专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012093363A2 INTEGRATED ACCESS TO AND INTERATION WITH MULTIPLICITY OF CLINICA DATA ANALYTIC MODULES 审中-公开
标题翻译：综合访问和与临床数据分析模块的多重性相关联
公开(公告)号：WO2012093363A2
公开(公告)日：2012-07-12
申请号：PCT/IB2012/050041
申请日：2012-01-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JANEVSKI, Angel , KAMALAKARAN, Sitharthan , REICHELT, Christian , BANERJEE, Nilanjana , VARADAN, Vinay , DIMITROVA, Nevenka
发明人： JANEVSKI, Angel , KAMALAKARAN, Sitharthan , REICHELT, Christian , BANERJEE, Nilanjana , VARADAN, Vinay , DIMITROVA, Nevenka
IPC分类号： G06F9/30
CPC分类号： G06F19/3443 , G06F19/00 , G06F19/325 , G16H40/63 , G16H50/70
摘要： A state machine (22) stores a current state (30) comprising a clinical context defined by available patient-related information relating to a medical patient, and identifies one or more available analytical tools of a set of analytical tools (24) that are applicable to the current state. A graphical user interface module (16) receives a user selection of an available analytical tool. The state machine loads patient-related information (40) to the user-selected available analytical tool (24 sel ) and invokes the user-selected available analytical tool to operate on the loaded patient-related information to generate additional patient-related information relating to the medical patient and/or graphical patient-related content relating to the medical patient. The state machine transitions from the current state (30) to a next state (30') and/or invokes the graphical user interface module to display the graphical patient related content.
摘要翻译：状态机（22）存储当前状态（30），其包括由与医疗患者有关的可用患者相关信息定义的临床上下文，并且识别可应用的一组分析工具（24）中的一个或多个可用分析工具到目前状态。图形用户界面模块（16）接收可用分析工具的用户选择。状态机将患者相关信息（40）加载到用户选择的可用分析工具（24sel），并且调用用户选择的可用分析工具对所加载的患者相关信息进行操作，以生成与患者相关的附加信息与患者有关的医疗病人和/或图形患者相关内容。状态机从当前状态（30）转换到下一状态（30'）和/或调用图形用户界面模块以显示图形的患者相关内容。

2. 发明申请

WO2012168810A3 CROSS-MODAL APPLICATION OF COMBINATION SIGNATURES INDICATIVE OF A PHENOTYPE 审中-公开
公开(公告)号：WO2012168810A3
公开(公告)日：2012-12-13
申请号：PCT/IB2012/052551
申请日：2012-05-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JANEVSKI, Angel , KAMALAKARAN, Sitharthan , BANERJEE, Nilanjana , VARADAN, Vinay , DIMITROVA, Nevenka , SURYANARAYANAN, Sankararaman
发明人： JANEVSKI, Angel , KAMALAKARAN, Sitharthan , BANERJEE, Nilanjana , VARADAN, Vinay , DIMITROVA, Nevenka , SURYANARAYANAN, Sankararaman
IPC分类号： G06F19/18
摘要： The present invention relates to a method of adapting a composite signature of a phenotype. The method comprises the steps of providing for a composite signature of a phenotype with at least two different data types, which were respectively generated by two different modalities of measuring a specimen. Due to an adaption of one part of the signature of the phenotype the resulting adapted phenotype signature can be used as an input for a signature evaluation tool that was derived from data measured by a third modality of measurement.

3. 发明申请

WO2009138909A1 A MEDICAL ANALYSIS SYSTEM 审中-公开
标题翻译：医学分析系统
公开(公告)号：WO2009138909A1
公开(公告)日：2009-11-19
申请号：PCT/IB2009/051862
申请日：2009-05-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , JANEVSKI, Angel, J. , DIMITROVA, Nevenka , KAMALAKARAN, Sitharthan , ALSAFADI, Yasser, H. , BANERJEE, Nilanjana , BUCUR, Anca, I., D. , VAN LEEUWEN, Jasper, J., A. , VARADAN, Vinay, VV
发明人： JANEVSKI, Angel, J. , DIMITROVA, Nevenka , KAMALAKARAN, Sitharthan , ALSAFADI, Yasser, H. , BANERJEE, Nilanjana , BUCUR, Anca, I., D. , VAN LEEUWEN, Jasper, J., A. , VARADAN, Vinay, VV
IPC分类号： G06F19/00
CPC分类号： G16H50/70 , G06F19/00 , G06Q50/22
摘要： The present invention relates to effective diagnosis of patients and assisting clinicians in treatment planning. In particular, invention provides a medical analysis system that enables refinement of molecular classification. The system provides a molecular profiling solution that will allow improved diagnosis, prognosis, response prediction to provide the right chemotherapy, and follow-up to monitor for cancer recurrence.
摘要翻译：本发明涉及患者的有效诊断并协助临床医师进行治疗计划。特别地，本发明提供了能够细化分子分类的医学分析系统。该系统提供了一个分子谱分析解决方案，可以改进诊断，预后，反应预测，提供正确的化学疗法和随访监测癌症复发。

4. 发明申请

WO2012104764A3 METHOD FOR ESTIMATION OF INFORMATION FLOW IN BIOLOGICAL NETWORKS 审中-公开
公开(公告)号：WO2012104764A3
公开(公告)日：2012-08-09
申请号：PCT/IB2012/050405
申请日：2012-01-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VARADAN, Vinay , MITTAL, Prateek , KAMALAKARAN, Sitharthan , DIMITROVA, Nevenka , JANEVSKI, Angel , BANERJEE, Nilanjana
发明人： VARADAN, Vinay , MITTAL, Prateek , KAMALAKARAN, Sitharthan , DIMITROVA, Nevenka , JANEVSKI, Angel , BANERJEE, Nilanjana
IPC分类号： G06F19/12 , G06F19/20 , G06F19/24
摘要： The present invention relates to a method for stratifying a patient into a clinically relevant group comprising the identification of the probability of an alteration within one or more sets of molecular data from a patient sample in comparison to a database of molecular data of known phenotypes, the inference of the activity of a biological network on the basis of the probabilities, the identification of a network information flow probability for the patient via the probability of interactions in the network, the creation of multiple instances of network information flow for the patient sample and the calculation of the distance of the patient from other subjects in a patient database using multiple instances of the network information flow. The invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy wherein the biomedical marker or group of biomedical markers comprises altered biological pathway markers, as well as to an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer. Furthermore, a corresponding clinical decision support system is provided.

5. 发明申请

WO2012046191A2 IDENTIFICATION OF MULTI-MODAL ASSOCIATIONS BETWEEN BIOMEDICAL MARKERS 审中-公开
标题翻译：鉴定生物医学标记之间的多模式协会
公开(公告)号：WO2012046191A2
公开(公告)日：2012-04-12
申请号：PCT/IB2011/054366
申请日：2011-10-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , COLD SPRING HARBOR LABORATORY , BANERJEE, Nilanjana , JANEVSKI, Angel , KAMALAKARAN, Sitharthan , VARADAN, Vinay , DIMITROVA, Nevenka , LUCITO, Robert
发明人： BANERJEE, Nilanjana , JANEVSKI, Angel , KAMALAKARAN, Sitharthan , VARADAN, Vinay , DIMITROVA, Nevenka , LUCITO, Robert
IPC分类号： G06F19/12
CPC分类号： G06F19/20 , G06F19/12 , G06F19/18
摘要： The present invention relates to a method for identifying multi-modal associations between biomedical markers which allows for the determination of network nodes and/or high ranking network members or combinations thereof, indicative of having a diagnostic, prognostic or predictive value for a medical condition, in particular ovarian cancer. The present invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy, preferably a platinum based cancer therapy, wherein said biomedical marker or group of biomedical markers comprises at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 8, 19, 20 or all markers selected from PKMYT1, SKIL, RAB8A, HIRIP3, CTNNB1, NGFR, ZCCHC11, LSP1, CD200, PAX8, CYBRD1, HOXC11, TCEAL1, FZD10,FZD1, BBS4, IRS2, TLX3, TSPAN2, TXN, and CFLAR. Furthermore, an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, 1 diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer, is provided, as well as a corresponding method for classifying a subject comprising and a medical decision support system.
摘要翻译：本发明涉及一种用于识别生物医学标记之间的多模式关联的方法，其允许确定网络节点和/或高排名网络成员或其组合，指示具有用于医疗状况的诊断，预后或预测值，特别是卵巢癌。本发明还涉及与受试者对癌症治疗（优选基于铂的癌症治疗）的高反应性的高可能性相关联的生物医学标记物或生物医学标记物组，其中所述生物医学标记物或生物医学标记物组包含至少1， 2，3，4，5，6，7，8，9，10，11，12，13，14，15，16，17，8，19，20或者所有选自PKMYT1，SKIL，RAB8A，HIRIP3， CTNNB1，NGFR，ZCCHC11，LSP1，CD200，PAX8，CYBRD1，HOXC11，TCEAL1，FZD10，FZD1，BBS4，IRS2，TLX3，TSPAN2，TXN和CFLAR。此外，提供了用于检测，诊断，毕业，监测或预测医学状况或用于检测1诊断，监测或预测受试者对于针对所述医学病症，特别是卵巢癌的治疗的反应性的测定法，作为以及用于分类受试者的相应方法以及医疗决策支持系统。

6. 发明申请

WO2011128820A8 METHODS FOR THE ANALYSIS OF BREAST CANCER DISORDERS 审中-公开
公开(公告)号：WO2011128820A8
公开(公告)日：2011-10-20
申请号：PCT/IB2011/051517
申请日：2011-04-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DIMITROVA, Nevenka , KAPAETTU, Satyamoorthy , GORTHI, Aparna , KABEKKODU, Shama Prasada , CHAKRABARTY, Sanjiban , KESWARPU, Payal , BANERJEE, Nilanjana , JANEVSKI, Angel , HEBBAR, Prashantha , KHANDIGE, Surabhi
发明人： DIMITROVA, Nevenka , KAPAETTU, Satyamoorthy , GORTHI, Aparna , KABEKKODU, Shama Prasada , CHAKRABARTY, Sanjiban , KESWARPU, Payal , BANERJEE, Nilanjana , JANEVSKI, Angel , HEBBAR, Prashantha , KHANDIGE, Surabhi
IPC分类号： C12Q1/68
摘要： The present invention relates to methods, arrays and computer programs for assisting in classifying breast cancer diseases. In particular the invention relates to classifying breast cancer disorders by determining the methylation status of one or more sequences according to SEQ ID NO: 1-111. The classification may be further strengthened by also taking the expression levels of one or more proteins into account.

7. 发明申请

WO2010055487A2 COMPOSITIONS AND METHODS FOR MICRO-RNA EXPESSION PROFILING OF COLORECTAL CANCER 审中-公开
标题翻译：组合物和方法用于微小RNA显色分析
公开(公告)号：WO2010055487A2
公开(公告)日：2010-05-20
申请号：PCT/IB2009/055057
申请日：2009-11-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WU, Ying , ZHU, Hongguang , LI, Jian , XU, Liang , VERHAEGH, Wilhelmus, F., J. , REN, Yiping , JANEVSKI, Angel , VARADAN, Vinay , LI, Zhaoyong , DIMITROVA, Nevenka
发明人： WU, Ying , ZHU, Hongguang , LI, Jian , XU, Liang , VERHAEGH, Wilhelmus, F., J. , REN, Yiping , JANEVSKI, Angel , VARADAN, Vinay , LI, Zhaoyong , DIMITROVA, Nevenka
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/141 , C12N2320/10 , C12N2330/10 , C12N2330/31 , C12Q1/6816 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates compositions and methods for microRNA (miRNA) expression profiling of colorectal cancer. In particular, the invention relates to a diagnostic kit of molecular markers for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer, the kit comprising a plurality of nucleic acid molecules, each nucleic acid molecule encoding a miRNA sequence, wherein one or more of the plurality of nucleic acid molecules are differentially expressed in the target cells and in one or more control cells, and wherein the one or more differentially expressed nucleic acid molecules together represent a nucleic acid expression signature that is indicative for the presence of or the predisposition to develop colorectal cancer. The invention further relates to corresponding methods using such nucleic acid expression signatures for identifying one or more mammalian target cells exhibiting or having a predisposition to develop colorectal cancer as well as for preventing or treating such a condition. Finally, the invention is directed to a pharmaceutical composition for the prevention and/or treatment of colorectal cancer.
摘要翻译：本发明涉及用于结肠直肠癌的微小RNA（miRNA）表达谱的组合物和方法。特别地，本发明涉及用于鉴定表现出或具有发生结肠直肠癌倾向的一种或多种哺乳动物靶细胞的分子标记用诊断试剂盒，所述试剂盒包含多个核酸分子，编码miRNA序列的每个核酸分子，其中所述多个核酸分子中的一个或多个在靶细胞和一个或多个对照细胞中差异表达，并且其中所述一个或多个差异表达的核酸分子一起表示指示存在的核酸表达特征或发生结肠直肠癌的倾向。本发明还涉及使用这种核酸表达特征鉴定一种或多种表现出或具有发生结肠直肠癌倾向的哺乳动物靶细胞以及预防或治疗这种病症的相应方法。最后，本发明涉及用于预防和/或治疗结肠直肠癌的药物组合物。

8. 发明申请

WO2012001576A1 PATHWAY ANALYSIS FOR PROVIDING PREDICTIVE INFORMATION 审中-公开
标题翻译：路径分析提供预测信息
公开(公告)号：WO2012001576A1
公开(公告)日：2012-01-05
申请号：PCT/IB2011/052705
申请日：2011-06-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , COLD SPRING HARBOR LABORATORY , BANERJEE, Nilanjana , DIMITROVA, Nevenka , LUCITO, Robert
发明人： BANERJEE, Nilanjana , DIMITROVA, Nevenka , LUCITO, Robert
IPC分类号： G06F19/12
CPC分类号： G06F19/18 , C12Q1/6809 , G06F19/12 , G06F19/20 , G06F19/24
摘要： A method for assigning ranking scores to pathways in a set of pathways for classifying patients is disclosed. The method comprises the steps of comparing biomolecular datasets from different groups of patients and performing an analysis in order to assign ranking scores to pathways in a set of pathways. Furthermore, a method for using cancer pathway evaluation to support clinical decision making is disclosed. This assessment is further used for stratifying ovarian cancer patients based on chemosensitivity to platinum based drugs, the standard chemotherapy. We present the method for evaluation and ranking of the most relevant pathways responsible for platinum sensitivity. Clinical decision support software system should be able to then visualize this information for a clinician, contextualize it within a patient data set and help make a final decision on the potential responsiveness.
摘要翻译：公开了一种用于将排序评分分配给用于分类患者的一组途径中的途径的方法。该方法包括比较来自不同组患者的生物分子数据集并执行分析以便将一系列途径中的路径分配评级的步骤。此外，公开了一种使用癌症途径评估来支持临床决策的方法。该评估进一步用于基于对铂类药物（标准化学疗法）的化学敏感性对卵巢癌患者进行分层。我们介绍了负责铂敏感性的最相关途径的评估和排名方法。临床决策支持软件系统应该能够为临床医生可视化这些信息，并在病人数据集内进行语境化，并帮助对潜在的反应能力做出最终决定。

9. 发明申请

WO2003084229A1 METHOD AND SYSTEM FOR PROVIDING COMPLEMENTARY INFORMATION FOR A VIDEO PROGRAM 审中-公开
标题翻译：为视频节目提供补充信息的方法和系统
公开(公告)号：WO2003084229A1
公开(公告)日：2003-10-09
申请号：PCT/IB2003/001344
申请日：2003-04-01
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZIMMERMAN, John , DIMITROVA, Nevenka , LI, Dongge , BONT, Johanna, M. , LAMERS, Andreas, H., E. , JANEVSKI, Angel , NIKOLOVSKA, Lira
发明人： ZIMMERMAN, John , DIMITROVA, Nevenka , LI, Dongge , BONT, Johanna, M. , LAMERS, Andreas, H., E. , JANEVSKI, Angel , NIKOLOVSKA, Lira
IPC分类号： H04N7/16
CPC分类号： H04N21/454 , H04N5/445 , H04N7/163 , H04N7/17318 , H04N21/4307 , H04N21/4331 , H04N21/4532 , H04N21/4622 , H04N21/4722 , H04N21/4782 , H04N21/482 , H04N21/6581 , H04N21/84 , H04N21/8586
摘要： A method for providing complementary information 226 for a video program is provided that includes receiving complementary information 226 for a video program. A query is received from a consumer. The query is related to a specified portion of the complementary information 226. A query response is provided to the consumer based on the specified portion of the complementary information 226.
摘要翻译：提供了一种用于为视频节目提供补充信息226的方法，其包括为视频节目接收补充信息226。从消费者接收到查询。查询与补充信息226的指定部分相关。基于补充信息226的指定部分向消费者提供查询响应。

10. 发明申请

WO2003084230A1 METHOD AND SYSTEM FOR PROVIDING PERSONALIZED NEWS 审中-公开
标题翻译：提供个性化新闻的方法和系统
公开(公告)号：WO2003084230A1
公开(公告)日：2003-10-09
申请号：PCT/IB2003/001375
申请日：2003-04-01
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZIMMERMAN, John , NIKOLOVSKA, Lira , DE BONT, Johanna, M. , LAMERS, Andreas, H., E. , DIMITROVA, Nevenka , JANEVSKI, Angel , AGNIHOTRI, Lalitha
发明人： ZIMMERMAN, John , NIKOLOVSKA, Lira , DE BONT, Johanna, M. , LAMERS, Andreas, H., E. , DIMITROVA, Nevenka , JANEVSKI, Angel , AGNIHOTRI, Lalitha
IPC分类号： H04N7/16
CPC分类号： H04N21/454 , H04N5/445 , H04N7/163 , H04N21/25891 , H04N21/4331 , H04N21/4532 , H04N21/458 , H04N21/4622 , H04N21/488 , H04N21/8126 , H04N21/858
摘要： A method for providing personalized news to a consumer is provided that includes receiving news from a plurality of external sources. A subset of the received news is identified based on a consumer profile for the consumer. The identified news is stored. The stored news is prioritized. At least a portion of the prioritized news is provided to the consumer.
摘要翻译：提供了一种向消费者提供个性化消息的方法，其包括从多个外部源接收消息。基于消费者的消费者资料识别收到的消息的一个子集。存储已识别的消息。储存的新闻优先。向消费者提供至少一部分优先消息。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式