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1. 发明申请

WO2007072415A3 LUMINESCENCE SENSOR OPERATING IN REFLECTION MODE 审中-公开
标题翻译：在反射模式下操作的发光传感器
公开(公告)号：WO2007072415A3
公开(公告)日：2007-10-11
申请号：PCT/IB2006054940
申请日：2006-12-19
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN HERPEN MAARTEN M J W , KLUNDER DERK J W , STAPERT HENDRIK R
发明人： VAN HERPEN MAARTEN M J W , KLUNDER DERK J W , STAPERT HENDRIK R
IPC分类号： G01N21/63
CPC分类号： G01N21/648 , G01N21/6428
摘要： The present invention relates to a luminescence sensor (10), such as a luminescence biosensor or a luminescence chemical sensor, comprising at least one aperture (1) having a first lateral dimension larger than the diffraction limit of excitation radiation (3) in a medium the at least one aperture (1) is filled with and a second lateral dimension below the diffraction limit of excitation radiation (3) in a medium the at least one aperture (1) is filled with. The invention furthermore relates to a method for the detection of luminescence radiation (5), e.g. fluorescence radiation, generated by at least one optically variable molecule (2), e.g. fluorophore, in the at least one aperture (1). The excitation radiation (3) is preferably polarised to suppress the excitation radiation (3) in the apertures (1). The luminescence sensor (10) according to the present invention is able to detect relatively low concentrations of optically variable molecules (2), e.g. fluorophores.
摘要翻译：本发明涉及一种发光传感器（10），例如发光生物传感器或发光化学传感器，其包括至少一个孔（1），其具有比介质中的激发辐射（3）的衍射极限大的第一横向尺寸所述至少一个孔（1）在所述至少一个孔（1）填充的介质中填充有低于激发辐射（3）的衍射极限的第二横向尺寸。本发明还涉及用于检测发光辐射（5）的方法，例如，由至少一个光学可变分子（2）产生的荧光辐射，例如。在所述至少一个孔（1）中的荧光团。激发辐射（3）优选地被极化以抑制孔（1）中的激发辐射（3）。根据本发明的发光传感器（10）能够检测相对低浓度的光学可变分子（2），例如，荧光团。

2. 发明申请

WO2007063457A3 BIO CHIP DEVICE WITH A SAMPLE COMPARTMENT AND A LIGHT SENSITIVE ELEMENT, METHOD FOR THE DETECTION OF FLUORESCENT PARTICLES WITHIN AT LEAST ONE SAMPLE COMPARTMENT OF A BIO CHIP DEVICE 审中-公开
标题翻译：具有样品瓶的生物芯片装置和光敏元件，用于在最小的一个生物芯片装置的一个样品瓶中检测荧光颗粒的方法
公开(公告)号：WO2007063457A3
公开(公告)日：2007-11-01
申请号：PCT/IB2006054397
申请日：2006-11-23
申请人： KONINKL PHILIPS ELECTRONICS NV , PONJEE MARC W G , JOHNSON MARK T , BALISTRERI MARCELLO L M , VAN HERPEN MAARTEN M J W , KLUNDER DERK J W
发明人： PONJEE MARC W G , JOHNSON MARK T , BALISTRERI MARCELLO L M , VAN HERPEN MAARTEN M J W , KLUNDER DERK J W
IPC分类号： G01N21/64 , G01N21/25
CPC分类号： G01N21/6454
摘要： The invention provides a bio chip device comprising at least one sample compartment and at least one light sensitive element, the at least one sample compartment being provided on a first side of the at least one light sensitive element, wherein incident light is provided incident from a second side opposite of the first side of the at least one light sensitive element. Further, the invention provides a method for the detection of fluorescent particles within at least one sample compartment of a bio chip device.
摘要翻译：本发明提供一种包括至少一个样品室和至少一个光敏元件的生物芯片装置，所述至少一个样品室设置在所述至少一个光敏元件的第一侧上，其中入射光从第二侧与所述至少一个光敏元件的第一侧相对。此外，本发明提供了一种用于检测生物芯片器件的至少一个样品室内的荧光颗粒的方法。

3. 发明申请

WO2007072418A3 INCREASING ENERGY DENSITY IN SUB-WAVELENGTH WIRE-GRIDS 审中-公开
标题翻译：在亚波长电网中增加能量密度
公开(公告)号：WO2007072418A3
公开(公告)日：2007-10-11
申请号：PCT/IB2006054943
申请日：2006-12-19
申请人： KONINKL PHILIPS ELECTRONICS NV , KLUNDER DERK J W , VAN HERPEN MAARTEN M J W
发明人： KLUNDER DERK J W , VAN HERPEN MAARTEN M J W
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , B82Y15/00 , G01N21/05 , G01N21/21 , G01N21/6428 , G01N21/6452 , G01N2021/0346 , G01N2201/0636 , G01N2201/0638 , G02B6/107
摘要： The invention relates to wire-grid luminescence sensors and to a design and a method for increasing the energy density in the sub-wavelength slits or nano cavities of the wire-grid. By providing a first reflector or mirror on the back or output side of the and by using TM polarized excitation light, each slit form a small optical resonator with an increased energy density. By providing a second reflector at the front or input side, the energy density can be even further increased. The increased energy density in the slits leads to increased useful excitation volume and binding area.
摘要翻译：本发明涉及线栅发光传感器以及用于增加线栅的亚波长狭缝或纳米腔中的能量密度的设计和方法。通过在背面或输出侧提供第一反射镜或反射镜，并且通过使用TM偏振激发光，每个狭缝形成具有增加的能量密度的小型光学谐振器。通过在前侧或输入侧设置第二反射器，能量密度可进一步提高。狭缝中增加的能量密度导致有用的激发体积和结合面积增加。

4. 发明申请

WO2007010428A3 LUMINESCENCE SENSOR USING MULTI-LAYER SUBSTRATE STRUCTURE 审中-公开
标题翻译：使用多层基板结构的发光传感器
公开(公告)号：WO2007010428A3
公开(公告)日：2007-04-05
申请号：PCT/IB2006052300
申请日：2006-07-07
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN HERPEN MAARTEN M J W , KLUNDER DERK J W
发明人： VAN HERPEN MAARTEN M J W , KLUNDER DERK J W
IPC分类号： G01J1/58 , G01N21/76 , G01N33/58
CPC分类号： G01N21/76 , G01N21/648 , G01N33/54306 , G01N33/582
摘要： The present invention provides a luminescence sensor (2), such as e.g. a luminescence biosensor, comprising a multi-layer structure. The multi-layer structure comprises at least a first layer (2a) formed of a first material and a second layer (2b) formed of a second material. The first material has a first binding capacity towards luminophores and the second material has a second binding capacity towards luminophores, the first the first binding capacity being different from the second binding capacity. The luminescence sensor (2) according to the present invention shows a high sensitivity because it provides preferred binding sites for luminophores at locations where the combined excitation and detection efficiency is the highest.
摘要翻译：本发明提供一种发光传感器（2），例如，发光生物传感器，包括多层结构。多层结构至少包括由第一材料形成的第一层（2a）和由第二材料形成的第二层（2b）。第一材料具有朝向发光体的第一结合能力，第二材料具有朝向发光体的第二结合能力，第一材料具有与第二结合能力不同的第一结合能力。根据本发明的发光传感器（2）显示出高灵敏度，因为它在组合的激发和检测效率最高的位置处为发光体提供优选的结合位点。

5. 发明申请

WO2008041190A3 METHODS AND SYSTEMS FOR DETECTION WITH FRONT IRRADIATION 审中-公开
标题翻译：用于检测前辐照的方法和系统
公开(公告)号：WO2008041190A3
公开(公告)日：2008-07-03
申请号：PCT/IB2007054022
申请日：2007-10-03
申请人： KONINKL PHILIPS ELECTRONICS NV , JOHNSON MARK T , PONJEE MARC W G , BALISTRERI MARCELLO L M , VAN HERPEN MAARTEN M J W , KLUNDER DERK J W
发明人： JOHNSON MARK T , PONJEE MARC W G , BALISTRERI MARCELLO L M , VAN HERPEN MAARTEN M J W , KLUNDER DERK J W
IPC分类号： G01N21/64 , B01L3/00
CPC分类号： G01N21/6428 , B01L3/5027 , G01N21/6454
摘要： A radiation detection system (100) is described comprising a measurement region (104) in a measurement chamber adapted for receiving at least one sample (108) to be examined and adapted for receiving excitation radiation for impingement on the at least one sample (108) and for generating sample radiation. The radiation detection system (100) furthermore comprises at least one detector element (106) for detection of the generated sample radiation. The radiation detection system thereby is a front irradiation system, i.e. the excitation radiation is incident on a first side of the measurement region (104) in a measurement chamber and the at least one detector element (106) is positioned at a second side of the measurement region (104) in a measurement chamber, the second side being opposite to the first side with respect to the measurement region (104) in a measurement chamber, such that detection occurs at the side facing the first side. The detection system (100) also comprises optical means (112) adapted for guiding said excitation radiation aside the at least one detector element (106).
摘要翻译：描述了包括测量室中的测量区域（104）的辐射检测系统（100），所述测量室适于接收待检查的至少一个样本（108）并且适于接收用于撞击所述至少一个样本（108）的激发辐射，并用于产生样品辐射。辐射探测系统（100）还包括用于探测所产生的样本辐射的至少一个探测器元件（106）。由此辐射检测系统是前照射系统，即激发辐射入射到测量室中的测量区域（104）的第一侧上，并且至少一个检测器元件（106）定位在测量室的第二侧测量室中的测量区域（104），第二侧相对于测量室中的测量区域（104）与第一侧相对，使得检测发生在面向第一侧的一侧。检测系统（100）还包括适于将所述激发辐射引导到所述至少一个检测器元件（106）旁边的光学装置（112）。

6. 发明申请

WO2007034395A3 LUMINESCENCE SENSOR COMPRISING AT LEAST TWO WIRE GRIDS 审中-公开
标题翻译：包含最少两根网格的发光体传感器
公开(公告)号：WO2007034395A3
公开(公告)日：2008-10-30
申请号：PCT/IB2006053336
申请日：2006-09-18
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN HERPEN MAARTEN M J W , VAN HOUTEN HENK , KLUNDER DERK J W
发明人： VAN HERPEN MAARTEN M J W , VAN HOUTEN HENK , KLUNDER DERK J W
IPC分类号： G01N21/64 , G02B5/30
CPC分类号： G01N21/6428 , G01N21/6445 , G01N21/648 , G02B5/3058
摘要： The present invention proposes a sub-wavelength luminescence sensor, such as e.g. a luminescence biosensor or a luminescence chemical sensor, comprising at least two wire grids (1, 2) positioned perpendicular with respect to each other. The luminescence sensor, in which the excitation radiation is efficiently used and the luminescence radiation is efficiently detected, has an improved signal-to-noise ratio and a separated excitation and luminescence radiation.
摘要翻译：本发明提出了一种亚波长发光传感器，例如，发光生物传感器或发光化学传感器，其包括相对于彼此垂直定位的至少两个线栅（1,2）。其中有效地利用激发辐射和有效地检测发光辐射的发光传感器具有改善的信噪比和分离的激发和发光辐射。

7. 发明申请

WO2007066255A3 SENSOR WITH IMPROVED SIGNAL-TO-NOISE RATIO AND IMPROVED ACCURACY 审中-公开
标题翻译：传感器具有改善的信噪比和提高的准确性
公开(公告)号：WO2007066255A3
公开(公告)日：2007-09-20
申请号：PCT/IB2006054476
申请日：2006-11-28
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN HERPEN MAARTEN M J W , BALISTRERI MARCELLO L M , KLUNDER DERK J W , LIEDENBAUM COEN T H F
发明人： VAN HERPEN MAARTEN M J W , BALISTRERI MARCELLO L M , KLUNDER DERK J W , LIEDENBAUM COEN T H F
IPC分类号： G01N21/64
CPC分类号： G01N21/6456
摘要： The present invention provides a sensor and a method for detecting an optically variable molecule (9) in a sample (3). The sensor comprises an excitation radiation source (1) for irradiating the sample (4) and exciting the optically variable molecule (9), thus generating a luminescence signal (7). The sensor furthermore comprises a modulation means (4) for modulating the excitation radiation beam (2) in a direction different from, preferably substantially perpendicular to, a scanning direction of the excitation radiation beam (2) over the sample (3). The method and sensor according to the invention lead to an improved signal- to-noise ratio by reducing and even minimising the background signal in the luminescence signal (7) and to an improved accuracy by minimising signals coming from false-positives.
摘要翻译：本发明提供了用于检测样品（3）中的光学可变分子（9）的传感器和方法。该传感器包括用于照射样品（4）并且激励光学可变分子（9）的激发辐射源（1），由此产生发光信号（7）。该传感器还包括调制装置（4），用于在与样品（3）上的激发辐射束（2）的扫描方向不同的方向上，优选基本上垂直于该方向上调制激发辐射束（2）。根据本发明的方法和传感器通过减少并甚至最小化发光信号（7）中的背景信号而导致改进的信噪比，并通过最小化来自假阳性的信号来提高准确度。

8. 发明申请

WO2009016584A3 LIGHT OUTPUT DEVICE 审中-公开
标题翻译：光输出装置
公开(公告)号：WO2009016584A3
公开(公告)日：2009-03-19
申请号：PCT/IB2008053033
申请日：2008-07-29
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN HERPEN MAARTEN M J W
发明人： VAN HERPEN MAARTEN M J W
IPC分类号： F21S8/10 , B32B17/10 , F21K99/00 , H01L25/075
CPC分类号： B32B17/10036 , B32B17/10174 , B32B17/10706 , B32B17/10761 , F21K9/00
摘要： A light output device comprises an at least partly light transmissive substrate arrangement (1, 2) with a plurality of light source arrangements (4) integrated into the structure of the substrate arrangement. At least one of the light source arrangements comprises a casing comprising exactly 2, 3 or 4 discrete semiconductor LED chips. The invention thus provides an embedded multi-chip package/casing in a transparent substrate arrangement. The small number of LEDs per casing gives two possible advantages; one is that a colour output is made possible and the other is that it enables an improvement in efficiency to be obtained but without excessive increase in cost.
摘要翻译：光输出装置包括至少部分透光的衬底布置（1,2），其具有集成到衬底布置的结构中的多个光源装置（4）。光源装置中的至少一个包括精确地2,3或4个分立的半导体LED芯片的壳体。因此，本发明提供了一种在透明衬底布置中的嵌入式多芯片封装/外壳。每个套管的LED数量很少可以有两个优点：一个是可以实现颜色输出，另一个是使得能够获得效率的提高，而不会过度增加成本。

9. 发明申请

WO2009060356A3 LIGHT OUTPUT DEVICE 审中-公开
标题翻译：光输出装置
公开(公告)号：WO2009060356A3
公开(公告)日：2009-07-09
申请号：PCT/IB2008054512
申请日：2008-10-30
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN HERPEN MAARTEN M J W , PENTERMAN ROEL
发明人： VAN HERPEN MAARTEN M J W , PENTERMAN ROEL
IPC分类号： G02F1/01 , F21V14/00
CPC分类号： F21V14/003 , F21Y2105/10 , F21Y2115/10 , G02F1/0126 , G02F1/0147 , G02F2203/03 , H01J61/025 , H01K1/26 , H01K1/28 , H01K1/34 , Y02B20/125
摘要： A light output device comprises at least one light source having a light source output comprising at least a light output, and a switchable member through which the light output is provided, and which is switchable between at least two optical states. These at least two opticalstates provide different levels of uniformity of the light output. The switching of the switchable member is induced by the light source output.
摘要翻译：光输出装置包括至少一个光源，其具有至少包括光输出的光源输出;以及可切换构件，通过该可切换构件提供光输出，并且其可在至少两个光学状态之间切换。这些至少两个光学状态提供了光输出的不同水平的均匀性。可切换构件的切换由光源输出引起。

10. 发明申请

WO2009016561A3 LIGHT OUTPUT DEVICE 审中-公开
标题翻译：光输出装置
公开(公告)号：WO2009016561A3
公开(公告)日：2009-03-26
申请号：PCT/IB2008052986
申请日：2008-07-25
申请人： KONINKL PHILIPS ELECTRONICS NV , VAN HERPEN MAARTEN M J W , BREMER PETRUS J , LIEDENBAUM COEN T H F
发明人： VAN HERPEN MAARTEN M J W , BREMER PETRUS J , LIEDENBAUM COEN T H F
IPC分类号： G09G3/32 , B32B17/10 , G09F9/33 , H05B33/08
CPC分类号： G09G3/32 , B32B17/10036 , B32B17/10174 , B32B17/10706 , B32B17/10761 , F21K9/00 , G09G3/2014 , G09G2300/0426 , G09G2300/08 , H05B33/0824
摘要： A light output device comprises a substrate arrangement comprising a plurality of light source circuits integrated into the structure of the substrate arrangement. Each light source circuit comprises a light source device arrangement (4) having two terminals and a transistor circuit (7). Each light source circuit is supplied with power from an associated pair the power connections (10,11,14,15,20), and at least two light source circuits (4,7) share the same pair of power connections. A set of control connections (18) are provided for receiving external control signals for controlling the transistor circuits (7). A set of non-overlapping electrodes (10,11,14,15,18,20) provide the internal connections between the power connections, the light source device terminals and the transistor circuits, and each light source device is individually independently controllable.
摘要翻译：光输出装置包括基板装置，该基板装置包括集成到基板布置的结构中的多个光源电路。每个光源电路包括具有两个端子的光源器件装置（4）和晶体管电路（7）。每个光源电路从相关联的对提供电力，电源连接（10,11,14,15,20）和至少两个光源电路（4,7）共享同一对电源连接。提供一组控制连接（18）用于接收用于控制晶体管电路（7）的外部控制信号。一组不重叠的电极（10,11,14,15,18,20）提供电源连接，光源装置端子和晶体管电路之间的内部连接，并且每个光源装置可独立控制。

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