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1. 发明申请

WO2010119373A1 USING MUSCLE TENSION SENSING TO LOCATE AN ANALYTE MEASUREMENT SITE ON THE SKIN 审中-公开
标题翻译：使用肌肉张力感测来定位皮肤上的分析测量站点
公开(公告)号：WO2010119373A1
公开(公告)日：2010-10-21
申请号：PCT/IB2010/051498
申请日：2010-04-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LIU, Yan , MOESKOPS, Bastiaan, W., M. , VON BASUM, Golo , BONOMI, Alberto, G.
发明人： LIU, Yan , MOESKOPS, Bastiaan, W., M. , VON BASUM, Golo , BONOMI, Alberto, G.
IPC分类号： A61B5/00 , A61B5/0488
CPC分类号： A61B5/0488 , A61B5/0059 , A61B5/061 , A61B5/14532 , A61B2562/0209 , A61B2562/046
摘要： Apparatus for determining where to locate a measuring device (3) on skin, the apparatus having a muscle tension sensing device (1) arranged to sense muscle tension at different locations on the skin, and a processor (2) for determining and outputting an indication of where to locate the measuring device on the muscle, based on the sensed muscle tensions. This can help make the skin measurements such as non invasive glucose measurements more consistent, and more accurate.
摘要翻译：用于确定在皮肤上定位测量装置（3）的位置的装置，所述装置具有布置成感测皮肤上不同位置处的肌肉张力的肌肉张力感测装置（1），以及用于确定和输出指示基于感测到的肌肉紧张度，将测量装置定位在肌肉上的位置。这可以帮助皮肤测量如非侵入性葡萄糖测量更一致，更准确。

2. 发明申请

WO2009141755A1 DEVICE FOR ADAPTING PRESSURE EXERTED BY A PROBE TO A MEASUREMENT AND/OR TREATMENT SITE 审中-公开
标题翻译：将探头适应压力测量和/或治疗场所的装置
公开(公告)号：WO2009141755A1
公开(公告)日：2009-11-26
申请号：PCT/IB2009/051942
申请日：2009-05-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LIU, Yan , MOESKOPS, Bastiaan, W., M. , THUMMA, Kiran, K. , VON BASUM, Golo
发明人： LIU, Yan , MOESKOPS, Bastiaan, W., M. , THUMMA, Kiran, K. , VON BASUM, Golo
IPC分类号： A61B5/103
CPC分类号： A61B5/103 , A61B5/0059 , A61B5/14532 , A61B5/6834 , A61B5/6843 , A61B8/4281
摘要： The present invention provides a device (35) for adapting pressure exerted by a probe (10) at a measurement and/or treatment site (15) on a human or animal body. The device comprises a probe (10) comprising at least one pressure sensor (11) for measuring pressure at an interface between the probe (10) and skin (16) of the human or animal body and a pressure and/or suction system (12) comprising at least one force element (17). The device (35) furthermore comprises a controller (13) for controlling the at least one force element (17) of the pressure and/or suction system (12) so as to activate it and allow it to adjust the pressure at the measurement and/or treatment site (15) to a desired pressure value when the measured pressure is different from the desired pressure value by at least a predetermined offset value. The present invention also provides a method for making such a device (35) and a method adapting pressure exerted by a probe (10) at a measurement and/or treatment site (15) on a human or animal body by using such a device (35).
摘要翻译：本发明提供了一种用于在人体或动物身体的测量和/或治疗部位（15）处适配由探针（10）施加的压力的装置（35）。所述装置包括探针（10），所述探针（10）包括用于测量人或动物体的探针（10）和皮肤（16）之间的界面处的压力的压力传感器（11）和压力和/或抽吸系统（12））包括至少一个力元件（17）。装置（35）还包括用于控制压力和/或抽吸系统（12）的至少一个力元件（17）的控制器（13），以便启动压力和/或抽吸系统（12）并允许其在测量时调节压力，当所测量的压力与期望的压力值不同至少预定的偏移值时，/或处理部位（15）达到所需的压力值。本发明还提供了一种用于制造这种装置（35）的方法，以及通过使用这种装置（115）在人体或动物身体的测量和/或治疗部位（15）适应由探针（10）施加的压力的方法（ 35）。

3. 发明申请

WO2009144623A1 CONTROL OF MEASUREMENT AND/OR TREATMENT MEANS OF A PROBE 审中-公开
标题翻译：探测器和/或处理手段的控制
公开(公告)号：WO2009144623A1
公开(公告)日：2009-12-03
申请号：PCT/IB2009/052094
申请日：2009-05-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LIU, Yan , MOESKOPS, Bastiaan, W., M. , VON BASUM, Golo , THUMMA, Kiran, K.
发明人： LIU, Yan , MOESKOPS, Bastiaan, W., M. , VON BASUM, Golo , THUMMA, Kiran, K.
IPC分类号： A61B5/00 , A61B5/103
CPC分类号： A61B5/444 , A61B5/0059 , A61B5/14532 , A61B5/1455 , A61B5/14552 , A61B5/443 , A61B5/6843 , A61B2562/0247 , A61B2562/046
摘要： The present invention provides a system (110) for controlling measurement and/or treatment means of a probe (10). The system (110) comprises a probe (10) with an outwardly curved probe head (11) having a contact surface (12) adapted for contacting skin (13) of a human or animal body. A plurality of pressure sensors (23) is distributed over the contact surface (12), the plurality of pressure sensors (23) being for obtaining a feedback signal indicative of locations where contact exists between the probe (10) and skin (13) of the human or animal body, also referred to as target locations. The system (110) furthermore comprises a controller (17) for selectively driving measurement and/or treatment means located at the target location based on the feedback signal from the pressure sensors (23). The present invention also provides a method for making a system (110) for controlling measurement and/or treatment means of a probe (10) and a method for controlling measurement and/or treatment means of a probe (10).
摘要翻译：本发明提供一种用于控制探针（10）的测量和/或处理装置的系统（110）。系统（110）包括具有向外弯曲的探针头（11）的探针（10），所述探头具有适于接触人体或动物体的皮肤（13）的接触表面（12）。多个压力传感器（23）分布在接触表面（12）上，多个压力传感器（23）用于获得指示探针（10）和皮肤（13）之间存在触点的位置的反馈信号人体或动物体，也称为目标位置。系统（110）还包括控制器（17），用于基于来自压力传感器（23）的反馈信号选择性地驱动位于目标位置处的测量和/或处理装置。本发明还提供了一种用于制造用于控制探针（10）的测量和/或处理装置的系统（110）的方法和用于控制探针（10）的测量和/或处理装置的方法。

4. 发明申请

WO2009144622A1 LOCATION INDICATING DEVICE 审中-公开
标题翻译：位置指示装置
公开(公告)号：WO2009144622A1
公开(公告)日：2009-12-03
申请号：PCT/IB2009/052093
申请日：2009-05-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LIU, Yan , MOESKOPS, Bastiaan, W., M. , KOLEN, Alexander, F. , WAGEMAKERS, Femke , VON BASUM, Golo
发明人： LIU, Yan , MOESKOPS, Bastiaan, W., M. , KOLEN, Alexander, F. , WAGEMAKERS, Femke , VON BASUM, Golo
IPC分类号： A61B5/053 , A61B5/103 , A61B5/15
CPC分类号： A61B5/0531 , A61B5/0053 , A61B5/150022 , A61B5/150106 , A61B5/150748 , A61B5/150824 , A61B5/151 , A61B5/4824 , A61B5/4827 , A61B5/489 , A61B5/6842 , A61B2562/0209 , A61B2562/046
摘要： The present invention provides a location indicating device (10) for determining on skin of a human or animal body a location for performing measurement of a physiological parameter in and/or treatment of the human or animal body. The location indicating device (10) comprises a matrix (7) of electrodes for determining skin resistance at different locations on skin of a human or animal body and a calculating unit (8) for calculating a location with highest skin resistance. The location indicating device (10) furthermore comprises visualisation means (9) for indicating the location of highest skin resistance to a user. The present invention also provides a method for making such a location indicating device (10) and a method for determining on skin of a human or animal body a location for performing measurement of a physiological parameter in and/or treatment of the human or animal body by using such a location indicating device (10).
摘要翻译：本发明提供一种位置指示装置（10），用于在人体或动物体的皮肤上确定用于在人体或动物体内进行和/或治疗的生理参数的测量的位置。位置指示装置（10）包括用于确定人体或动物体皮肤上不同位置处的皮肤电阻的电极矩阵（7）和用于计算具有最高皮肤电阻的位置的计算单元（8）。位置指示装置（10）还包括用于指示对使用者的最高皮肤电阻位置的可视化装置（9）。本发明还提供了一种用于制造这样的位置指示装置（10）的方法和用于在人或动物身体的皮肤上确定用于在人或动物体内进行和/或治疗的生理参数的测量的位置的方法通过使用这样的位置指示装置（10）。

5. 发明申请

WO2009141769A1 REPRODUCIBLE POSITIONING OF SENSING AND/OR TREATMENT DEVICES 审中-公开
标题翻译：感测和/或治疗装置的重新定位
公开(公告)号：WO2009141769A1
公开(公告)日：2009-11-26
申请号：PCT/IB2009/051998
申请日：2009-05-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LIU, Yan , VON BASUM, Golo , MOESKOPS, Bastiaan, W., M. , CIUHU, Calina , THUMMA, Kiran, K.
发明人： LIU, Yan , VON BASUM, Golo , MOESKOPS, Bastiaan, W., M. , CIUHU, Calina , THUMMA, Kiran, K.
IPC分类号： A61B5/06 , G06T7/00 , A61B19/00
CPC分类号： A61B5/6842 , A61B5/0059 , A61B5/0066 , A61B5/061 , A61B5/064 , A61B5/14532 , A61B5/441 , A61B5/6843 , A61B34/20 , A61B34/70 , A61B90/90 , A61B2034/2065 , A61B2090/373 , A61B2090/3937 , A61B2090/395 , A61B2562/02 , G06F19/00 , G06T7/33 , G06T2207/30088 , G06T2207/30101 , G06T2207/30204
摘要： The present invention provides a repositioning system (10) for positioning a sensing and/or treatment device (6) at a target location (16), the repositioning system (10) comprising an imaging system (2) for identifying a target location (16) having a marker (12) on a body part (11) of a human being or an animal, thereby obtaining a reference image (13) ofthe target location (16), and for acquiring at least one measured image (14) of the target location (16).The imaging system (2) furthermore comprises registration means (3) for registering the at least one measured image (14) to the reference image (13), and signal generating means for generating a driving signal (5) indicative of the target location direction when spatial alignment between the at least one measured image (14) and reference image (13) is not approached within a predetermined threshold value. The repositioning system (10) furthermore comprises actuator means (4) for driving the sensing and/or treatment device (6) to guide it towards the target location thereby using the driving signal (5). The present invention also provides a method for making such a repositioning system (10) and a method for positioning a sensing and/or treatment device (6) on a target location (16) on a body part (11) of a human being or an animal by using such a repositioning system (10).
摘要翻译：本发明提供一种用于将感测和/或治疗装置（6）定位在目标位置（16）处的重新定位系统（10），所述重新定位系统（10）包括用于识别目标位置（16）的成像系统（2））在人或动物的身体部分（11）上具有标记（12），从而获得目标位置（16）的参考图像（13），并且用于获取至少一个测量图像（14）目标位置（16）。成像系统（2）还包括用于将至少一个测量图像（14）登记到参考图像（13）的登记装置（3）和用于产生驱动信号（5）的信号产生装置指示在所述至少一个测量图像（14）和参考图像（13）之间的空间对准未在预定阈值内接近时的所述目标位置方向。重新定位系统（10）还包括用于驱动感测和/或治疗装置（6）以将其引向目标位置的致动器装置（4），从而使用驱动信号（5）。本发明还提供了一种用于制造这种重新定位系统（10）的方法和用于将感测和/或治疗装置（6）定位在人的身体部分（11）上的目标位置（16）上的方法，或通过使用这种重新定位系统（10）的动物。

6. 发明申请

WO2010013184A1 ANALYSIS BY PHOTO ACOUSTIC DISPLACEMENT AND INTERFEROMETRYL 审中-公开
标题翻译：通过照片声学位移和干扰素分析
公开(公告)号：WO2010013184A1
公开(公告)日：2010-02-04
申请号：PCT/IB2009/053219
申请日：2009-07-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , THUMMA, Kiran, K. , MOESKOPS, Bastiaan, W., M. , VON BASUM, Golo , LIU, Yan
发明人： THUMMA, Kiran, K. , MOESKOPS, Bastiaan, W., M. , VON BASUM, Golo , LIU, Yan
IPC分类号： A61B5/00 , G01B9/02
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/0064 , A61B5/0095 , A61B5/14532
摘要： A device for analyzing a material, the device having a photo acoustic generator (40) for generating pressure waves in the material by pulsed illumination by a light source, and a sensor (20, 30, 50) for producing a signal using self mixing interferometry, the signal representing displacements of the material due to the pressure waves, and a signal processor (60) for processing the signal to analyze the material. This combination of photo acoustic stimulation and self mixing interferometry sensing helps reduce or avoid errors or distortions caused by sensor contact on the material, and can provide a better ratio of sensitivity for a given degree of compactness of the device.
摘要翻译：一种用于分析材料的装置，所述装置具有用于通过光源的脉冲照明在材料中产生压力波的光声发生器（40），以及用于使用自混合干涉测量法产生信号的传感器（20,30,50）表示由压力波引起的材料位移的信号，以及用于处理信号以分析材料的信号处理器（60）。光声刺激和自混合干涉测量传感的这种组合有助于减少或避免由材料上的传感器接触引起的误差或失真，并且可以为设备的给定程度的紧凑性提供更好的灵敏度比。

7. 发明申请

WO2009141758A1 PERFUSION REGULATION DEVICE 审中-公开
标题翻译：灌注调节装置
公开(公告)号：WO2009141758A1
公开(公告)日：2009-11-26
申请号：PCT/IB2009/051948
申请日：2009-05-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MOESKOPS, Bastiaan, W., M. , LIU, Yan , THUMMA, Kiran, K. , VON BASUM, Golo
发明人： MOESKOPS, Bastiaan, W., M. , LIU, Yan , THUMMA, Kiran, K. , VON BASUM, Golo
IPC分类号： A61B5/026
CPC分类号： A61B5/0261 , A61B5/0053 , A61B5/14532 , A61B5/14546 , A61B5/6843 , Y10T29/49826
摘要： A perfusion, regulation device (10) for regulating tissue perfusion at a target site (2) on a human or animal body. The perfusion regulation device (10) comprises a pressure regulator (4) for determining and regulating pressure exerted by the perfusion regulation device (10) on the target site (2) and a perfusion monitor (5) for measuring tissue perfusion at the target site (2). The perfusion regulation device (10) furthermore comprises a control system (6) for driving the pressure regulator (4) so as to regulate pressure exerted by the perfusion regulation device (10) to the target site (2) thereby using feedback from the perfusion monitor (5). There is also a method for making such a perfusion regulation device (10) and a method for regulating tissue perfusion at a target site (2) on a human or animal body using such a perfusion regulation device (10).
摘要翻译：一种用于调节人体或动物体上目标部位（2）的组织灌注的灌注调节装置（10）。灌注调节装置（10）包括用于确定和调节由灌注调节装置（10）施加在目标部位（2）上的压力的压力调节器（4）和用于测量目标部位组织灌注的灌注监测器（5）（2）。灌注调节装置（10）还包括用于驱动压力调节器（4）以便调节由灌注调节装置（10）施加到目标部位（2）的压力的控制系统（6），由此使用来自灌注的反馈监视器（5）。还有一种使用这种灌注调节装置（10）制造这种灌注调节装置（10）的方法和用于调节人体或动物体上目标部位（2）的组织灌注的方法。

8. 发明申请

WO2009136338A1 AN ADAPTABLE PROBE HAVING ILLUMINATION AND DETECTION ELEMENTS 审中-公开
标题翻译：具有照明和检测元素的适应性探测器
公开(公告)号：WO2009136338A1
公开(公告)日：2009-11-12
申请号：PCT/IB2009/051801
申请日：2009-05-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MOESKOPS, Bastiaan, W., M. , VON BASUM, Golo , LIU, Yan , THUMMA, Kiran, K.
发明人： MOESKOPS, Bastiaan, W., M. , VON BASUM, Golo , LIU, Yan , THUMMA, Kiran, K.
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/14532 , A61B5/1455 , A61B5/14552 , A61B2562/0233 , A61B2562/046
摘要： A device for analyzing a material using illumination and optical sensing has an adaptable probe having an array of locations switchable for use as optical sources for the illumination or as optical receivers for the sensing, and a controller arranged to determine a pattern of locations of sources and receivers for the analyzing, and to switch the locations according to the pattern to adapt the probe. By adapting the probe, localized interference effects can be reduced or avoided, and measurements can be concentrated where a stronger signal can be obtained. This adaption can be repeated to adapt to dynamically changing spatial properties of the interfering effects.
摘要翻译：用于使用照明和光学感测来分析材料的装置具有适应性探针，该探针具有能够用作照明的光源或用作感测的光学接收器的位置阵列，以及布置成确定源的位置图案的控制器，接收器进行分析，并根据模式切换位置以适应探头。通过调整探头，可以减少或避免局部的干扰效应，并且可以将测量集中在可以获得更强信号的地方。可以重复这种适应以适应动态变化的干扰效应的空间属性。

9. 发明申请

WO2009136311A2 CONTACT PRESSURE CONTROL FOR PROBE FOR MATERIAL ANALYSIS 审中-公开
标题翻译：接触压力控制用于材料分析
公开(公告)号：WO2009136311A2
公开(公告)日：2009-11-12
申请号：PCT/IB2009/051708
申请日：2009-04-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , THUMMA, Kiran, K. , MOESKOPS, Bastiaan, W., M. , LIU, Yan , VON BASUM, Golo
发明人： THUMMA, Kiran, K. , MOESKOPS, Bastiaan, W., M. , LIU, Yan , VON BASUM, Golo
IPC分类号： A61B5/00 , A61B19/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/6843 , A61B2090/065 , A61B2562/0266
摘要： A device for analyzing a material using illumination and optical sensing, has a probe (120) arranged to provide the illumination and for receiving light for the optical sensing, and having an optical grating (100) at a contact region of the probe for use in detecting contact pressure of the contact region on the material. A sensor senses light affected by the grating, and a controller (85) controls a contact pressure of the probe on the material, according to the determined contact pressure. By using a grating, there is little or no additional complexity in the construction of the probe, and little or no addition in the contact area of the probe. By determining contact pressure and adapting the probe position, interference effects in the analysis of the material caused by or made worse by contact pressure being too high or too low or fluctuating too much, can be reduced or avoided.
摘要翻译：一种用于使用照明和光学感测来分析材料的装置，具有布置成提供照明并用于接收用于光学感测的光并且在探针的接触区域处具有光栅（100）的探针（120），用于检测材料上的接触区域的接触压力。传感器感测受光栅影响的光，并且控制器（85）根据确定的接触压力来控制探针在材料上的接触压力。通过使用光栅，在探针的构造中几乎没有或没有额外的复杂性，并且在探针的接触区域中很少或没有添加。通过确定接触压力并适应探针位置，可以减少或避免由接触压力引起的或由接触压力过大或过低或波动过大的材料的分析中的干扰效应。

10. 发明申请

WO2010140085A1 REFLECTANCE SPECTRUM MEASUREMENT AT VARIOUS ANGLES 审中-公开
标题翻译：反射光谱测量在各种角度
公开(公告)号：WO2010140085A1
公开(公告)日：2010-12-09
申请号：PCT/IB2010/052354
申请日：2010-05-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LIU, Yan , VON BASUM, Golo , MOESKOPS, Bastiaan, Wilhelmus, Maria , UZUNBAJAKAVA, Natallia, Eduardauna , THILWIND, Rachel, Estelle
发明人： LIU, Yan , VON BASUM, Golo , MOESKOPS, Bastiaan, Wilhelmus, Maria , UZUNBAJAKAVA, Natallia, Eduardauna , THILWIND, Rachel, Estelle
IPC分类号： G01N21/47 , A61B5/00
CPC分类号： G01N21/4738 , A61B5/14532 , A61B5/1455 , A61B2562/0242 , G01N21/359
摘要： Measuring reflectance of skin uses an adjustable probe having an illuminator (100) for directing light of more than one wavelength at a given angle onto the skin, a collector (95, 110, 122, 128) for collecting light reflected from the sample at a given angle, and an adjuster (5, 98, 122, 200, Ml, M2), for continuously adjusting the angle of the illuminating light or the collected light. Reflectance is determined according to a predetermined relationship between penetration depth at which the reflections occur, and the wavelength and the angle of adjustment. The angle can be continuously adjusted according to the relationship, or measurements can be selected, so as to maintain a constant penetration depth for a spectrum of wavelengths.
摘要翻译：测量皮肤的反射率使用具有照射器（100）的可调节探针，用于将指定角度的多于一个波长的光引导到皮肤上，收集器（95,110,122,128），用于收集从样品反射的光以及用于连续调节照明光或收集的光的角度的调节器（5,98,122,200，M1，M2）。根据反射发生的穿透深度与波长与调整角度之间的预定关系来确定反射率。可以根据关系连续地调整角度，或者可以选择测量值，以保持波长谱的恒定的穿透深度。

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