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1. 发明申请

WO2009060401A2 PRINTER DEVICE AND METHOD FOR PRODUCING BIOLOGICAL TEST ARRAYS 审中-公开
标题翻译：打印机设备和生产生物测试阵列的方法
公开(公告)号：WO2009060401A2
公开(公告)日：2009-05-14
申请号：PCT/IB2008/054627
申请日：2008-11-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DIJKSMAN, Johan, F. , PIERIK, Anke , RENSEN, Judith, M. , WISMANS, Antonius, J., J. , VAN DEN BESSELAAR, Leonardus, J., C. , VERNHOUT, Martin, M. , RAAIJMAKERS, Adrianus, T., A., M. , BRUYNINCKX, Michel, J., M.
发明人： DIJKSMAN, Johan, F. , PIERIK, Anke , RENSEN, Judith, M. , WISMANS, Antonius, J., J. , VAN DEN BESSELAAR, Leonardus, J., C. , VERNHOUT, Martin, M. , RAAIJMAKERS, Adrianus, T., A., M. , BRUYNINCKX, Michel, J., M.
IPC分类号： B41J3/00 , B01L3/02 , B01J19/00
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00385 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01L2200/143 , B01L2300/0819 , B01L2400/0439 , B41J3/28
摘要： The invention relates to a printer device for producing biological test arrays by depositing an array of bioactive fluids onto a substrate, the device comprising print heads with nozzles for depositing droplets of the bioactive fluid onto the substrates, positioning means for positioning the print heads relative to the substrates, first detection means for detecting the landing position of a droplet relative to the position of the nozzle from which it originates, second detection means for detecting the position of the substrates, and control means coupled to the detection means and the positioning means. The control means are programmed to compare the position of a substrate and the landing position of the droplets, and adjust the position of the print heads relative to said substrate upon depositing a droplet onto said substrate. The invention further relates to the use of such a device in the production of biological test arrays. The invention also relates to a method for producing a biological test array. The invention moreover relates to a biological test array. The method according to the invention is failure proof, and results in biological test arrays of superior quality.
摘要翻译：本发明涉及一种用于通过将生物活性流体阵列沉积到基底上来产生生物测试阵列的打印机装置，该装置包括具有喷嘴的打印头，用于将生物活性流体的液滴沉积到基底上，用于相对于基板定位打印头的装置，用于检测液滴相对于其所起源的喷嘴位置的着落位置的第一检测装置，用于检测基板位置的第二检测装置，检测装置和定位装置。控制装置被编程以比较衬底的位置和液滴的着落位置，并且在将液滴沉积到所述衬底上时调整打印头相对于所述衬底的位置。本发明还涉及这种装置在生物测试阵列生产中的用途。本发明还涉及生产生物测试阵列的方法。本发明还涉及生物测试阵列。根据本发明的方法是故障证明的，并且导致具有优良质量的生物测试阵列。

2. 发明申请

WO2007042966A2 INKJET DEVICE FOR THE CONTROLLED POSITIONING OF DROPLETS OF A SUBSTANCE ONTO A SUBSTRATE, METHOD FOR THE CONTROLLED POSITIONING OF DROPLETS OF A SUBSTANCE, METHOD FOR DETERMINING THE DEGENERATION OF THE SUBSTANCE DURING THE PRINTING PROCESS AND USE OF AN INKJET DEVICE 审中-公开
标题翻译：用于控制定位到基板上的物质的喷墨装置，用于控制定位物质滴液的方法，用于确定印刷过程中物质变质和使用的方法
公开(公告)号：WO2007042966A2
公开(公告)日：2007-04-19
申请号：PCT/IB2006/053602
申请日：2006-10-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PIERIK, Anke , WISMANS, Antonius, J., J. , DE WIJS, Willem-Jan, A. , DIJKSMAN, Johan, F. , VERNHOUT, Martin, M. , RAAIJMAKERS, Adrianus, T., A., M. , VAN DEN BESSELAAR, Leonardus, J., C.
发明人： PIERIK, Anke , WISMANS, Antonius, J., J. , DE WIJS, Willem-Jan, A. , DIJKSMAN, Johan, F. , VERNHOUT, Martin, M. , RAAIJMAKERS, Adrianus, T., A., M. , VAN DEN BESSELAAR, Leonardus, J., C.
IPC分类号： B41J2/05
CPC分类号： B41J2/04586 , B01J19/0046 , B01J2219/00378 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01L3/0268 , B01L2200/143 , B01L2300/0819 , B01L2400/0439 , B41J2/04508 , B41J2/0456 , B41J2/04561 , B41J2/04571 , G01N35/1002 , G01N2035/1041
摘要： The invention provides a device for the controlled positioning of droplets of a substance onto a substrate, the device comprising at least a print head comprising a nozzle provided to eject the droplet, the inkjet device further comprising a control camera arranged such that after ejection of the droplet out of the nozzle, the droplet is detected by the control camera. In case either the droplet volume or velocity or flight path or viscosity or surface tension start to deviate from preset values, the software can correct for this in a closed loop manner. If the droplet is not ejected at all, the control software stops the printer and an operator can maintain the print head.
摘要翻译：本发明提供了一种用于将物质液滴受控地定位到基底上的装置，该装置至少包括一个打印头，该打印头包括设置成喷射液滴的喷嘴，该喷墨装置还包括一个控制相机，液滴从喷嘴出来，液滴由控制摄像机检测。如果液滴体积或速度或飞行路径或粘度或表面张力开始偏离预设值，软件可以以闭环方式进行纠正。如果液滴根本不喷出，则控制软件停止打印机，操作者可以保持打印头。

3. 发明申请

WO2007063459A1 INK JET DEVICE AND METHOD FOR PRODUCING A BIOLOGICAL ASSAY SUBSTRATE BY RELEASING A PLURALITY OF SUBSTANCES ONTO THE SUBSTRATE 审中-公开
标题翻译：用于通过将大量物质释放到基底上来生产生物测定基底的墨水喷射装置和方法
公开(公告)号：WO2007063459A1
公开(公告)日：2007-06-07
申请号：PCT/IB2006/054402
申请日：2006-11-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DIJKSMAN, Johan, F. , PIERIK, Anke , WISMANS, Antonius, J., J. , VAN DEN BESSELAAR, Leonardus, J., C. , VERNHOUT, Martin, M. , RAAIJMAKERS, Adrianus, T., A., M. , SCHROEDERS, Richard, J., M. , IMMINK, Albert, H., J. , VERBEEK, Roy, G., F., A.
发明人： DIJKSMAN, Johan, F. , PIERIK, Anke , WISMANS, Antonius, J., J. , VAN DEN BESSELAAR, Leonardus, J., C. , VERNHOUT, Martin, M. , RAAIJMAKERS, Adrianus, T., A., M. , SCHROEDERS, Richard, J., M. , IMMINK, Albert, H., J. , VERBEEK, Roy, G., F., A.
IPC分类号： B01J19/00 , B01L11/00 , B01L3/02
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01L99/00 , B01L2200/14 , B01L2200/143 , B01L2300/0819 , B01L2400/0439 , G01N35/00663 , G01N35/1002 , G01N2035/1006 , G01N2035/1041
摘要： The invention provides an ink jet device (10) for producing a biological assay- substrate by releasing a plurality of substances onto the substrate, the device comprising printing means (20) , detection means (30,32,45,45' ), filling means and cleaning means (120) , and wherein the ink jet device further comprises control means for an automated production such that the production of the biological assay substrate is error tolerant for a multitude of error sources.
摘要翻译：本发明提供了一种用于通过将多种物质释放到基底上来生产生物测定基板的喷墨装置（10），该装置包括印刷装置（20），检测装置（30,32,45,45'），填充物装置和清洁装置（120），并且其中所述喷墨装置还包括用于自动化生产的控制装置，使得所述生物测定基板的生产对于许多误差源是错误的。

4. 发明申请

WO2007042964A1 A METHOD AND APPARATUS FOR PRINTING A PATTERN OF DISTINCT DOTS OF DIFFERENT REAGENT FLUIDS USING A PRINTING HEAD COMPRISING A SET OF NOZZLES 审中-公开
标题翻译：使用包含一组喷嘴的印刷头印刷不同试剂流体的图案的方法和装置
公开(公告)号：WO2007042964A1
公开(公告)日：2007-04-19
申请号：PCT/IB2006/053589
申请日：2006-10-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PIERIK, Anke , DIJKSMAN, Johan, F. , VERNHOUT, Martin, M. , RAAIJMAKERS, Adrianus, T., A., M. , VAN DEN BESSELAAR, Leonardus, J., C. , WISMANS, Antonius, J., J. , STAPERT, Hendrik, R.
发明人： PIERIK, Anke , DIJKSMAN, Johan, F. , VERNHOUT, Martin, M. , RAAIJMAKERS, Adrianus, T., A., M. , VAN DEN BESSELAAR, Leonardus, J., C. , WISMANS, Antonius, J., J. , STAPERT, Hendrik, R.
IPC分类号： G01N35/10 , B01J19/00 , B01L3/02
CPC分类号： B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00385 , B01J2219/00527 , B01J2219/00659 , B01J2219/00662 , B01J2219/00691 , B01L3/0268
摘要： Method for printing a pattern of distinct dots of different reagent fluids on a number of substrates (8) , which printed substrates (8) are generally used as chemical assays. The application also relates to an apparatus (1) for use in said method. It improves the printing of these substrates (8) by using a printing apparatus (1) comprising a printing head (10) that contains a set of several nozzles, in combination with a specific sequence of printing from different nozzles. The application leads towards a faster production time, while maintaining the high requirements for printing of substrates that are to be used as chemical assays. The printing apparatus (1) has a controller (15) for coordinating the specific sequence for printing the pattern.
摘要翻译：在多个基板（8）上印刷不同试剂流体的不同点的图案的方法，该印刷基板（8）通常用作化学测定。本申请还涉及用于所述方法的装置（1）。通过使用包括一组包含几个喷嘴的打印头（10）的打印装置（1），结合来自不同喷嘴的特定打印顺序来改进这些基板（8）的印刷。该应用导致更快的生产时间，同时保持对用作化学测定的底物的印刷的高要求。打印装置（1）具有用于协调用于打印图案的特定顺序的控制器（15）。

5. 发明申请

WO2007042967A1 INK JET DEVICE FOR THE CONTROLLED POSITIONING OF DROPLETS OF A SUBSTANCE ONTO A SUBSTRATE, METHOD FOR THE CONTROLLED POSITIONING OF DROPLETS OF A SUBSTANCE, AND USE OF AN INK JET DEVICE 审中-公开
标题翻译：用于控制定位到基板上的物质的喷墨装置，用于控制物质滴定位的方法和使用喷墨装置
公开(公告)号：WO2007042967A1
公开(公告)日：2007-04-19
申请号：PCT/IB2006/053611
申请日：2006-10-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PIERIK, Anke , DIJKSMAN, Johan, F. , VAN DAM, Dirkjan, B. , WISMANS, Antonius, J., J.
发明人： PIERIK, Anke , DIJKSMAN, Johan, F. , VAN DAM, Dirkjan, B. , WISMANS, Antonius, J., J.
IPC分类号： B01J19/00 , G01N35/10 , B01L3/02 , B41J2/125
CPC分类号： B41J2/125 , B01J19/0046 , B01J2219/00364 , B01J2219/00378 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00689 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01L3/0268 , B01L2200/143 , G01N35/1002 , G01N35/1065 , G01N2035/1041
摘要： The invention provides an ink jet device for the controlled positioning of droplets of a substance onto a substrate, the device comprising at least a print head with a nozzle designed to eject the droplet, the device further comprising at least one acoustic sensor arranged for detecting the landing of the droplet on the substrate. A feedback loop stops the printing process the moment the landing of a droplet is not detected within a predetermined delay time.
摘要翻译：本发明提供了一种用于将物质液滴受控定位到基底上的喷墨装置，该装置至少包括具有设计成喷射液滴的喷嘴的打印头，该装置还包括至少一个声传感器，液滴在基片上着落。在预定的延迟时间内没有检测到液滴着陆的时刻，反馈回路停止打印过程。

6. 发明申请

WO2007042972A2 METHOD OF PRINTING A PATTERN OF DISTINCT DOTS OF DIFFERENT REAGENT FLUIDS ON A POROUS SUBSTRATE USING A PRESSURE DROP, POROUS SUBSTRATE PRINTED WITH DISTINCT DOTS HAVING AN ENHANCED DEPTH OF PENETRATION, AND APPARATUS FOR THE PRINTING METHOD 审中-公开
标题翻译：使用压力下降法打印多孔试剂流体在多孔基材上的分离方法的方法，用具有增强的渗透深度的不同方式印刷的多孔基材和印刷方法的装置
公开(公告)号：WO2007042972A2
公开(公告)日：2007-04-19
申请号：PCT/IB2006/053641
申请日：2006-10-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PIERIK, Anke , DIJKSMAN, Johan, F. , DE WIJS, Willem-Jan, A. , WISMANS, Antonius, J., J.
发明人： PIERIK, Anke , DIJKSMAN, Johan, F. , DE WIJS, Willem-Jan, A. , WISMANS, Antonius, J., J.
IPC分类号： B01J19/00 , C12Q1/68
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/0036 , B01J2219/00385 , B01J2219/00414 , B01J2219/00423 , B01J2219/00527 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00641 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00711 , B01J2219/00716 , B01L2300/0819 , B01L2400/0487 , B01L2400/049 , B82Y30/00
摘要： The invention relates to a method of printing a pattern of distinct dots (40, 62) of different reagent fluids (23) on a porous substrate (8) while a pressure drop is applied across the thickness of the substrate from the printing side (36) to the opposite side (34). The printed porous substrate (8) is used for a chemical assays. The invention also relates to a porous substrate (8) obtainable by said method, wherein the distinct dots (40, 62) of fluid have an enhanced penetration depth. A printing apparatus for carrying out the method according to the invention is also included in the invention. The invention leads to a reduction in the loss of reagent fluid in the printing process and an enhancement of the sensitivity of the substrate.
摘要翻译：本发明涉及一种在多孔基材（8）上印刷不同试剂流体（23）的不同点（40,62）的图案的方法，同时从印刷侧（36 ）到相对侧（34）。印刷的多孔基材（8）用于化学测定。本发明还涉及通过所述方法可获得的多孔基底（8），其中流体的不同点（40,62）具有增强的穿透深度。用于执行根据本发明的方法的打印设备也包括在本发明中。本发明导致印刷过程中试剂流体损失的减少以及基材敏感性的提高。

7. 发明申请

WO2008072192A2 BIOLOGICAL ASSAY SUBSTRATE AND METHOD AND DEVICE FOR PRODUCING SUCH SUBSTRATE 审中-公开
标题翻译：生物测定底物和生产这种底物的方法和装置
公开(公告)号：WO2008072192A2
公开(公告)日：2008-06-19
申请号：PCT/IB2007/055039
申请日：2007-12-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , IMMINK, Albert, H., J. , DE THEIJE, Femke, K. , DIJKSMAN, Johan, F. , SCHROEDERS, Richard, J., M. , PIERIK, Anke , WISMANS, Antonius, J., J.
发明人： IMMINK, Albert, H., J. , DE THEIJE, Femke, K. , DIJKSMAN, Johan, F. , SCHROEDERS, Richard, J., M. , PIERIK, Anke , WISMANS, Antonius, J., J.
IPC分类号： G01N33/543 , C12Q1/68 , G01N27/00
CPC分类号： G01N27/3275
摘要： The invention provides a biological assay substrate suitable for detecting at least one analyte in at least one sample fluid. The substrate comprises one or more capture probes able to each specifically bind at least one target analyte, and further comprises verification means which can detect the state of at least part of the capture probes. The invention also relates to a method and device for producing the biological assay substrate, and to a method for examining analyte fluids using the substrate.
摘要翻译：本发明提供适于检测至少一种样品流体中的至少一种分析物的生物测定基底。所述底物包含一种或多种捕获探针，所述捕获探针能够各自特异性结合至少一种目标分析物，并且还包含能够检测至少部分捕获探针的状态的验证装置。本发明还涉及生产生物测定底物的方法和装置，以及使用该底物检查分析物流体的方法。

8. 发明申请

WO2008065602A1 PULSATING COOLING SYSTEM 审中-公开
标题翻译：脉冲冷却系统
公开(公告)号：WO2008065602A1
公开(公告)日：2008-06-05
申请号：PCT/IB2007/054796
申请日：2007-11-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , AARTS, Ronaldus, M. , NIEUWENDIJK, Joris, A., M. , WISMANS, Antonius, J., J.
发明人： AARTS, Ronaldus, M. , NIEUWENDIJK, Joris, A., M. , WISMANS, Antonius, J., J.
IPC分类号： H01L23/467 , H01L23/473
CPC分类号： H01L23/467 , H01L23/4735 , H01L2924/0002 , H01L2924/3011 , H01L2924/00
摘要： A cooling device comprising at least one transducer (1) having a membrane adapted to generate pressure waves at a working frequency, characterized by a first and a second cavity (3, 4), said transducer being arranged between said first and second cavities, such that said membrane forms an fluid tight seal between said cavities, each cavity having at least one opening (7, 8) adapted to emit a pulsating net output fluid flow, wherein said cavities and openings are formed such that, at said working frequency, a first harmonic fluid flow emitted by said opening(s) (7) of a first one of said cavities is in anti-phase with a second harmonic fluid flow emitted by said opening(s) (8) of a second one of said cavities, so that a sum of harmonic fluid flow from said openings is essentially zero. With this design, sound reproduction at the working frequency is largely cancelled due to the counter phase of the outlets resulting in a close to zero far-field volume velocity.
摘要翻译：一种冷却装置，包括至少一个换能器（1），其具有适于产生工作频率的压力波的膜，其特征在于第一和第二腔（3,4），所述换能器布置在所述第一和第二腔之间，所述膜在所述空腔之间形成流体密封的密封，每个空腔具有适于发射脉动净输出流体流的至少一个开口（7,8），其中所述空腔和开口形成为使得在所述工作频率下，由所述空腔中的第一个的所述开口（7）发射的一次谐波流体流与由所述空腔中的第二个的所述开口（8）发射的二次谐波流体流反相，使得来自所述开口的谐波流体的总和基本为零。通过这种设计，由于出口的相对相位导致接近于零的远场体积速度，工作频率下的声音再现被大大地消除。

9. 发明公开

EP1934050A2 INKJET DEVICE FOR THE CONTROLLED POSITIONING OF DROPLETS OF A SUBSTANCE ONTO A SUBSTRATE, METHOD FOR THE CONTROLLED POSITIONING OF DROPLETS OF A SUBSTANCE, METHOD FOR DETERMINING THE DEGENERATION OF THE SUBSTANCE DURING THE PRINTING PROCESS AND USE OF AN INKJET DEVICE 有权转让
标题翻译：喷墨设备和方法上的衬底SUBSTANTZ的受控熔滴的定位。
公开(公告)号：EP1934050A2
公开(公告)日：2008-06-25
申请号：EP06809477.0
申请日：2006-10-03
申请人： Koninklijke Philips Electronics N.V.
发明人： PIERIK, Anke , WISMANS, Antonius, J., J. , DE WIJS, Willem-Jan, A. , DIJKSMAN, Johan, F. , VERNHOUT, Martin, M. , RAAIJMAKERS, Adrianus, T., A., M. , VAN DEN BESSELAAR, Leonardus, J., C.
IPC分类号： B41J2/05
CPC分类号： B41J2/04586 , B01J19/0046 , B01J2219/00378 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01L3/0268 , B01L2200/143 , B01L2300/0819 , B01L2400/0439 , B41J2/04508 , B41J2/0456 , B41J2/04561 , B41J2/04571 , G01N35/1002 , G01N2035/1041
摘要： An inkjet device for controlled positioning of a droplet of a substance onto a substrate includes a print head having a nozzle configured to eject the droplet. A camera is configured to detect and generate images of the droplet after ejection of the droplet from the nozzle. If the droplet volume, velocity, flight path, viscosity or surface tension start to deviate from preset values, a computer is configured to correct for this in a closed loop manner. If the droplet fails to eject, the computer is configured to stop the inkjet device and an operator can maintain the print head. The computer is configured to determine viscosity and surface tension of the droplet from characteristics of the droplet identified from the droplet images, and the computer is configured to control the positioning of the droplet onto the substrate during the printing process based on the determined viscosity and surface tension.

10. 发明公开

EP1933974A1 INK JET DEVICE FOR THE CONTROLLED POSITIONING OF DROPLETS OF A SUBSTANCE ONTO A SUBSTRATE, METHOD FOR THE CONTROLLED POSITIONING OF DROPLETS OF A SUBSTANCE, AND USE OF AN INK JET DEVICE 审中-公开
标题翻译：用于物质控制定位喷墨设备滴在基板上，方法降的控制定位的物质和喷墨设备的使用
公开(公告)号：EP1933974A1
公开(公告)日：2008-06-25
申请号：EP06809483.8
申请日：2006-10-03
申请人： Koninklijke Philips Electronics N.V.
发明人： PIERIK, Anke , DIJKSMAN, Johan, F. , VAN DAM, Dirkjan, B. , WISMANS, Antonius, J., J.
IPC分类号： B01J19/00 , G01N35/10 , B01L3/02 , B41J2/125
CPC分类号： B41J2/125 , B01J19/0046 , B01J2219/00364 , B01J2219/00378 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00689 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01L3/0268 , B01L2200/143 , G01N35/1002 , G01N35/1065 , G01N2035/1041
摘要： The invention provides an ink jet device for the controlled positioning of droplets of a substance onto a substrate, the device comprising at least a print head with a nozzle designed to eject the droplet, the device further comprising at least one acoustic sensor arranged for detecting the landing of the droplet on the substrate. A feedback loop stops the printing process the moment the landing of a droplet is not detected within a predetermined delay time.

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