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1. 发明申请

WO2008062354A1 A SYSTEM, DEVICE, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR IN VIVO IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：系统，装置，方法，计算机可读介质和用于在解剖结构中进行组织成像的用途
公开(公告)号：WO2008062354A1
公开(公告)日：2008-05-29
申请号：PCT/IB2007/054674
申请日：2007-11-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , VAN DEN HAM, Rene , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
发明人： BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , VAN DEN HAM, Rene , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00 , A61B8/12
CPC分类号： A61B5/0095 , A61B5/0035 , A61B5/0084 , A61B5/0086 , A61B8/12 , A61B8/4416
摘要： A system is provided that may be used for locating and diagnosing lesions in the human body in vivo. In some embodiments, once the exact position of a lesion is found, a biopsy may be taken from the lesion using e.g. ultra sound techniques for guidance of the biopsy needle. Use of the system drastically reduces the negative biopsy samples compared to currently used "blind sampling" techniques. This reduces patient discomfort and minimizes infections as the number of biopsy samples is reduced. A method and computer- readable medium is also provided.
摘要翻译：提供了可用于在体内定位和诊断人体损伤的系统。在一些实施例中，一旦发现病变的确切位置，可以使用例如病变从病变中取出活组织检查。超声技术用于指导活检针。与目前使用的“盲采”技术相比，使用该系统大大减少了活检样本的阴性。这减少了患者的不适，并使活检样本的数量减少了感染的最小程度。还提供了一种方法和计算机可读介质。

2. 发明申请

WO2009081321A1 RECEIVING PORTION FOR RECEIVING A TURBID MEDIUM, SAID PORTION COMPRISING A LINER 审中-公开
标题翻译：用于接收涡轮机介质的接收部分，包含衬套的部分
公开(公告)号：WO2009081321A1
公开(公告)日：2009-07-02
申请号：PCT/IB2008/055288
申请日：2008-12-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ENTREKIN, Robert, R. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , BAKKER, Levinus, P.
发明人： ENTREKIN, Robert, R. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , BAKKER, Levinus, P.
IPC分类号： A61B5/00 , A61B8/08 , G01N21/47
CPC分类号： A61B5/4312 , A61B5/0035 , A61B5/0091 , A61B8/0825 , A61B8/4281 , A61B8/5238 , G01N21/4795 , G01N29/032 , G01N29/222 , G01N2291/02475 , G01N2291/044 , G01N2291/106
摘要： A receiving portion (2) for receiving a turbid medium (1) during examination in a device for imaging the interior of turbid media is provided. The receiving portion (2) encloses a receiving volume in which the turbid medium (1) is placed for examination. The receiving volume has a boundary formed by an inner surface facing the turbid medium. The inner surface is lined with an acoustically absorbing material (7) which is optically translucent for light having a wavelength in the range from 400 nm to 1400 nm, or at least between 650 nm and 950 nm.
摘要翻译：提供了一种用于在用于对混浊介质内部成像的设备中的检查期间接收混浊介质（1）的接收部分（2）。接收部分（2）包围其中放置混浊介质（1）以供检查的接收容积。接收体积具有由面向混浊介质的内表面形成的边界。内表面衬有吸声材料（7），其对于波长在400nm至1400nm，或至少在650nm与950nm之间的光是光学半透明的。

3. 发明申请

WO2008146198A3 DEVICE FOR IMAGING AN INTERIOR OF AN OPTICALLY TURBID MEDIUM USING DIFFUSE OPTICAL TOMOGRAPHY AND ULTRASOUND 审中-公开
公开(公告)号：WO2008146198A3
公开(公告)日：2008-12-04
申请号：PCT/IB2008/051992
申请日：2008-05-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , HARBERS, Rik , SUIJVER, Jan, F.
发明人： BAKKER, Levinus, P. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , HARBERS, Rik , SUIJVER, Jan, F.
IPC分类号： A61B5/00 , A61B8/08
摘要： The invention relates to a device for imaging the interior of a volume of an object using diffuse optical tomography and ultrasound. According to the invention a volume in which the object is accommodated and into which optical and ultrasound signals are sent is bound by a wall structure comprising entrance and exit positions for both the optical and ultrasound signals. In this way, the object can be positioned relative to the wall structure resulting in a well-defined measurement geometry. The invention improves the comparability of scans of an object that have been made at different points in time as the positioning of the object in a first scan can be precisely reproduced in a further scan relative to the wall structure.

4. 发明申请

WO2008146195A2 DEVICE FOR IMAGING AN INTERIOR OF AN OPTICALLY TURBID MEDIUM USING DIFFUSE OPTICAL TOMOGRAPHY AND ULTRASOUND 审中-公开
标题翻译：用于成像使用DIFFUSE OPTICAL TOMOGRAPHY和ULTRASOUND的光学涡卷介质内部的装置
公开(公告)号：WO2008146195A2
公开(公告)日：2008-12-04
申请号：PCT/IB2008/051958
申请日：2008-05-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ENTREKIN, Robert, R. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , BAKKER, Levinus, P. , COMPEN, Hendrikus, A., C., M. , DEHN, Frank , VAN DER VAART, Nijs, C. , DECKERS, Jacobus, A., J., M. , SUIJVER, Jan, F.
发明人： ENTREKIN, Robert, R. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , BAKKER, Levinus, P. , COMPEN, Hendrikus, A., C., M. , DEHN, Frank , VAN DER VAART, Nijs, C. , DECKERS, Jacobus, A., J., M. , SUIJVER, Jan, F.
IPC分类号： A61B5/00 , A61B8/08
CPC分类号： A61B5/4312 , A61B5/0073 , A61B5/0091 , A61B8/0825 , A61B8/5238
摘要： The invention relates to a device for imaging the interior of a volume of an object using diffuse optical tomography and ultrasound. According to the invention a volume in which the object is accommodated and into which optical and ultrasound signals are sent is bound by a wall structure comprising entrance and exit positions for both the optical and ultrasound signals. In this way, the object can be positioned relative to the wall structure resulting in a well-defined measurement geometry. The invention improves the comparability of scans of an object that have been made at different points in time as the positioning of the object in a first scan can be precisely reproduced in a further scan relative to the wall structure.
摘要翻译：本发明涉及一种使用漫射光学层析成像和超声波成像物体体积内部的装置。根据本发明，其中容纳物体并且发送光学和超声信号的体积被包括光学和超声信号两者的入射和出射位置的壁结构所约束。以这种方式，物体可以相对于壁结构定位，从而产生明确的测量几何形状。本发明改进了在不同时间点进行的物体的扫描的可比性，因为可以在相对于墙壁结构的进一步扫描中精确地再现第一扫描中的物体的定位。

5. 发明申请

WO2008059437A2 DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：用于成像涡轮介质内部的装置
公开(公告)号：WO2008059437A2
公开(公告)日：2008-05-22
申请号：PCT/IB2007/054601
申请日：2007-11-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
发明人： BAKKER, Levinus, P. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (55) comprising a receptacle (20) with the receptacle (20) comprising a measurement volume (15) for receiving the turbid medium (55). The device (1) is adapted such that the inner surface of the receptacle (20), including at least part of the optical channels (70) is covered with a layer (80).
摘要翻译：本发明涉及一种用于对包括容器（20）的混浊介质（55）的内部进行成像的设备（1），容器（20）包括用于容纳混浊介质（55）。该装置（1）适于使得包括光学通道（70）的至少一部分的容器（20）的内表面覆盖有层（80）。

6. 发明申请

WO2009060370A3 METHOD AND DEVICE FOR IMAGING AN INTERIOR OF AN OPTICALLY TURBID MEDIUM 审中-公开
公开(公告)号：WO2009060370A3
公开(公告)日：2009-05-14
申请号：PCT/IB2008/054559
申请日：2008-11-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B.
发明人： BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B.
IPC分类号： A61B5/00 , G01N21/64
摘要： The invention relates to a method and a device (30, 125) for imaging an interior of an optically turbid medium (40). Light from a light source (35) is coupled into the turbid medium (40). Detection light emanating from the turbid medium (40) as a result of coupling (5) light from the light source (35) into the turbid medium (40) is collected. A first characteristic and a second characteristic of collected detection light are measured simultaneously. Next, the ratio of a first linear combination of the measured characteristics and a second linear combination of the measured characteristics is taken based on the recognition that the noise in both linear combinations is correlated.

7. 发明申请

WO2007060602A2 A METHOD AND DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：一种用于成像涡轮介质内部的方法和装置
公开(公告)号：WO2007060602A2
公开(公告)日：2007-05-31
申请号：PCT/IB2006/054349
申请日：2006-11-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , 'T HOOFT, Gert , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
发明人： BAKKER, Levinus, P. , 'T HOOFT, Gert , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091
摘要： The invention relates to a method and device (1) for imaging an interior of a turbid medium (55). A turbid medium (55) inside a measurement volume (15) is irradiated from a plurality of source positions (25a) with light from a light source (5), and light emanating from the measurement volume (15) is detected from a plurality of detection positions (25b). An image of the interior of the turbid medium (55) is reconstructed from the detected light. In both the method and the device (1), detector signals can be amplified for each source position-detection position pair by a multi-gain amplification unit comprising an amplifier circuit (60). The amplification factor is selected from a number of possible amplification factors based on detected signal strength in the prior art. According to the invention, however, the method and device are adapted such that the amplification factor is selected for at least one source position-detection position pair on the basis of an estimate of expected electrical signal strength.
摘要翻译：本发明涉及一种用于对混浊介质（55）的内部进行成像的方法和设备（1）。利用来自光源（5）的光从多个源位置（25a）照射测量体积（15）内的混浊介质（55），并且从多个测量体积（15）中检测从测量体积（15）发出的光检测位置（25b）。从检测到的光重建混浊介质（55）的内部的图像。在该方法和装置（1）中，可以通过包括放大器电路（60）的多增益放大单元为每个源位置检测位置对放大检测器信号。基于现有技术中的检测信号强度，从许多可能的放大因子中选择放大因子。然而，根据本发明，该方法和装置被调整为使得基于预期电信号强度的估计为至少一个源位置检测位置对选择放大因子。

8. 发明申请

WO2007060571A1 A DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：用于形成涡轮介质内部的装置
公开(公告)号：WO2007060571A1
公开(公告)日：2007-05-31
申请号：PCT/IB2006/054226
申请日：2006-11-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B.
发明人： BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B.
IPC分类号： A61B5/00 , G01N21/64
CPC分类号： G01N21/4795 , A61B5/0091 , G01N21/6456 , G01N2021/1787 , G01N2021/6421
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (25). The device (1) may be used to accommodate a turbid medium (25) inside a measurement volume (20) and irradiate the turbid medium (25) with light from a light source (5), after which light emanating from the measurement volume (20) is detected and used to determine an image of the interior of the turbid medium (25). The device (1) is adapted such that additional means are introduced for irradiating the turbid medium (25) with light causing fluorescent emission in a contrast agent present in the turbid medium (25), for detecting the fluorescent emission in at least two spectral regions, and for calculating an image reconstruction for the at least two spectral regions detected. By detecting the fluorescent emission spectroscopically, that is as a function of wavelength, information can be obtained from which the concentration of a predetermined component present inside the turbid medium can be determined.
摘要翻译：本发明涉及一种用于对浑浊介质（25）的内部进行成像的装置（1）。装置（1）可用于容纳测量体积（20）内部的混浊介质（25），并用来自光源（5）的光照射混浊介质（25），之后从测量体积 20）被检测并用于确定混浊介质（25）的内部的图像。装置（1）适于使得附加装置被引入以用在浑浊介质（25）中存在的造影剂中引起荧光发射的光照射混浊介质，以检测至少两个光谱区域中的荧光发射并且用于计算所检测的至少两个光谱区域的图像重建。通过检测荧光发射光谱，即作为波长的函数，可以获得可以确定存在于混浊介质内的预定成分的浓度的信息。

9. 发明申请

WO2009019653A3 IMAGING SYSTEM COMPRISING AN OPTICAL TWO-WAY SWITCH 审中-公开
公开(公告)号：WO2009019653A3
公开(公告)日：2009-02-12
申请号：PCT/IB2008/053143
申请日：2008-08-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DER VOORT, Marjolein
发明人： VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DER VOORT, Marjolein
IPC分类号： G02B6/35 , A61B5/00
摘要： The invention relates to an optical imaging method for imaging an object comprising the following steps: - coupling light from a light source to an illumination position for illuminating the object, with the illumination position being selected from a plurality of illumination positions for illuminating the object using an optical switch, with the optical switch being optically coupled to the light source and to the plurality of illumination positions; - collecting light emanating from the object at least one collection position, with the light emanating from the object as a result of coupling light from the light source to the selected illumination position for illuminating the object. According to the invention the method is amended in that the method further comprises the following step: - coupling light collected at a collection position through the optical switch. The method allows to couple the process of receiving light from the object to be imaged to the process of coupling light from the light source to the object to be imaged. The invention also relates to an optical switch for use in the method.

10. 发明申请

WO2008062346A1 A SYSTEM, METHOD, COMPUTER-READABLE MEDIUM AND USE FOR IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：系统，方法，计算机可读介质和用于在解剖结构中形成组织的用途
公开(公告)号：WO2008062346A1
公开(公告)日：2008-05-29
申请号：PCT/IB2007/054626
申请日：2007-11-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DEN HAM, René , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
发明人： VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DEN HAM, René , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： A61B5/4381 , A61B5/0073 , A61B5/0084 , A61B5/0086 , A61B8/12
摘要： A system for imaging of prostate cancer in a prostate in vivo is provided. The system utilizes Diffuse Optical Tomography (DOT) for creating a 3D image for the detection of suspicious prostate tissue. The DOT image may be used to guide the biopsy, thereby reducing the number of false negatives. A method, computer-readable medium and use are also provided.
摘要翻译：提供了一种用于前列腺体内前列腺癌成像的系统。该系统利用漫射光学层析成像（DOT）创建用于检测可疑前列腺组织的3D图像。 DOT图像可用于指导活组织检查，从而减少假阴性的数量。还提供了一种方法，计算机可读介质和使用。

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