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    • 5. 发明申请
    • A METHOD AND APPARATUS FOR DETERMINING LOCATION INFORMATION OF A POSITION IN A MULTI-STOREY BUILDING
    • 一种用于确定多层建筑中位置位置信息的方法和装置
    • WO2013070170A1
    • 2013-05-16
    • PCT/SG2011/000397
    • 2011-11-08
    • YFIND TECHNOLOGIES PTE. LTD.HAN, YangTING, See Ho
    • HAN, YangTING, See Ho
    • H04W4/02
    • G01S5/0252G01S5/0278H04W4/043
    • A method and apparatus for determining location information of a position in a multi-storey building, the method comprising: retrieving observation data comprising observed addresses and corresponding observed received signal strengths of wireless access points detected at the position from a memory; retrieving, for each storey of the building, a radio map comprising a plurality of location points in the respective storey of the building from a database; selecting one or more location points comprising the observed addresses from the radio map; determining a storey estimate of the position by calculating a sum probability for each storey of the building; and setting the storey estimate as the storey of the building having highest value of the calculated sum probability.
    • 一种用于确定多层建筑物中的位置的位置信息的方法和装置,所述方法包括:检索观察数据,所述观测数据包括在存储器的位置处检测到的无线接入点的观测地址和相应的观测到的接收信号强度; 对于所述建筑物的每个楼层检索包括从数据库在所述建筑物的相应楼层中的多个位置点的无线电地图; 从所述无线电图中选择包括所述观测地址的一个或多个位置点; 通过计算建筑物每层的总概率来确定位置的层次估计; 并将层叠估计设置为具有计算的和概率的最高值的建筑物的层。
    • 6. 发明申请
    • A FUNCTIONAL COMPLEMENTATION ASSAY FOR DEFINED GPCR OLIGOMERS
    • 定义GPCR低分子的功能补充测定
    • WO2010002468A1
    • 2010-01-07
    • PCT/US2009/003933
    • 2009-07-01
    • THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKJAVITCH, Jonathan, A.HAN, Yang
    • JAVITCH, Jonathan, A.HAN, Yang
    • C12P21/06C07K14/00C07H21/04
    • C07K14/705C07K2319/00
    • The present invention is directed to, inter alia , a biological reagent that includes a complex having a first GPCR and a second GPCR linked to a G-protein, the linkage between the second GPCR and the G-protein being of a length, which prevents productive interaction between the G-protein and the second GPCR, wherein the first GPCR and the second GPCR linked to the G-protein alone are incapable of producing a signal when presented with a ligand. The invention also provides methods of producing such a biological reagent, as well as methods of determining oligomeric GPCR interactions, methods of identifying compounds that have an effect on GPCR oligomers, methods of identifying a compound capable of interacting with GPCR oligomers, methods of identifying a compound having the ability to modulate binding between a GPCR oligomer and its ligand, and methods for evaluating differential G-protein coupling.
    • 本发明特别涉及生物试剂,其包括具有与G-蛋白质连接的第一GPCR和第二GPCR的复合物,第二GPCR与G蛋白之间的连接长度可防止 G-蛋白与第二GPCR之间的生产性相互作用,其中与G-蛋白单独连接的第一GPCR和第二GPCR在呈现配体时不能产生信号。 本发明还提供了生产这种生物试剂的方法,以及确定寡聚GPCR相互作用的方法,鉴定对GPCR寡聚体具有影响的化合物的方法,鉴定能够与GPCR寡聚体相互作用的化合物的方法,鉴定 具有调节GPCR寡聚体及其配体之间的结合能力的化合物以及用于评估差异G蛋白偶联的方法。