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1. 发明申请

WO2007125479A2 BIOSENSOR DEVICE 审中-公开
标题翻译：生物传感器设备
公开(公告)号：WO2007125479A2
公开(公告)日：2007-11-08
申请号：PCT/IB2007/051510
申请日：2007-04-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , FURUKAWA, Yukiko , ORSEL, Joukje, G. , STAPERT, Hendrik, R.
发明人： FURUKAWA, Yukiko , ORSEL, Joukje, G. , STAPERT, Hendrik, R.
IPC分类号： G01N33/50
CPC分类号： G01N33/5438 , G01N27/3275 , Y10T29/49002
摘要： A biosensor device (10) for detecting of molecules of an analyte in a sample (23) comprising: an identification element (18) comprising at least one self assembling monolayer (26) having a first surface, a transducer element (20) comprising a metal electrode (34) for receiving an electric signal from the reaction of the molecules in the sample with the at least one self assembling monolayer (26), and at least one electronic element (14, 16) for receiving the electric signal from the transducer element (20), for processing, and/or storing the electric signal. The at least one self-assembling monolayer (26) comprises at least one carboxylic acid-group for coupling the at least one self-assembling monolayer (26) to the surface (32) of the metal electrode (34).
摘要翻译：一种用于检测样品（23）中分析物的分子的生物传感器装置（10），包括：识别元件（18），包括至少一个具有第一表面的自组装单层（26），换能器元件（20）金属电极（34），用于从样品中的分子与至少一个自组装单层（26）的反应接收电信号;以及至少一个电子元件（14,16），用于从换能器接收电信号元件（20），用于处理和/或存储电信号。所述至少一个自组装单层（26）包含至少一个用于将所述至少一个自组装单层（26）耦合到所述金属电极（34）的表面（32）的羧酸基团。

2. 发明申请

WO2005031352A1 LABEL-FREE DETECTION OF BIOMOLECULES 审中-公开
标题翻译：无标记检测生物分子
公开(公告)号：WO2005031352A1
公开(公告)日：2005-04-07
申请号：PCT/IB2004/051794
申请日：2004-09-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ORSEL, Joukje, G. , HOFSTRAAT, Johannes, W. , STAPERT, Hendrik, R.
发明人： ORSEL, Joukje, G. , HOFSTRAAT, Johannes, W. , STAPERT, Hendrik, R.
IPC分类号： G01N33/543
CPC分类号： G01N33/5438
摘要： The invention provides a method and a device for label-free detection of biomolecules or analytes in a sample liquid. The method comprises the steps of allowing an analyte to bind to one of at least two conductive surfaces. An alternating electrical field between at least two conductive surfaces. Amplitude and phase of an alternating current, flowing between the at least two conductive surfaces, are compared with amplitude and phase of a reference signal. From the difference between both currents it is possible to determine whether an analyte is present at the conductive surface.
摘要翻译：本发明提供了用于在样品液体中无标记检测生物分子或分析物的方法和装置。该方法包括允许分析物结合至少两个导电表面之一的步骤。在至少两个导电表面之间的交替电场。在至少两个导电表面之间流动的交流电的幅度和相位与参考信号的幅度和相位进行比较。从两个电流之间的差异可以确定分析物是否存在于导电表面。

3. 发明申请

WO2005024425A1 NANOPARTICLES FOR DETECTING ANALYTES 审中-公开
标题翻译：用于检测分析物的纳米颗粒
公开(公告)号：WO2005024425A1
公开(公告)日：2005-03-17
申请号：PCT/IB2004/051698
申请日：2004-09-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , STAPERT, Hendrik, R. , HIKMET, Rifat, A., M. , ORSEL, Joukje, G.
发明人： STAPERT, Hendrik, R. , HIKMET, Rifat, A., M. , ORSEL, Joukje, G.
IPC分类号： G01N33/543
CPC分类号： B82Y5/00 , B82Y10/00 , G01N33/54326
摘要： The invention relates to a device for detecting an analyte comprising a group that can form a covalent bond with the analyte and a detectable moiety, characterized in that the device is a nanoparticle and the detectable moiety is magneto-active, electro-active, or optically active, and to a method for detecting an analyte using a nanoparticle comprising a magneto-active, electro-active or optically active group and a group that can form a covalent bond with the analyte, comprising the steps: a) protecting groups that can form a covalent bond with the nanoparticle, if present on the capture probe; b) bonding the analyte to the optionally protected capture probe to obtain an analyte-capture probe complex of which the analyte contains at least one group that can form a covalent bond with the nanoparticle; c) bringing into contact the analyte-capture probe complex and the nanoparticle to form a covalent bond with each other; d) detecting the analyte which is covalently bonded to the nanoparticle by an amperometric, impedimetric, magnetic, or optical method.
摘要翻译：本发明涉及一种用于检测分析物的装置，包括可以与分析物和可检测部分形成共价键的基团，其特征在于该装置是纳米颗粒，可检测部分是磁性的，电活性的或光学的以及使用包含磁性，电活性或光学活性基团的纳米颗粒和可与分析物形成共价键的基团检测分析物的方法，包括以下步骤：a）保护可形成的基团与纳米颗粒共价键，如果存在于捕获探针上; b）将分析物结合到任选保护的捕获探针，以获得分析物捕获探针复合物，其中分析物含有至少一个可与纳米颗粒形成共价键的基团; c）使分析物捕获探针复合物和纳米颗粒接触以形成彼此的共价键; d）通过电流，阻抗，磁性或光学方法检测与纳米颗粒共价结合的分析物。

4. 发明申请

WO2011158174A1 MULTI EPITOPE ASSAY 审中-公开
标题翻译：多重抗生素测定
公开(公告)号：WO2011158174A1
公开(公告)日：2011-12-22
申请号：PCT/IB2011/052570
申请日：2011-06-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SABATTE, Gwenola , PRINS, Menno, W., J. , EVERS, Toon, H. , HARDEMAN, Wilhelmina, M. , ORSEL, Joukje, G.
发明人： SABATTE, Gwenola , PRINS, Menno, W., J. , EVERS, Toon, H. , HARDEMAN, Wilhelmina, M. , ORSEL, Joukje, G.
IPC分类号： G01N33/543
CPC分类号： G01N33/5306 , G01N33/54306 , G01N33/54333
摘要： The present invention is related to a method for detection of a biological target in an affinity assay, the method comprising the steps of providing a biological sample volume containing the biological target, adding a first capturing moiety to the biological sample volume comprising the biological target, wherein the first capturing moiety is adhered to a particle, concentration of the captured biological target into an elution volume that is smaller than the biological sample volume in step a), cleavage of the first capturing moiety or the biological target from the particle and direct or indirect detection and/or quantification of the biological target in a sandwich or competitive affinity assay format, wherein the biological target is associated with at least one capturing moiety, preferably at least two capturing moieties.
摘要翻译：本发明涉及亲和测定中生物靶标检测方法，该方法包括以下步骤：提供含生物靶的生物样品体积，向包含生物靶标的生物样品体积添加第一捕获部分，其中所述第一捕获部分被粘附到颗粒上，所捕获的生物靶的浓度在步骤a）中小于生物样品体积的洗脱体积，从所述颗粒切割所述第一捕获部分或所述生物靶，并直接或间接检测和/或以三明治或竞争亲和测定格式定量生物学靶标，其中生物靶标与至少一个捕获部分，优选至少两个捕获部分相关联。

5. 发明公开

EP1664777A1 NANOPARTICLES FOR DETECTING ANALYTES 审中-公开
标题翻译：纳米粒子厘定分析物
公开(公告)号：EP1664777A1
公开(公告)日：2006-06-07
申请号：EP04769948.3
申请日：2004-09-07
申请人： Koninklijke Philips Electronics N.V.
发明人： STAPERT, Hendrik, R. , HIKMET, Rifat, A., M. , ORSEL, Joukje, G.
IPC分类号： G01N33/543
CPC分类号： B82Y5/00 , B82Y10/00 , G01N33/54326
摘要： The invention relates to a device for detecting an analyte comprising a group that can form a covalent bond with the analyte and a detectable moiety, characterized in that the device is a nanoparticle and the detectable moiety is magneto-active, electro-active, or optically active, and to a method for detecting an analyte using a nanoparticle comprising a magneto-active, electro-active or optically active group and a group that can form a covalent bond with the analyte, comprising the steps: a) protecting groups that can form a covalent bond with the nanoparticle, if present on the capture probe; b) bonding the analyte to the optionally protected capture probe to obtain an analyte-capture probe complex of which the analyte contains at least one group that can form a covalent bond with the nanoparticle; c) bringing into contact the analyte-capture probe complex and the nanoparticle to form a covalent bond with each other; d) detecting the analyte which is covalently bonded to the nanoparticle by an amperometric, impedimetric, magnetic, or optical method.

6. 发明公开

EP1671125A1 LABEL-FREE DETECTION OF BIOMOLECULES 审中-公开
标题翻译： MARK式检测生物分子
公开(公告)号：EP1671125A1
公开(公告)日：2006-06-21
申请号：EP04770032.3
申请日：2004-09-20
申请人： Koninklijke Philips Electronics N.V.
发明人： ORSEL, Joukje, G. , HOFSTRAAT, Johannes, W. , STAPERT, Hendrik, R.
IPC分类号： G01N33/543
CPC分类号： G01N33/5438
摘要： The invention provides a method and a device for label-free detection of biomolecules or analytes in a sample liquid. The method comprises the steps of allowing an analyte to bind to one of at least two conductive surfaces. An alternating electrical field between at least two conductive surfaces. Amplitude and phase of an alternating current, flowing between the at least two conductive surfaces, are compared with amplitude and phase of a reference signal. From the difference between both currents it is possible to determine whether an analyte is present at the conductive surface.

7. 发明公开

EP2583101A1 MULTI EPITOPE ASSAY 有权转让
标题翻译：多表位-TEST
公开(公告)号：EP2583101A1
公开(公告)日：2013-04-24
申请号：EP11729750.7
申请日：2011-06-14
申请人： Koninklijke Philips Electronics N.V.
发明人： SABATTE, Gwenola , PRINS, Menno, W., J. , EVERS, Toon, H. , HARDEMAN, Wilhelmina, M. , ORSEL, Joukje, G.
IPC分类号： G01N33/543
CPC分类号： G01N33/5306 , G01N33/54306 , G01N33/54333
摘要： The present invention is related to a method for detection of a biological target in an affinity assay, the method comprising the steps of providing a biological sample volume containing the biological target, adding a first capturing moiety to the biological sample volume comprising the biological target, wherein the first capturing moiety is adhered to a particle, concentration of the captured biological target into an elution volume that is smaller than the biological sample volume in step a), cleavage of the first capturing moiety or the biological target from the particle and direct or indirect detection and/or quantification of the biological target in a sandwich or competitive affinity assay format, wherein the biological target is associated with at least one capturing moiety, preferably at least two capturing moieties.

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