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1. 发明申请

WO2009001300A1 LENS SYSTEM 审中-公开
标题翻译：镜头系统
公开(公告)号：WO2009001300A1
公开(公告)日：2008-12-31
申请号：PCT/IB2008/052532
申请日：2008-06-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus Hendrikus Wilhelmus , SHIMIZU, Jeff , KUIPER, Stein
发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus , SHIMIZU, Jeff , KUIPER, Stein
IPC分类号： G02B23/24
CPC分类号： G02B23/243 , G02B26/103
摘要： A lens system comprises a first lens group and a second lens group, and is configured to form an image at a first magnification and at a second magnification. The lens system has a common optical axis in both magnifications. The lens system is further configured to form an intermediate image between the first lens group and the second lens group at the first magnification. The intermediate image formed in the first magnification is further imaged onto an optical detector. In the first magnification, the second lens group acts as a relay lens imaging the intermediate image onto the optical detector. In the second magnification, the first and second lens groups together form an image on the optical detector without forming an intermediate image.
摘要翻译：透镜系统包括第一透镜组和第二透镜组，并且被配置为以第一放大率和第二放大率形成图像。透镜系统具有两个放大倍率的共同光轴。透镜系统还被配置为在第一放大率下在第一透镜组和第二透镜组之间形成中间图像。在第一放大率中形成的中间图像进一步成像到光学检测器上。在第一放大率中，第二透镜组用作将中间图像成像到中间透镜到光学检测器上。在第二放大倍数中，第一和第二透镜组一起在光学检测器上形成图像，而不形成中间图像。

2. 发明申请

WO2008017967A1 DEVICE, SYSTEM AND METHOD FOR INTERACTING WITH A CELL OR TISSUE IN A BODY 审中-公开
标题翻译：用于与身体中的细胞或组织相互作用的装置，系统和方法
公开(公告)号：WO2008017967A1
公开(公告)日：2008-02-14
申请号：PCT/IB2007/051326
申请日：2007-04-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZOU, Hans , KUIPER, Stein , HENDRIKS, Bernardus Hendrikus Wilhelmus , SUIJVER, Jan Frederik , PIERIK, Anke , RENSEN, Judith Margreet , DIJKSMAN, Johan Frederik , SHIMIZU, Jeff , DEN TOONDER, Jacob Marinus Jan
发明人： ZOU, Hans , KUIPER, Stein , HENDRIKS, Bernardus Hendrikus Wilhelmus , SUIJVER, Jan Frederik , PIERIK, Anke , RENSEN, Judith Margreet , DIJKSMAN, Johan Frederik , SHIMIZU, Jeff , DEN TOONDER, Jacob Marinus Jan
IPC分类号： A61B5/00
CPC分类号： A61B5/6882 , A61B1/041 , A61B5/0031 , A61B5/073 , A61B5/4839
摘要： A device or support, system and method are provided for precisely targeted and/or highly controlled interaction with a targeted cell or tissue in a body, with the support providing an ergonomic connecting interface for selectively connecting the support to a cell or tissue with at least minimal adverse affect to such cell or tissue, the system providing a remote facility that may be operatively associated with the support, and the method providing steps for employing the support and/or system so as to, inter alia, improve treatment, diagnostic and/or monitoring techniques and increase sensitivity and specificity with respect to interacting with, for example, diseased or abnormal cells or tissue without adversely effecting surrounding healthy cells or tissue, and/or the body in general.
摘要翻译：提供了一种装置或支撑件，系统和方法，用于与身体中的靶细胞或组织精确地靶向和/或高度受控的相互作用，其中所述支持物提供符合人体工程学的连接界面，用于至少选择性地将支持物连接到细胞或组织对这种细胞或组织的最小的不利影响，该系统提供可能与支持物可操作地相关联的远程设施，以及提供使用支持和/或系统的方法，以便除其他外改善治疗，诊断和/ 或监测技术，并提高与例如患病或异常细胞或组织的相互作用的灵敏度和特异性，而不会不利地影响周围的健康细胞或组织和/或身体。

3. 发明申请

WO2008135922A1 METHODS AND APPARATUSES OF MICROBEAMFORMING WITH ADJUSTABLE FLUID LENSES 审中-公开
标题翻译：具有可调节流体镜片的微球的方法和装置
公开(公告)号：WO2008135922A1
公开(公告)日：2008-11-13
申请号：PCT/IB2008/051686
申请日：2008-04-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HALL, Christopher Stephen , CHIN, Chien Ting , SUIJVER, Jan Frederik , HENDRIKS, Bernardus Hendrikus Wilhelmus , KUIPER, Stein
发明人： HALL, Christopher Stephen , CHIN, Chien Ting , SUIJVER, Jan Frederik , HENDRIKS, Bernardus Hendrikus Wilhelmus , KUIPER, Stein
IPC分类号： G10K11/30
CPC分类号： G10K11/30
摘要： An acoustic probe (100, 300) includes an acoustic transducer (15, 444), and a plurality of variably-refracting acoustic lens elements (10, 210a, 210b, 442) coupled to the acoustic transducer. Each variably-refracting acoustic lens element has at least a pair of electrodes (150, 160) adapted to adjust at least one characteristic of the variably-refracting acoustic lens element in response to a selected voltage applied across the electrodes. In one embodiment, each variably-refracting acoustic lens element includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.
摘要翻译：声探针（100,300）包括声换能器（15,444）和耦合到声换能器的多个可变折射声透镜元件（10,210a，210b，442）。每个可变折射声透镜元件具有至少一对电极（150,160），其适于响应于跨过电极施加的选定电压来调节可变折射声透镜元件的至少一个特性。在一个实施例中，每个可变折射声透镜元件包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。第一流体介质中声波的声速不同于第二流体介质中声波的声速。第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

4. 发明申请

WO2008090504A1 METHOD AND APPARATUS FOR ULTRASONIC DETECTION OF MOTION USING ADJUSTABLE FLUID LENSES 审中-公开
标题翻译：使用可调节流体镜检测运动的超声波检测方法和装置
公开(公告)号：WO2008090504A1
公开(公告)日：2008-07-31
申请号：PCT/IB2008/050194
申请日：2008-01-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HALL, Christopher, S. , CHIN, Chien, Ying , SUIJVER, Jan, Frederik , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , KUIPER, Stein
发明人： HALL, Christopher, S. , CHIN, Chien, Ying , SUIJVER, Jan, Frederik , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , KUIPER, Stein
IPC分类号： A61B8/08
CPC分类号： G10K11/30 , A61B8/08 , A61B8/4281 , A61B8/488
摘要： A system (200) for detection of motion in a body includes an acoustic probe (242, 100), a motion detection processor (270), a variable voltage supply (290), and a controller (210). The acoustic probe (242, 100) includes an acoustic transducer (244, 20), and a variably-refracting acoustic lens (242, 10) coupled to the acoustic transducer. The variably-refracting acoustic lens has at least a pair of electrodes (150, 160a, 160b) adapted to adjust at least one characteristic of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. The motion detection processor is coupled to the acoustic transducer and executes an algorithm to detect motion of an object in response to acoustic energy received by the acoustic transducer. The variable voltage supply applies selected voltages to the pair of electrodes. The controller controls the variable voltage supply to apply the selected voltages to the pair of electrodes.
摘要翻译：用于检测身体运动的系统（200）包括声探针（242,100），运动检测处理器（270），可变电压源（290）和控制器（210）。声探针（242,100）包括声换能器（244,20）和耦合到声换能器的可变折射声透镜（242,10）。所述可变折射声透镜具有至少一对电极（150,160a，160b），所述至少一对电极（150,160a，160b）响应于施加在所述电极上的选定电压而调节所述可变折射声透镜的至少一个特性。运动检测处理器耦合到声换能器并执行一种算法，以响应于由声换能器接收的声能来检测物体的运动。可变电压源将选定的电压施加到该对电极。控制器控制可变电压源以将所选择的电压施加到该对电极。

5. 发明申请

WO2012101549A1 ENDOSCOPE WITH WIRELESS LENS MODULE ADD-ON 审中-公开
标题翻译：内窥镜与无线镜头模块添加
公开(公告)号：WO2012101549A1
公开(公告)日：2012-08-02
申请号：PCT/IB2012/050240
申请日：2012-01-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KUIPER, Stein , HENDRIKS, Bernardus Hendrikus Wilhelmus , WOLF, Ronald Martin , DECKERS, Jacobus Adrianus Johanna Maria
发明人： KUIPER, Stein , HENDRIKS, Bernardus Hendrikus Wilhelmus , WOLF, Ronald Martin , DECKERS, Jacobus Adrianus Johanna Maria
IPC分类号： A61B1/00 , A61B1/06 , A61B1/05
CPC分类号： A61B1/00101 , A61B1/00029 , A61B1/00034 , A61B1/00096 , A61B1/00103 , A61B1/00188 , A61B1/0019 , A61B1/05 , A61B1/053 , A61B1/0676 , A61B1/0684
摘要： An endoscope that may be used with a wireless lens module that can be attached to an insertion end of the endoscope. The endoscope comprises a hollow elongate tube extending from a handle end to the insertion end of the endoscope for insertion into the body of a patient. A mechanical connector at the insertion end of the endoscope allows for at times attaching the lens module at the insertion end of the endoscope and also for disconnecting the lens module form the endoscope. One or more wireless electrical elements at the insertion end of the endoscope provides wireless electrical power to the lens module. The lens module includes one or more fixed position lenses aligned along the axis of a light path; and one or more electrically-operated, actively-adjustable lens aligned along the axis of a light path. A mechanical connector of the lens module allows the module to be attached in a fixed position at the insertion end of the endoscope. The module includes one or more wireless electrical elements for receiving wireless electrical power from the inductor at the insertion end of the endoscope for operating the actively-adjustable lens. Either the lens module or the endoscope includes an light sensor aligned along the axis of a light path for converting focused light into electronic image signals.
摘要翻译：一种内窥镜，其可以与可附接到内窥镜的插入端的无线透镜模块一起使用。内窥镜包括从手柄端延伸到内窥镜的插入端的中空细长管，用于插入患者体内。在内窥镜的插入端的机械连接器有时将透镜模块安装在内窥镜的插入端，并且还用于将透镜模块从内窥镜断开。在内窥镜的插入端处的一个或多个无线电元件为透镜模块提供无线电力。透镜模块包括沿着光路的轴线对准的一个或多个固定位置透镜; 以及沿着光路的轴线对准的一个或多个电动的，主动调节的透镜。透镜模块的机械连接器允许模块在内窥镜的插入端处固定在固定位置。该模块包括一个或多个无线电气元件，用于在内窥镜的插入端处从电感器接收无线电力，用于操作主动可调透镜。透镜模块或内窥镜包括沿着光路的轴线对准的光传感器，用于将聚焦的光转换成电子图像信号。

6. 发明申请

WO2010020901A1 A LIQUID COMPOSITION AND A METHOD OF MANUFACTURING THE LIQUID COMPOSITION 审中-公开
标题翻译：液体组合物和制备液体组合物的方法
公开(公告)号：WO2010020901A1
公开(公告)日：2010-02-25
申请号：PCT/IB2009/053454
申请日：2009-08-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KUIPER, Stein , HENDRIKS, Bernardus Hendrikus Wilhelmus
发明人： KUIPER, Stein , HENDRIKS, Bernardus Hendrikus Wilhelmus
IPC分类号： G02B3/14 , C07B59/00
CPC分类号： G02B3/14 , G02B26/005
摘要： The invention provides a liquid composition for an electrowetting device/liquid lens, and a method of manufacturing the liquid composition. The method of manufacturing comprises: replacing (21) a type of atom, which is included in an initial liquid and has a corresponding isotope, with the corresponding isotope of the atom to form a second liquid, so that a density difference between the second liquid and a first liquid is reduced, wherein the second liquid and the first liquid are non-miscible or separated by a flexible membrane, and the initial liquid is a liquid used for generating the second liquid; and combining (22) the second liquid with the first liquid.
摘要翻译：本发明提供了一种用于电润湿装置/液体透镜的液体组合物及其制造方法。制造方法包括：将包含在初始液体中并具有相应同位素的一类原子与原子的相应同位素取代（21），以形成第二液体，使得第二液体之间的密度差并且第一液体被还原，其中第二液体和第一液体是不可混溶的或由柔性膜分离的，并且初始液体是用于产生第二液体的液体; 以及将所述第二液体与所述第一液体组合（22）。

7. 发明申请

WO2008023286A2 SYSTEM FOR VARIABLY REFRACTING ULTRASOUND AND/OR LIGHT 审中-公开
标题翻译：用于改变超声波和/或光的系统
公开(公告)号：WO2008023286A2
公开(公告)日：2008-02-28
申请号：PCT/IB2007/051327
申请日：2007-04-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , U.S. PHILIPS CORPORATION , KUIPER, Stein , HENDRIKS, Bernardus Hendrikus Wilhelmus , SUIJVER, Jan Frederik
发明人： KUIPER, Stein , HENDRIKS, Bernardus Hendrikus Wilhelmus , SUIJVER, Jan Frederik
IPC分类号： G10K11/30
CPC分类号： G10K11/30
摘要： The disclosure is directed to a system for variably refracting, and is transparent for, ultrasound as well as for light. By choosing liquids with the right optical and acoustical properties, it is possible to variably refract (including focusing and deflecting or steering) ultrasound while not affecting the refraction of light, or vice versa. Two lenses in series, or preferably one lens, allow for variably refracting ultrasound and light.
摘要翻译：本公开涉及用于可变折射并且对于超声波以及用于光的透明系统。通过选择具有正确光学和声学特性的液体，可以可变地折射（包括聚焦和偏转或转向）超声波，同时不影响光的折射，反之亦然。串联的两个镜片，或者优选地，一个透镜允许可变地折射超声波和光。

8. 发明申请

WO2008120167A2 OPTICAL BIOPSY DEVICE 审中-公开
标题翻译：光学生物设备
公开(公告)号：WO2008120167A2
公开(公告)日：2008-10-09
申请号：PCT/IB2008/051197
申请日：2008-03-31
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus Hendrikus Wilhelmus , KUIPER, Stein
发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus , KUIPER, Stein
IPC分类号： G02B3/10 , G02B23/24 , G02B3/02 , G02B26/02 , G02B26/10
CPC分类号： G02B23/243 , A61B5/0068 , A61B5/0084 , A61B10/00 , A61B90/20 , A61B90/361 , A61B2017/00061 , A61B2090/3616 , G02B3/0081 , G02B3/02 , G02B3/10 , G02B26/10 , G02B26/103
摘要： An objective lens system for an optical biopsy device has a lens that comprises a first part configured for viewing at a first magnification, and a second part configured for viewing at a second magnification. The second magnification is substantially different from the first magnification. The first magnification enables viewing a larger area of a target and the second magnification enables viewing the target at a cellular level with high sensitivity and specificity. Combining viewing at two different magnifications in a single objective lens results in a compact optical biopsy device.
摘要翻译：用于光学活检装置的物镜系统具有透镜，该透镜包括被配置为以第一放大率观看的第一部分和被配置为以第二放大率观看的第二部分。第二放大率与第一放大率基本不同。第一放大使得能够观察到目标的较大区域，并且第二放大能够以高灵敏度和特异性在细胞水平上观察目标。将单个物镜中的两种不同放大倍数的观察结合在一起形成了紧凑的光学活检装置。

9. 发明申请

WO2008015599A3 A METHOD OF IN VIVIO DETECTION AND/OR DIAGNOSIS OF CANCER USING FLUORESCENCE BASED DNA IMAGE CYTOMETRY 审中-公开
公开(公告)号：WO2008015599A3
公开(公告)日：2008-02-07
申请号：PCT/IB2007/052764
申请日：2007-07-11
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , HENDRIKS, Bernardus Hendrikus Wilhelmus , DE BOER, Ruth Wilhelmine Ireen , SPEKOWIUS, Gerhard , KUIPER, Stein , VAN DER VAART, Nijs Cornelis
发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus , DE BOER, Ruth Wilhelmine Ireen , SPEKOWIUS, Gerhard , KUIPER, Stein , VAN DER VAART, Nijs Cornelis
IPC分类号： G01N15/14 , C12Q1/68 , G01N21/64
摘要： The invention relates to a method of determining in vivo in a human or animal subject the amount of nuclear DNA by first localizing cell nuclei of living tissue and subsequently measuring the nuclear UV absorbance using confocal scanning microscopy. The invention relates also to a method for detecting cancerous cells in vivo in a human or animal subject by first identifying the localization of cell nuclei in living tissue and subsequently determining the nuclear UV absorbance by laser scanning confocal microscopy. Furthermore, the invention relates to a method of diagnosing cancer in a human or animal subject in vivo relying on a combination of identifying the localization of cell nuclei in living tissue and measuring nuclear UV absorbance by laser scanning confocal microscopy.

10. 发明申请

WO2008001235A2 AN IN VITRO METHOD OF DETECTING AND/OR DIAGNOSING CANCER USING UV LIGHT BASED DNA IMAGE CYTOMETRY 审中-公开
标题翻译：使用基于紫外线的DNA图像细胞计数检测和/或诊断癌症的体外方法
公开(公告)号：WO2008001235A2
公开(公告)日：2008-01-03
申请号：PCT/IB2007/051810
申请日：2007-05-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , HENDRIKS, Bernardus Hendrikus Wilhelmus , VOSSENAAR, Erik Robert , SPEKOWIUS, Gerhard , VAN DER VAART, Nijs Cornelis , KUIPER, Stein
发明人： HENDRIKS, Bernardus Hendrikus Wilhelmus , VOSSENAAR, Erik Robert , SPEKOWIUS, Gerhard , VAN DER VAART, Nijs Cornelis , KUIPER, Stein
IPC分类号： G01N33/53 , G01N33/50 , G01N33/58 , G01N33/574 , C12Q1/68 , G01N33/487 , G06T7/00 , G01N15/14
CPC分类号： G01N33/582 , C12Q1/68 , G01N15/147 , G01N21/33 , G01N33/5035 , G01N33/5076 , G01N33/5308 , G01N33/574 , G06K9/00134 , G06T7/0012 , G06T7/41 , G06T2207/10056 , G06T2207/30024 , C12Q2523/313
摘要： The invention relates to a method of determining in vitro the amount of nuclear DNA within a human or animal cell using UV absorption measurement with UV light. The invention also relates to a method for detecting in vitro cancerous cells in a biological sample relying on the aforementioned principles. The invention also relates to an in vitro method of diagnosing or predicting the likely occurrence of cancer in a human or animal subject.
摘要翻译：本发明涉及使用UV光的紫外吸收测量体外测定人或动物细胞内核DNA的量的方法。本发明还涉及一种用于根据上述原理检测生物样品中的体外癌细胞的方法。本发明还涉及诊断或预测人或动物受试者中癌症可能发生的体外方法。

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