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1. 发明申请

WO2013001423A1 AN APPARATUS FOR OPTICAL ANALYSIS OF AN ASSOCIATED TISSUE SAMPLE 审中-公开
标题翻译：用于相关组织样品的光学分析的装置
公开(公告)号：WO2013001423A1
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053133
申请日：2012-06-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MUELLER, Manfred , HENDRIKS, Bernardus Hendrikus Wilhelmus , BIERHOFF, Waltherus Cornelis Jozef , LUCASSEN, Gerhardus Wilhelmus , HORIKX, Jeroen Jan Lambertus , NACHABE, Rami , VAN DER VOORT, Marjolein
发明人： MUELLER, Manfred , HENDRIKS, Bernardus Hendrikus Wilhelmus , BIERHOFF, Waltherus Cornelis Jozef , LUCASSEN, Gerhardus Wilhelmus , HORIKX, Jeroen Jan Lambertus , NACHABE, Rami , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/0084
摘要： In order to improve fluorescence measurements, there is provided an apparatus and, a method and a computer program for optical analysis of an associated tissue sample, the apparatus comprising a spectrometer comprising an optical detector, a light source, a first light emitter 219 arranged for emitting photons into the associated tissue sample, a first light collector 221 arranged for receiving photons from the associated tissue sample, a second light emitter 223, a second light collector 225, wherein a reflectance spectrum is obtained via the first light emitter 219 and collector 221 and a fluorescence spectrum is obtained via the second light emitter 223 and collector 225, and where a first distance d1 between the first light emitter and collector is larger than a second distance d2 between the second light emitter and collector. By combining the data thus obtained, an intrinsic fluorescence spectrum may be obtained.
摘要翻译：为了改进荧光测量，提供了一种用于相关组织样本的光学分析的装置和方法以及计算机程序，该装置包括光谱仪，该光谱仪包括光学检测器，光源，第一光发射器219，将光子发射到相关联的组织样本中，布置成从相关联的组织样本接收光子的第一光收集器221，第二光发射器223，第二光收集器225，其中通过第一光发射器219和集电极221获得反射光谱并且通过第二光发射器223和集电极225获得荧光光谱，并且其中第一光发射器和集电极之间的第一距离d1大于第二发光体和集电极之间的第二距离d2。通过组合由此获得的数据，可以获得固有的荧光光谱。

2. 发明申请

WO2010015979A1 A MOVING PARTICLE DISPLAY DEVICE 审中-公开
标题翻译：移动颗粒显示装置
公开(公告)号：WO2010015979A1
公开(公告)日：2010-02-11
申请号：PCT/IB2009/053344
申请日：2009-07-31
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MUELLER, Manfred , STROEMER, Jan, F.
发明人： MUELLER, Manfred , STROEMER, Jan, F.
IPC分类号： G02F1/167
CPC分类号： G02F1/167 , G02F2001/1676
摘要： A moving particle display device comprises an array of display cells, each cell comprising an enclosed volume containing display particles. The display cells are the disposed between the first and second electrode arrangements, and the particles are provided for movement between a first region adjacent the first electrode arrangement and a second region adjacent the second electrode arrangement. Each cell is associated with a group of electrodes (60,62,63) used to control the particle movement within the cell, wherein for most of the cells, the group of electrodes is arranged to provide asymmetry in the electric field lines (140) in the enclosed volume, thereby to influence the particle flow conditions within the display cell.
摘要翻译：移动的粒子显示装置包括显示单元的阵列，每个单元包括包含显示粒子的封闭体积。显示单元设置在第一和第二电极布置之间，并且提供颗粒以在与第一电极布置相邻的第一区域与邻近第二电极布置的第二区域之间移动。每个电池与用于控制电池内的颗粒运动的一组电极（60,62,63）相关联，其中对于大多数电池，电极组被布置成在电场线（140）中提供不对称性，在封闭体积中，从而影响显示单元内的颗粒流动状态。

3. 发明申请

WO2010136925A1 ELECTROPHORETIC DEVICE 审中-公开
标题翻译：电泳装置
公开(公告)号：WO2010136925A1
公开(公告)日：2010-12-02
申请号：PCT/IB2010/052102
申请日：2010-05-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LENSSEN, Kars-Michiel Hubert , MUELLER, Manfred , VAN DELDEN, Martinus Hermanus W.M.
发明人： LENSSEN, Kars-Michiel Hubert , MUELLER, Manfred , VAN DELDEN, Martinus Hermanus W.M.
IPC分类号： G02F1/167
CPC分类号： G02F1/167 , G02F2001/1676 , G02F2201/122
摘要： The invention relates to an electrophoretic device comprising one or more cells. Each of the one or more cells of the device comprises a bottom substrate having a bottom substrate area (110), a top substrate (120) having a top substrate area, and a spacer structure (130) spacing apart the bottom and top substrates to form a space containing a suspension of particles (140) in a medium, the particles being movable through application of an electric field. The bottom substrate comprises a bottom electrode having an effective bottom electrode area, and the top substrate comprises one or more independently- addressable top electrodes (121, 122) having an effective top electrode area. The bottom and top electrodes are arranged to establish the electric field, and to control a distribution of the particles from a distributed state to a collected state. The effective top electrode area is in the form of a pattern. The ratio of the effective bottom electrode area to the effective top electrode area is larger than one, and the ratio of the top substrate area to the effective top electrode area is larger than or equal to 5. The electrophoretic device of the invention has built-in grey scales, an improved manuf acturability through a relatively simple electrode arrangement, and allows the formation of a transparent state.
摘要翻译：本发明涉及一种包括一个或多个细胞的电泳装置。器件的一个或多个单元中的每一个包括底部衬底，其具有底部衬底区域（110），具有顶部衬底区域的顶部衬底（120）和将底部和顶部衬底间隔开的间隔结构（130）在介质中形成包含颗粒悬浮液（140）的空间，颗粒可通过施加电场而移动。底部衬底包括具有有效底部电极区域的底部电极，并且顶部衬底包括具有有效顶部电极区域的一个或多个可独立寻址的顶部电极（121,122）。底部和顶部电极被布置成建立电场，并且控制颗粒从分布状态到收集状态的分布。有效的顶部电极区域是图案的形式。有效底电极面积与有效顶部电极面积的比值大于1，顶部衬底面积与有效顶部电极面积的比例大于或等于5.本发明的电泳装置具有内置电极，在灰度级中，通过相对简单的电极布置提高了制造能力，并且允许形成透明状态。

4. 发明申请

WO2013068885A1 DETECTION APPARATUS FOR DETERMINING A STATE OF TISSUE 审中-公开
标题翻译：用于确定组织状态的检测装置
公开(公告)号：WO2013068885A1
公开(公告)日：2013-05-16
申请号：PCT/IB2012/056008
申请日：2012-10-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V.
发明人： MUELLER, Manfred , HENDRIKS, Bernardus Hendrikus Wilhelmus , LUCASSEN, Gerhardus Wilhelmus , HORIKX, Jeroen Jan Lambertus
IPC分类号： A61B5/00
CPC分类号： A61B5/0071 , A61B18/1492 , A61B2018/00577 , A61B2018/00642
摘要： The invention relates to a detection apparatus (30) for determining a state of tissue. The detection apparatus (30) comprises a fluorescence spectrum providing unit (2, 3) for providing a fluorescence spectrum of the tissue, a differentiation unit (4) for generating a derivative of the fluorescence spectrum,and a tissue state determination unit (5) for determining the state of the tissue from the derivative. This allows determining the state of the tissue, even if characteristics, which are related to the state of the tissue, are only hardly visible or not visible at all in the fluorescence spectrum. The reliability of determining the state of the tissue, for instance, whether the tissue is cancerous or not, can therefore be improved.
摘要翻译：本发明涉及一种用于确定组织状态的检测装置（30）。检测装置（30）包括用于提供组织的荧光光谱的荧光光谱提供单元（2,3），用于产生荧光光谱的衍生物的分化单元（4）和组织状态确定单元（5）用于从衍生物确定组织的状态。即使与组织的状态相关的特征在荧光光谱中完全几乎看不到或看不见也能够确定组织的状态。因此，可以提高确定组织状态的可靠性，例如组织是否癌变。

5. 发明公开

EP2097133A1 CELL LYSIS OR ELECTROPORATION DEVICE COMPRISING AT LEAST ONE PYROELECTRIC MATERIAL 审中-公开
标题翻译：细胞裂解或至少电热电材料
公开(公告)号：EP2097133A1
公开(公告)日：2009-09-09
申请号：EP07849494.5
申请日：2007-12-14
申请人： Koninklijke Philips Electronics N.V.
发明人： MUELLER, Manfred , JOHNSON, Mark T. , GILLIES, Murray F. , PONJEE, Marc W. G.
IPC分类号： A61N1/32
CPC分类号： A61N1/327 , A61N1/0416 , A61N1/042 , C12M35/02 , C12M47/06
摘要： The present invention relates to a cell lysis or electroporation device comprising at least one pyroelectric material.

6. 发明申请

WO2008075275A1 CELL LYSIS OR ELECTROPORATION DEVICE COMPRISING AT LEAST ONE PYROELECTRIC MATERIAL 审中-公开
标题翻译：包含至少一种PYROELECTRIC材料的细胞分析或电泳装置
公开(公告)号：WO2008075275A1
公开(公告)日：2008-06-26
申请号：PCT/IB2007/055116
申请日：2007-12-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , MUELLER, Manfred , JOHNSON, Mark, T. , GILLIES, Murray, F. , PONJEE, Marc, W., G.
发明人： MUELLER, Manfred , JOHNSON, Mark, T. , GILLIES, Murray, F. , PONJEE, Marc, W., G.
IPC分类号： A61N1/32
CPC分类号： A61N1/327 , A61N1/0416 , A61N1/042 , C12M35/02 , C12M47/06
摘要： The present invention relates to a cell lysis or electroporation device comprising at least one pyroelectric material.
摘要翻译：本发明涉及包含至少一种热电材料的细胞裂解或电穿孔装置。

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