTEL, Timo, Frederik , KNOPP, Tobias , BUZUG, Thorsten, Manuel
IPC分类号： A61B5/05 , A61N2/02
CPC分类号： A61B5/05 , A61B5/0515 , A61N2/02
摘要： The present invention relates to an MPI (Magnetic Particle Imaging) apparatus and a method for influencing and/or detecting magnetic particles in a field of view. Rather than moving the FFP (field free point) along a single, time-consuming high density trajectory it is proposed to use a number of low density trajectories with travelling phase, wherein each of said low density trajectories has the form of a closed curve differently located within the field of view.
摘要翻译：本发明涉及一种在视场中影响和/或检测磁性颗粒的MPI（Magnetic Particle Imaging）装置和方法。提出使用具有行进相位的多个低密度轨迹，而不是沿着单个耗时的高密度轨迹移动FFP（场自由点），其中每个所述低密度轨迹具有不同的闭合曲线的形式位于视野内。

4. 发明公开

EP2467056A1 APPARATUS AND METHOD FOR GENERATING AND MOVING A MAGNETIC FIELD HAVING A FIELD FREE LINE 失效转让
标题翻译：设备和方法产生和发展由于自由行磁场中
公开(公告)号：EP2467056A1
公开(公告)日：2012-06-27
申请号：EP10752631.1
申请日：2010-08-19
申请人： Koninklijke Philips Electronics N.V. , Philips Intellectual Property & Standards GmbH
发明人： KNOPP, Tobias , SATTEL, Timo, Frederik , BIEDERER, Sven , BUZUG, Thorsten, Manuel
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/0515 , G01R33/445
摘要： The present invention relates to an apparatus and a method for generating and changing a magnetic field in a field of view (28), said magnetic field having a, in particular ball-shaped or line-shaped, first sub-zone (62) having a low magnetic field strength and a second sub-zone (64) having a higher magnetic field strength. The proposed apparatus comprises at least three pairs of first coils (136a-136d), wherein the coils are arranged along a ring around the field of view and wherein the two coils of each pair are opposingly arranged on opposite sides of the field of view, at least one pair of second coils (116) opposingly arranged on opposite sides of the field of view at the open sides of said ring, generator means (110, 130) for generating current signals for provision to said first and second coils for generating the desired magnetic fields by said first and second coils, and control means (150) for controlling said generator means.

5. 发明公开

EP2533688A1 APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A FIELD OF VIEW HAVING AN ARRAY OF SINGLE-SIDED TRANSMIT COIL SETS 失效转让
标题翻译：装置及方法视野的影响和/或检测磁性颗粒单边传动线圈组数组
公开(公告)号：EP2533688A1
公开(公告)日：2012-12-19
申请号：EP11706013.7
申请日：2011-01-28
申请人： Koninklijke Philips Electronics N.V. , Philips Intellectual Property & Standards GmbH
发明人： BUZUG, Thorsten, Manuel , SATTEL, Timo, Frederik , KNOPP, Tobias , BIEDERER, Sven
IPC分类号： A61B5/05 , G01R33/38
CPC分类号： A61B5/05 , A61B5/0515
摘要： The present invention relates to an apparatus and a method for influencing and/or detecting magnetic particles in a field of view. To increase the field of view and, at the same time, allow access to the patient during imaging, the apparatus comprises two or more transmit coil sets (200) wherein neighboring coil sets are partially overlapping, a transmit coil set comprising: a pair (210) of concentrically arranged selection field coils (211, 212) for generating a magnetic selection field (50) having a pattern in space of its magnetic field strength such that a first sub-zone (52) having a low magnetic field strength and a second sub-zone (54) having a higher magnetic field strength are formed in the field of view (28), and at least one pair (220, 230) of drive field coils (221, 222; 231, 232) for changing the position in space of the two sub-zones (52, 54) in the field of view (28) by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, said at least one pair (220, 230) of drive field coils being arranged parallel to said pair (210) of selection field coils (211, 212) and being formed by two neighboring coil loops.

6. 发明公开

EP2475298A1 APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES 有权
标题翻译：装置和方法用于影响和/或检测磁性粒子
公开(公告)号：EP2475298A1
公开(公告)日：2012-07-18
申请号：EP10782007.8
申请日：2010-09-06
申请人： Koninklijke Philips Electronics N.V. , Philips Intellectual Property & Standards GmbH
发明人： BIEDERER, Sven , SATTEL, Timo, Frederik , KNOPP, Tobias , BUZUG, Thorsten, Manuel
IPC分类号： A61B5/05 , A61N2/02
CPC分类号： A61B5/05 , A61B5/0515 , A61N2/02
摘要： The present invention relates to an MPI (Magnetic Particle Imaging) apparatus and a method for influencing and/or detecting magnetic particles in a field of view. Rather than moving the FFP (field free point) along a single, time-consuming high density trajectory it is proposed to use a number of low density trajectories with travelling phase, wherein each of said low density trajectories has the form of a closed curve differently located within the field of view.

7. 发明授权

EP2467056B1 APPARATUS AND METHOD FOR GENERATING AND MOVING A MAGNETIC FIELD HAVING A FIELD FREE LINE 失效转让
标题翻译：用于产生和移动具有自由场的磁场的装置和方法
公开(公告)号：EP2467056B1
公开(公告)日：2018-03-14
申请号：EP10752631.1
申请日：2010-08-19
申请人： Koninklijke Philips N.V. , Philips Intellectual Property & Standards GmbH
发明人： KNOPP, Tobias , SATTEL, Timo, Frederik , BIEDERER, Sven , BUZUG, Thorsten, Manuel
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/0515 , G01R33/445
摘要： The present invention relates to an apparatus and a method for generating and changing a magnetic field in a field of view (28), said magnetic field having a, in particular ball-shaped or line-shaped, first sub-zone (62) having a low magnetic field strength and a second sub-zone (64) having a higher magnetic field strength. The proposed apparatus comprises at least three pairs of first coils (136a-136d), wherein the coils are arranged along a ring around the field of view and wherein the two coils of each pair are opposingly arranged on opposite sides of the field of view, at least one pair of second coils (116) opposingly arranged on opposite sides of the field of view at the open sides of said ring, generator means (110, 130) for generating current signals for provision to said first and second coils for generating the desired magnetic fields by said first and second coils, and control means (150) for controlling said generator means.

8. 发明授权

EP2475298B1 APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES 有权
标题翻译： VORRICHTUNG UND VERFAHREN ZUR BEEINFLUSSUNG UND / ODER DETEKTION VON MAGNETPARTIKELN
公开(公告)号：EP2475298B1
公开(公告)日：2017-02-15
申请号：EP10782007.8
申请日：2010-09-06
申请人： Koninklijke Philips N.V. , Philips Intellectual Property & Standards GmbH
发明人： BIEDERER, Sven , SATTEL, Timo, Frederik , KNOPP, Tobias , BUZUG, Thorsten, Manuel
IPC分类号： A61B5/05 , A61N2/02
CPC分类号： A61B5/05 , A61B5/0515 , A61N2/02

9. 发明授权

EP2533688B1 APPARATUS AND METHOD FOR INFLUENCING AND/OR DETECTING MAGNETIC PARTICLES IN A FIELD OF VIEW HAVING AN ARRAY OF SINGLE-SIDED TRANSMIT COIL SETS 失效转让
标题翻译：装置及方法视野的影响和/或检测磁性颗粒单边传动线圈组数组
公开(公告)号：EP2533688B1
公开(公告)日：2013-11-20
申请号：EP11706013.7
申请日：2011-01-28
申请人： Koninklijke Philips N.V. , Philips Intellectual Property & Standards GmbH
发明人： BUZUG, Thorsten, Manuel , SATTEL, Timo, Frederik , KNOPP, Tobias , BIEDERER, Sven
IPC分类号： A61B5/05 , G01R33/38
CPC分类号： A61B5/05 , A61B5/0515
摘要： The present invention relates to an apparatus and a method for influencing and/or detecting magnetic particles in a field of view. To increase the field of view and, at the same time, allow access to the patient during imaging, the apparatus comprises two or more transmit coil sets (200) wherein neighboring coil sets are partially overlapping, a transmit coil set comprising: a pair (210) of concentrically arranged selection field coils (211, 212) for generating a magnetic selection field (50) having a pattern in space of its magnetic field strength such that a first sub-zone (52) having a low magnetic field strength and a second sub-zone (54) having a higher magnetic field strength are formed in the field of view (28), and at least one pair (220, 230) of drive field coils (221, 222; 231, 232) for changing the position in space of the two sub-zones (52, 54) in the field of view (28) by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, said at least one pair (220, 230) of drive field coils being arranged parallel to said pair (210) of selection field coils (211, 212) and being formed by two neighboring coil loops.

10. 发明申请

WO2012136255A1 SPULENSYSTEM FÜR MAGNETIC PARTICLE IMAGING MIT MINIMIERTEN OHMSCHEN VERLUSTEN 审中-公开
标题翻译：探头系统用于以最小的电阻损耗磁性粒子成像
公开(公告)号：WO2012136255A1
公开(公告)日：2012-10-11
申请号：PCT/EP2011/055376
申请日：2011-04-06
申请人： UNIVERSITÄT ZU LÜBECK , KNOPP, Tobias , SATTEL, Timo , BUZUG, Torsten
发明人： KNOPP, Tobias , SATTEL, Timo , BUZUG, Torsten
IPC分类号： H01F7/20 , A61B5/05
CPC分类号： A61B5/0515 , G01R33/1276 , H01F7/20
摘要： Die Erfindung betrifft ein Spulensystem zur Erzeugung eines Magnetfeldes mit einem feldfreien Punkt an einer vorgebbaren Position auf einer vorgegebenen Strecke und mit einem vorgebbaren Magnetfeldgradienten im feldfreien Punkt, gekennzeichnet durch N ≥ 2 koplanare Spulen, angeordnet am ersten Ende der Strecke und M ≥ 2 koplanare Spulen am zweiten Ende der Strecke, wobei alle Spulen koaxial ausgerichtet sind. Des Weiteren umfasst das Spulensystem eine Steuereinrichtung, die angepasst ist, um die Ströme in den N + M Spulen so zu steuern, dass bei jeder Vorgabe wenigstens der Position des feldfreien Punktes auf der Strecke und des Magnetfeldgradienten im feldfreien Punkt jene Spulenströme, die zu minimalen ohmschen Verlusten führen, aus der Lösung eines linearen Gleichungssystems bestimmt und eingestellt werden.
摘要翻译：本发明涉及一种线圈系统用于在预定路径上，并与在无场点规定的磁场中的预定位置，其特征在于，N = 2的共面线圈，布置在所述轨道的所述第一端和M = 2个的共面线圈产生具有无场点的磁场在链路，从而使所有的线圈同轴地对准的第二端。此外，线圈系统包括适于控制所述N + M线圈的电流，使得为每个规格的控制装置中的至少所述轨道，并在无场点的磁场梯度在无场点的位置，所述线圈的电流，在最低限度，导致欧姆损耗从方程和组的线性系统的解来确定。

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