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1. 发明申请

WO2007141700A3 MICROELECTRONIC SENSOR DEVICE FOR DNA DETECTION 审中-公开
公开(公告)号：WO2007141700A3
公开(公告)日：2007-12-13
申请号：PCT/IB2007/051960
申请日：2007-05-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , VOSSENAAR, Erik Robbert , PONJEE, Marc Wilhelmus Gijsbert , STAPERT, Hendrik Roelof , JOHNSON, Mark Thomas
发明人： VOSSENAAR, Erik Robbert , PONJEE, Marc Wilhelmus Gijsbert , STAPERT, Hendrik Roelof , JOHNSON, Mark Thomas
IPC分类号： C12Q1/68 , B01L3/00
摘要： The invention relates to a microelectronic sensor device and a method for the investigation of biological target substances (20), for example oligonucleotides like DNA fragments. In one embodiment, the device comprises a reaction surface (RS) to which target specific reactants (10) are attached and which lies between a sample chamber (SC) and an array of selectively controllable heating elements (HE). The temperature profile in the sample chamber (SC) can be controlled as desired to provide for example conditions for a PCR and/or for a controlled melting of hybridizations. The reactant (10) and/or the target substance (20) comprises a label (12) with an observable property, like fluorescence, that changes if the target substance (20) is bound to the reactant (10), said property being detected by an array of sensor elements, for example photosensors (SE). The fluorescence of the label (12) may preferably be transferred by FRET to a different fluorescent label (22) or quenched if the target substance (20) is bound.

2. 发明申请

WO2008020364A2 BIOCHEMICAL SENSOR DEVICE 审中-公开
标题翻译：生化传感器装置
公开(公告)号：WO2008020364A2
公开(公告)日：2008-02-21
申请号：PCT/IB2007/053116
申请日：2007-08-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , JOHNSON, Mark Thomas , STAPERT, Hendrik Roelof , GILLIES, Murray Fulton , PONJEE, Marc Wilhelmus Gijsbert , WIDDERSHOVEN, Franciscus Petrus
发明人： JOHNSON, Mark Thomas , STAPERT, Hendrik Roelof , GILLIES, Murray Fulton , PONJEE, Marc Wilhelmus Gijsbert , WIDDERSHOVEN, Franciscus Petrus
CPC分类号： G01N33/5438
摘要： The present invention relates to a biological sensor device comprising a biological sensing element and an electrode arrangement, the electrode arrangement comprising an electrode (101) and an electrode structure (103, 105, 107, 109), the electrode structure (103, 105, 107, 109) being arranged around the biological sensing element (201) and around the electrode (101).
摘要翻译：本发明涉及一种包括生物感测元件和电极装置的生物传感器装置，该电极装置包括电极（101）和电极结构（103,105,107,109），电极结构（103,105,109） 107）围绕生物传感元件（201）并围绕电极（101）布置。

3. 发明申请

WO2008010105A2 DEVICE FOR ANALYZING SAMPLES INCLUDING A GAS EVOLVING MEANS 审中-公开
标题翻译：用于分析样品的装置，包括气体发展手段
公开(公告)号：WO2008010105A2
公开(公告)日：2008-01-24
申请号：PCT/IB2007/050808
申请日：2007-03-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , GILLIES, Murray, Fulton , VOSSENAAR, Erik Robbert , JOHNSON, Mark Thomas , STAPERT, Hendrik Roelof , FISH, David Andrew , KURT, Ralph , PENTERMAN, Roel , CATTANEO, Stefano
发明人： GILLIES, Murray, Fulton , VOSSENAAR, Erik Robbert , JOHNSON, Mark Thomas , STAPERT, Hendrik Roelof , FISH, David Andrew , KURT, Ralph , PENTERMAN, Roel , CATTANEO, Stefano
IPC分类号： G01N33/543 , C12Q1/68
CPC分类号： G01N33/54366 , G01N33/54393
摘要： The invention relates to a device for analyzing one or more samples for the presence, amount or identity of one ore more target molecules in the samples, comprising one or more capture sites whereby the device comprises a gas evolving means. The gas evolved by the gas evolving means moves unbound target molecules away from the capture site and therefore helps to increase the efficacy of the analysis.
摘要翻译：本发明涉及一种用于分析一个或多个样品中用于样品中一个或多个靶分子的存在，数量或同一性的装置，其包括一个或多个捕获位点，由此该装置包括气体逸出装置。通过气体放出手段产生的气体将未结合的靶分子移离捕获位点，从而有助于提高分析的功效。

4. 发明申请

WO2007107910A1 MICROELECTRONIC DEVICE WITH FIELD ELECTRODES 审中-公开
标题翻译：具有场电极的微电子器件
公开(公告)号：WO2007107910A1
公开(公告)日：2007-09-27
申请号：PCT/IB2007/050815
申请日：2007-03-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , GILLIES, Murray, Fulton , PONJEE, Marc Wilhelmus Gijsbert , JOHNSON, Mark Thomas
发明人： GILLIES, Murray, Fulton , PONJEE, Marc Wilhelmus Gijsbert , JOHNSON, Mark Thomas
IPC分类号： B01L3/00 , B03C5/00 , G01N27/447
CPC分类号： B01L3/50273 , B01L3/502715 , B01L2200/0647 , B01L2200/147 , B01L2300/0645 , B01L2300/0819 , B01L2300/1822 , B01L2300/1827 , B01L2400/0418 , B01L2400/0421 , B01L2400/0424 , B01L2400/0496 , B03C5/028
摘要： The invention relates to a microelectronic device, particularly a microelectronic biosensor, comprising an array of field electrodes (FE) for generating an alternating electrical field (E) in an adjacent sample chamber (SC). The field electrodes (FE) are coupled to associated local oscillators (OS), which are preferably tunable and connected in a matrix pattern to an external control unit (CU). The local oscillators (OS) allow high frequencies of the generated electrical fields (E), such that for example dielectrophoretic forces can be generated.
摘要翻译：本发明涉及一种微电子器件，特别是微电子生物传感器，其包括用于在相邻样品室（SC）中产生交变电场（E）的场电极（FE）阵列。场电极（FE）耦合到相关联的本地振荡器（OS），其优选地可调谐并以矩阵模式连接到外部控制单元（CU）。本地振荡器（OS）允许产生的电场（E）的高频率，使得例如可以产生介电电泳力。

5. 发明申请

WO2007077498A1 MICROELECTRONIC DEVICE WITH MAGNETIC EXCITATION WIRES 审中-公开
标题翻译：具有磁性激发线的微电子器件
公开(公告)号：WO2007077498A1
公开(公告)日：2007-07-12
申请号：PCT/IB2006/053926
申请日：2006-10-25
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , JOHNSON, Mark Thomas , IMMINK, Albert Hendrik Jan , PONJEE, Marc Wilhelmus Gijsbert , REIJME, Mirielle Ann , KAHLMAN, Josephus Arnoldus Henricus Maria , NIEUWENHUIS, Jeroen Hans , DE BOER, Bart Michiel
发明人： JOHNSON, Mark Thomas , IMMINK, Albert Hendrik Jan , PONJEE, Marc Wilhelmus Gijsbert , REIJME, Mirielle Ann , KAHLMAN, Josephus Arnoldus Henricus Maria , NIEUWENHUIS, Jeroen Hans , DE BOER, Bart Michiel
IPC分类号： G01N15/06 , G01N33/543
CPC分类号： G01N33/54326 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2400/0415 , B01L2400/043 , G01N27/745 , G01N33/5438
摘要： The invention relates to a microelectronic device (200), particularly a magnetic biosensor, comprising B/E-electrodes (21) that can generate a magnetic field (B) in a sample chamber (10). The device further comprises E-electrodes (23, 24) that can generate an electrical field (E) in the sample chamber (10) in cooperation with the B/E-electrodes (21). Thus the B/E-electrodes are used for two purposes. Electrical fields (E) in the sample chamber (10) may particularly be used for pumping and/or mixing of a fluid sample or for a stringency test of particle bindings.
摘要翻译：本发明涉及一种微电子器件（200），特别是包括可在样品室（10）中产生磁场（B））的B / E电极（21）的磁性生物传感器。所述装置还包括可与所述B / E电极（21）配合地在样品室（10）中产生电场（E）的E电极（23,24）。因此，B / E电极用于两个目的。样品室（10）中的电场（E）可特别用于泵送和/或混合流体样品或用于颗粒结合的严格性测试。

6. 发明申请

WO2009031105A2 NON-HOMOGENEOUS MODIFICATION OF LIQUIDS 审中-公开
标题翻译：液体的非均匀改性
公开(公告)号：WO2009031105A2
公开(公告)日：2009-03-12
申请号：PCT/IB2008/053561
申请日：2008-09-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , JOHNSON, Mark Thomas , GILLIES, Murray Fulton , PONJEE, Marc Wilhelmus Gijsbert , BOHMER, Marcel Rene
发明人： JOHNSON, Mark Thomas , GILLIES, Murray Fulton , PONJEE, Marc Wilhelmus Gijsbert , BOHMER, Marcel Rene
IPC分类号： C12Q1/68 , G01N27/49 , B01L3/00
CPC分类号： B03C5/026 , B01L3/502761 , B01L2200/16 , B01L2400/0677 , C12Q1/6806 , C12Q1/6825 , C12Q1/6848 , C12Q2563/155 , C12Q2527/119 , C12Q2523/307
摘要： The present invention relates to the modification of the chemical composition of liquids, and more specifically to methods for the non-homogeneous modification of the composition of liquids. Specifically, the present invention relates to a method for the non-homogeneous modification of the composition of a liquid, the method comprising the steps of providing a primary liquid having a first composition, the primary liquid comprising particles containing a substance; and inducing release of the substance from the particles into the primary liquid; wherein a non-homogeneous modification of the composition of the primary liquid is effected by applying an electrical signal to an electrode in contact with the primary liquid.
摘要翻译：本发明涉及液体化学组成的改变，更具体地涉及液体组成的非均匀改性方法。具体而言，本发明涉及一种用于对液体组合物进行非均匀改性的方法，该方法包括以下步骤：提供具有第一组成的原液，该原液包含含有物质的颗粒; 并诱导物质从颗粒中释放到主液体中; 其中通过将电信号施加到与主液体接触的电极上来实现主液体组成的非均匀改变。

7. 发明申请

WO2007129240A1 DEVICE AND METHOD FOR THE CONTROLLED RELEASE OF A PREDEFINED QUANTITY OF A SUBSTANCE 审中-公开
标题翻译：用于控制释放物质的预定数量的装置和方法
公开(公告)号：WO2007129240A1
公开(公告)日：2007-11-15
申请号：PCT/IB2007/051501
申请日：2007-04-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , BUDZELAAR, Franciscus Paulus Maria , JOHNSON, Mark Thomas , PONJEE, Marc Wilhelmus Gijsbert , KURT, Ralph
发明人： BUDZELAAR, Franciscus Paulus Maria , JOHNSON, Mark Thomas , PONJEE, Marc Wilhelmus Gijsbert , KURT, Ralph
IPC分类号： H01L27/10 , A61K9/00 , A61M5/142 , A61M5/172
CPC分类号： A61K9/0097 , A61M5/14276 , A61M5/172 , A61M2205/0244
摘要： This invention provides a device for the controlled release of a predefined quantity of a substance and a method of controllably releasing a predefined quantity of a substance from a compartment (20). The device comprises a first number of compartments in a substrate (11), each compartment being closed by at least one release mechanism (30). The device further comprises a second number of actuating contacts (40) for the release of the substance from one compartment of the first number of compartments by means of applying an actuation signal between at least a first actuation contact and a second actuation contact of the second number of actuation contacts, wherein the first number exceeds the second number, and each of the actuation contacts comprises at least one conductor path in or on the substrate for.electrically connecting at least one compartment, and the actuation contacts form a mesh-like structure in or on the substrate.
摘要翻译：本发明提供了一种用于控制释放预定量物质的装置以及从隔间（20）可控释放预定量物质的方法。该装置包括在基板（11）中的第一数量的隔室，每个隔室由至少一个释放机构（30）封闭。该装置还包括第二数量的致动触头（40），用于通过在至少第一致动触点和第二触发器的第二触发触点之间施加致动信号来释放物质从第一数量的隔室的一个隔室致动触头的数量，其中第一数量超过第二数量，并且每个致动触头包括在基板中或基板上的至少一个导体路径，用于电连接至少一个隔室，并且致动触头形成网状结构在衬底中或衬底上。

8. 发明申请

WO2007010432A1 SUBSTRATE MATERIAL FOR ANALYZING FLUIDS 审中-公开
标题翻译：用于分析流体的基材
公开(公告)号：WO2007010432A1
公开(公告)日：2007-01-25
申请号：PCT/IB2006/052327
申请日：2006-07-10
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , KURT, Ralph , STAPERT, Hendrik Roelof , JOHNSON, Mark Thomas , BROER, Dirk Jan , PENTERMAN, Roel , PEETERS, Emiel
发明人： KURT, Ralph , STAPERT, Hendrik Roelof , JOHNSON, Mark Thomas , BROER, Dirk Jan , PENTERMAN, Roel , PEETERS, Emiel
IPC分类号： G01N33/543 , G01N33/544 , G01N33/548
CPC分类号： B01L3/5023 , B01L3/5027 , B01L2300/123 , B01L2400/0406 , B01L2400/0481 , G01N33/54366 , G01N33/544 , G01N33/548 , Y10T428/249921
摘要： The invention relates to a substrate material for analyzing fluids which is elastic and allows radial lateral movement of sample within the substrate material upon application of pressure.
摘要翻译：本发明涉及一种用于分析流体的基底材料，该基底材料是弹性的并且在施加压力时允许样品在基底材料内的径向横向移动。

9. 发明申请

WO2012164496A1 AUTOSTEREOSCOPIC DISPLAY DEVICE 审中-公开
标题翻译：自动显示设备
公开(公告)号：WO2012164496A1
公开(公告)日：2012-12-06
申请号：PCT/IB2012/052695
申请日：2012-05-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NEWTON, Philip Steven , JOHNSON, Mark Thomas , KROON, Bart , KRIJN, Marcellinus Petrus Carolus Michael , SEMPEL, Adrianus , DE ZWART, Siebe Tjerk
发明人： NEWTON, Philip Steven , JOHNSON, Mark Thomas , KROON, Bart , KRIJN, Marcellinus Petrus Carolus Michael , SEMPEL, Adrianus , DE ZWART, Siebe Tjerk
IPC分类号： G02B27/22 , H04N13/04
CPC分类号： G02B27/2214 , H04N13/305
摘要： An autostereoscopic display device uses a display arrangement such as an emissive display arrangement or a reflective display arrangement and an autostereoscopic lens arrangement. A light controlling layer is provided between the display arrangement and the lens arrangement, with a refractive index lower than the surrounding materials. This reduces waveguiding in the lens arrangement by increasing the total internal reflection for shallow angles (near the plane of the display) before the light enters the lens arrangement.
摘要翻译：自动立体显示装置使用诸如发光显示装置或反射显示装置和自动立体镜透镜装置之类的显示装置。在显示装置和透镜装置之间提供光控层，其折射率低于周围的材料。通过在光进入透镜装置之前增加用于浅角度（靠近显示器平面）的全内反射，这减少了透镜装置中的波导。

10. 发明申请

WO2012093323A1 A PRESENCE DETECTION SYSTEM AND A LIGHTING SYSTEM. 审中-公开
标题翻译：现状检测系统和照明系统。
公开(公告)号：WO2012093323A1
公开(公告)日：2012-07-12
申请号：PCT/IB2011/056002
申请日：2011-12-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DOOREN, Marieke , JOHNSON, Mark Thomas , CENNINI, Giovanni
发明人： VAN DOOREN, Marieke , JOHNSON, Mark Thomas , CENNINI, Giovanni
IPC分类号： G01S5/16 , G01S17/48
CPC分类号： G01S17/06 , G01S5/16 , G01S17/48
摘要： A presence detection systemfor detecting presence of a living being (2) within an area (4), the systemcomprising a first light source (6a) providing light of a first spectrum, a first sensing means (8a;10a) which is arranged to filter the light of the first spectrum. The first sensing means produces a first presence detection signal (12a) based on the light of the first spectrumoriginated from the first light source and reflected from the living being (2). The presence detection system comprises a processor device (14) for concluding the living being's presence within the area (4) based on the first presence detection signal (12a). The processor device provides a position (22a) of the living being (2) within the area based on the intensityofthe first presence detection signal (12a) and based on the known position of the first light source (6a) within the area (4). The invention further relates to a lighting system comprising the above described presence detection system. Fig.
摘要翻译：一种存在检测系统，用于检测在区域（4）内存在生物（2）的系统，所述系统包括提供第一光谱的光的第一光源（6a），布置成过滤的第一感测装置（8a; 10a）第一光谱的光。第一感测装置基于从第一光源射出的第一光谱并从活体（2）反射的光产生第一存在检测信号（12a）。存在检测系统包括：处理器装置（14），用于基于第一存在检测信号（12a），在区域（4）内总结生存状态。处理器装置基于第一存在检测信号（12a）的强度并且基于区域（4）内的第一光源（6a）的已知位置，在区域内提供居住区域（2）的位置（22a）。本发明还涉及包括上述存在检测系统的照明系统。图。

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